ES2054009T3 - Agentes antihipertensores de glutaramida cicloalquil sustituida. - Google Patents

Agentes antihipertensores de glutaramida cicloalquil sustituida.

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Publication number
ES2054009T3
ES2054009T3 ES89308740T ES89308740T ES2054009T3 ES 2054009 T3 ES2054009 T3 ES 2054009T3 ES 89308740 T ES89308740 T ES 89308740T ES 89308740 T ES89308740 T ES 89308740T ES 2054009 T3 ES2054009 T3 ES 2054009T3
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Spain
Prior art keywords
alkyl
aryl
heterocyclyl
alkoxy
group
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Expired - Lifetime
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ES89308740T
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English (en)
Inventor
John Christopher Dr Danilewicz
Keith Dr James
Ryszard Jurek Dr Kobylecki
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Pfizer Inc
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Pfizer Inc
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Publication of ES2054009T3 publication Critical patent/ES2054009T3/es
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    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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Abstract

COMPONENTES DE LA FORMULA: EN DONDE A COMPLETA UN ANILLO CARBOCICLICO DE 5 O 6 MIEMBROS QUE DEBEN SER SATURADOS O MONOINSATURADOS; R1 ES H O ALQUILICO (C3-C4); R Y R4 SON H, ALQUILICO (C1-C6), CICLOALQUILICO C3-C7, BENCIL O UN GRUPO ESTERFORMADO BIOLABILO ALETRNATIVO; Y ES O UN ENLACE DIRECTO O UN GRUPO ALQUILENO DE 1 A 6 CARBONOS; R2 ES H, ARIL, HETEROCICLIL, R6CONR5-, R7NR5SO2O R8SO2NR5-, CON LA PREVISION DE QUE Y NO ES UN ENLACE DIRECTO CUANDOR2 ES H, ARIL O HETEROCICLIL; EN DONDE R5 ES H, ALQUILICO (C1-C6) O ALQUILICO (C1-C6)ARIL; R6 ES ALQUILICO (C1-C6), ARIL, ALQUILICO(C1-C6)ARIL, HETEROCICLIL, ALQUILICO(C1-C6)HETEROCICLIL O UN GRUPO DE LA FORMULA R9R10R11CEN DONDE R9 ESD H, OH, ALCOXI(C1-C6), ALQUILICO(C1-C6), ALQUILICO(C1-C6)HIDROXI, ALQUILICO(C1-C6)ARIL, ALCOHILENICO(C2-C6), HETEROCICLIL, ALQUILICO(C1-C6)HETEROCICLIL, R12CONH-, R12SO2NH- O (R13)2N-; R10 Y R11 SON H O ALQUILICO(C1-C6); O R10 ES H Y R11 ES ALQUILICO(C1-C6)AMINO, IMIDAZOLILMETIL, ARIL, ALQUILICO(C1-C6)ARIL, ALCOXI(C1-C6)ALCOXI(C1-C6)ARIL, ALQUILICO(C1-C6)HIDROXI O ALQUILICO(C1-C6)METILTIO O LOS DOS GRUPOS R10 Y R11 FORMAN UN ANILLO CARBOCICLICO DE 3 A 6 MIEMBROS O UN ANILLO PIRROLIDINE O PIPERIDINE QUE DEBE SER OPCIONALMENTE SUSTITUIDO POR AMINO, ALCANOIL (C2-C4) O AROIL; R12 ES ALQUILICO(C1-C6), CICLOALQUILICO(C3-C7), ARIL, ALQUILICO(C1-C6)ARIL, HETEROCICLIL O ALQUILICO(C1-C6)HETEROCICLIL; CADA R13 ES H, ALQUILICO(C1-C6), ALQUILICO(C1-C6)ARIL O LOS DOS GRUPOS R13 FORMAN UN GRUPO PIRROLIDINIL, PIPERIDINO, MORFOLINO, PIPERAZIMIL O PIPERAZIMIL-ALQUILICO(C1-C4)-N; R7 ES ALQUILICO (C1-C6), ARIL, ALQUILICO(C1-C6)ARIL, HETEROCICLIL, ALQUILICO(C1-C6) HETEROCICLIL O UN GRUPO DE LA FORMULA R10R11R14C- EN DONDE R10 Y R11 ESTAN COMO PREVIAMENTE DEFINIDOS Y R14 ES (R13)2NCO-, R12OCH2- O R15OCO, EN DONDE R12 Y R13 SON COMO SE DEFINIO PREVIAMENTE Y R15 ES ALQUILICO(C1-C6), CICLOALQUILICO(C3-C7) O ALQUILICO(C1-C6)ARIL; Y R8 ES ALQUILICO(C1-C6), ARIL, ALQUILICO(C1-C6)ARIL, HETEROCICLIL O ALQUILICO(C1-C6)HETEROCICLIL; R3 ES UN GRUPO DE LA FORMULA: EN DONDE R16 ES H, HALO, OH-4, (ALCOXI C1-C6)-4, (CICLOALCOXI C3-C7)-4, (ALCOHOLENICOXI C2-C6)-4, [CARBONILOXI(ALCOXIC1-C6)]-4, [CARBONILOXI(CICLOALCOXIC3-C7)]-4, O -SO2NH(ALQUILICOC1-C4)-3; Y R20 ES H, ALQUILICO C1-C4, ALCOXI C1-C4, ALCANOIL C2-C6 O HALO, O R3 ES UN GRUPO DE LA FORMULA EN DONDE DICHOS GRUPOS DEBEN OPCIONALMENTE SER SUSTITUIDOS EN EL ANILLO DE BENCENO FUNDIDO POR ALQUILICO C1-C4, ALCOXI C1-C4, OH, HALO O CF3; SON AGENTES ANTIHIPERTENSIVOS DE UTILIDAD EN TRATAMIENTO DE HIPERTENSION, ATAQUE DE CORAZON E INSUFICIENCIA RENAL.
ES89308740T 1988-09-05 1989-08-30 Agentes antihipertensores de glutaramida cicloalquil sustituida. Expired - Lifetime ES2054009T3 (es)

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GB888820844A GB8820844D0 (en) 1988-09-05 1988-09-05 Therapeutic agents

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Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8812597D0 (en) * 1988-05-27 1988-06-29 Pfizer Ltd Therapeutic agents
GB8925933D0 (en) * 1989-11-16 1990-01-04 Pfizer Ltd Glutaric acid derivatives and preparation thereof
US5260467A (en) * 1989-11-16 1993-11-09 Pfizer Inc. Glutaric acid derivatives and preparation thereof
US5157138A (en) * 1989-11-16 1992-10-20 Pfizer, Inc. Glutaric acid derivatives and preparation thereof
US5389610A (en) * 1989-11-21 1995-02-14 Schering Corporation Carboxyalkylcarbonyl aminoacid endopeptidase inhibitors
GB8926512D0 (en) * 1989-11-23 1990-01-10 Pfizer Ltd Therapeutic agents
GB9004260D0 (en) * 1990-02-26 1990-04-18 Pfizer Ltd Therapeutic agents
US5166143A (en) * 1990-05-31 1992-11-24 E. R. Squibb & Sons, Inc. Method for preventing onset of restenosis after angioplasty employing an ace inhibitor
FR2665440B1 (fr) * 1990-07-31 1994-02-04 Lipha Nouveaux cycloalkylsulfonamides substitues, procedes de preparation et medicaments les contenant.
US5643921A (en) * 1990-09-26 1997-07-01 E.R. Squibb & Sons, Inc. Cardiopulmonary bypass and organ transplant using a potassium channel activator
DE4036706A1 (de) * 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
GB9103454D0 (en) * 1991-02-19 1991-04-03 Pfizer Ltd Therapeutic agents
US5298492A (en) * 1992-08-04 1994-03-29 Schering Corporation Diamino acid derivatives as antihypertensives
US5208236A (en) * 1992-09-23 1993-05-04 Schering Corporation N-(acylaminomethyl)glutaryl amino acids and use
DE69424846T2 (de) * 1993-11-16 2000-11-16 Novartis Ag Zyklische Aminosäure-Derivate mit ACE und NEP inhibierender Aktivität
GB9324931D0 (en) 1993-12-04 1994-01-26 Pfizer Ltd Glutaramide derivatives
US5512592A (en) * 1994-09-09 1996-04-30 Wake Forest University Method of producing cardiotonic effect and improving cardiac contractile function by administration of carnosine
AU8063098A (en) * 1997-06-10 1998-12-30 Eli Lilly And Company Combinatorial process for preparing substituted phenylalanine libraries
ATE355269T1 (de) * 1999-11-18 2006-03-15 Ajinomoto Kk Phenylalaninderivate
EP1363622A4 (en) * 2001-02-01 2005-04-13 Shire Lab Inc PHARMACEUTICAL COMPOSITIONS WITH SAMPATRILAT DISPERSED IN A LIPOID CARRIER
WO2002087621A1 (en) * 2001-04-30 2002-11-07 Shire Laboratories Inc. Pharmaceutical composition including ace/nep inhibitors and bioavailability enhancers
US7160859B2 (en) * 2002-10-11 2007-01-09 University Of Medicine & Dentistry Of New Jersey Mst1 modulation of apoptosis in cardiac tissue and modulators of Mst1 for treatment and prevention of cardiac disease
US7045653B2 (en) 2002-12-23 2006-05-16 Pfizer, Inc. Pharmaceuticals
GB0230036D0 (en) * 2002-12-23 2003-01-29 Pfizer Ltd Novel pharmaceuticals
GB0230025D0 (en) * 2002-12-23 2003-01-29 Pfizer Ltd Novel pharmaceuticals
JP2011517313A (ja) 2007-12-11 2011-06-02 ビアメト ファーマシューティカルズ，インク． 金属結合部分を標的化部分と組み合わせて使用する金属酵素阻害剤
EP2434895A4 (en) 2009-05-13 2013-08-07 Intra Cellular Therapies Inc ORGANIC CONNECTIONS
US8993631B2 (en) 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
BR112013016595B1 (pt) 2010-12-15 2021-04-27 Theravance Biopharma R&D Ip, Llc Composto inibidor de neprilisina, processos para a preparação e intermediários do referido composto, composição farmacêutica e uso do composto
AU2011343903B2 (en) 2010-12-15 2016-06-30 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
JP5959066B2 (ja) 2011-02-17 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
AU2012217615B2 (en) 2011-02-17 2016-09-29 Theravance Biopharma R&D Ip, Llc Substituted aminobutyric derivatives as neprilysin inhibitors
EP2714660B1 (en) 2011-05-31 2018-09-26 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
CN103596928B (zh) 2011-05-31 2017-02-15 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
EP2714648B1 (en) 2011-05-31 2017-08-16 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
BR112014030743B1 (pt) 2012-06-08 2022-09-06 Theravance Biopharma R&D Ip, Llc Composto inibidor de neprilisina, processo para a preparação do referido composto, composição farmacêutica e uso do referido composto
US8871792B2 (en) 2012-06-08 2014-10-28 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
MX366149B (es) 2012-08-08 2019-06-28 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina.
JP6549040B2 (ja) 2013-02-17 2019-07-24 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規使用
PT2964616T (pt) 2013-03-05 2017-08-08 Theravance Biopharma R&D Ip Llc Inibidores da neprilisina
WO2015116786A1 (en) 2014-01-30 2015-08-06 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
CN105960398A (zh) 2014-01-30 2016-09-21 施万生物制药研发Ip有限责任公司 5-联苯-4-杂芳基羰基氨基-戊酸衍生物作为脑啡肽酶抑制剂
US10131671B2 (en) 2014-08-07 2018-11-20 Intra-Cellular Therapies, Inc. Organic compounds
EP3256446B1 (en) 2015-02-11 2022-05-18 Theravance Biopharma R&D IP, LLC (2s,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as neprilysin inhibitor
EP3259255B1 (en) 2015-02-19 2020-10-21 Theravance Biopharma R&D IP, LLC (2r,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxy-4-[(5-methyloxazole-2-carbonyl)amino]pentanoic acid
PT3408260T (pt) 2016-03-08 2021-07-23 Theravance Biopharma R&D Ip Llc Ácido (2s,4r)-5-(5¿-cloro-2¿-fluoro-[1,1¿-bifenil]-4-il)-2- (etoximetil)-4-(3-hidroxi-isoxazole-5-carboxamido)-2- metilpentanoico cristalino e suas utilizações
WO2017172795A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel compositions and methods
WO2019152697A1 (en) 2018-01-31 2019-08-08 Intra-Cellular Therapies, Inc. Novel uses

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3376649D1 (en) * 1982-06-17 1988-06-23 Schering Corp Substituted dipeptides, methods for their production, pharmaceutical compositions containing them, method for making such pharmaceutical compositions
DE3565677D1 (de) * 1984-06-08 1988-11-24 Ciba Geigy Ag N-substituted butyramide derivatives
EP0225292A3 (en) * 1985-12-06 1988-11-30 Ciba-Geigy Ag Certain n-substituted butyramide derivatives
KR880007441A (ko) * 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제
GB8811873D0 (en) * 1988-05-19 1988-06-22 Pfizer Ltd Therapeutic agents
GB8812597D0 (en) * 1988-05-27 1988-06-29 Pfizer Ltd Therapeutic agents

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JPH02124862A (ja) 1990-05-14
AU604195B2 (en) 1990-12-06
DK436289A (da) 1990-03-06
PT91623B (pt) 1995-05-31
IL91460A (en) 1995-08-31
PH26272A (en) 1992-04-01
JPH0660144B2 (ja) 1994-08-10
ZA896760B (en) 1991-04-24
EP0358398A1 (en) 1990-03-14
MY106606A (en) 1995-06-30
FI111715B (fi) 2003-09-15
AU4105289A (en) 1990-03-08
FI894158A (fi) 1990-03-06
CY1811A (en) 1995-10-20
HUT51293A (en) 1990-04-28
US4975444A (en) 1990-12-04
CZ282142B6 (cs) 1997-05-14
NZ230550A (en) 1991-02-26
DE68905272T2 (de) 1993-06-17
CN1031051C (zh) 1996-02-21
NO177747C (no) 1995-11-15
PT91623A (pt) 1990-03-30
RU2012556C1 (ru) 1994-05-15
HU215440B (hu) 2000-04-28
PL161527B1 (en) 1993-07-30
DE68905272D1 (de) 1993-04-15
HU211536A9 (en) 1995-12-28
ATE86606T1 (de) 1993-03-15
MX17418A (es) 1993-11-01
IL91460A0 (en) 1990-04-29
FI894158A0 (fi) 1989-09-04
IE62020B1 (en) 1994-12-14
NO893546D0 (no) 1989-09-04
CN1040986A (zh) 1990-04-04
DK436289D0 (da) 1989-09-04
CZ510889A3 (en) 1997-02-12
NO177747B (no) 1995-08-07
RU2108322C1 (ru) 1998-04-10
NO893546L (no) 1990-03-06
EP0358398B1 (en) 1993-03-10
DK175082B1 (da) 2004-05-24
YU168489A (en) 1991-06-30
CA1341046C (en) 2000-07-04
IE892833L (en) 1990-03-05
HK130394A (en) 1994-12-02
DD284222A5 (de) 1990-11-07
GB8820844D0 (en) 1988-10-05
EG18936A (en) 1994-11-30

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