PA8597301A1 - Derivados de imidazol-4-il-etinil-piridina - Google Patents

Derivados de imidazol-4-il-etinil-piridina

Info

Publication number
PA8597301A1
PA8597301A1 PA20048597301A PA8597301A PA8597301A1 PA 8597301 A1 PA8597301 A1 PA 8597301A1 PA 20048597301 A PA20048597301 A PA 20048597301A PA 8597301 A PA8597301 A PA 8597301A PA 8597301 A1 PA8597301 A1 PA 8597301A1
Authority
PA
Panama
Prior art keywords
imidazol
piridina
derivatives
iletinil
etinil
Prior art date
Application number
PA20048597301A
Other languages
English (en)
Inventor
Eric Vieira
Bernd Buettelmann
Georg Jaeschke
Simona Maria Ceccarelli
Sabine Kolczewski
Richard Hugh Philip Porter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8597301A1 publication Critical patent/PA8597301A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

DERIVADOS DE 4-[1-ARIL-IMIDAZOL-4-ILETINIL] -2-ALQUIL-PIRIDINA Y 1-HETEROARIL-IMIDAZOL-4-ILETINIL]-2-ALQUIL- PRIRIDINA Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS PARA EL TRATAMIENTO O PREVENCION DE TRASTORNOS MEDIADOS COMPLETAMENTE O EN PARTE POR EL RECEPTOR 5 DE GLUTAMATO METOBOTROPICO, POR EJEMPLO PROCESOS DEGERATIVOS AGUDOS, TRAUMATICOS Y CRONICOS DEL SISTEMA NERVIOSO, TAL COMO LA ENFERMEDAD DE ALZERHIMER, DEMENCIA SENIL, ENFERMEDAD DE PARKINSON, COREA DE HUNTINGTON, ESCLEROSIS LATERAL AMIOTROFICA Y ESQUIZOFRENIA Y ANSIEDAD, DEPRESION, DOLOR Y DEPENDENCIA DE FARMACOS.
PA20048597301A 2003-03-10 2004-03-05 Derivados de imidazol-4-il-etinil-piridina PA8597301A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03004952 2003-03-10

Publications (1)

Publication Number Publication Date
PA8597301A1 true PA8597301A1 (es) 2004-09-16

Family

ID=32981724

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20048597301A PA8597301A1 (es) 2003-03-10 2004-03-05 Derivados de imidazol-4-il-etinil-piridina

Country Status (31)

Country Link
US (1) US7153874B2 (es)
EP (1) EP1606277B8 (es)
JP (1) JP4404896B2 (es)
KR (1) KR100742019B1 (es)
CN (1) CN100358889C (es)
AR (1) AR043501A1 (es)
AT (1) ATE395345T1 (es)
AU (1) AU2004220382B2 (es)
BR (1) BRPI0408093A (es)
CA (1) CA2516682C (es)
CL (1) CL2004000449A1 (es)
CO (1) CO5601027A2 (es)
DE (1) DE602004013746D1 (es)
DK (1) DK1606277T3 (es)
ES (1) ES2305739T3 (es)
HK (1) HK1089443A1 (es)
HR (1) HRP20050774A2 (es)
IL (1) IL170129A (es)
MX (1) MXPA05009524A (es)
MY (1) MY135491A (es)
NO (1) NO20054136L (es)
NZ (1) NZ541643A (es)
PA (1) PA8597301A1 (es)
PE (1) PE20041061A1 (es)
PL (1) PL1606277T3 (es)
PT (1) PT1606277E (es)
RU (1) RU2342383C2 (es)
SI (1) SI1606277T1 (es)
TW (1) TWI292318B (es)
WO (1) WO2004080998A1 (es)
ZA (1) ZA200506834B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
US7452909B2 (en) * 2003-09-04 2008-11-18 Hoffman-La Roche Inc. Imidazole derivatives
EP1756086B1 (en) * 2004-06-01 2008-06-04 F.Hoffmann-La Roche Ag Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists
ES2307182T3 (es) 2004-06-01 2008-11-16 F. Hoffmann-La Roche Ag Piridin-4-il-etinil-imidazoles y pirazoles como antagonistas receptores de mglur5.
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
DE102006011574A1 (de) * 2006-03-10 2007-10-31 Grünenthal GmbH Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2008030651A1 (en) * 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
JP5405311B2 (ja) 2006-12-21 2014-02-05 エフ．ホフマン−ラ ロシュ アーゲー ｍＧｌｕＲ５受容体アンタゴニストの多形
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US8334287B2 (en) * 2009-07-17 2012-12-18 Hoffmann-La Roche Inc. Imidazoles
US8586581B2 (en) * 2009-12-17 2013-11-19 Hoffmann-La Roche Inc Ethynyl compounds useful for treatment of CNS disorders
SG194120A1 (en) 2011-04-26 2013-11-29 Hoffmann La Roche Ethynyl derivatives as positive allosteric modulators of the mglur5
UA116023C2 (uk) 2013-07-08 2018-01-25 Ф. Хоффманн-Ля Рош Аг Етинільні похідні як антагоністи метаботропного глутаматного рецептора
EP3400220B1 (en) * 2016-01-05 2021-03-24 Hua Medicine (Shanghai) Ltd. Pyrazole derivatives
KR102628073B1 (ko) 2017-01-10 2024-01-22 바이엘 악티엔게젤샤프트 해충 방제제로서의 헤테로사이클 유도체
CN110382485B (zh) 2017-01-10 2022-05-10 拜耳公司 作为害虫防治剂的杂环烯衍生物
CN114746408A (zh) * 2019-12-02 2022-07-12 豪夫迈·罗氏有限公司 炔基-(杂芳基)-甲酰胺hcn1抑制剂
CN111416154B (zh) * 2020-05-22 2021-08-06 松山湖材料实验室 高电压锂离子电池电解液硅基吡啶添加剂、电解液及其电池
WO2022207479A1 (en) 2021-03-27 2022-10-06 Syngenta Crop Protection Ag Microbiocidal isonicotinic amide derivatives
WO2023089049A2 (en) 2021-11-19 2023-05-25 Syngenta Crop Protection Ag Microbiocidal isonicotinic amide derivatives

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US3303199A (en) 1963-07-15 1967-02-07 Geigy Chem Corp Certain imidazolone derivatives and process for making same
US3341548A (en) 1964-04-29 1967-09-12 Hoffmann La Roche Nitroimidazoles and their preparation
DE2035905A1 (de) 1970-07-20 1972-02-03 Chemische Fabrik Stockhausen & Cie.,4150Krefeld Imidazolverbindungen und deren Herstellungsverfahren
CA1174673A (en) 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
US4711962A (en) 1984-10-18 1987-12-08 Stauffer Chemical Company Process for selective preparation of ratios of isomers formed on N-substitution of asymmetric imidazoles
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
ES2084702T3 (es) 1989-06-30 1996-05-16 Du Pont Imidazoles sustituidos utiles como inhibidores de la angiotensina ii.
TW544448B (en) 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
KR100357650B1 (ko) 1997-08-14 2002-10-25 에프. 호프만-라 로슈 아게 신경계 장애를 치료하기 위한 헤테로사이클릭 비닐에테르
CA2383524C (en) 1999-08-31 2010-09-28 Merck & Co., Inc. Thiazolyl alkynyl compounds and methods of use thereof
CA2430696C (en) 2000-12-04 2009-01-27 F. Hoffmann-La Roche Ag Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists
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Also Published As

Publication number Publication date
SI1606277T1 (sl) 2008-08-31
NZ541643A (en) 2008-03-28
MXPA05009524A (es) 2005-10-18
AR043501A1 (es) 2005-08-03
ES2305739T3 (es) 2008-11-01
CA2516682C (en) 2010-02-02
RU2342383C2 (ru) 2008-12-27
EP1606277A1 (en) 2005-12-21
AU2004220382A1 (en) 2004-09-23
CL2004000449A1 (es) 2005-01-07
EP1606277B8 (en) 2008-10-15
US20040229917A1 (en) 2004-11-18
DE602004013746D1 (de) 2008-06-26
PT1606277E (pt) 2008-07-08
JP4404896B2 (ja) 2010-01-27
AU2004220382B2 (en) 2007-08-02
WO2004080998A1 (en) 2004-09-23
US7153874B2 (en) 2006-12-26
CA2516682A1 (en) 2004-09-23
HRP20050774A2 (en) 2006-09-30
KR20050109074A (ko) 2005-11-17
RU2005131165A (ru) 2007-04-20
MY135491A (en) 2008-04-30
EP1606277B1 (en) 2008-05-14
ATE395345T1 (de) 2008-05-15
BRPI0408093A (pt) 2006-02-14
KR100742019B1 (ko) 2007-07-23
TW200423935A (en) 2004-11-16
DK1606277T3 (da) 2008-08-18
NO20054136L (no) 2005-09-26
ZA200506834B (en) 2006-05-31
PE20041061A1 (es) 2005-01-22
TWI292318B (en) 2008-01-11
CN100358889C (zh) 2008-01-02
PL1606277T3 (pl) 2008-10-31
CN1759111A (zh) 2006-04-12
HK1089443A1 (en) 2006-12-01
NO20054136D0 (no) 2005-09-06
IL170129A (en) 2013-02-28
JP2006519802A (ja) 2006-08-31
CO5601027A2 (es) 2006-01-31

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