DE3855451D1 - Substituiertes 1,4,7-Triscarboxymethyl-1,4,7,10-tetraazacyclododecan und Analoga - Google Patents

Substituiertes 1,4,7-Triscarboxymethyl-1,4,7,10-tetraazacyclododecan und Analoga

Info

Publication number
DE3855451D1
DE3855451D1 DE3855451T DE3855451T DE3855451D1 DE 3855451 D1 DE3855451 D1 DE 3855451D1 DE 3855451 T DE3855451 T DE 3855451T DE 3855451 T DE3855451 T DE 3855451T DE 3855451 D1 DE3855451 D1 DE 3855451D1
Authority
DE
Germany
Prior art keywords
triscarboxymethyl
tetraazacyclododecane
analogs
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3855451T
Other languages
English (en)
Other versions
DE3855451T2 (de
Inventor
Michael F Tweedle
Glen T Gaughan
James J Hagan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Publication of DE3855451D1 publication Critical patent/DE3855451D1/de
Application granted granted Critical
Publication of DE3855451T2 publication Critical patent/DE3855451T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE3855451T 1987-04-24 1988-04-18 Substituiertes 1,4,7-Triscarboxymethyl-1,4,7,10-tetraazacyclododecan und Analoga Expired - Lifetime DE3855451T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4241687A 1987-04-24 1987-04-24
US07/137,267 US4885363A (en) 1987-04-24 1987-12-23 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs

Publications (2)

Publication Number Publication Date
DE3855451D1 true DE3855451D1 (de) 1996-09-05
DE3855451T2 DE3855451T2 (de) 1997-01-09

Family

ID=26719197

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3855451T Expired - Lifetime DE3855451T2 (de) 1987-04-24 1988-04-18 Substituiertes 1,4,7-Triscarboxymethyl-1,4,7,10-tetraazacyclododecan und Analoga

Country Status (5)

Country Link
US (1) US4885363A (de)
EP (1) EP0292689B1 (de)
JP (1) JP2604796B2 (de)
CA (1) CA1296715C (de)
DE (1) DE3855451T2 (de)

Families Citing this family (219)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US5316757A (en) * 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
US5362476A (en) * 1984-10-18 1994-11-08 Board Of Regents, The University Of Texas System Alkyl phosphonate polyazamacrocyclic cheates for MRI
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US5422096A (en) * 1985-05-08 1995-06-06 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
MX174467B (es) * 1986-01-23 1994-05-17 Squibb & Sons Inc 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos
GB8603537D0 (en) * 1986-02-13 1986-03-19 Parker D Conjugate compound
US5271927A (en) * 1986-02-13 1993-12-21 Celltech Limited Antibody conjugates with macrocyclic ligands
DE3684711D1 (de) * 1986-04-07 1992-05-07 Francois Dietlin In der tomo-densitometrie zu verwendende zusammensetzungen.
US5132409A (en) * 1987-01-12 1992-07-21 Bracco Industria Chimica S.P.A. Macrocyclic chelating agents and chelates thereof
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
FR2637895B1 (fr) * 1988-10-14 1992-11-06 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands
US5049667A (en) * 1987-04-14 1991-09-17 Guerbet S.A. Nitrogen-containing cyclic ligands
US4994560A (en) * 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
US5006643A (en) * 1987-06-24 1991-04-09 The Dow Chemical Company Process for preparing isothiocyanato functionalized metal complexes
EP0466200B1 (de) * 1987-07-16 1996-04-24 Nycomed Imaging As Aminocarbonsäure und Derivate
US5531978A (en) * 1987-07-16 1996-07-02 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
GB8719042D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
GB8719041D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
DE3728600A1 (de) * 1987-08-27 1989-03-09 Hoechst Ag Verfahren zur markierung von substanzen mit technetium oder rhenium
GB8801646D0 (en) * 1988-01-26 1988-02-24 Nycomed As Chemical compounds
WO1989011475A1 (en) * 1988-05-25 1989-11-30 The United States Of America, As Represented By Th Macrocyclic chelates and methods of use thereof
CN1033030C (zh) * 1988-06-24 1996-10-16 唐化学原料公司 大环双官能螯合剂及其配合物和抗体共轭物的制备方法
US5756065A (en) * 1988-06-24 1998-05-26 The Dow Chemical Company Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
DE353450T1 (de) * 1988-06-24 1990-09-06 The Dow Chemical Co., Midland, Mich. Macrocyclische bifunktionelle chelatbildner, komplexe davon und ihre konjugierten antikoerper.
BR8907282A (pt) * 1988-12-23 1991-03-12 Dow Chemical Co Processo para preparar complexos de metal funcionalizados com isotiocianato
DE69024826T2 (de) * 1989-02-10 1996-06-27 Celltech Therapeutics Ltd Aza-Macrozyklen und Verfahren zu deren Herstellung
US5342936A (en) * 1989-02-10 1994-08-30 David Parker Tetra-aza macrocycles and processes for their preparation
US6139603A (en) * 1989-02-22 2000-10-31 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Process for recovering oxygen
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
US5914095A (en) * 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
US5384108A (en) * 1989-04-24 1995-01-24 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
US5292868A (en) * 1989-05-26 1994-03-08 Akzo N.V. Chelating agents for attaching metal ions to proteins
US5808003A (en) * 1989-05-26 1998-09-15 Perimmune Holdings, Inc. Polyaminocarboxylate chelators
ATE130303T1 (de) * 1989-06-16 1995-12-15 Neorx Corp Radionukleid-chelatverbindungen zur radiomarkierung von proteinen.
US5247077A (en) * 1989-06-23 1993-09-21 Celltech Limited Tri-aza macrocycles and processes for their preparation
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
CA2065290C (en) * 1989-08-28 2000-12-12 Randall B. Lauffer Hydroxy-aryl metal chelates for diagnostic nmr imaging
US5800802A (en) * 1989-10-11 1998-09-01 Subramanian; Ramaswamy Chelator IDAC-2
GB8923843D0 (en) * 1989-10-23 1989-12-13 Salutar Inc Compounds
US5446145A (en) * 1990-01-19 1995-08-29 Nycomed Salutar, Inc. Polychelant compounds
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5236695A (en) * 1989-11-27 1993-08-17 Concat, Ltd. MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
AU6709390A (en) * 1989-12-22 1991-06-27 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-tris-carboxymethyl -1,4,7,10-tetraazacyclododecane
AU625529B2 (en) * 1989-12-22 1992-07-16 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes
US5679810A (en) * 1990-01-19 1997-10-21 Salutar, Inc. Linear oligomeric polychelant compounds
US5494655A (en) * 1990-03-09 1996-02-27 The Regents Of The University Of California Methods for detecting blood perfusion variations by magnetic resonance imaging
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
AU7587091A (en) * 1990-03-26 1991-10-21 United States of America, as represented by the Secretary, U.S. Department of Commerce, The A fonctionalized complexand
AU654951B2 (en) * 1990-04-18 1994-12-01 Celltech Limited Tetra-aza macrocycles, processes for their preparation and their use in magnetic resonance imaging
US5684135A (en) * 1990-04-18 1997-11-04 Celltech Therapeutics Limited Conjugate compounds containing aza-macro-cycles and processes for their preparation
CA2039399C (en) * 1990-04-25 2000-09-05 C. Allen Chang Dual functioning excipient for metal chelate contrast agents
US5079346A (en) * 1990-05-01 1992-01-07 Trustees Of The University Of Pennsylvania Gallium-labelled imaging agents
IT1243801B (it) * 1990-08-29 1994-06-28 Bracco Ind Chimica Spa Intermedi per agenti chelanti con simmetria prefissata, e procedimentoper la loro preparazione
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5463030A (en) * 1991-05-03 1995-10-31 Research Foundation Of The State Of New York Metal chelating agents for medical application
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
WO1992021017A1 (en) * 1991-05-23 1992-11-26 Unger Evan C Liposoluble compounds for magnetic resonance imaging
CA2072934C (en) * 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US6875864B2 (en) * 1991-08-01 2005-04-05 Bracco International B.V. Aminocarboxylate ligands having substituted aromatic amide moieties
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
US5480990A (en) * 1991-12-10 1996-01-02 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents
US5739294A (en) * 1991-12-10 1998-04-14 The Dow Chemical Company Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
GB9127060D0 (en) * 1991-12-20 1992-02-19 Unilever Plc Bleach activation
US5324503A (en) * 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
EP0565930A1 (de) * 1992-03-27 1993-10-20 Nihon Medi-Physics Co., Ltd. Tetracyclododecan-Tetraessigsäurederivate und ihre Verwendung als diagnostische Mittel
SG52470A1 (en) * 1992-04-13 1998-09-28 Dow Chemical Co Process for preparing macrocyclic chelating agents and formation of chelates and conjugates thereof
US5310535A (en) * 1992-04-24 1994-05-10 The Dow Chemical Company Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies
US5505931A (en) * 1993-03-04 1996-04-09 The Dow Chemical Company Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents
US6204259B1 (en) 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US5468467A (en) * 1993-04-23 1995-11-21 Bracco International B.V. Methods for the in vivo measurement of the concentration of non-imaging nmr-detectable xenobiotic compounds
US5744119A (en) * 1993-05-11 1998-04-28 Sterling Winthrop Preparation of a radioconjugate formulation
DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
US5409689A (en) * 1993-08-13 1995-04-25 Concat, Ltd. MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms
US5733528A (en) * 1993-12-03 1998-03-31 Dibra S.P.A. Paramagnetic chelates for nuclear magnetic resonance diagnosis
AU2194695A (en) * 1994-03-28 1995-10-17 Regents Of The University Of California, The Method for preparing radionuclide-labeled chelating agent-ligand complexes
EP0702677A1 (de) * 1994-04-08 1996-03-27 BRACCO International B.V. Aromatische amidverbindungen und seine metallchelate
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
US6693190B1 (en) * 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
IT1274038B (it) * 1994-07-29 1997-07-14 Bracco Spa Chelanti macrociclici loro chelati e relativi usi in campo diagnostico
TW319763B (de) * 1995-02-01 1997-11-11 Epix Medical Inc
GB9504910D0 (en) * 1995-03-10 1995-04-26 Nycomed Imaging As Compounds
GB9504922D0 (en) * 1995-03-10 1995-04-26 Nycomed As Process
CN1181751A (zh) * 1995-03-10 1998-05-13 耐克麦德瑟鲁塔公司 N－芳甲基氮丙啶和从它们开始制得的1,4,7,10－四氮杂环十二烷衍生物以及作为中间体的n－芳甲基乙醇胺磺酸酯的制备
US6770261B2 (en) 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US5707605A (en) * 1995-06-02 1998-01-13 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US5980862A (en) * 1995-06-02 1999-11-09 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
CN1053910C (zh) * 1995-11-14 2000-06-28 武汉大学 合成环状多氨多羧酸螯合物造影剂的方法
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US6107090A (en) 1996-05-06 2000-08-22 Cornell Research Foundation, Inc. Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US5888476A (en) * 1996-11-13 1999-03-30 Mallinckrodt Medical, Inc. Magnetic resonance blood pool agents
US5861138A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Ligands for MRI contrast agent
US5861140A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Tripodal paramagnetic contrast agents for MR imaging
US7060247B2 (en) 1997-04-22 2006-06-13 The Curators Of The University Of Missouri Gastrin receptor-avid peptide conjugates
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US5824288A (en) * 1997-08-21 1998-10-20 Hoechst Celanese Corporation Thio-substituted pyridines as MRI ligand precursors
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US6713046B1 (en) * 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
WO1999025389A2 (en) 1997-11-17 1999-05-27 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
US6056939A (en) * 1998-08-28 2000-05-02 Desreux; Jean F. Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
EP1191948A2 (de) * 1999-06-11 2002-04-03 Neorx Corporation Hochdosierte radionuklide komplexe zur knochenmark-unterdrückung
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
FR2802928B1 (fr) * 1999-12-22 2003-01-31 Air Liquide Polyazacycloalcanes eventuellement greffes sur une matrice solide, complexes organometalliques les incorporant comme ligands. utilisation desdits composes a l'extraction de metaux lourds
US6565828B2 (en) 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
US6656450B2 (en) 2000-07-17 2003-12-02 California Institute Of Technology, Inc. Macrocyclic magnetic resonance imaging contrast agents
US7311893B2 (en) * 2000-07-25 2007-12-25 Neurochem (International) Limited Amyloid targeting imaging agents and uses thereof
RU2311413C2 (ru) 2000-09-29 2007-11-27 Анормед, Инк. Циклические полиамины, содержащие в кольце n атомов азота, защищенных по принципу "все, кроме одного (n-1)", и способы их получения
AU2002211517A1 (en) 2000-10-04 2002-04-15 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
JP2004536034A (ja) 2001-01-08 2004-12-02 ネオルクス コーポレイション 治療的および診断的化合物、組成物および方法
US6517814B2 (en) 2001-01-09 2003-02-11 Bristol-Myers Squibb Pharma Company Macrocyclic chelants useful for metallopharmaceuticals
US7048907B2 (en) 2001-02-05 2006-05-23 Biophysics Assay Laboratory, Inc. Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products
CN1622832A (zh) * 2001-02-23 2005-06-01 布里斯托尔-迈尔斯斯奎布药品公司 用于动脉粥样硬化和易病变性斑块成像的标记的巨噬细胞清除剂受体拮抗剂
US20030004236A1 (en) * 2001-04-20 2003-01-02 Meade Thomas J. Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
WO2002087632A1 (en) * 2001-05-02 2002-11-07 Metaprobe, Inc. High throughput screening methods using magnetic resonance imaging agents
US20030007974A1 (en) * 2001-05-30 2003-01-09 Nanus David M. Endopeptidase/anti-PSMA antibody fusion proteins for treatment of cancer
CA2448570A1 (en) * 2001-05-31 2002-12-05 Miravant Pharmaceuticals, Inc. Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and mri diagnosis
US7666414B2 (en) * 2001-06-01 2010-02-23 Cornell Research Foundation, Inc. Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen
WO2002098897A2 (en) * 2001-06-01 2002-12-12 Cornell Research Foundation, Inc. Modified antibodies to prostate-specific membrane antigen and uses thereof
US7514078B2 (en) * 2001-06-01 2009-04-07 Cornell Research Foundation, Inc. Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
US7893223B2 (en) 2001-07-17 2011-02-22 Bracco Imaging S.P.A. Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
WO2003024388A2 (en) * 2001-09-20 2003-03-27 Cornell Research Foundation, Inc. Methods and compositions for treating and preventing skin disorders using binding agents specific for psma
EP1302465A1 (de) * 2001-10-11 2003-04-16 BRACCO IMAGING S.p.A. Verbesserte MRI-Bildgebung mittels umkehrbares binding zu einem paramagnetischen Komplex
PT1463751E (pt) 2001-12-21 2013-08-26 Human Genome Sciences Inc Proteínas de fusão de albumina
US20030198597A1 (en) * 2002-04-22 2003-10-23 Meade Thomas J. Novel macrocyclic activatible magnetic resonance imaging contrast agents
US20030228621A1 (en) * 2002-05-24 2003-12-11 Yong Qin Common ligand universal enzyme assay and compositions for use therein
US7563882B2 (en) * 2002-06-10 2009-07-21 University Of Rochester Polynucleotides encoding antibodies that bind to the C35 polypeptide
US20040136998A1 (en) * 2002-10-30 2004-07-15 Bander Neil H. Methods and compositions for treating or preventing insulin-related disorders using binding agents specific for prostate specific membrane antigen
EP1581794B1 (de) * 2003-01-10 2008-09-17 Millennium Pharmaceuticals, Inc. Verfahren zur bestimmung des wiederauftretens von prostata krebs
US7922998B2 (en) * 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
AU2003303714B2 (en) * 2003-01-13 2009-02-19 Bracco Imaging S.P.A. Improved linkers for radiopharmaceutical compounds
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US20060239923A1 (en) * 2003-01-13 2006-10-26 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US8420050B2 (en) * 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
WO2004064869A2 (en) * 2003-01-22 2004-08-05 The General Hospital Corporation Amyloid-binding, metal-chelating agents
WO2004112840A2 (en) * 2003-06-25 2004-12-29 Guerbet Peptide conjugate for magnetic resonance imaging
CA2783275A1 (en) * 2003-07-24 2005-02-03 Bracco Imaging S.P.A. Stable radiopharmaceutical compositions and methods for their preparation
EP1708751B1 (de) * 2003-12-04 2011-09-28 Vaccinex, Inc. Verfahren zum abtöten von tumorzellen mittels targeting von auf apoptotischen tumorzellen exponierten internen antigenen
WO2005070456A2 (en) * 2004-01-09 2005-08-04 Millennium Pharmaceuticals, Inc. Diagnosing and treating female reproductive tract or chilhood cancer with pmsa antibodies
EP1610818A4 (de) * 2004-03-03 2007-09-19 Millennium Pharm Inc Modifizierte antikörper gegen ein prostataspezifisches membranantigen und verwendung dafür
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
WO2005115105A2 (en) * 2004-05-10 2005-12-08 Northwestern University Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase
US7504088B2 (en) 2004-06-09 2009-03-17 Kereos, Inc. Lipophilic derivatives of chelate monoamides
EP1778699A4 (de) * 2004-08-10 2009-02-25 Dow Global Technologies Inc Targeting von chelanten und chelaten
CA2581639C (en) * 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
EP2014728A1 (de) 2005-01-13 2009-01-14 Cinvention Ag Verbundstoffmaterialbeschichtungen
WO2006124726A2 (en) 2005-05-12 2006-11-23 The General Hospital Corporation Novel biotinylated compositions
EP1937753A1 (de) * 2005-10-18 2008-07-02 Cinvention Ag Duroplastische teilchen und herstellungsverfahren dafür
GB0524987D0 (en) 2005-12-08 2006-01-18 Ge Healthcare Ltd Novel imaging agents for fibrosis
AR059193A1 (es) 2006-01-31 2008-03-12 Bayer Schering Pharma Ag Modulacion de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias
WO2007104135A1 (en) * 2006-03-10 2007-09-20 Mds (Canada) Inc. Bifunctional polyazamacrocyclic chelating agents
KR20080108989A (ko) 2006-03-14 2008-12-16 말린크로트, 인코포레이티드 테트라아자거대고리 유도체의 금속 착체
US20090317335A1 (en) * 2006-04-20 2009-12-24 Wenbin Lin Hybrid Nanomaterials as Multimodal Imaging Contrast Agents
WO2008026937A1 (en) 2006-08-30 2008-03-06 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) and compounds and compositions for use in the method
AU2007329592A1 (en) * 2006-11-21 2008-06-12 Barnes-Jewish Hospital Methods of imaging employing chelating agents
BRPI0806916A2 (pt) * 2007-01-19 2014-04-29 Cinv Ag Implante poroso, não degradável feito por moldagem de pó
BRPI0807993A2 (pt) * 2007-02-28 2014-06-17 Cinv Ag Sistema de cultivo de alta superfície.
WO2008104599A1 (en) * 2007-02-28 2008-09-04 Cinvention Ag High surface cultivation system bag
EP2072060A1 (de) 2007-12-18 2009-06-24 Institut Curie Verfahren und Zusammensetzungen zur Herstellung und Verwendung von Toxinkonjugaten
NZ586544A (en) * 2007-12-26 2012-07-27 Vaccinex Inc Anti-c35 antibody in combination with an ani-her2 antibody in cancer therapies and methods
EP2100900A1 (de) 2008-03-07 2009-09-16 Universitätsspital Basel Bombesin-analoge Peptid-antagonistische Konjugate
US8580231B2 (en) 2008-05-23 2013-11-12 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
US20100029909A1 (en) * 2008-05-23 2010-02-04 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
JP5681102B2 (ja) 2008-05-30 2015-03-04 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッドＳｉｅｍｅｎｓ Ｍｅｄｉｃａｌ Ｓｏｌｕｔｉｏｎｓ ＵＳＡ，Ｉｎｃ． 分子イメージング手法のための化合物
EP2384323A4 (de) * 2008-11-11 2013-07-31 Univ Nanyang Tech Intravaskuläre kontrastmittel
US20100129290A1 (en) * 2008-11-26 2010-05-27 I.S.T. Corporation Smart contrast agent and detection method for detecting transition metal ions
US20120093725A1 (en) 2009-04-10 2012-04-19 Inserm (Institut National De La Sante Et De La Recherche Medicale Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies
GB0922014D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel integrin binders
KR101253100B1 (ko) * 2010-02-16 2013-04-10 경북대학교 산학협력단 폴리아자마크로사이클릭 화합물, 그 제조 방법 및 생의학적 적용
GB201017088D0 (en) 2010-08-20 2010-11-24 Ge Healthcare Ltd Imaging tuberculosis
CN102399199B (zh) * 2010-09-19 2014-01-08 广州康臣药物研究有限公司 一种磁共振成像造影剂的制备方法
WO2012072819A1 (en) 2010-12-03 2012-06-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Agents for the molecular imaging of serine-protease in human pathologies
US9598499B2 (en) 2010-12-30 2017-03-21 Institut National De La Santé Et De La Recherche Médicale (Inserm) Antigen binding formats for use in therapeutic treatments or diagnostic assays
RS60001B1 (sr) 2011-04-21 2020-04-30 Bayer Ip Gmbh Pripremanje gadobutrola visoke čistoće
WO2013048832A1 (en) 2011-09-29 2013-04-04 Ge Healthcare Limited 18 f - labelled 6 - ( 2 - fluoroethoxy) - 2 - naphthaldehyde for detecting cancer stem cells
US9120837B2 (en) 2012-01-06 2015-09-01 Molecular Insight Pharmaceuticals Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase IX
EP2639227A1 (de) 2012-03-14 2013-09-18 Bracco Imaging S.p.A Neue Klasse von Diazepinderivatchelatbildnern und Komplexe mit paramagnetischen Metallen als MRI-Kontrastmittel
EP2836597A1 (de) 2012-04-11 2015-02-18 Institut National de la Santé et de la Recherche Médicale (INSERM) Matrixmetallproteinase-9 (mmp-9-)-aptamer und verwendungen davon
EP3441467A3 (de) 2012-08-31 2019-04-24 The General Hospital Corporation Biotinkomplexe zur behandlung und diagnose von morbus alzheimer
EP2733153A1 (de) 2012-11-15 2014-05-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur Herstellung von Immunkonjugaten und Verwendungen davon
EP2740726A1 (de) 2012-12-07 2014-06-11 3B Pharmaceuticals GmbH Neurotensin-Rezeptorligande
CN105025933B (zh) 2013-01-14 2019-03-26 分子制药洞察公司 三嗪类放射性药物和放射性显影剂
WO2014122228A1 (en) 2013-02-07 2014-08-14 Westfaelische Wilhelms-Universitaet Muenster Labelled compounds that bind to alpha-v-beta-3 integrin
EP2954934A1 (de) 2014-06-11 2015-12-16 3B Pharmaceuticals GmbH Konjugat aus einem Neurotensinrezeptorliganden und Verwendung davon
EP2954933A1 (de) 2014-06-10 2015-12-16 3B Pharmaceuticals GmbH Konjugat mit einem Neurotensinrezptorligand
CN106794264B (zh) 2014-06-10 2021-03-23 3B制药有限公司 包含神经降压肽受体配体的缀合物及其用途
CA3002512C (en) 2015-12-10 2021-08-03 Bracco Imaging Spa Macrocyclic chelating ligand and use thereof as contrast agent
EP3753929B1 (de) 2015-12-10 2022-10-26 Bracco Imaging SPA Dimere kontrastmittel
WO2017178301A1 (en) 2016-04-13 2017-10-19 Bracco Imaging Spa Contrast agents
EP3279197A1 (de) 2016-08-03 2018-02-07 Friedrich-Alexander-Universität Erlangen-Nürnberg Diagnose, behandlung und vorbeugung von zuständen, die mit dem neurotensin-rezeptor verbunden sind
ES2809736T3 (es) 2016-09-27 2021-03-05 Bayer Pharma AG Método para producir la forma cristalina de modificación a de calcobutrol
US11358982B2 (en) 2016-11-01 2022-06-14 Ohio State Innovation Foundation Methods for the iodination of biomolecules
CN108084105B (zh) * 2016-11-23 2020-07-24 四川科伦药物研究院有限公司 钆特醇中间体及其合成方法和利用该钆特醇中间体制备钆特醇的方法
WO2018108780A1 (en) 2016-12-12 2018-06-21 Bracco Imaging Spa Dimeric contrast agents
US11607462B2 (en) 2017-05-16 2023-03-21 Northwestern University Systems and methods for minimally-invasive assessment of toxicity-induced tissue injury
WO2018213853A1 (en) * 2017-05-19 2018-11-22 The Research Foundation For The State University Of New York Compounds for use as iron(iii) mri contrast agents
FR3069245B1 (fr) * 2017-07-21 2019-07-26 Guerbet Ligands macrocycliques lipophiles, leurs complexes ainsi que leurs utilisations medicales
CN108047151B (zh) * 2018-01-03 2020-08-04 广州康瑞泰药业有限公司 一种高收率钆布醇的制备方法
EP3763726A1 (de) 2019-07-08 2021-01-13 3B Pharmaceuticals GmbH Verbindungen mit fibroblasten-aktivierendem proteinligand und deren verwendung
JP2022541752A (ja) 2019-07-08 2022-09-27 ３ベー ファーマシューティカルズ ゲーエムベーハー 線維芽細胞活性化タンパク質リガンドを含む化合物およびその使用
WO2022123462A1 (en) 2020-12-09 2022-06-16 3B Pharmaceuticals Gmbh Radiolabelled prostate specific membrane antigen (psma) inhibitors and use thereof
EP4050018A1 (de) 2021-01-07 2022-08-31 3B Pharmaceuticals GmbH Verbindungen mit fibroblasten-aktivierendem proteinligand und deren verwendung
AU2022205523A1 (en) 2021-01-07 2023-07-13 3B Pharmaceuticals Gmbh Compounds comprising a fibroblast activation protein ligand and use thereof
EP4122499A1 (de) 2021-07-23 2023-01-25 3B Pharmaceuticals GmbH Inhibitoren des fibroblastenaktivierungsproteins und verwendung davon
EP4377296A1 (de) 2021-07-26 2024-06-05 Arvinas Operations, Inc. Verfahren zur herstellung einer bifunktionellen verbindung
TW202340226A (zh) 2021-12-17 2023-10-16 德商３Ｂ製藥有限公司 碳酸酐酶ix配位體
WO2024052431A1 (en) 2022-09-07 2024-03-14 3B Pharmaceuticals Gmbh Prostate specific membrane antigen (psma) ligands and use thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3201472A (en) * 1958-12-02 1965-08-17 Geigy Chem Corp Tertiary-amino-alkylated primary amines
US4156683A (en) * 1973-03-26 1979-05-29 Schering Corporation Complexes of macrocyclic compounds
US4085106A (en) * 1976-01-07 1978-04-18 E. I. Du Pont De Nemours And Company Bicyclic and tricyclic trisaminomethanes
JPS53144592A (en) * 1977-05-19 1978-12-15 Tabuse Iwao 122alkyll1*4*7*100tetrazacyclotridecane
JPS53144593A (en) * 1977-05-19 1978-12-15 Iwao Tabuse Alklycyclum
US4190462A (en) * 1978-07-04 1980-02-26 Shell Oil Company Dissolving barium sulfate scale with aqueous solutions of salts of carboxymethyl monocyclic macrocyclic polyamines
GB2108106B (en) * 1978-07-04 1983-09-01 Shell Int Research Novel macrocyclic compounds and salts thereof useful for dissolving barium sulphate scale
US4543213A (en) * 1978-07-24 1985-09-24 The United States Of America As Represented By The United States Department Of Energy Process for preparing 2,3-dihydroxybenzoic acid amides of tetraazaalkanes and cycloalkanes
NO149961C (no) * 1981-06-01 1984-07-25 Borregaard Ind Fremgangsmaate for fremstilling av n-(2-hydroksyetyl)-derivater av makrocykliske polyaminer, inneholdende flere nitrogenatomer i 1,4-forhold i ringen
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
DE3316703A1 (de) * 1983-05-04 1984-11-08 Schering AG, 1000 Berlin und 4709 Bergkamen Orales kontrastmittel fuer die kernspintomographie und dessen herstellung
FR2550449B1 (fr) * 1983-08-12 1986-01-31 Commissariat Energie Atomique Agents de relaxation specifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie medicale par resonance magnetique nucleaire
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
DE3772785D1 (de) * 1986-01-23 1991-10-17 Squibb & Sons Inc 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga.
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
GB8603537D0 (en) * 1986-02-13 1986-03-19 Parker D Conjugate compound
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate

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