ES2071292T3 - Soluciones inyectables estables de factor viii. - Google Patents
Soluciones inyectables estables de factor viii.Info
- Publication number
- ES2071292T3 ES2071292T3 ES91901746T ES91901746T ES2071292T3 ES 2071292 T3 ES2071292 T3 ES 2071292T3 ES 91901746 T ES91901746 T ES 91901746T ES 91901746 T ES91901746 T ES 91901746T ES 2071292 T3 ES2071292 T3 ES 2071292T3
- Authority
- ES
- Spain
- Prior art keywords
- viii
- stable injectable
- factor solutions
- disacarids
- mol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 229960004222 factor ix Drugs 0.000 abstract 1
- 229960000301 factor viii Drugs 0.000 abstract 1
- 229940102223 injectable solution Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
SOLUCION ESTABLE INYECTABLE QUE CONTIENE FACTOR VIII O FACTOR IX ADECUADO PARA EL TRATAMIENTO HUMANO, DISACARIDOS NATURALES O SINTETICOS, PREFERENTEMENTE SACAROSA, EN UNA CONCENTRACION DE 0,1 HASTA 0,65 MOL/L, Y UNO O VARIOS AMINOACIDOS EN UNA CONCENTRACION DE 0,1 HASTA 1,0 MOL/L. UN PROCEDIMIENTO PARA LA OBTENCION DE LAS MISMAS Y LA UTILIZACION DE DISACARIDOS NATURALES O SINTETICOS, PREFERENTEMENTE SACAROSA, Y UNO O MAS AMINOACIDOS PARA LA ESTABILIZACION DE LOS FACTORES VIII Y IX.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4001451A DE4001451A1 (de) | 1990-01-19 | 1990-01-19 | Stabile injizierbare loesungen von faktor viii und faktor ix |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2071292T3 true ES2071292T3 (es) | 1995-06-16 |
Family
ID=6398370
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91901746T Expired - Lifetime ES2071292T3 (es) | 1990-01-19 | 1990-12-19 | Soluciones inyectables estables de factor viii. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5328694A (es) |
EP (1) | EP0511234B1 (es) |
JP (1) | JPH05504342A (es) |
AT (1) | ATE120960T1 (es) |
DE (2) | DE4001451A1 (es) |
DK (1) | DK0511234T3 (es) |
ES (1) | ES2071292T3 (es) |
WO (1) | WO1991010439A1 (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4111393A1 (de) * | 1991-04-09 | 1992-10-15 | Behringwerke Ag | Stabilisierte faktor viii-praeparationen |
GB9122609D0 (en) * | 1991-10-24 | 1991-12-04 | Brownlee George G | Improvements relating to the treatment of haemophilia |
EP0627924B1 (en) * | 1992-10-02 | 2000-12-27 | Genetics Institute, Inc. | Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer |
SE9301581D0 (sv) * | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Protein formulation |
US6288030B1 (en) | 1993-12-22 | 2001-09-11 | Amgen Inc. | Stem cell factor formulations and methods |
US6242417B1 (en) | 1994-03-08 | 2001-06-05 | Somatogen, Inc. | Stabilized compositions containing hemoglobin |
IL113010A (en) * | 1994-03-31 | 1999-10-28 | Pharmacia & Upjohn Ab | Pharmaceutical formulation comprising factor viii with an activity of at least 500iu/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
US6372716B1 (en) * | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
SE9501189D0 (sv) * | 1995-03-31 | 1995-03-31 | Pharmacia Ab | Protein formulation |
US5770700A (en) * | 1996-01-25 | 1998-06-23 | Genetics Institute, Inc. | Liquid factor IX formulations |
US5763401A (en) * | 1996-07-12 | 1998-06-09 | Bayer Corporation | Stabilized albumin-free recombinant factor VIII preparation having a low sugar content |
MXPA01008515A (es) | 1999-02-22 | 2003-06-06 | Baxter Int | Formulaciones novedosas de factor viii libres de albumina. |
AU1344102A (en) * | 2000-10-12 | 2002-04-22 | Genentech Inc | Reduced-viscosity concentrated protein formulations |
US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
WO2003055512A1 (en) | 2001-12-21 | 2003-07-10 | Novo Nordisk Health Care Ag | Liquid composition of factor vii polypeptides |
RU2366451C2 (ru) | 2002-06-21 | 2009-09-10 | Ново Нордиск Хелт Кэр Аг | Стабилизированные твердые композиции полипептидов фактора vii |
US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
MXPA05010555A (es) * | 2003-04-04 | 2006-03-09 | Genentech Inc | Formulaciones de proteina y anticuerpo de alta concentracion. |
DE602004025100D1 (de) | 2003-05-23 | 2010-03-04 | Novo Nordisk Healthcare Ag | Stabilisierung von proteinen in lösung |
ATE547114T1 (de) | 2003-06-25 | 2012-03-15 | Novo Nordisk Healthcare Ag | Flüssige zusammensetzungen von factor vii polypeptiden |
RU2388460C2 (ru) | 2003-08-14 | 2010-05-10 | Ново Нордиск Хелс Кеа Аг | Жидкая водная фармацевтическая композиция, содержащая полипептид фактора vii |
AU2004274430A1 (en) | 2003-09-12 | 2005-03-31 | Antigenics, Inc. | Vaccine for treatment and prevention of herpes simplex virus infection |
SI2298287T1 (en) | 2003-12-19 | 2018-08-31 | Novo Nordisk Health Care Ag | Stabilized compositions of factor VII polypeptides |
KR100624013B1 (ko) * | 2004-06-25 | 2006-09-19 | 주식회사 녹십자홀딩스 | 동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제 |
FI121025B (fi) * | 2004-12-07 | 2010-06-15 | Sandvik Mining & Constr Oy | Menetelmä putkiporaukseen, porausyksikkö sekä adapterilaite |
CA2591852A1 (en) | 2004-12-27 | 2006-07-06 | Baxter International Inc. | Polymer-von willebrand factor-conjugates |
KR20080108147A (ko) * | 2006-03-31 | 2008-12-11 | 백스터 인터내셔널 인코포레이티드 | 페질화된 인자 viii |
US7645860B2 (en) | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
BRPI0917656A2 (pt) | 2008-08-21 | 2017-07-11 | Octapharma Ag | Fatores viii e ix humanos produzidos de forma recombinante |
BRPI0918589B1 (pt) * | 2008-09-03 | 2021-07-13 | Octapharma Ag | Composições de proteção para fator viii recombinantemente produzido |
NZ593190A (en) | 2008-11-07 | 2013-01-25 | Baxter Int | Factor viii formulations |
CA2754528A1 (en) | 2009-03-06 | 2010-09-10 | Genetech, Inc. | Antibody formulation |
NZ729629A (en) | 2014-08-04 | 2021-12-24 | Csl Ltd | Factor viii formulation |
SG10201912485PA (en) | 2015-05-13 | 2020-02-27 | Agenus Inc | Vaccines for treatment and prevention of cancer |
CA3096909A1 (en) | 2018-04-26 | 2019-10-31 | Agenus Inc. | Heat shock protein-binding peptide compositions and methods of use thereof |
KR20220029733A (ko) | 2019-07-04 | 2022-03-08 | 체에스엘 베링 렝나우 아게 | 응고 인자 viii의 시험관내 안정성을 증가시키기 위한 절단된 폰 빌레브란트 인자 (vwf) |
EP4240757A2 (en) | 2020-11-09 | 2023-09-13 | Takeda Pharmaceutical Company Limited | Purification of fviii from plasma using silicon oxide adsorption |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4186192A (en) * | 1978-12-18 | 1980-01-29 | Cutter Laboratories, Inc. | Stabilized immune serum globulin |
DE2916711A1 (de) * | 1979-04-25 | 1980-11-06 | Behringwerke Ag | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
DE3176491D1 (en) * | 1980-03-05 | 1987-11-26 | Miles Lab | Pasteurized therapeutically active protein compositions |
DE3045153A1 (de) * | 1980-11-29 | 1982-07-08 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x |
US4495278A (en) * | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
JPS5874617A (ja) * | 1981-10-28 | 1983-05-06 | Green Cross Corp:The | 人由来血液凝固第7因子含有水溶液の加熱処理方法 |
JPS58191881A (ja) * | 1982-05-01 | 1983-11-09 | 服部 盛義 | 自動車用ドア−の両開き装置 |
DE3237512A1 (de) * | 1982-10-09 | 1984-04-12 | Behringwerke Ag, 3550 Marburg | Verfahren zur pasteurisierung von antihaemophilem kryopraezipitat (ahk) und danach hergestelltes antihaemophiles kryopraezipitat |
JPS59112630A (ja) * | 1982-12-17 | 1984-06-29 | Matsushita Electric Ind Co Ltd | ワイヤボンデイング装置 |
JPS59134730A (ja) * | 1983-01-20 | 1984-08-02 | Green Cross Corp:The | 血液凝固第8因子の加熱処理法 |
DE3336631A1 (de) * | 1983-10-08 | 1985-04-18 | Behringwerke Ag, 3550 Marburg | Verfahren zur pasteurisierung von plasma oder von konzentraten der blutgerinnungsfaktoren ii, vii, ix und x |
DE3432083A1 (de) * | 1984-08-31 | 1986-03-06 | Behringwerke Ag, 3550 Marburg | Pasteurisierte, isoagglutininfreie faktor viii-praeparation und verfahren zu ihrer herstellung |
US4847362A (en) * | 1985-02-01 | 1989-07-11 | New York University | Method for purifying antihemophilic factor |
DE3625090A1 (de) * | 1986-07-24 | 1988-01-28 | Behringwerke Ag | Mittel zur therapie faktor viii-resistenter haemophilie a und verfahren zu seiner herstellung |
CA1329760C (en) * | 1987-10-29 | 1994-05-24 | Ted C. K. Lee | Plasma and recombinant protein formulations in high ionic strength media |
US5110907A (en) * | 1989-08-01 | 1992-05-05 | Alpha Therapeutic Corporation | Factor viii complex purification using heparin affinity chromatography |
-
1990
- 1990-01-19 DE DE4001451A patent/DE4001451A1/de not_active Ceased
- 1990-12-19 DK DK91901746.7T patent/DK0511234T3/da active
- 1990-12-19 JP JP91502059A patent/JPH05504342A/ja active Pending
- 1990-12-19 EP EP91901746A patent/EP0511234B1/de not_active Revoked
- 1990-12-19 WO PCT/EP1990/002238 patent/WO1991010439A1/de not_active Application Discontinuation
- 1990-12-19 DE DE59008910T patent/DE59008910D1/de not_active Revoked
- 1990-12-19 ES ES91901746T patent/ES2071292T3/es not_active Expired - Lifetime
- 1990-12-19 AT AT91901746T patent/ATE120960T1/de not_active IP Right Cessation
-
1992
- 1992-07-20 US US07/916,644 patent/US5328694A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5328694A (en) | 1994-07-12 |
EP0511234B1 (de) | 1995-04-12 |
EP0511234A1 (de) | 1992-11-04 |
WO1991010439A1 (de) | 1991-07-25 |
DK0511234T3 (da) | 1995-08-21 |
DE59008910D1 (de) | 1995-05-18 |
ATE120960T1 (de) | 1995-04-15 |
JPH05504342A (ja) | 1993-07-08 |
DE4001451A1 (de) | 1991-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2071292T3 (es) | Soluciones inyectables estables de factor viii. | |
MX172076B (es) | Composicion de enriquecimiento para el cabello | |
ATE187646T1 (de) | Verwendung von kupfer enthaltenden wirkstoffen zur beschleunigung der wundheilung | |
ES2115057T3 (es) | Distribucion facilitada de oxigeno asociada a hemodilucion. | |
BR9403783A (pt) | Uso de uma composição cosmética | |
DE59508360D1 (de) | Liposomal verkapseltes taxol, seine herstellung und seine verwendung | |
ES2063013T3 (es) | Procedimiento para eliminar pirogenos. | |
DE69032200D1 (de) | Verfahren zur Behandlung von Schnittblumen | |
DK310489D0 (da) | Lysudsendende anordning til brug ved medicinsk behandling | |
ATE107515T1 (de) | Zusammensetzung zur behandlung von entzündung. | |
DE59006842D1 (de) | Verwendung von Guanidinderivaten zur Herstellung eines Arzneimittels mit NPY-antagonistischer Wirkung. | |
NO169222C (no) | Flaske for vannoedforpleining | |
ES2151607T3 (es) | Factor 12 de crecimiento y de diferenciacion. | |
ES2122214T3 (es) | Empleo de l-carnitina y alcanoil l-carnitinas en el almacenamiento de sangre para transfusiones y estabilizacion de soluciones que la contienen. | |
ATE107168T1 (de) | Verwendung von gepiron zur herstellung eines pharmazeutischen präparats zur behandlung atypischer depression. | |
ES2022192B3 (es) | Eteres de oximas sustituidos, su utilizacion como biorreguladores para la reduccion del nivel de etileno endogeno en las plantas. | |
ES2059507T3 (es) | Moleculas biologicamente activas. | |
ES2106031T3 (es) | Una composicion comprendiendo un factor de crecimiento, su metodo de obtencion y uso. | |
DE69033606D1 (de) | Verfahren zur verbesserung der wundheilung und gewebeerneuerung | |
ES2062067T3 (es) | Procedimiento de preparacion de alfa, omega-diaminas alifaticas, compuestos nuevos y su empleo en tincion capilar. | |
DE59003020D1 (de) | Piroxicam enthaltende pharmazeutische Zusammensetzung zur topischen Anwendung. | |
ATE136465T1 (de) | Verwendung von gibberellinen zur herstellung eines arzneimittels zur behandlung von prostatitis | |
ES2191206T3 (es) | Nueva utilizacion de la creatina. | |
SE9402331D0 (sv) | New use | |
SE8200757L (sv) | Biologiskt aktiva peptider |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 511234 Country of ref document: ES |