ES2059394T3 - Metodo y dispositivo inmunocromatograficos cualitativos. - Google Patents

Metodo y dispositivo inmunocromatograficos cualitativos.

Info

Publication number
ES2059394T3
ES2059394T3 ES87309723T ES87309723T ES2059394T3 ES 2059394 T3 ES2059394 T3 ES 2059394T3 ES 87309723 T ES87309723 T ES 87309723T ES 87309723 T ES87309723 T ES 87309723T ES 2059394 T3 ES2059394 T3 ES 2059394T3
Authority
ES
Spain
Prior art keywords
default
sbp
signal
sbp members
absorbent material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87309723T
Other languages
English (en)
Inventor
David J Litman
Thomas M Li
Laura Lee Buelteman
Emmy Tong-In Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of ES2059394T3 publication Critical patent/ES2059394T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/948—Sedatives, e.g. cannabinoids, barbiturates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9486—Analgesics, e.g. opiates, aspirine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/97—Test strip or test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/816—Alkaloids, amphetamines, and barbiturates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/822—Identified hapten

Abstract

SE DESCRIBE UN METODO PARA DETERMINAR LA PRESENCIA DE UNA CANTIDAD DETECTABLE MINIMA PREDETERMINADA DE UNO O MAS ANALITOS EN UNA MUESTRA QUE SE SOSPECHA CONTIENE EL ANALITO. CADA ANALITO ES UN MIEMBRO DE UN PAR ENLAZANTE ESPECIFICO ("MIEMBRO SBP"), QUE CONSTA DE UN LIGANDO Y SU RECEPTOR COMPLEMENTARIO. EL METODO COMPRENDE PONER EN CONTACTO CON UNA DSOLUCION DE ENSAYO, QUE CONTIENE DICHA MUESTRA Y CANTIDADES PREDETERMINADAS DE DOS O MAS PRIMEROS MIEMBROS SBP, CADA UNO ANALOGO RESPECTIVAMENTE A UNO DE DICHOS ANALITOS, UNA PARTE DE CONTACTO DE UNA PIEZA DE MATERIAL ABSORBENTE CAPAZ DE SER ATRAVESADA EN UNA DIRECCION POR LO MENOS POR LA DISOLUCION DE ENSAYO, POR MIGRACION CAPILAR. EL MATERIAL ABSORBENTE CONTIENE CANTIDADES PREDETERMINADAS DE DOS MAS SEGUNDOS MIEMBROS SBP, CADA UNO RESPECTIVAMENTE CAPACES DE UNIR UNO DE LOS ANALITOS Y EL CORRESPONDIENTE MIEMBRO SBP. LOS SEGUNDOS MIEMBROS SBP ESTAN ENLAZADOS NO DIFUSIVAMENTE AL MATERIAL ABSORBENTE POR LO MENOS ENTRE LA PARTE DE CONTACTO Y UNPUNTO PREDETERMINADO EN LA PIEZA DE MATERIAL ABSORBENTE SEPARADO DE LA PARTE DE CONTACTO, DE MODO QUE EN PRESENCIA DE UNA CANTIDAD PREDETERMINADA DE UNO O MAS ANALITOS EL PRIMER MIEMBRO SBP ANALOGO EMIGRA POR LO MENOS AL SITIO PREDETERMINADO EN LA PIEZA DE MATERIAL ABSORBENTE. A CONTINUACION, POR LO MENOS A UNA PARTE DE LA DISOLUCION DE ENSAYO SE LE PERMITE QUE ATRAVIESE EL MATERIAL ABSORBENTE POR MEDIO DE UNA MIGRACION CAPILAR. EL SITIO PREDETERMINADO SE EXAMINA PARA LA PRESENCIA DE UNO O MAS PRIMEROS MIEMBROS SBP, LO QUE USUALMENTE SE INDICA POR LA PRESENCIA DE UNA SEÑAL MARCADA. TAL SEÑAL PUEDE SER DIRECTAMENTE DETECTABLE, O EL SITIO PREDETERMINADO PUEDE EXPONERSE A UN MEDIO PRODUCTOR DE SEÑAL CAPAZ DE INTERACTUAR CON LOS PRIMEROS MIEMBROS SBP PARA PRODUCIR UNA SEÑAL DETECTABLE EN EL SITIO PREDETERINADO, EN RELACION CON LA CANTIDAD DE UNO O MAS DE LOS ANALITOS EN LA MUESTRA.
ES87309723T 1986-11-07 1987-11-03 Metodo y dispositivo inmunocromatograficos cualitativos. Expired - Lifetime ES2059394T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/928,233 US5030558A (en) 1986-11-07 1986-11-07 Qualitative immunochromatographic method and device

Publications (1)

Publication Number Publication Date
ES2059394T3 true ES2059394T3 (es) 1994-11-16

Family

ID=25455923

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87309723T Expired - Lifetime ES2059394T3 (es) 1986-11-07 1987-11-03 Metodo y dispositivo inmunocromatograficos cualitativos.

Country Status (8)

Country Link
US (1) US5030558A (es)
EP (1) EP0267006B1 (es)
JP (1) JP3304350B2 (es)
AU (1) AU617090B2 (es)
CA (1) CA1285868C (es)
DE (1) DE3787613T2 (es)
ES (1) ES2059394T3 (es)
NZ (1) NZ222455A (es)

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Also Published As

Publication number Publication date
EP0267006A2 (en) 1988-05-11
EP0267006B1 (en) 1993-09-29
CA1285868C (en) 1991-07-09
AU8080487A (en) 1988-05-12
DE3787613D1 (de) 1993-11-04
EP0267006A3 (en) 1989-10-25
JP3304350B2 (ja) 2002-07-22
US5030558A (en) 1991-07-09
JPS63159760A (ja) 1988-07-02
DE3787613T2 (de) 1994-03-10
AU617090B2 (en) 1991-11-21
NZ222455A (en) 1990-05-28

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