ES2052728T3 - Produccion de compuestos de 2-(2-piridilmetilsulfinil)-bencimidazol. - Google Patents

Produccion de compuestos de 2-(2-piridilmetilsulfinil)-bencimidazol.

Info

Publication number
ES2052728T3
ES2052728T3 ES88307191T ES88307191T ES2052728T3 ES 2052728 T3 ES2052728 T3 ES 2052728T3 ES 88307191 T ES88307191 T ES 88307191T ES 88307191 T ES88307191 T ES 88307191T ES 2052728 T3 ES2052728 T3 ES 2052728T3
Authority
ES
Spain
Prior art keywords
compounds
production
piridylmetilsulfinyl
bencimidazole
benzimidazole compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88307191T
Other languages
English (en)
Spanish (es)
Inventor
Masayasu Kato
Yoshio Toyoshima
Norio Iwano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16330618&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2052728(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2052728T3 publication Critical patent/ES2052728T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES88307191T 1987-08-04 1988-08-03 Produccion de compuestos de 2-(2-piridilmetilsulfinil)-bencimidazol. Expired - Lifetime ES2052728T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19480987 1987-08-04

Publications (1)

Publication Number Publication Date
ES2052728T3 true ES2052728T3 (es) 1994-07-16

Family

ID=16330618

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88307191T Expired - Lifetime ES2052728T3 (es) 1987-08-04 1988-08-03 Produccion de compuestos de 2-(2-piridilmetilsulfinil)-bencimidazol.

Country Status (11)

Country Link
US (1) US5578732A (cg-RX-API-DMAC10.html)
EP (1) EP0302720B1 (cg-RX-API-DMAC10.html)
KR (1) KR960000047B1 (cg-RX-API-DMAC10.html)
AT (1) ATE82283T1 (cg-RX-API-DMAC10.html)
CA (1) CA1263119A (cg-RX-API-DMAC10.html)
DE (1) DE3875848T2 (cg-RX-API-DMAC10.html)
DK (1) DK171989B1 (cg-RX-API-DMAC10.html)
ES (1) ES2052728T3 (cg-RX-API-DMAC10.html)
GR (1) GR3006974T3 (cg-RX-API-DMAC10.html)
HU (1) HU199828B (cg-RX-API-DMAC10.html)
IE (1) IE61717B1 (cg-RX-API-DMAC10.html)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
SE8804629D0 (sv) * 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
EP0481764B1 (en) 1990-10-17 2000-03-29 Takeda Chemical Industries, Ltd. Pyridine derivatives, their production and use
ES2026761A6 (es) * 1990-10-31 1992-05-01 Genesis Para La Investigacion Procedimiento de obtencion del omeprazol.
WO1993006097A1 (en) * 1991-09-20 1993-04-01 Merck & Co., Inc. Novel process for the preparation of anti-ulcer agents
RU95105442A (ru) * 1992-07-08 1997-02-20 Монсанто Компани (US) Способ лечения язвы желудка у свиней, изделие для лечения язвы желудка у свиней
ES2060541B1 (es) * 1993-02-26 1995-11-16 Vinas Lab Nuevo procedimiento para la sintesis de un derivado de 2-(2-piridilmetilsufinil) bencimidazol, y nuevos productos intermedios obtenidos con el mismo.
ES2063705B1 (es) * 1993-06-14 1995-07-16 S A L V A T Lab Sa Intermedio para la sintesis de lansoprazol y su procedimiento de obtencion.
US5374730A (en) 1993-11-04 1994-12-20 Torcan Chemical Ltd. Preparation of omeprazole and lansoprazole
TW385306B (en) * 1996-11-14 2000-03-21 Takeda Chemical Industries Ltd Method for producing crystals of benzimidazole derivatives
CA2204580A1 (en) * 1997-05-06 1998-11-06 Michel Zoghbi Synthesis of pharmaceutically useful pyridine derivatives
US6437139B1 (en) 1997-05-06 2002-08-20 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives
KR100458170B1 (ko) * 1997-05-26 2005-05-03 동아제약주식회사 2-[3-메톡시-4-(2,2,2-트리플로로에톡시)2-피리딜]메틸설피닐-1h-벤즈이미다졸의신규제조방법
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6303787B1 (en) * 1998-05-27 2001-10-16 Natco Pharma Limited Intermediates and an improved process for the preparation of Omeprazole employing the said intermediates
US6191148B1 (en) 1998-08-11 2001-02-20 Merck & Co., Inc. Omerazole process and compositions thereof
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
TWI275587B (en) 1999-06-17 2007-03-11 Takeda Chemical Industries Ltd A crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
PL333847A1 (en) * 1999-06-18 2001-01-02 Inst Farmaceutyczny Crystalline forms of lansoprozole and method of obtaining lansoprazole in pharmacologically advanthageous crystalline form
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
DE60020967T2 (de) 1999-06-30 2006-05-04 Takeda Pharmaceutical Co. Ltd. Kristalle von lansoprazole
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
KR100362947B1 (ko) * 1999-09-21 2002-11-30 주식회사 대웅 설폭시드 화합물의 제조방법
DE19951960C2 (de) * 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
WO2001087874A1 (en) 2000-05-15 2001-11-22 Takeda Chemical Industries, Ltd. Process for producing crystal
EP1337525B8 (en) * 2000-12-01 2011-10-05 Takeda Pharmaceutical Company Limited Process for the crystallization of (r)- or (s)-lansoprazole
MXPA03006904A (es) 2001-02-02 2004-12-06 Teva Pharma Procesos para la produccion de 2-(2-piridilmetil) sulfinil - 1h - bencimidazoles sustituidos.
KR100430575B1 (ko) * 2001-02-21 2004-05-10 주식회사 씨트리 란소프라졸 및 그 중간체의 제조방법
KR100783020B1 (ko) * 2001-03-23 2007-12-07 동아제약주식회사 2-메틸클로라이드 피리딘 유도체 및 이를 이용한 벤즈이미다졸 유도체의 제조 방법
US20040248941A1 (en) * 2001-09-25 2004-12-09 Keiji Kamiyama Benzimidazone compound, process for producing the same, and use thereof
JP2005533755A (ja) * 2002-03-27 2005-11-10 テバ ファーマシューティカル インダストリーズ リミティド ランソプラゾール多形及びその調製方法
KR100873419B1 (ko) * 2002-06-18 2008-12-11 페어차일드코리아반도체 주식회사 높은 항복 전압, 낮은 온 저항 및 작은 스위칭 손실을갖는 전력용 반도체 소자
WO2004011455A1 (en) * 2002-07-26 2004-02-05 Teva Pharmaceutical Industries Ltd. Preparation of lansoprazole and related compounds
DE60316791T2 (de) * 2002-08-21 2008-07-24 Teva Pharmaceutical Industries Ltd. Verfahren zur aufreinigung von lanzoprazol
EP1764364A1 (en) * 2002-08-21 2007-03-21 Teva Pharmaceutical Industries Ltd A method for the purification of lansoprazole
EP1552833B1 (en) * 2002-10-16 2016-12-28 Takeda Pharmaceutical Company Limited Process for producing an amorphous optically active isomer of lansoprazole
JP2005527638A (ja) * 2002-11-18 2005-09-15 テバ ファーマシューティカル インダストリーズ リミティド ５００ｐｐｍより多く約３０００ｐｐｍまでの水および２００ｐｐｍより多く約５０００ｐｐｍまでのアルコールを含有する安定ランソプラゾール
EP1572680A2 (en) 2002-12-19 2005-09-14 Eva Pharmaceutical Industries Ltd. Solid states of pantoprazole sodium, known pantoprazole sodium hydrates, processes for their preparation.
WO2004072061A1 (en) * 2003-02-05 2004-08-26 Teva Pharmaceutical Industries Ltd. Method of stabilizing lansoprazole
FR2852956B1 (fr) * 2003-03-28 2006-08-04 Negma Gild Procede de preparation enantioselective de derives de sulfoxydes
CA2520157A1 (fr) * 2003-03-28 2004-10-14 Sidem Pharma Procede de preparation enantioselective de derives de sulfoxydes
MXPA05013316A (es) 2003-06-10 2006-03-17 Teva Pharma Proceso para preparar bencimidazoles 2[-(piridinil)metil]sulfinil-sustituidos y derivados clorados novedosos de pantoprazol.
EP1768668A2 (en) 2004-06-16 2007-04-04 Tap Pharmaceutical Products, Inc. Multiple ppi dosage form
ES2441970T3 (es) 2004-09-13 2014-02-07 Takeda Pharmaceutical Company Limited Método para producir lansoprazol
EP1681056A1 (en) * 2005-01-14 2006-07-19 Krka Tovarna Zdravil, D.D., Novo Mesto Process for preparing lansoprazole
KR100758600B1 (ko) * 2006-01-05 2007-09-13 주식회사 대웅제약 란소프라졸 결정형 ａ의 제조방법
US8129536B2 (en) * 2006-09-22 2012-03-06 Orchid Chemicals & Pharmaceuticals Limited Method for the purification of lansoprazole
EP2114919A2 (en) 2007-01-31 2009-11-11 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically pure omeprazole via salt formation with a chiral amine or treatment with an entiomer converting enzyme and chromatographic seperation
WO2009066309A2 (en) * 2007-07-12 2009-05-28 Cadila Healthcare Limited Process for preparation of omeprazole
BRPI0818286A2 (pt) 2007-10-12 2020-08-11 Takeda Pharmaceuticals North America, Inc. métodos de tratamento de distúrbios gastrointestinais independente da ingestão de alimento.
AR070972A1 (es) 2008-03-10 2010-05-19 Takeda Pharmaceutical Cristal de compuestos de bencimidazol (lansoprazol)
ES2343935B1 (es) * 2008-12-29 2011-04-28 Laboratorios Viñas S.A. Intermedios utiles para la obtencion de 2-(2-piridinilmetilsulfinil)-1h-benzimidazoles y procedimientos correspondientes.
KR20100101405A (ko) * 2009-03-09 2010-09-17 한미홀딩스 주식회사 비결정형의 (+)-란소프라졸 제조방법 및 이에 사용되는 (+)-란소프라졸 알코올레이트
WO2010134099A1 (en) 2009-05-21 2010-11-25 Cadila Healthcare Limited One pot process for preparing omeprazole and related compounds
CN102180865B (zh) * 2011-03-17 2013-01-16 浙江工业大学 一种兰索拉唑的合成方法
US9119769B2 (en) 2011-12-30 2015-09-01 The Curators Of The University Of Missouri Method for transforming pharmaceutical crystal forms
CN104203938A (zh) 2012-01-21 2014-12-10 朱比兰特生命科学有限公司 用于制备2-吡啶基甲基亚硫酰基苯并咪唑、它们的类似物和光学活性对映体的方法
CN103724325B (zh) * 2013-12-10 2016-04-13 南京工业大学 制备亚磺酰基-1-氢-苯并咪唑衍生物的方法
CN104019635B (zh) * 2014-06-19 2015-05-27 上海慈瑞医药科技有限公司 一种兰索拉唑原料药化合物及其干燥工艺
CN116891458A (zh) * 2023-06-19 2023-10-17 南京唯创远医药科技有限公司 一种艾普拉唑的制备方法

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SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
HU195220B (en) * 1983-05-03 1988-04-28 Byk Gulden Lomberg Chem Fqb Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler

Also Published As

Publication number Publication date
CA1263119A (en) 1989-11-21
DE3875848D1 (de) 1992-12-17
KR890003738A (ko) 1989-04-17
IE882376L (en) 1989-02-04
HUT49346A (en) 1989-09-28
ATE82283T1 (de) 1992-11-15
DE3875848T2 (de) 1993-03-25
GR3006974T3 (cg-RX-API-DMAC10.html) 1993-06-30
EP0302720B1 (en) 1992-11-11
KR960000047B1 (ko) 1996-01-03
DK428188D0 (da) 1988-08-01
DK428188A (da) 1989-02-05
US5578732A (en) 1996-11-26
DK171989B1 (da) 1997-09-08
HU199828B (en) 1990-03-28
IE61717B1 (en) 1994-11-30
EP0302720A1 (en) 1989-02-08

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