ES2065975T3 - Derivados de benceno condensados. - Google Patents

Derivados de benceno condensados.

Info

Publication number
ES2065975T3
ES2065975T3 ES89122394T ES89122394T ES2065975T3 ES 2065975 T3 ES2065975 T3 ES 2065975T3 ES 89122394 T ES89122394 T ES 89122394T ES 89122394 T ES89122394 T ES 89122394T ES 2065975 T3 ES2065975 T3 ES 2065975T3
Authority
ES
Spain
Prior art keywords
group
methylene
hydrogen atom
benzene derivatives
ethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89122394T
Other languages
English (en)
Inventor
Tomoji Aotsuka
Motoki C O Zeria Phar Torizuka
Mitsuo C O Zeria Pharmac Soeda
Kuniyoshi C O Zeria Phar Ogura
Yoshiaki C O Zeria Phar Tanaka
Hisayoshi C O Zeria Pharm Kato
Naoki C O Zeria Pharmac Nakata
Naoyoshi C O Zeria Pharm Miura
Hikari C O Zeria Pharma Morita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeria Pharmaceutical Co Ltd
Original Assignee
Zeria Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1260070A external-priority patent/JPH0822847B2/ja
Application filed by Zeria Pharmaceutical Co Ltd filed Critical Zeria Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2065975T3 publication Critical patent/ES2065975T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE DESCUBREN NUEVOS DERIVADOS DE BENCENO CONDENSADO TENIENDO TENIENDO PROPIEDADES INHIBIDORA DE PROPILO ENDOPEPTIDASA, ANTI- HIPOOXIGENACION, Y ANTI- AMNESICA. LOS COMPUESTOS ESTAN REPRESENTADOS POR LA SIGUIENTE FORMULA (I), EN DONDE A REPRESENTA UN GRUPO METILENO, ETILENO O PROPILENO, B REPRESENTA UN GRUPO METILENO O ETILENO, M DENOTA UN ENTERO DE 0 A 5, X E Y, LAS CUALES PUEDEN SER LO MISMO O DIFERENTE, REPRESENTAN INDIVIDUALMENTE UN GRUPO METILENO, O ATOMO DE AZUFRE, R1 REPRESENTA UN ATOMO DE HIDROGENO, UN CARBOXILO, ALQUILOOXILOCARBONILO INFERIOR, HIDROXILOMETILO, O GRUPO FORMILO, R2 REPRESENTA UN ATOMO DE HIDROGENO, UN ATOMO HALOGENO, UN ALQUILO INFERIOR, ALCOXILO INFERIOR, NITROGENO, O GRUPO AMINO, R3 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR, Y LA LINEA PUNTEADA PUEDE ESTAR PRESENTE OPCIONALMENTE. SE USAN COMO MEDICINAS PARA TRATAR O PREVENIR DESORDENES DE CIRCULACION CEREBRAL, DESORDENES DEL METABOLISMO CEREBRAL, O DISTURBIOS DE MEMORIA.
ES89122394T 1988-12-08 1989-12-05 Derivados de benceno condensados. Expired - Lifetime ES2065975T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP30887888 1988-12-08
JP1260070A JPH0822847B2 (ja) 1988-12-08 1989-10-06 縮合ベンゼン誘導体、それを含有する医薬及び該化合物の製造中間体

Publications (1)

Publication Number Publication Date
ES2065975T3 true ES2065975T3 (es) 1995-03-01

Family

ID=26544433

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89122394T Expired - Lifetime ES2065975T3 (es) 1988-12-08 1989-12-05 Derivados de benceno condensados.

Country Status (8)

Country Link
US (1) US5028604A (es)
EP (1) EP0372484B1 (es)
AT (1) ATE113279T1 (es)
AU (1) AU616824B2 (es)
CA (1) CA2004028C (es)
DE (1) DE68919054T2 (es)
DK (1) DK616189A (es)
ES (1) ES2065975T3 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1230706B (it) * 1989-02-10 1991-10-29 Poli Ind Chimica Spa Derivati dell'acido 3 piroglutamoil tiazolidin 4 carbossilico e loro proprieta' farmacologiche.
HU204040B (en) * 1989-07-11 1991-11-28 Richter Gedeon Vegyeszet Process for producing new thiazoles and thiazines and pharmaceutical compositions comprising same
ATE133407T1 (de) * 1990-06-07 1996-02-15 Zeria Pharm Co Ltd Neue arylalkanoylaminderivate und diese enthaltendes arzneimittel
JP3810097B2 (ja) * 1993-01-15 2006-08-16 明治製菓株式会社 ピロリジン−２−イルカルボニル複素環式化合物誘導体
HUT76640A (en) * 1995-08-17 1997-10-28 Chinoin Gyogyszer Es Vegyeszet Compounds of pharmaceutical activity cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use
US6500948B1 (en) * 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
US6218424B1 (en) * 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
HUP9700442A1 (hu) * 1997-02-14 1999-09-28 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Gyűrűs amidszármazékok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk
US6121311A (en) * 1999-04-28 2000-09-19 Japan Tobacco Inc. Method for treating cocainism
ZA200508439B (en) 2003-05-05 2007-03-28 Probiodrug Ag Medical use of inhibitors of glutaminyl and glutamate cyclases
ZA200603165B (en) 2003-11-03 2007-07-25 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
KR101099206B1 (ko) 2004-02-05 2011-12-27 프로비오드룩 아게 신규한 글루타미닐 시클라제 저해제
EP1760076A1 (en) * 2005-09-02 2007-03-07 Ferring B.V. FAP Inhibitors
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
EP2091948B1 (en) 2006-11-30 2012-04-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
MX2009009234A (es) 2007-03-01 2009-12-01 Probiodrug Ag Uso nuevo de inhibidores de ciclasa de glutaminilo.
EP2865670B1 (en) 2007-04-18 2017-01-11 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
US8524654B2 (en) * 2007-05-21 2013-09-03 The Uab Research Foundation Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation
TWI485134B (zh) 2009-05-04 2015-05-21 波麥堤克生化科學公司 取代的芳族化合物及其藥學用途
ES2548913T3 (es) 2009-09-11 2015-10-21 Probiodrug Ag Derivados heterocíclicos como inhibidores de glutaminil ciclasa
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
AU2011226074B2 (en) 2010-03-10 2015-01-22 Vivoryon Therapeutics N.V. Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
EP2813218B1 (en) * 2013-06-14 2022-08-24 Shin-Etsu Chemical Co., Ltd. Method for producing aqueous enteric coating liquid, solid preparation, and method for producing same
DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54138551A (en) * 1978-04-14 1979-10-27 Sumitomo Chem Co Ltd Novel asymmetric synthesis of optically active 2-alkanoyl- 1,2,3,4-tetrahydro-2-naphthol compound
CA1320734C (en) * 1986-02-04 1993-07-27 Suntory Limited Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
US4792969A (en) * 1986-11-13 1988-12-20 Fujitsu Limited Line condition data collecting system for a telephone exchange
JPH08806B2 (ja) * 1986-11-18 1996-01-10 サントリー株式会社 プロリルエンドペプチダ−ゼ阻害作用を有する新規ピロリジンアミド誘導体
ES2052619T3 (es) * 1987-02-23 1994-07-16 Ono Pharmaceutical Co Un procedimiento para la preparacion de los nuevos derivados de tiazolidina.
JPH0832704B2 (ja) * 1987-11-30 1996-03-29 キッセイ薬品工業株式会社 プロリルエンドペプチダーゼ阻害剤
JPH01250370A (ja) * 1987-12-23 1989-10-05 Zeria Pharmaceut Co Ltd 新規アミノ酸イミド誘導体、製法ならびに用途

Also Published As

Publication number Publication date
AU4591489A (en) 1990-06-14
DK616189A (da) 1990-06-11
DE68919054T2 (de) 1995-05-11
CA2004028C (en) 1998-09-22
ATE113279T1 (de) 1994-11-15
US5028604A (en) 1991-07-02
DE68919054D1 (de) 1994-12-01
EP0372484A3 (en) 1991-02-27
DK616189D0 (da) 1989-12-07
CA2004028A1 (en) 1990-06-08
AU616824B2 (en) 1991-11-07
EP0372484A2 (en) 1990-06-13
EP0372484B1 (en) 1994-10-26

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