ES2070929T3 - Nuevos compuestos antivirales. - Google Patents

Nuevos compuestos antivirales.

Info

Publication number
ES2070929T3
ES2070929T3 ES89870170T ES89870170T ES2070929T3 ES 2070929 T3 ES2070929 T3 ES 2070929T3 ES 89870170 T ES89870170 T ES 89870170T ES 89870170 T ES89870170 T ES 89870170T ES 2070929 T3 ES2070929 T3 ES 2070929T3
Authority
ES
Spain
Prior art keywords
carbon atoms
acyl
aryl
antiviral compounds
new antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89870170T
Other languages
English (en)
Inventor
Richard Allen Partis
Francis Jan Koszyk
Richard August Mueller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2070929T3 publication Critical patent/ES2070929T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PRESENTAN DERIVADOS O-ACILATADOS DE 1,5-DIDEOXI-1,5-IMINO-D-GLUCITOL Y SUS DERIVADOS N-ALKIL, N-ACIL Y N-ARIL EN LOS CUALES ENTRE 1 Y 4 DE LOS GRUPOS DE HIDROXIL LIBRES ESTAN ACILATADOS CON GRUPOS ACIL QUE TENGAN ENTRE 1 Y 8 ATOMOS DE CARBONO Y EN EL CUAL LOS SUSTITUYENTES N-ALKIL Y N-ACIL CONTENGAN ENTRE 4 Y 40 ATOMOS DE CARBONO Y LOS SUSTITUYENTES N-ARIL CONTENGAN ENTRE 7 Y 40 ATOMOS DE CARBONO, CON LA PREMISA DE QUE CUANDO N-ARIL SEA BENZILOXICARBONIL, LOS GRUPOS O-ACIL CONTENGAN ENTRE4 Y 8 ATOMOS DE CARBONO.
ES89870170T 1988-11-03 1989-10-31 Nuevos compuestos antivirales. Expired - Lifetime ES2070929T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26676788A 1988-11-03 1988-11-03
US07/418,091 US5003072A (en) 1988-11-03 1989-10-12 1,5-dideoxy-1,5-imino-D-glucitol derivatives

Publications (1)

Publication Number Publication Date
ES2070929T3 true ES2070929T3 (es) 1995-06-16

Family

ID=26952022

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89870170T Expired - Lifetime ES2070929T3 (es) 1988-11-03 1989-10-31 Nuevos compuestos antivirales.

Country Status (9)

Country Link
US (1) US5003072A (es)
EP (1) EP0367748B1 (es)
JP (1) JP2907462B2 (es)
AT (1) ATE117678T1 (es)
CA (1) CA2002106C (es)
DE (1) DE68920819T2 (es)
ES (1) ES2070929T3 (es)
GR (1) GR3015931T3 (es)
MX (1) MX9203547A (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5144037A (en) * 1988-11-03 1992-09-01 G. D. Searle & Co. 1,5-dideoxy-1,5-imino-d-glucitol derivatives
US5310745A (en) * 1988-11-03 1994-05-10 G. D. Searle & Co. Antiviral compounds
DE4009561A1 (de) * 1990-03-24 1991-09-26 Bayer Ag Neue desoxynojirimycinderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5273981A (en) * 1990-10-18 1993-12-28 Monsanto Company Intramolecular carbamate derivative of 2,3-Di-O-blocked-1,4-dideoxy-4-fluoro-nojirimycins
US5216168A (en) * 1992-04-01 1993-06-01 G. D. Searle & Co. 2- and 3- amino and azido derivatives of 1,5-iminosugars
US5258518A (en) * 1992-04-01 1993-11-02 G. D. Searle & Co. 2-substituted tertiary carbinol derivatives of deoxynojirimycin
US5206251A (en) * 1992-04-01 1993-04-27 G. D. Searle & Co. 2- and 3- amino and azido derivatives of 1,5-iminosugars
US5331096A (en) * 1992-04-01 1994-07-19 G. D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
US5268482A (en) * 1992-04-01 1993-12-07 G. D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
US5342951A (en) * 1992-04-01 1994-08-30 G.D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
ES2095032T3 (es) * 1992-04-01 1997-02-01 Searle & Co Derivados 2- y 3-amino y azido de 1,5-iminoazucares como compuestos antivirales.
WO1995022975A1 (en) * 1994-02-25 1995-08-31 G.D. Searle & Co. Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus
US5451679A (en) * 1994-03-08 1995-09-19 G. D. Searle & Co. 2-chloro and 2-bromo derivatives of 1,5-iminosugars
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
MY122499A (en) 1997-11-10 2006-04-29 Searle & Co Use of alkylated iminosugars to treat multidrug resistance
KR20010033028A (ko) * 1997-12-11 2001-04-25 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 막-관련 바이러스 복제의 억제
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
CN1202824C (zh) * 1998-02-12 2005-05-25 G·D·瑟尔公司 N－取代的1,5－二脱氧－1,5－亚氨基－d－葡糖醇化合物用于制备治疗肝炎病毒感染的药物中的用途
EP1714676A3 (en) * 1998-02-12 2006-11-15 G.D. Searle LLC. Use of N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
BR9907882A (pt) * 1998-02-12 2000-10-17 Searle & Co Uso de compostos de 1,5-didesóxi-1,5-imino-d-glucitol n-substituìdos para o tratamento de infecções de vìrus de hepatite
WO2001008672A2 (en) 1999-02-12 2001-02-08 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
US6545021B1 (en) * 1999-02-12 2003-04-08 G.D. Searle & Co. Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
GB0100889D0 (en) 2001-01-12 2001-02-21 Oxford Glycosciences Uk Ltd Compounds
CN1422156A (zh) * 2000-02-14 2003-06-04 法马西亚公司 N－取代的－1,5－二脱氧－1,5－亚氨基－d－葡萄糖醇化合物在治疗肝炎病毒感染中的用途
JP4585851B2 (ja) * 2002-07-17 2010-11-24 アクテリオン ファーマシューティカルズ リミテッド グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体
EP1534676B1 (en) * 2002-07-17 2012-09-12 Actelion Pharmaceuticals Ltd. Piperidinetriol derivatives as inhibitors of glycosylceramide synthase
GB0313677D0 (en) * 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compound
GB0313678D0 (en) * 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compounds
ES2537089T3 (es) * 2005-06-08 2015-06-02 Amicus Therapeutics, Inc. Purificación de imino- y amino-azúcares
BRPI0613221A2 (pt) * 2005-06-08 2010-12-28 Amicus Therapeutics Inc furanose cristalina e método para produzir uma furanose cristalina
BRPI0613224A2 (pt) * 2005-06-08 2010-12-28 Amicus Therapeutics Inc método para estabilizar um açúcar triflatado, método para aumentar o rendimento da reação de um produto de açúcar e composição de açúcar triflatado estabilizada
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
ITMI20122090A1 (it) 2012-12-06 2014-06-07 Dipharma Francis Srl Sintesi di un inibitore delle glicosiltransferasi
ITMI20130083A1 (it) * 2013-01-22 2014-07-23 Dipharma Francis Srl Imminozucchero in forma cristallina
RU2678085C2 (ru) * 2014-07-21 2019-01-23 ДИФАРМА ФРАНЦИС С.р.л. Иминосахар в кристаллической форме
ITUB20150176A1 (it) 2015-04-17 2016-10-17 Dipharma Francis Srl Sintesi di un azazucchero e i suoi intermedi
WO2021116487A1 (en) 2019-12-13 2021-06-17 Som Innovation Biotech, S.A. Compounds for use in the treatment of niemann-pick c disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1555654A (en) * 1977-06-25 1979-11-14 Exxon Research Engineering Co Agricultural burner apparatus
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2942365A1 (de) * 1979-10-19 1981-05-14 Bayer Ag, 5090 Leverkusen 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE126696T1 (de) * 1985-12-23 1995-09-15 Hutchinson Fred Cancer Res Regulierung der retroviralen replikation, infektion und pathogenese.
US4849430A (en) * 1988-03-09 1989-07-18 Monsanto Company Method of inhibiting virus

Also Published As

Publication number Publication date
EP0367748B1 (en) 1995-01-25
DE68920819D1 (de) 1995-03-09
MX9203547A (es) 1992-09-01
JPH02172975A (ja) 1990-07-04
EP0367748A3 (en) 1991-05-08
GR3015931T3 (en) 1995-07-31
JP2907462B2 (ja) 1999-06-21
ATE117678T1 (de) 1995-02-15
US5003072A (en) 1991-03-26
EP0367748A2 (en) 1990-05-09
DE68920819T2 (de) 1995-08-17
CA2002106A1 (en) 1990-05-03
CA2002106C (en) 1998-12-08

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