ES2073483T3 - Derivados del cromano. - Google Patents

Derivados del cromano.

Info

Publication number
ES2073483T3
ES2073483T3 ES90114008T ES90114008T ES2073483T3 ES 2073483 T3 ES2073483 T3 ES 2073483T3 ES 90114008 T ES90114008 T ES 90114008T ES 90114008 T ES90114008 T ES 90114008T ES 2073483 T3 ES2073483 T3 ES 2073483T3
Authority
ES
Spain
Prior art keywords
chroman
derivatives
pecos
alopecia
angina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90114008T
Other languages
English (en)
Inventor
Rolf Dr Gericke
Manfred Dr Baumgarth
Ingeborg Dr Lues
Rolf Dr Bergmann
Peyer Jacques Dr De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2073483T3 publication Critical patent/ES2073483T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

EL INVENTO SE REFIERE A UN NUEVO DERIVADO DE CROMANO QUE PRESENTA LA FORMULA (I), TIENE UNA ACCION EFICAZ SOBRE EL SISTEMA CARDIOVASCULAR Y SE EMPLEA PARA EL TRATAMIENTO DE LA ANGINA DE PECHO, INCONTINENCIA, ALOPECIA, INSUFICIENCIA CARDIACA Y ELEVADA TENSION SANGUINEA. TENIENDO R1 A R8 Y Z UN SIGNIFICADO DESCRITO EN LA PATENTE.
ES90114008T 1989-08-05 1990-07-21 Derivados del cromano. Expired - Lifetime ES2073483T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3926001A DE3926001A1 (de) 1989-08-05 1989-08-05 Chromanderivate

Publications (1)

Publication Number Publication Date
ES2073483T3 true ES2073483T3 (es) 1995-08-16

Family

ID=6386618

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90114008T Expired - Lifetime ES2073483T3 (es) 1989-08-05 1990-07-21 Derivados del cromano.

Country Status (19)

Country Link
US (1) US5130322A (es)
EP (1) EP0415065B1 (es)
JP (1) JPH0366681A (es)
KR (1) KR910004602A (es)
AR (1) AR245711A1 (es)
AT (1) ATE124407T1 (es)
AU (1) AU623797B2 (es)
DE (2) DE3926001A1 (es)
DK (1) DK0415065T3 (es)
ES (1) ES2073483T3 (es)
FI (1) FI95700C (es)
HU (1) HU213391B (es)
IE (1) IE68313B1 (es)
IL (1) IL95277A (es)
NO (1) NO176477C (es)
NZ (1) NZ234773A (es)
PT (1) PT94902B (es)
TW (1) TW209860B (es)
ZA (1) ZA906144B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
US5284838A (en) * 1987-06-23 1994-02-08 Elf Sanofi Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma
DE4102103A1 (de) * 1991-01-25 1992-08-20 Bayer Ag Substituierte benzoxazepine und benzthiazepine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
KR950009863B1 (ko) * 1991-05-22 1995-08-29 재단법인한국화학연구소 벤조피란 유도체와 그의 제조방법
KR950009862B1 (ko) * 1991-05-22 1995-08-29 재단법인한국화학연구소 벤조피란 유도체와 그의 제조방법(1)
TW257762B (es) * 1991-06-14 1995-09-21 Nippon Chemicals Pharmaceutical Co Ltd
US5250547A (en) * 1991-08-29 1993-10-05 Syntex (U.S.A.) Inc. Benzopyran derivatives
EP0677519A4 (en) * 1993-11-10 1996-04-03 Japan Tobacco Inc CHROMAN DERIVATIVE AND THERAPEUTIC USE THEREOF.
US5470861A (en) * 1994-08-04 1995-11-28 Hoffmann-La Roche Inc. Method of promoting hair growth
DE19647000A1 (de) * 1996-11-14 1998-05-20 Hoechst Ag 3-Amido-chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
JP2001151767A (ja) * 1999-09-17 2001-06-05 Nissan Chem Ind Ltd ベンゾピラン誘導体
JP2001158780A (ja) * 1999-09-24 2001-06-12 Nissan Chem Ind Ltd ４−オキシベンゾピラン誘導体
JP2001172275A (ja) * 1999-10-05 2001-06-26 Nissan Chem Ind Ltd ４−オキシベンゾピラン誘導体
WO2011013987A2 (ko) * 2009-07-29 2011-02-03 한국화학연구원 2,2-이치환-2h-크로멘 화합물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2107706A (en) * 1981-09-25 1983-05-05 Beecham Group Plc Benzopyrans
DE3364145D1 (de) * 1982-04-08 1986-07-24 Beecham Group Plc Antihypertensive benzopyranols
EP0093534A1 (en) * 1982-04-28 1983-11-09 Beecham Group Plc Novel chromanols
ATE56007T1 (de) * 1984-06-22 1990-09-15 Beecham Group Plc Wirksame benzopyranverbindungen.
GB8419516D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8419515D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
PT84806B (pt) * 1986-05-03 1989-12-29 Beecham Group Plc Processo para a preparacao de benzopiranos
DE3726261A1 (de) * 1986-12-23 1988-07-07 Merck Patent Gmbh Chromanderivate
CH674984A5 (es) * 1987-05-16 1990-08-15 Sandoz Ag
AU618007B2 (en) * 1987-06-23 1991-12-12 Sanofi 2,2-dimethylchroman-3-ol derivatives, process for their preparation and pharmaceutical compositions in which they are present
FI90343C (fi) * 1987-06-23 1994-01-25 Merck Patent Gmbh Menetelmä korkeaa verenpainetta alentavien ja rytmihäiriöitä vastustavien trans-2,2-dimetyylikroman-3-olijohdannaisten valmistamiseksi
US4971982A (en) * 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives

Also Published As

Publication number Publication date
NO903431D0 (no) 1990-08-03
HUT58713A (en) 1992-03-30
FI903863A0 (fi) 1990-08-03
FI95700B (fi) 1995-11-30
IE902822A1 (en) 1991-02-27
US5130322A (en) 1992-07-14
HU904889D0 (en) 1991-01-28
KR910004602A (ko) 1991-03-29
TW209860B (es) 1993-07-21
DK0415065T3 (da) 1995-08-28
EP0415065B1 (de) 1995-06-28
NO176477B (no) 1995-01-02
NZ234773A (en) 1992-10-28
ZA906144B (en) 1991-05-29
AU6013490A (en) 1991-02-07
IL95277A0 (en) 1991-06-30
PT94902B (pt) 1997-06-30
JPH0366681A (ja) 1991-03-22
AU623797B2 (en) 1992-05-21
NO903431L (no) 1991-02-06
PT94902A (pt) 1991-04-18
DE59009322D1 (de) 1995-08-03
AR245711A1 (es) 1994-02-28
IL95277A (en) 1995-10-31
HU213391B (en) 1997-06-30
FI95700C (fi) 1996-03-11
DE3926001A1 (de) 1991-02-07
NO176477C (no) 1995-04-12
ATE124407T1 (de) 1995-07-15
EP0415065A1 (de) 1991-03-06
IE68313B1 (en) 1996-06-12

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