ES2061456T3 - Compuestos de quinoxalina y preparacion y uso de los mismos. - Google Patents

Compuestos de quinoxalina y preparacion y uso de los mismos.

Info

Publication number
ES2061456T3
ES2061456T3 ES87112060T ES87112060T ES2061456T3 ES 2061456 T3 ES2061456 T3 ES 2061456T3 ES 87112060 T ES87112060 T ES 87112060T ES 87112060 T ES87112060 T ES 87112060T ES 2061456 T3 ES2061456 T3 ES 2061456T3
Authority
ES
Spain
Prior art keywords
compounds
preparation
quinoxaline compounds
ethynyl
so2c1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87112060T
Other languages
English (en)
Inventor
Tage Honore
Joergen Drejer
Poul Jacobsen
Flemming Elmelund Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2061456T3 publication Critical patent/ES2061456T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPUESTOS DE DIHIDROXIQUINOXALINAS HETEROCICLICOS QUE TIENEN LA FORMULA EN DONDE R1 ES HALOGENO, CN, CF3, ETINILO O N3 Y R2 ES SO2C1-3-ALQUILO, CF3, NO2, ETINILO O CN. LA INVENCION SE REFIERE TAMBIEN A UN METODO PARA LA PREPARACION E LOS COMPUESTOS, A LAS COMPOSICIONES FARMACEUTICAS DE LOS MISMOS Y A SU USO. LOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE INDICACIONES PROVOCADAS POR UNA HIPERACTIVIDAD DE LOS NEUROTRANSMISORES EXCITANTES, EN PARTICULAR DE LOS RECEPTORES DE QUISCUALATOS Y ESPECIALMENTE COMO NEUROLEPTICOS.
ES87112060T 1986-09-16 1987-08-19 Compuestos de quinoxalina y preparacion y uso de los mismos. Expired - Lifetime ES2061456T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90786586A 1986-09-16 1986-09-16

Publications (1)

Publication Number Publication Date
ES2061456T3 true ES2061456T3 (es) 1994-12-16

Family

ID=25424773

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87112060T Expired - Lifetime ES2061456T3 (es) 1986-09-16 1987-08-19 Compuestos de quinoxalina y preparacion y uso de los mismos.

Country Status (12)

Country Link
EP (1) EP0260467B1 (es)
JP (1) JPS6383074A (es)
AT (1) ATE99296T1 (es)
CA (1) CA1298298C (es)
DE (1) DE3788612T2 (es)
DK (1) DK161319C (es)
ES (1) ES2061456T3 (es)
FI (1) FI88718C (es)
IE (1) IE66149B1 (es)
NO (1) NO173499C (es)
PT (1) PT85727B (es)
ZA (1) ZA876312B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK716188D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Quinoxalinforbindelser, deres fremstilling og anvendelse
HU221425B (en) * 1990-11-06 2002-10-28 Yamanouchi Pharma Co Ltd Condensed pyrazine derivatives, process for their production and pharmaceutical preparations containing these compounds
PT99864B (pt) * 1990-12-21 1999-06-30 Schering Ag Processo para a preparacao de novas composicoes farmaceuticas contendo antagonistas de receptor de quisqualato
DK73091D0 (da) * 1991-04-22 1991-04-22 Novo Nordisk As Quinoxalinforbindelser, deres fremstilling og anvendelse
PT647137E (pt) * 1992-06-22 2008-11-24 Univ California Antagonistas dos receptores da glicina e a sua utilização
AU688459B2 (en) * 1994-04-08 1998-03-12 Shionogi & Co., Ltd. Oxopyridinylquinoxaline derivative
DE4428152A1 (de) * 1994-06-22 1996-01-04 Basf Ag Neue Amido-chinoxalindione, ihrer Herstellung und Verwendung
BR9509055A (pt) * 1994-09-30 1998-06-23 Basf Ag Imidazoloquinoxalinona uso da mesma e composiçao farmacêutica
DE4436852A1 (de) * 1994-10-14 1996-04-18 Basf Ag Pyrrolyl-tetrahydrobenzochinoxalindione, ihre Herstellung und Verwendung
DE19521058A1 (de) * 1995-06-09 1996-12-12 Basf Ag Verfahren zur Herstellung von Aromaten enthaltenden Polyetherpolyolen
US5719153A (en) * 1995-08-15 1998-02-17 American Home Products Corporation 5H,8H-2-oxa-1,3,5,8-tetraaza-cyclopenta b!-naphthalene-6,7-diones
FR2743363A1 (fr) * 1996-01-10 1997-07-11 Rhone Poulenc Rorer Sa 5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazine-a-ones substituees en position 2, leur preparation et les medicaments les contenant
DE19624808A1 (de) 1996-06-21 1998-01-02 Basf Ag Pyrrolylchinoxalindione, ihre Herstellung und Verwendung
EP3427729A1 (en) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid for use in treating epileptic diseases, disorders or conditions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992378A (en) * 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
DE3364438D1 (en) * 1982-10-18 1986-08-14 Pfizer Triazoloquinoxalines as antidepressants and antifatigue agents

Also Published As

Publication number Publication date
PT85727A (en) 1987-10-01
JPS6383074A (ja) 1988-04-13
PT85727B (pt) 1990-08-31
DE3788612D1 (de) 1994-02-10
EP0260467B1 (en) 1993-12-29
CA1298298C (en) 1992-03-31
DK161319C (da) 1991-12-09
DK471687A (da) 1988-03-17
FI88718C (fi) 1993-06-28
EP0260467A3 (en) 1990-02-07
IE66149B1 (en) 1995-12-13
DE3788612T2 (de) 1994-04-28
NO873873L (no) 1988-03-17
DK161319B (da) 1991-06-24
ZA876312B (en) 1988-02-24
FI88718B (fi) 1993-03-15
IE872165L (en) 1988-03-16
NO173499C (no) 1993-12-22
EP0260467A2 (en) 1988-03-23
ATE99296T1 (de) 1994-01-15
FI873790A0 (fi) 1987-09-01
NO173499B (no) 1993-09-13
JPH0532391B2 (es) 1993-05-14
FI873790A (fi) 1988-03-17
DK471687D0 (da) 1987-09-10
NO873873D0 (no) 1987-09-15

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