ES2070929T3 - Nuevos compuestos antivirales. - Google Patents

Nuevos compuestos antivirales.

Info

Publication number
ES2070929T3
ES2070929T3 ES89870170T ES89870170T ES2070929T3 ES 2070929 T3 ES2070929 T3 ES 2070929T3 ES 89870170 T ES89870170 T ES 89870170T ES 89870170 T ES89870170 T ES 89870170T ES 2070929 T3 ES2070929 T3 ES 2070929T3
Authority
ES
Spain
Prior art keywords
carbon atoms
acyl
aryl
antiviral compounds
new antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89870170T
Other languages
English (en)
Inventor
Richard Allen Partis
Francis Jan Koszyk
Richard August Mueller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2070929T3 publication Critical patent/ES2070929T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PRESENTAN DERIVADOS O-ACILATADOS DE 1,5-DIDEOXI-1,5-IMINO-D-GLUCITOL Y SUS DERIVADOS N-ALKIL, N-ACIL Y N-ARIL EN LOS CUALES ENTRE 1 Y 4 DE LOS GRUPOS DE HIDROXIL LIBRES ESTAN ACILATADOS CON GRUPOS ACIL QUE TENGAN ENTRE 1 Y 8 ATOMOS DE CARBONO Y EN EL CUAL LOS SUSTITUYENTES N-ALKIL Y N-ACIL CONTENGAN ENTRE 4 Y 40 ATOMOS DE CARBONO Y LOS SUSTITUYENTES N-ARIL CONTENGAN ENTRE 7 Y 40 ATOMOS DE CARBONO, CON LA PREMISA DE QUE CUANDO N-ARIL SEA BENZILOXICARBONIL, LOS GRUPOS O-ACIL CONTENGAN ENTRE4 Y 8 ATOMOS DE CARBONO.
ES89870170T 1988-11-03 1989-10-31 Nuevos compuestos antivirales. Expired - Lifetime ES2070929T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26676788A 1988-11-03 1988-11-03
US07/418,091 US5003072A (en) 1988-11-03 1989-10-12 1,5-dideoxy-1,5-imino-D-glucitol derivatives

Publications (1)

Publication Number Publication Date
ES2070929T3 true ES2070929T3 (es) 1995-06-16

Family

ID=26952022

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89870170T Expired - Lifetime ES2070929T3 (es) 1988-11-03 1989-10-31 Nuevos compuestos antivirales.

Country Status (9)

Country Link
US (1) US5003072A (es)
EP (1) EP0367748B1 (es)
JP (1) JP2907462B2 (es)
AT (1) ATE117678T1 (es)
CA (1) CA2002106C (es)
DE (1) DE68920819T2 (es)
ES (1) ES2070929T3 (es)
GR (1) GR3015931T3 (es)
MX (1) MX9203547A (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310745A (en) * 1988-11-03 1994-05-10 G. D. Searle & Co. Antiviral compounds
US5144037A (en) * 1988-11-03 1992-09-01 G. D. Searle & Co. 1,5-dideoxy-1,5-imino-d-glucitol derivatives
DE4009561A1 (de) * 1990-03-24 1991-09-26 Bayer Ag Neue desoxynojirimycinderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5273981A (en) * 1990-10-18 1993-12-28 Monsanto Company Intramolecular carbamate derivative of 2,3-Di-O-blocked-1,4-dideoxy-4-fluoro-nojirimycins
US5206251A (en) * 1992-04-01 1993-04-27 G. D. Searle & Co. 2- and 3- amino and azido derivatives of 1,5-iminosugars
US5342951A (en) * 1992-04-01 1994-08-30 G.D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
ATE142201T1 (de) * 1992-04-01 1996-09-15 Searle & Co 2- und 3-amino und azidoderivate von 1,5- iminozuckern als antivirale arzneimittel
US5258518A (en) * 1992-04-01 1993-11-02 G. D. Searle & Co. 2-substituted tertiary carbinol derivatives of deoxynojirimycin
US5268482A (en) * 1992-04-01 1993-12-07 G. D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
US5216168A (en) * 1992-04-01 1993-06-01 G. D. Searle & Co. 2- and 3- amino and azido derivatives of 1,5-iminosugars
US5331096A (en) * 1992-04-01 1994-07-19 G. D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
AU1876095A (en) * 1994-02-25 1995-09-11 G.D. Searle & Co. Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus
US5451679A (en) * 1994-03-08 1995-09-19 G. D. Searle & Co. 2-chloro and 2-bromo derivatives of 1,5-iminosugars
US20030100532A1 (en) * 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
AU753336B2 (en) 1997-11-10 2002-10-17 G.D. Searle & Co. Use of alkylated iminosugars to treat multidrug resistance
EP1037636A4 (en) * 1997-12-11 2004-08-18 Univ Oxford INHIBITATION OF MEMBRANE-TIED VIRAL REPLICATION
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
EP1714676A3 (en) * 1998-02-12 2006-11-15 G.D. Searle LLC. Use of N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
ZA991142B (en) * 1998-02-12 2000-02-14 Searle & Co Use of N-substituted-1,5-dideoxy-1,5-imino-D-Glucitol compounds for treating hepatitis virus infections.
WO1999040916A1 (en) * 1998-02-12 1999-08-19 G.D. Searle & Co. Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
CA2362785A1 (en) 1999-02-12 2001-02-08 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
WO2000047198A2 (en) * 1999-02-12 2000-08-17 G.D. Searle & Co. Use of substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
GB0100889D0 (en) * 2001-01-12 2001-02-21 Oxford Glycosciences Uk Ltd Compounds
CN1422156A (zh) * 2000-02-14 2003-06-04 法马西亚公司 N－取代的－1,5－二脱氧－1,5－亚氨基－d－葡萄糖醇化合物在治疗肝炎病毒感染中的用途
ES2393331T3 (es) * 2002-07-17 2012-12-20 Actelion Pharmaceuticals Ltd. Derivados de piperidintriol como inhibidores de la glucosiliceramida sintasa
AU2003248960B2 (en) * 2002-07-17 2009-06-25 Idorsia Pharmaceuticals Ltd Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase
GB0313677D0 (en) * 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compound
GB0313678D0 (en) * 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compounds
JP2008543784A (ja) * 2005-06-08 2008-12-04 アミカス セラピューティックス インコーポレイテッド 結晶性糖組成物および作製方法
WO2008045015A1 (en) * 2005-06-08 2008-04-17 Amicus Therapeutics, Inc. Imino and amino sugar purification
EP1888610A1 (en) * 2005-06-08 2008-02-20 Amicus Therapeutics, Inc. Stabilization of triflated compounds
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
ITMI20122090A1 (it) 2012-12-06 2014-06-07 Dipharma Francis Srl Sintesi di un inibitore delle glicosiltransferasi
ITMI20130083A1 (it) * 2013-01-22 2014-07-23 Dipharma Francis Srl Imminozucchero in forma cristallina
RU2678085C2 (ru) * 2014-07-21 2019-01-23 ДИФАРМА ФРАНЦИС С.р.л. Иминосахар в кристаллической форме
ITUB20150176A1 (it) 2015-04-17 2016-10-17 Dipharma Francis Srl Sintesi di un azazucchero e i suoi intermedi
WO2021116487A1 (en) 2019-12-13 2021-06-17 Som Innovation Biotech, S.A. Compounds for use in the treatment of niemann-pick c disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1555654A (en) * 1977-06-25 1979-11-14 Exxon Research Engineering Co Agricultural burner apparatus
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2942365A1 (de) * 1979-10-19 1981-05-14 Bayer Ag, 5090 Leverkusen 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3650377T2 (de) * 1985-12-23 1996-02-22 Hutchinson Fred Cancer Res Regulierung der retroviralen replikation, infektion und pathogenese.
US4849430A (en) * 1988-03-09 1989-07-18 Monsanto Company Method of inhibiting virus

Also Published As

Publication number Publication date
EP0367748B1 (en) 1995-01-25
EP0367748A2 (en) 1990-05-09
CA2002106C (en) 1998-12-08
DE68920819T2 (de) 1995-08-17
ATE117678T1 (de) 1995-02-15
MX9203547A (es) 1992-09-01
US5003072A (en) 1991-03-26
DE68920819D1 (de) 1995-03-09
JPH02172975A (ja) 1990-07-04
GR3015931T3 (en) 1995-07-31
JP2907462B2 (ja) 1999-06-21
EP0367748A3 (en) 1991-05-08
CA2002106A1 (en) 1990-05-03

Similar Documents

Publication Publication Date Title
ES2070929T3 (es) Nuevos compuestos antivirales.
IL89921A0 (en) 1,3-dioxolane derivatives and pharmaceutical compositions containing the same
DE3855451T2 (de) Substituiertes 1,4,7-Triscarboxymethyl-1,4,7,10-tetraazacyclododecan und Analoga
GR3005844T3 (es)
GR3006275T3 (es)
ZA872879B (en) Anti-dementia agents
CA2059063A1 (en) Novel antiviral compounds
FI881609A0 (fi) Dihydropyridinamider, foerfarande foer deras framstaellning och deras anvaendning i laekemedel.
IT1241988B (it) 2- amminotetraline-6, 7-sostituite attive come immunomodulanti e composizioni farmaceutiche che le contengono
YU186689A (en) N-sulphenilated and n-acylated pyrazolins
AU564069B2 (en) 1,4-dihydropyridine derivatives containing mmono-or di-saccharide substitutents
DK376388A (da) Herbicide midler af acylerede 1,3,5-tricarbonylcyklohexanherbicider og modgifte derfor
HU9202873D0 (en) 1,4-dihydropyridine derivatives of paf-antagonistic effect
IT8703444A0 (it) Di gruppi di sigarette apparecchiatura per la formazione
KR890015080U (ko) 2종 지연펄스 발생회로
FR2621109B1 (fr) Rafraichisseur statique d'enceinte
EP0229655A3 (en) Morpholine derivatives containing substituted piperidine groups and use thereof as stabilizers
ATA265387A (de) Neue n-substituierte 3-piperidin- oder 3-tetrahydropyridincarbonsaeuren und derivate
IT1255474B (it) Derivati 1,4-benzotiazinici ad attivita' calcio antagonista
CS963287A1 (en) Compositions on base of polyamide 6 with reduced combustibility
IT211233Z2 (it) Filtro a bagno d'olio per canne fumarie di camini a fuoco di legna o di carbone
HK1000211A1 (en) N-substituted hindered amine stabilizers
ZA887006B (en) N-substituted hindered amine stabilizers
IT8800504V0 (it) Attrezzatura didattica per l'agevole apprendimento della tavola pitagorica

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 367748

Country of ref document: ES