AU6810087A - Pasteurized alpha-2 anti plasmin glycoprotein - Google Patents

Pasteurized alpha-2 anti plasmin glycoprotein

Info

Publication number
AU6810087A
AU6810087A AU68100/87A AU6810087A AU6810087A AU 6810087 A AU6810087 A AU 6810087A AU 68100/87 A AU68100/87 A AU 68100/87A AU 6810087 A AU6810087 A AU 6810087A AU 6810087 A AU6810087 A AU 6810087A
Authority
AU
Australia
Prior art keywords
solution
antiplasmin
pasteurized
glycoprotein
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU68100/87A
Inventor
Eric Paul Paques
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of AU6810087A publication Critical patent/AU6810087A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The process for the purification and, where appropriate, isolation and, where appropriate, pasteurisation of a solution of alpha2-antiplasmin entails, for the purification, dialysis against an aqueous solution of low ionic strength and removal of the resulting sediment. To isolate a particularly pure antiplasmin it is furthermore possible to purify the solution by chromatography using plasminogen bound to a solid phase. Also described is a process for the inactivation of organisms in an antiplasmin solution by heating in the presence of stabilisers. Plasmin prepared in this way can be used for therapeutic purposes.
AU68100/87A 1986-01-30 1987-01-29 Pasteurized alpha-2 anti plasmin glycoprotein Abandoned AU6810087A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3602688 1986-01-30
DE19863602688 DE3602688A1 (en) 1986-01-30 1986-01-30 METHOD FOR OBTAINING AND PRODUCING A PASTEURIZED PREPARATE OF (ALPHA) (ARROW DOWN) 2 (ARROW DOWN) -ANTIPLASMINE

Publications (1)

Publication Number Publication Date
AU6810087A true AU6810087A (en) 1987-08-06

Family

ID=6292902

Family Applications (1)

Application Number Title Priority Date Filing Date
AU68100/87A Abandoned AU6810087A (en) 1986-01-30 1987-01-29 Pasteurized alpha-2 anti plasmin glycoprotein

Country Status (7)

Country Link
EP (1) EP0230956B1 (en)
JP (1) JPH0819159B2 (en)
AT (1) ATE109354T1 (en)
AU (1) AU6810087A (en)
CA (1) CA1307373C (en)
DE (2) DE3602688A1 (en)
ES (1) ES2058066T3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10022092A1 (en) * 2000-05-08 2001-11-15 Aventis Behring Gmbh Stabilized protein preparation and process for its preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE651649A (en) * 1963-08-09
DE2726886A1 (en) * 1977-06-15 1979-01-18 Behringwerke Ag NEW GLYCOPROTEIN AND METHOD FOR THE PRODUCTION THEREOF
DE2916711A1 (en) * 1979-04-25 1980-11-06 Behringwerke Ag Blood coagulation factors and process for their manufacture
DE3176491D1 (en) * 1980-03-05 1987-11-26 Miles Lab Pasteurized therapeutically active protein compositions
DE3330770A1 (en) * 1983-08-26 1985-03-14 Behringwerke Ag, 3550 Marburg METHOD FOR PASTEURIZING HUMAN PLASMA
DE3336631A1 (en) * 1983-10-08 1985-04-18 Behringwerke Ag, 3550 Marburg METHOD FOR THE PASTEURIZATION OF PLASMA OR CONCENTRATES OF THE BLOOD COAGINING FACTORS II, VII, IX AND X

Also Published As

Publication number Publication date
JPS62209099A (en) 1987-09-14
DE3602688A1 (en) 1987-08-06
EP0230956A2 (en) 1987-08-05
EP0230956B1 (en) 1994-08-03
EP0230956A3 (en) 1989-03-22
JPH0819159B2 (en) 1996-02-28
ATE109354T1 (en) 1994-08-15
CA1307373C (en) 1992-09-08
DE3750298D1 (en) 1994-09-08
ES2058066T3 (en) 1994-11-01

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