DE68919054D1 - Kondensierte Benzen-Derivate. - Google Patents

Kondensierte Benzen-Derivate.

Info

Publication number
DE68919054D1
DE68919054D1 DE68919054T DE68919054T DE68919054D1 DE 68919054 D1 DE68919054 D1 DE 68919054D1 DE 68919054 T DE68919054 T DE 68919054T DE 68919054 T DE68919054 T DE 68919054T DE 68919054 D1 DE68919054 D1 DE 68919054D1
Authority
DE
Germany
Prior art keywords
group
methylene
hydrogen atom
benzene derivatives
ethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68919054T
Other languages
English (en)
Other versions
DE68919054T2 (de
Inventor
Tomoji Aotsuka
Motoki C O Zeria Phar Torizuka
Mitsuo C O Zeria Pharmac Soeda
Kuniyoshi C O Zeria Phar Ogura
Yoshiaki C O Zeria Phar Tanaka
Hisayoshi C O Zeria Pharm Kato
Naoki C O Zeria Pharmac Nakata
Naoyoshi C O Zeria Pharm Miura
Hikari C O Zeria Pharma Morita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeria Pharmaceutical Co Ltd
Original Assignee
Zeria Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1260070A external-priority patent/JPH0822847B2/ja
Application filed by Zeria Pharmaceutical Co Ltd filed Critical Zeria Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE68919054D1 publication Critical patent/DE68919054D1/de
Publication of DE68919054T2 publication Critical patent/DE68919054T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE68919054T 1988-12-08 1989-12-05 Kondensierte Benzen-Derivate. Expired - Fee Related DE68919054T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP30887888 1988-12-08
JP1260070A JPH0822847B2 (ja) 1988-12-08 1989-10-06 縮合ベンゼン誘導体、それを含有する医薬及び該化合物の製造中間体

Publications (2)

Publication Number Publication Date
DE68919054D1 true DE68919054D1 (de) 1994-12-01
DE68919054T2 DE68919054T2 (de) 1995-05-11

Family

ID=26544433

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68919054T Expired - Fee Related DE68919054T2 (de) 1988-12-08 1989-12-05 Kondensierte Benzen-Derivate.

Country Status (8)

Country Link
US (1) US5028604A (de)
EP (1) EP0372484B1 (de)
AT (1) ATE113279T1 (de)
AU (1) AU616824B2 (de)
CA (1) CA2004028C (de)
DE (1) DE68919054T2 (de)
DK (1) DK616189A (de)
ES (1) ES2065975T3 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1230706B (it) * 1989-02-10 1991-10-29 Poli Ind Chimica Spa Derivati dell'acido 3 piroglutamoil tiazolidin 4 carbossilico e loro proprieta' farmacologiche.
HU204040B (en) * 1989-07-11 1991-11-28 Richter Gedeon Vegyeszet Process for producing new thiazoles and thiazines and pharmaceutical compositions comprising same
WO1991018877A1 (fr) * 1990-06-07 1991-12-12 Zeria Pharmaceutical Co., Ltd. Nouveau derive d'arylalcanoylamine et medicament contenant ce derive
JP3810097B2 (ja) * 1993-01-15 2006-08-16 明治製菓株式会社 ピロリジン−２−イルカルボニル複素環式化合物誘導体
HUT76640A (en) * 1995-08-17 1997-10-28 Chinoin Gyogyszer Es Vegyeszet Compounds of pharmaceutical activity cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use
US6500948B1 (en) * 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
US6218424B1 (en) * 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
HUP9700442A1 (hu) * 1997-02-14 1999-09-28 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Gyűrűs amidszármazékok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk
US6121311A (en) * 1999-04-28 2000-09-19 Japan Tobacco Inc. Method for treating cocainism
DE602004026289D1 (de) 2003-05-05 2010-05-12 Probiodrug Ag Glutaminylcyclase-hemmer
US20050137142A1 (en) 2003-11-03 2005-06-23 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
EP1713780B1 (de) 2004-02-05 2012-01-18 Probiodrug AG Neue inhibitoren von glutaminylcyclase
EP1760076A1 (de) * 2005-09-02 2007-03-07 Ferring B.V. FAP Inhibitoren
EP2089383B1 (de) 2006-11-09 2015-09-16 Probiodrug AG 3-hydroxy-1,5-dihydropyrrol-2-one derivate als inhibitoren von glutaminylcyclase zur behandlung von geschwüren, krebs und anderen krankheiten
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
AU2008220785B2 (en) 2007-03-01 2013-02-21 Vivoryon Therapeutics N.V. New use of glutaminyl cyclase inhibitors
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
US8524654B2 (en) * 2007-05-21 2013-09-03 The Uab Research Foundation Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation
MY156780A (en) * 2009-05-04 2016-03-31 Prometic Biosciences Inc Substituted aromatic compounds and pharmaceutical uses thereof
US8486940B2 (en) 2009-09-11 2013-07-16 Probiodrug Ag Inhibitors
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
CN102791704B (zh) 2010-03-10 2015-11-25 前体生物药物股份公司 谷氨酰胺酰环化酶(qc, ec 2.3.2.5)的杂环抑制剂
US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
EP2813218B1 (de) * 2013-06-14 2022-08-24 Shin-Etsu Chemical Co., Ltd. Verfahren zur herstellung einer wässrigen enterischen beschichtungsflüssigkeit, feststoffpräparat und verfahren zur herstellung davon
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54138551A (en) * 1978-04-14 1979-10-27 Sumitomo Chem Co Ltd Novel asymmetric synthesis of optically active 2-alkanoyl- 1,2,3,4-tetrahydro-2-naphthol compound
CA1320734C (en) * 1986-02-04 1993-07-27 Suntory Limited Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
US4792969A (en) * 1986-11-13 1988-12-20 Fujitsu Limited Line condition data collecting system for a telephone exchange
JPH08806B2 (ja) * 1986-11-18 1996-01-10 サントリー株式会社 プロリルエンドペプチダ−ゼ阻害作用を有する新規ピロリジンアミド誘導体
ES2052619T3 (es) * 1987-02-23 1994-07-16 Ono Pharmaceutical Co Un procedimiento para la preparacion de los nuevos derivados de tiazolidina.
JPH0832704B2 (ja) * 1987-11-30 1996-03-29 キッセイ薬品工業株式会社 プロリルエンドペプチダーゼ阻害剤
JPH01250370A (ja) * 1987-12-23 1989-10-05 Zeria Pharmaceut Co Ltd 新規アミノ酸イミド誘導体、製法ならびに用途

Also Published As

Publication number Publication date
EP0372484A2 (de) 1990-06-13
EP0372484A3 (de) 1991-02-27
ATE113279T1 (de) 1994-11-15
DK616189D0 (da) 1989-12-07
US5028604A (en) 1991-07-02
AU4591489A (en) 1990-06-14
DK616189A (da) 1990-06-11
ES2065975T3 (es) 1995-03-01
CA2004028A1 (en) 1990-06-08
EP0372484B1 (de) 1994-10-26
AU616824B2 (en) 1991-11-07
DE68919054T2 (de) 1995-05-11
CA2004028C (en) 1998-09-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee