ES2062011T3 - Derivado de ciclohexano. - Google Patents
Derivado de ciclohexano.Info
- Publication number
- ES2062011T3 ES2062011T3 ES89308062T ES89308062T ES2062011T3 ES 2062011 T3 ES2062011 T3 ES 2062011T3 ES 89308062 T ES89308062 T ES 89308062T ES 89308062 T ES89308062 T ES 89308062T ES 2062011 T3 ES2062011 T3 ES 2062011T3
- Authority
- ES
- Spain
- Prior art keywords
- hetero
- cycle
- formula
- derivative
- carbamoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
UN DERIVADO DE CICLOHEXANO DE FORMULA (I), DONDE R1 ES HALOMETILO, O ARILTIOMETILO QUE PUEDE TENER AMINO, ALCOXI INFERIOR O ACILAMINO; R2 ES ALCOXI INFERIOR; R3 ES COMPUESTO DE FORMULA: (FIG. A) O (FIG. B); Y R4 ES H, ALQUILCARBAMOILO INFERIOR, ALQUILCARBAMOILOXI INFERIOR ALQUILCARBAMOILO, CARBONILO HETEROCICLICO O CARBAMOILO HETEROCICLICO O SUS SALES. TAMBIEN SE DESCRIBE UN PROCEDIMIENTO PARA OBTENER EL DERIVADO DE CICLOHEXANO, JUNTO CON UNA COMPOSICION FARMACEUTICA QUE TIENE EL MISMO COMO INGREDIENTE ACTIVO. LOS COMPUESTOS TIENEN ACTIVIDAD INHIBIDORA DE ANGIOGENESIS Y ADEMAS SON UTILES EN EL TRATAMIENTO DE, POR EJEMPLO, TUMORES, ARTRITIS REUMATICA, RETINOPATIA DIABETICA Y SORIASIS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888819257A GB8819257D0 (en) | 1988-08-12 | 1988-08-12 | Cyclohexane derivative |
GB898908005A GB8908005D0 (en) | 1989-04-10 | 1989-04-10 | Cyclohexane derivative |
GB898909794A GB8909794D0 (en) | 1989-04-28 | 1989-04-28 | Cyclohexane derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2062011T3 true ES2062011T3 (es) | 1994-12-16 |
Family
ID=27264023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89308062T Expired - Lifetime ES2062011T3 (es) | 1988-08-12 | 1989-08-08 | Derivado de ciclohexano. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4954496A (es) |
EP (1) | EP0354767B1 (es) |
JP (1) | JP2811783B2 (es) |
KR (1) | KR0130766B1 (es) |
CA (1) | CA1316921C (es) |
DE (1) | DE68911417T2 (es) |
ES (1) | ES2062011T3 (es) |
HU (1) | HU203543B (es) |
IE (1) | IE63045B1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5164410A (en) * | 1988-01-09 | 1992-11-17 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
US5180738A (en) * | 1988-09-01 | 1993-01-19 | Takeda Chemical Industries | Fumagillol derivatives and pharmaceutical compositions thereof |
DE68927904T2 (de) * | 1988-09-01 | 1997-09-04 | Takeda Chemical Industries Ltd | Fumagillol-Derivate |
US5166172A (en) * | 1988-09-01 | 1992-11-24 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
US6017954A (en) * | 1989-08-10 | 2000-01-25 | Children's Medical Center Corp. | Method of treating tumors using O-substituted fumagillol derivatives |
US5290807A (en) * | 1989-08-10 | 1994-03-01 | Children's Medical Center Corporation | Method for regressing angiogenesis using o-substituted fumagillol derivatives |
EP0415294A3 (en) * | 1989-08-31 | 1991-06-12 | Takeda Chemical Industries, Ltd. | Cyclohexanol derivatives, production and use thereof |
TW282399B (es) * | 1990-05-25 | 1996-08-01 | Takeda Pharm Industry Co Ltd | |
DE69231457T2 (de) * | 1991-06-21 | 2001-05-23 | Takeda Chemical Industries Ltd | Zyklodextrin-Zusammensetzung enthaltend Fumagillol-Derivate |
ATE153854T1 (de) * | 1992-12-16 | 1997-06-15 | Takeda Chemical Industries Ltd | Stabile pharmazeutische zubereitung mit fumagillolderivaten |
US5710148A (en) * | 1995-03-06 | 1998-01-20 | Senju Pharmaceuticals Co., Ltd. | Corneal opacification inhibitory composition |
FR2733499B1 (fr) * | 1995-04-27 | 1997-05-30 | Adir | Nouvelles tetrahydropyrano(3,2-d)oxazolones substituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2733498B1 (fr) * | 1995-04-27 | 1997-05-30 | Adir | Nouveaux composes cyclohexaniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
DE69714230T2 (de) * | 1996-03-06 | 2003-03-27 | Tsumura & Co | Neue iridoidderivate und neovaskularisations-inhibitoren die diese als aktviven inhaltstoff enthalten |
US6225478B1 (en) | 1997-03-05 | 2001-05-01 | Tsumura & Co. | Iridoid derivatives and neovascularization inhibitors containing the same as active ingredient |
US6548477B1 (en) | 2000-11-01 | 2003-04-15 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
US7105482B2 (en) | 2000-11-01 | 2006-09-12 | Praecis Pharmaceuticals, Inc. | Methionine aminopeptidase-2 inhibitors and methods of use thereof |
US6919307B2 (en) | 2000-11-01 | 2005-07-19 | Praecis Pharmaceuticals, Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
PL366216A1 (en) | 2000-11-01 | 2005-01-24 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2500016A (en) * | 1947-04-26 | 1950-03-07 | Canadian Ind | Epoxyethylcyclohexane hydroxy ethers |
-
1989
- 1989-07-28 US US07/386,232 patent/US4954496A/en not_active Expired - Lifetime
- 1989-08-02 IE IE250689A patent/IE63045B1/en not_active IP Right Cessation
- 1989-08-07 JP JP1204258A patent/JP2811783B2/ja not_active Expired - Fee Related
- 1989-08-08 DE DE89308062T patent/DE68911417T2/de not_active Expired - Lifetime
- 1989-08-08 EP EP89308062A patent/EP0354767B1/en not_active Expired - Lifetime
- 1989-08-08 ES ES89308062T patent/ES2062011T3/es not_active Expired - Lifetime
- 1989-08-10 CA CA000607999A patent/CA1316921C/en not_active Expired - Fee Related
- 1989-08-11 HU HU894156A patent/HU203543B/hu not_active IP Right Cessation
- 1989-08-11 KR KR1019890011447A patent/KR0130766B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE68911417T2 (de) | 1994-04-14 |
HUT51265A (en) | 1990-04-28 |
US4954496A (en) | 1990-09-04 |
KR900003163A (ko) | 1990-03-23 |
EP0354767B1 (en) | 1993-12-15 |
DE68911417D1 (de) | 1994-01-27 |
JPH0276866A (ja) | 1990-03-16 |
IE63045B1 (en) | 1995-03-22 |
CA1316921C (en) | 1993-04-27 |
IE892506L (en) | 1990-02-12 |
HU203543B (en) | 1991-08-28 |
JP2811783B2 (ja) | 1998-10-15 |
EP0354767A1 (en) | 1990-02-14 |
KR0130766B1 (ko) | 1998-04-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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