ES2058066T3 - Procedimiento para la obtencion y la produccion de un preparado pasteurizado de alfa2-antiplasmina. - Google Patents

Procedimiento para la obtencion y la produccion de un preparado pasteurizado de alfa2-antiplasmina.

Info

Publication number
ES2058066T3
ES2058066T3 ES87100685T ES87100685T ES2058066T3 ES 2058066 T3 ES2058066 T3 ES 2058066T3 ES 87100685 T ES87100685 T ES 87100685T ES 87100685 T ES87100685 T ES 87100685T ES 2058066 T3 ES2058066 T3 ES 2058066T3
Authority
ES
Spain
Prior art keywords
solution
antiplasmin
antiplasmine
alfa2
pasteurized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87100685T
Other languages
English (en)
Inventor
Eric Paul Dr Paques
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Application granted granted Critical
Publication of ES2058066T3 publication Critical patent/ES2058066T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA PURIFICACION Y EN SU CASO OBTENCION Y PASTEURIZACION DE UNA SOLUCION DE ALFA2-ANTIPLASMINA, SEGUN EL CUAL PARA LA PURIFICACION SE DIALIZA FRENTE A UNA SOLUCION ACUOSA DE MENOS CONCENTRACION IONICA Y SE SEPARA EL SEDIMENTO FORMADO. PARA LA OBTENCION DE UNA ANTIPLASMINA ESPECIALMENTE PURA, PUEDE PURIFICARSE, MEDIANTE CROMATOGRAFIA, LA SOLUCION DEL PLASMINOGENO UNIDO A UNA FASE SOLIDA. ULTERIORMENTE SE DESCRIBE UN METODO PARA LA INACTIVACION DE GERMENES EN UNA SOLUCION ANTIPLASMINA MEDIANTE EL CALENTAMIENTO EN PRESENCIA DE ESTABILIZADORES. LA PLASMINA PREPARADA DEL MODO INDICADO EN LA INVENCION PUEDE APLICARSE CON FINES TERAPEUTICOS.
ES87100685T 1986-01-30 1987-01-20 Procedimiento para la obtencion y la produccion de un preparado pasteurizado de alfa2-antiplasmina. Expired - Lifetime ES2058066T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863602688 DE3602688A1 (de) 1986-01-30 1986-01-30 Verfahren zur gewinnung und herstellung eines pasteurisierten praeparates von (alpha)(pfeil abwaerts)2(pfeil abwaerts)-antiplasmin

Publications (1)

Publication Number Publication Date
ES2058066T3 true ES2058066T3 (es) 1994-11-01

Family

ID=6292902

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87100685T Expired - Lifetime ES2058066T3 (es) 1986-01-30 1987-01-20 Procedimiento para la obtencion y la produccion de un preparado pasteurizado de alfa2-antiplasmina.

Country Status (7)

Country Link
EP (1) EP0230956B1 (es)
JP (1) JPH0819159B2 (es)
AT (1) ATE109354T1 (es)
AU (1) AU6810087A (es)
CA (1) CA1307373C (es)
DE (2) DE3602688A1 (es)
ES (1) ES2058066T3 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10022092A1 (de) * 2000-05-08 2001-11-15 Aventis Behring Gmbh Stabilisiertes Protein-Präparat und Verfahren zu seiner Herstellung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE651649A (es) * 1963-08-09
DE2726886A1 (de) * 1977-06-15 1979-01-18 Behringwerke Ag Neues glykoprotein und verfahren zu dessen herstellung
DE2916711A1 (de) * 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
EP0035204B2 (en) * 1980-03-05 1991-05-22 Miles Inc. Pasteurized therapeutically active protein compositions
DE3330770A1 (de) * 1983-08-26 1985-03-14 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von humanplasma
DE3336631A1 (de) * 1983-10-08 1985-04-18 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von plasma oder von konzentraten der blutgerinnungsfaktoren ii, vii, ix und x

Also Published As

Publication number Publication date
ATE109354T1 (de) 1994-08-15
EP0230956A2 (de) 1987-08-05
CA1307373C (en) 1992-09-08
EP0230956B1 (de) 1994-08-03
JPS62209099A (ja) 1987-09-14
AU6810087A (en) 1987-08-06
DE3750298D1 (de) 1994-09-08
JPH0819159B2 (ja) 1996-02-28
EP0230956A3 (en) 1989-03-22
DE3602688A1 (de) 1987-08-06

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