ES2067322T3 - Lactamas substituidas en n utiles como antagonistas de colecistoquinina. - Google Patents

Lactamas substituidas en n utiles como antagonistas de colecistoquinina.

Info

Publication number
ES2067322T3
ES2067322T3 ES92901239T ES92901239T ES2067322T3 ES 2067322 T3 ES2067322 T3 ES 2067322T3 ES 92901239 T ES92901239 T ES 92901239T ES 92901239 T ES92901239 T ES 92901239T ES 2067322 T3 ES2067322 T3 ES 2067322T3
Authority
ES
Spain
Prior art keywords
useful
cholecystocinin
antagonists
lactams
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92901239T
Other languages
English (en)
Inventor
Daniel Paul Becker
Daniel Lee Flynn
Clara Ines Villamil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2067322T3 publication Critical patent/ES2067322T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS LACTAMOS N-SUSTITUIDOS TENIENDO LA FORMULA (1) QUE PUEDEN SER UTILIZADOS EN EL TRATAMIENTO Y EN LA PREVENCION DE DESORDENES RELACIONADOS CON LA COLECISTOQUININA (CCK) DE LOS SISTEMAS GASTROINTESTINAL, NERVIOSO CENTRAL Y REGULADOR DEL APETITO DE LOS MAMIFEROS.
ES92901239T 1990-12-11 1991-11-25 Lactamas substituidas en n utiles como antagonistas de colecistoquinina. Expired - Lifetime ES2067322T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/626,590 US5202344A (en) 1990-12-11 1990-12-11 N-substituted lactams useful as cholecystokinin antagonists

Publications (1)

Publication Number Publication Date
ES2067322T3 true ES2067322T3 (es) 1995-03-16

Family

ID=24511043

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92901239T Expired - Lifetime ES2067322T3 (es) 1990-12-11 1991-11-25 Lactamas substituidas en n utiles como antagonistas de colecistoquinina.

Country Status (12)

Country Link
US (2) US5202344A (es)
EP (1) EP0561941B1 (es)
JP (1) JPH06503827A (es)
AT (1) ATE116638T1 (es)
AU (1) AU9057191A (es)
CA (1) CA2097517A1 (es)
DE (1) DE69106532T2 (es)
DK (1) DK0561941T3 (es)
ES (1) ES2067322T3 (es)
IE (1) IE62703B1 (es)
PT (1) PT99739A (es)
WO (1) WO1992010476A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE912285A1 (en) * 1990-07-12 1992-01-15 Black James Foundation Amino acid derivatives
DE4127404A1 (de) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US6083943A (en) * 1993-09-17 2000-07-04 Pfizer Inc Substituted azaheterocyclecarboxylic acid
DK0719253T3 (da) * 1993-09-17 2004-07-26 Pfizer 3-amino-5-carboxy-substituerede piperidiner og 3-amino-4-carboxy-substituerede pyrrolidiner som tachykininantagonister
US5719296A (en) * 1995-10-30 1998-02-17 Merck & Co., Inc. Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
US6187536B1 (en) 1997-02-18 2001-02-13 Thomas Jefferson University Methods of identifying and detecting pancreatic cancer
AU1061500A (en) * 1998-11-09 2000-05-29 James Black Foundation Limited Gastrin and cholecystokinin receptor ligands
US6207638B1 (en) 2000-02-23 2001-03-27 Pacifichealth Laboratories, Inc. Nutritional intervention composition for enhancing and extending satiety
GB0011095D0 (en) * 2000-05-08 2000-06-28 Black James Foundation astrin and cholecystokinin receptor ligands (III)
US6429190B1 (en) 2000-12-15 2002-08-06 Pacifichealth Laboratories, Inc. Method for extending the satiety of food by adding a nutritional composition designed to stimulate cholecystokinin(CCK)
WO2002047614A2 (en) 2000-12-15 2002-06-20 Pacific Health Laboratories, Inc. Nutritional composition for improving the efficacy of a lipase inhibitor
NZ532018A (en) * 2001-10-03 2004-12-24 Ucb S Pyrrolidinone derivatives
GB0130705D0 (en) * 2001-12-21 2002-02-06 Glaxo Group Ltd Chemical compounds
WO2004022536A1 (en) * 2002-09-04 2004-03-18 Glenmark Pharmaceuticals Limited New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
BR0314721A (pt) 2002-10-23 2005-08-02 Glenmark Pharmaceuticals Ltd Compostos tricìclicos úteis para tratamento de distúrbios inflamatórios e alérgicos, processo para sua preparação e composições farmacêuticas contendo-os
DE602004020332D1 (de) 2003-04-11 2009-05-14 Glenmark Pharmaceuticals Sa Neue heterozyklische verbindungen, die sich für die behandlung von entzündlichen und allergischen erkrankungen eignen: verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten
WO2004110997A1 (en) 2003-06-19 2004-12-23 Glaxo Group Limited 3- sulfonylamino- pyrrolidine- 2- one derivatives as inhibitors of factor xa
GB0314299D0 (en) 2003-06-19 2003-07-23 Glaxo Group Ltd Chemical compounds
GB0314373D0 (en) 2003-06-19 2003-07-23 Glaxo Group Ltd Chemical compounds
EP1799632A2 (en) 2004-10-13 2007-06-27 Glenmark Pharmaceuticals S.A. Process for the preparation of n-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide
MX2007007345A (es) 2004-12-17 2007-09-07 Glenmark Pharmaceuticals Sa Compuestos heterociclicos novedosos utiles para el tratamiento de trastornos inflamatorios y alergicos.
SI1831227T1 (sl) 2004-12-17 2013-09-30 Glenmark Pharmaceuticals S.A. Nove heterociklične spojine uporabne za zdravljenje vnetnih in alergijskih motenj
FR2913888B1 (fr) * 2007-03-21 2010-01-01 Jean Pierre Breda Procede et dispositif d'irradiation par rayonnement d'energie photonique modulee
GB0910003D0 (en) * 2009-06-11 2009-07-22 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases
KR20150036333A (ko) * 2012-07-02 2015-04-07 피엔비 베스퍼 라이프 사이언스 피브이티 리미티드 신규한 콜레시스토키닌 수용체 리간드
CN105814019B (zh) * 2013-11-28 2019-12-06 杏林制药株式会社 脲衍生物、或其药理学上所容许的盐
WO2019173182A1 (en) 2018-03-05 2019-09-12 Bristol-Myers Squibb Company Phenylpyrrolidinone formyl peptide 2 receptor agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474093A (en) * 1966-05-03 1969-10-21 American Home Prod Enamine adducts of n-acyloxy-n-acylaminoacetanilide
US4200572A (en) * 1975-09-03 1980-04-29 Smithkline Corporation Substituted azetidinones
US4085100A (en) * 1976-11-01 1978-04-18 Smithkline Corporation Intermediate for dephthaloylation of azetidinone compounds
US4260743A (en) * 1979-12-31 1981-04-07 Gist-Brocades N.V. Preparation of β-lactams and intermediates therefor
US4757068A (en) * 1984-06-26 1988-07-12 Merck & Co., Inc. Lactams and bicyclic lactams useful as cholecystokinin antagonists

Also Published As

Publication number Publication date
DE69106532D1 (de) 1995-02-16
US5314886A (en) 1994-05-24
DK0561941T3 (da) 1995-03-06
WO1992010476A1 (en) 1992-06-25
EP0561941B1 (en) 1995-01-04
AU9057191A (en) 1992-07-08
IE62703B1 (en) 1995-02-22
ATE116638T1 (de) 1995-01-15
JPH06503827A (ja) 1994-04-28
CA2097517A1 (en) 1992-06-12
US5202344A (en) 1993-04-13
IE914293A1 (en) 1992-06-17
DE69106532T2 (de) 1995-06-08
EP0561941A1 (en) 1993-09-29
PT99739A (pt) 1992-11-30

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