FI95260C - 7-(difenyylimetyyli)oksi-9a-metoksimitosaani sekä sen valmistus - Google Patents
7-(difenyylimetyyli)oksi-9a-metoksimitosaani sekä sen valmistusInfo
- Publication number
- FI95260C FI95260C FI911184A FI911184A FI95260C FI 95260 C FI95260 C FI 95260C FI 911184 A FI911184 A FI 911184A FI 911184 A FI911184 A FI 911184A FI 95260 C FI95260 C FI 95260C
- Authority
- FI
- Finland
- Prior art keywords
- methoxymitosane
- oxy
- ethylamino
- diphenylmethyl
- pyridyldithio
- Prior art date
Links
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 abstract 3
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 abstract 2
- WKYZYLKGCNBEMG-WUDYKRTCSA-N [(1as,8s,8ar,8bs)-6-hydroxy-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate Chemical compound C1N2C(C(=C(C)C(=O)C3=O)O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 WKYZYLKGCNBEMG-WUDYKRTCSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- ITLHXEGAYQFOHJ-UHFFFAOYSA-N [diazo(phenyl)methyl]benzene Chemical compound C=1C=CC=CC=1C(=[N+]=[N-])C1=CC=CC=C1 ITLHXEGAYQFOHJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960004857 mitomycin Drugs 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI943884A FI95383C (fi) | 1990-03-08 | 1994-08-24 | Menetelmä 7-/2-(4-nitrofenyyliditio)etyyliamino/-9a-metoksimitosaanin valmistamiseksi |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/491,380 US5075454A (en) | 1990-03-08 | 1990-03-08 | 7-(diphenylmethyl)oxy-9a-methoxymitosane |
| US49138090 | 1990-03-08 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI911184A0 FI911184A0 (fi) | 1991-03-08 |
| FI911184L FI911184L (fi) | 1991-09-09 |
| FI95260B FI95260B (fi) | 1995-09-29 |
| FI95260C true FI95260C (fi) | 1996-01-10 |
Family
ID=23951969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI911184A FI95260C (fi) | 1990-03-08 | 1991-03-08 | 7-(difenyylimetyyli)oksi-9a-metoksimitosaani sekä sen valmistus |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US5075454A (fi) |
| EP (1) | EP0445813B1 (fi) |
| JP (1) | JP2991348B2 (fi) |
| KR (1) | KR0152495B1 (fi) |
| AT (1) | ATE125811T1 (fi) |
| AU (1) | AU630022B2 (fi) |
| CA (1) | CA2037687C (fi) |
| CY (1) | CY1885A (fi) |
| DE (1) | DE69111640T2 (fi) |
| DK (1) | DK0445813T3 (fi) |
| ES (1) | ES2077091T3 (fi) |
| FI (1) | FI95260C (fi) |
| GR (1) | GR3017040T3 (fi) |
| HK (1) | HK4496A (fi) |
| IE (1) | IE68314B1 (fi) |
| PT (1) | PT96966B (fi) |
| TW (1) | TW219938B (fi) |
| ZA (1) | ZA911672B (fi) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6495348B1 (en) | 1993-10-07 | 2002-12-17 | Regents Of The University Of Minnesota | Mitomycin biosynthetic gene cluster |
| US6524812B1 (en) | 1993-10-07 | 2003-02-25 | Regents Of The University Of Minnesota | Genes encoding resistance to DNA alkylating agents |
| US5703111A (en) * | 1996-01-05 | 1997-12-30 | Bristol-Myers Squibb Company | Stable injectable formulation of BMY-25067 |
| CA2208690A1 (en) * | 1996-09-06 | 1998-03-06 | James Robert Mccandless | Package for compounding rubber, compounded rubber and tire having tread thereof |
| KR20180003312U (ko) | 2017-05-16 | 2018-11-26 | 남송학 | 구근줄기 절단 및 선별 배출장치 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3306821A (en) * | 1962-09-04 | 1967-02-28 | Upjohn Co | Porfiromycin derivatives and method of making same |
| US4059573A (en) * | 1973-08-01 | 1977-11-22 | Glaxo Laboratories Limited | Extraction of N-blocked amino acids from aqueous media |
| JPS5840088A (ja) * | 1981-09-04 | 1983-03-08 | Kyowa Hakko Kogyo Co Ltd | 発酵法によるマイトマイシンａの製造法 |
| DE116208T1 (de) * | 1982-12-07 | 1985-02-28 | Kyowa Hakko Kogyo Co., Ltd., Tokio/Tokyo | Mitomycin-analoge. |
| US4803212A (en) * | 1983-04-11 | 1989-02-07 | Bristol-Myers Company | Amino disulfides |
| US4691023A (en) * | 1984-02-24 | 1987-09-01 | Bristol-Myers Company | Amino disulfides |
| JPS60255789A (ja) * | 1984-06-01 | 1985-12-17 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体，その製造法および抗腫瘍剤 |
| US4814445A (en) * | 1984-09-04 | 1989-03-21 | Bristol-Myers Company | Process for preparing mitomycin analogs |
| AU581673B2 (en) * | 1984-09-04 | 1989-03-02 | Bristol-Myers Company | Substituted 7-oxomitosanes |
| US4866189A (en) * | 1985-04-12 | 1989-09-12 | Bristol-Myers Company | Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof |
| US4720543A (en) * | 1985-06-06 | 1988-01-19 | Georgetown University | 1a-7-substituted derivatives of mitomycin and uses thereof |
| US5023253A (en) * | 1987-12-21 | 1991-06-11 | University Patents, Inc. | 6-substituted mitomycin analogs |
-
1990
- 1990-03-08 US US07/491,380 patent/US5075454A/en not_active Expired - Lifetime
-
1991
- 1991-03-06 CA CA002037687A patent/CA2037687C/en not_active Expired - Fee Related
- 1991-03-07 ES ES91103504T patent/ES2077091T3/es not_active Expired - Lifetime
- 1991-03-07 AT AT91103504T patent/ATE125811T1/de not_active IP Right Cessation
- 1991-03-07 EP EP91103504A patent/EP0445813B1/en not_active Expired - Lifetime
- 1991-03-07 DE DE69111640T patent/DE69111640T2/de not_active Expired - Fee Related
- 1991-03-07 DK DK91103504.6T patent/DK0445813T3/da active
- 1991-03-07 ZA ZA911672A patent/ZA911672B/xx unknown
- 1991-03-07 AU AU72698/91A patent/AU630022B2/en not_active Ceased
- 1991-03-07 KR KR1019910003665A patent/KR0152495B1/ko not_active Expired - Fee Related
- 1991-03-07 PT PT96966A patent/PT96966B/pt active IP Right Grant
- 1991-03-07 IE IE76291A patent/IE68314B1/en not_active IP Right Cessation
- 1991-03-07 JP JP3041704A patent/JP2991348B2/ja not_active Expired - Fee Related
- 1991-03-08 FI FI911184A patent/FI95260C/fi not_active IP Right Cessation
- 1991-03-16 TW TW080102108A patent/TW219938B/zh active
-
1992
- 1992-09-16 US US07/945,793 patent/US5352798A/en not_active Expired - Fee Related
-
1995
- 1995-08-08 GR GR950402154T patent/GR3017040T3/el unknown
-
1996
- 1996-01-11 HK HK4496A patent/HK4496A/en not_active IP Right Cessation
- 1996-04-05 CY CY188596A patent/CY1885A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA911672B (en) | 1991-11-27 |
| CA2037687C (en) | 2001-10-30 |
| IE910762A1 (en) | 1991-09-11 |
| ATE125811T1 (de) | 1995-08-15 |
| DK0445813T3 (da) | 1995-09-18 |
| CY1885A (en) | 1996-04-05 |
| TW219938B (fi) | 1994-02-01 |
| DE69111640D1 (de) | 1995-09-07 |
| HK4496A (en) | 1996-01-19 |
| PT96966B (pt) | 1998-07-31 |
| KR0152495B1 (en) | 1998-10-15 |
| GR3017040T3 (en) | 1995-11-30 |
| US5352798A (en) | 1994-10-04 |
| KR910016754A (ko) | 1991-11-05 |
| IE68314B1 (en) | 1996-06-12 |
| FI95260B (fi) | 1995-09-29 |
| JP2991348B2 (ja) | 1999-12-20 |
| DE69111640T2 (de) | 1996-01-25 |
| PT96966A (pt) | 1991-10-31 |
| JPH04211688A (ja) | 1992-08-03 |
| EP0445813A1 (en) | 1991-09-11 |
| CA2037687A1 (en) | 1991-09-09 |
| FI911184L (fi) | 1991-09-09 |
| EP0445813B1 (en) | 1995-08-02 |
| US5075454A (en) | 1991-12-24 |
| AU7269891A (en) | 1991-09-12 |
| ES2077091T3 (es) | 1995-11-16 |
| FI911184A0 (fi) | 1991-03-08 |
| AU630022B2 (en) | 1992-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MA | Patent expired |