ES2087907T3 - Nuevo polisacarido sulfatado, sales farmaceuticamente aceptables del mismo, procedimiento para prepararlos y medicamento que los contiene como ingrediente activo. - Google Patents

Nuevo polisacarido sulfatado, sales farmaceuticamente aceptables del mismo, procedimiento para prepararlos y medicamento que los contiene como ingrediente activo.

Info

Publication number
ES2087907T3
ES2087907T3 ES90902694T ES90902694T ES2087907T3 ES 2087907 T3 ES2087907 T3 ES 2087907T3 ES 90902694 T ES90902694 T ES 90902694T ES 90902694 T ES90902694 T ES 90902694T ES 2087907 T3 ES2087907 T3 ES 2087907T3
Authority
ES
Spain
Prior art keywords
reaction
same
pharmaceutically acceptable
active ingredient
acceptable salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90902694T
Other languages
English (en)
Inventor
Hui Fan
Song Yu
Etsuji Yamanaka
Kazuhiro Numata
Aza Seicho Sho Oka
Norihiko Kagasuno Kawau Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2087907T3 publication Critical patent/ES2087907T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

ESTE INVENTO SE REFIERE AL POLISACARIDO SULFATADO D-HG, PREPARADO A PARTIR DE LA DESPOLIMERIZACION DE FGAG (UN EXTRACTO DE PEPINO DE MAR, QUE CONTIENE UN POLISACARIDO SULFATADO CON UNA ACCION SIMILAR A LA HEPARINA) O A SU SAL; CON LAS SIGUIENTES PROPIEDADES PSICOQUIMICAS, A LAS SALES DERIVADAS DE EL, A UN METODO PARA PREPARAR LO, Y A LAS DROGAS PARA TRATAR LA COAGULACION INTRAVASCULAR DIFUSA (CID) Y LA TROMBOSIS, QUE CONTIENEN EL MISMO COMO INGREDIENTE ACTIVO: (1) PESO MOLECULAR: DE 3000 A 42000 SEGUN EL HP GPC; (2) FORMA: BLANCO, AMORFO, Y CON ALTO PODER HIGROSCOPICO; (3): SOLUBILIDAD: SOLUBLE EN AGUA E INSOLUBLE EN SOLVENTES ORGANICOS TALES COMO EL ETANOL Y LA ACETONA ; (4) ROTACION ESPECIFICA: (A); (5) REACCION AL COLOR: REACCION DE ELSON-MORGAN (+); REACCION DEL ACIDO SULFURICO-CARBOZOL (+); REACCION DEL ACIDO CISTEINO-SULFURICO (+); REACCION DEL ACIDO ORCINOL-HIDROCLORICO (+); REACCION DEL AZUR A METACROMASIA (+); (6) ANALISIS COMPOSITIVO: GALACTOSAMINA: ACIDO GLUCURONICO: FUCOSA: RADICAL SULFATO = 1: 0.8 +/ /- 0.9
ES90902694T 1989-02-06 1990-02-06 Nuevo polisacarido sulfatado, sales farmaceuticamente aceptables del mismo, procedimiento para prepararlos y medicamento que los contiene como ingrediente activo. Expired - Lifetime ES2087907T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2829989 1989-02-06

Publications (1)

Publication Number Publication Date
ES2087907T3 true ES2087907T3 (es) 1996-08-01

Family

ID=12244736

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90902694T Expired - Lifetime ES2087907T3 (es) 1989-02-06 1990-02-06 Nuevo polisacarido sulfatado, sales farmaceuticamente aceptables del mismo, procedimiento para prepararlos y medicamento que los contiene como ingrediente activo.

Country Status (12)

Country Link
EP (1) EP0408770B1 (es)
JP (1) JP2714718B2 (es)
KR (1) KR970000528B1 (es)
AT (1) ATE138938T1 (es)
AU (1) AU634521B2 (es)
CA (1) CA2026992C (es)
DD (1) DD297165A5 (es)
DE (1) DE69027256T2 (es)
DK (1) DK0408770T3 (es)
ES (1) ES2087907T3 (es)
HU (1) HU211988A9 (es)
WO (1) WO1990008784A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU644464B2 (en) * 1990-08-02 1993-12-09 Taiho Pharmaceutical Co., Ltd. Anti-human immunodeficiency virus agent
JPH0491027A (ja) * 1990-08-02 1992-03-24 Taiho Yakuhin Kogyo Kk 抗ヒト免疫不全症ウィルス剤
US6255296B1 (en) * 1994-01-11 2001-07-03 Endomatrix, Inc. Composition and method for treating a patient susceptible to or suffering from a cardiovascular disorder or disease
EP0811635B1 (en) * 1995-12-20 2002-10-30 Taiho Pharmaceutical Co., Ltd. Intravascular membrane thickening inhibitor
US5876762A (en) * 1996-08-05 1999-03-02 Coastside Bio Resources Process for obtaining medically active fractions from sea cucumbers
US6399105B1 (en) 1999-01-20 2002-06-04 Peter Donald Collin Sea cucumber carotenoid lipid fraction products and methods of use
FR2797768B1 (fr) * 1999-09-01 2003-06-13 Ifremer Utilisation d'un polysaccharide sulfate de bas poids moleculaire pour l'obtention d'un medicament actif contre la thrombose vasculaire
CA2907887C (en) 2013-03-26 2020-10-06 Kunming Institute Of Botany, Chinese Academy Of Sciences Low-molecular-weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof
CN103788222B (zh) 2014-01-08 2016-08-31 中国科学院昆明植物研究所 Fuc3S4S取代的低聚糖胺聚糖及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3118588C2 (de) * 1981-05-11 1983-07-07 Luitpold-Werk, Chemisch-Pharmazeutische Fabrik, 8000 München Verfahren zur Herstellung eines injizierbaren hochreinen Chondroitinpolysulfates, hiernach erhältliches Produkt und pharmazeutische Zusammensetzung
JPS63128001A (ja) * 1986-11-19 1988-05-31 Taiho Yakuhin Kogyo Kk Ｆｇａｇ及びその塩、その製造方法並びにそれを含有する播種性血管内凝固症候群治療剤
JP2785611B2 (ja) * 1992-10-13 1998-08-13 宇部興産株式会社 被処理鋼板材コイルの先端口出し装置

Also Published As

Publication number Publication date
AU5032590A (en) 1990-08-24
WO1990008784A1 (en) 1990-08-09
EP0408770A4 (en) 1992-03-18
CA2026992C (en) 1998-11-10
JP2714718B2 (ja) 1998-02-16
ATE138938T1 (de) 1996-06-15
AU634521B2 (en) 1993-02-25
DE69027256T2 (de) 1996-12-19
DD297165A5 (de) 1992-01-02
KR910700269A (ko) 1991-03-14
EP0408770B1 (en) 1996-06-05
DK0408770T3 (da) 1996-10-07
KR970000528B1 (ko) 1997-01-13
HU211988A9 (en) 1996-01-29
DE69027256D1 (de) 1996-07-11
CA2026992A1 (en) 1990-08-07
EP0408770A1 (en) 1991-01-23

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