ES2040834T3 - Procedimiento de purificacion de albumina de suero. - Google Patents

Procedimiento de purificacion de albumina de suero.

Info

Publication number
ES2040834T3
ES2040834T3 ES198888202578T ES88202578T ES2040834T3 ES 2040834 T3 ES2040834 T3 ES 2040834T3 ES 198888202578 T ES198888202578 T ES 198888202578T ES 88202578 T ES88202578 T ES 88202578T ES 2040834 T3 ES2040834 T3 ES 2040834T3
Authority
ES
Spain
Prior art keywords
purification procedure
serum albumine
followed
employing
anion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888202578T
Other languages
English (en)
Inventor
Boudewijn Wynand Konig
Michiel Nicolaas Hamers
Cornelis Jacobus Van Der Laken
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Application granted granted Critical
Publication of ES2040834T3 publication Critical patent/ES2040834T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE PURIFICA EN UNA SERIE DE ETAPAS ALBUMINA DEL SUERO PRODUCIDA POR TECNICAS RECOMBINANTES, REALIZANDO INICIALMENTE UNA PRECIPITACION ALCALINA, SEGUIDA OPCIONALMENTE DE INCUBACION CON UN ABSORBENTE CAMBIADOR DE ANIONES, SEGUIDA POR CROMATOGRAFIA DE AFINIDAD EMPLEANDO UNA FASE SOLIDQ HIDROFOBA Y USANDO UN ANION LIPIDICO SOLUBLE EN AGUA COMO DESORBENTE DE LA FASE ACUOSA.
ES198888202578T 1987-11-18 1988-11-17 Procedimiento de purificacion de albumina de suero. Expired - Lifetime ES2040834T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87202261 1987-11-18

Publications (1)

Publication Number Publication Date
ES2040834T3 true ES2040834T3 (es) 1993-11-01

Family

ID=8197703

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888202578T Expired - Lifetime ES2040834T3 (es) 1987-11-18 1988-11-17 Procedimiento de purificacion de albumina de suero.

Country Status (13)

Country Link
EP (1) EP0319067B1 (es)
JP (1) JP2562192B2 (es)
KR (1) KR970003053B1 (es)
AT (1) ATE70455T1 (es)
AU (1) AU620355B2 (es)
CA (1) CA1312031C (es)
DE (1) DE3867046D1 (es)
DK (1) DK639288A (es)
ES (1) ES2040834T3 (es)
FI (1) FI92404C (es)
GR (1) GR3003828T3 (es)
IE (1) IE61423B1 (es)
IL (1) IL88326A (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3230091B2 (ja) * 1990-06-25 2001-11-19 ウェルファイド株式会社 ヒト血清アルブミンの着色抑制方法
US5849874A (en) * 1991-07-12 1998-12-15 Gist-Brocades, N.V. Process for the purification of serum albumin
ATE186547T1 (de) 1991-07-12 1999-11-15 Dsm Nv Verfahren zur reinigung von serumalbumin
FR2690444B1 (fr) * 1992-04-22 1995-07-13 Rucheton Marcel Procede de preparation d'une solution d'albumine plasmatique purifiee.
US5440018A (en) * 1992-05-20 1995-08-08 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
US5521287A (en) * 1992-05-20 1996-05-28 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
ES2046122B1 (es) * 1992-06-04 1994-10-01 Grifols Grupo Sa Procedimiento para la obtencion de albumina serica humana purificada.
JP3360315B2 (ja) * 1992-07-31 2002-12-24 三菱ウェルファーマ株式会社 ヒト血清アルブミンの高度精製方法
US5728553A (en) 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
CA2116385A1 (en) * 1993-02-25 1994-08-26 Akinori Sumi Human serum albumin and process for producing the same
FR2746109B1 (fr) 1996-03-12 1998-04-17 Rhone Poulenc Rorer Sa Milieu pour la conservation de materiel biologique
DE19749277C2 (de) * 1997-11-07 2000-05-25 Univ Leipzig Peptid der Sequenz NH¶2¶-Phe-His-Glu-Asn-Trp-Pro-Ser-COOH und seine Verwendung
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
JP4798832B2 (ja) 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 ヒト血清アルブミン多量体の除去方法
JP4798830B2 (ja) * 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 ヒト血清アルブミン多量体の単量体化方法
AU783571B2 (en) * 2000-10-24 2005-11-10 Km Biologics Co., Ltd. Method of monomerizing human serum albumin polymers
GB0217033D0 (en) 2002-07-23 2002-08-28 Delta Biotechnology Ltd Gene and polypeptide sequences
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
JP5631533B2 (ja) 2004-12-23 2014-11-26 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ 遺伝子発現技術
EP2594583A1 (en) 2007-08-08 2013-05-22 Novozymes Biopharma DK A/S Transferrin variants and conugates
JP5936112B2 (ja) 2009-02-11 2016-06-15 アルブミディクス アクティーゼルスカブ アルブミン変異体及び複合体
BR112012009450A2 (pt) 2009-10-30 2017-05-23 Novozymes Biopharma Dk As variantes de albumina
CN106977608A (zh) 2010-04-09 2017-07-25 阿尔布麦狄克斯公司 白蛋白衍生物和变体
EP2780364A2 (en) 2011-11-18 2014-09-24 Eleven Biotherapeutics, Inc. Proteins with improved half-life and other properties
US9944691B2 (en) 2012-03-16 2018-04-17 Albumedix A/S Albumin variants
GB2512156A (en) 2012-11-08 2014-09-24 Novozymes Biopharma Dk As Albumin variants
WO2016145389A1 (en) 2015-03-12 2016-09-15 Board Of Trustees Of Michigan State University Compositions and methods for measuring c-peptide binding and diagnosing immune-mediated diseases
CN108137674B (zh) 2015-08-20 2022-12-06 阿尔布梅迪克斯医疗有限公司 白蛋白变体和缀合物
CN108431204A (zh) 2015-12-22 2018-08-21 阿尔布梅迪克斯医疗有限公司 改良的表达蛋白质的菌株
AU2018286919B2 (en) 2017-06-20 2022-10-06 Albumedix Ltd. Improved protein expression strains
CN111871396A (zh) * 2020-08-03 2020-11-03 中国科学院过程工程研究所 一种白蛋白静电亲和双模式层析介质及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1471006A (en) * 1973-07-11 1977-04-21 New Zealand Inventions Dev Preparation of albumin
SE405549B (sv) * 1975-10-09 1978-12-18 Pharmacia Fine Chemicals Ab Forfarande for isolering av albumin ur plasmaprodukter genom kromatografisk fraktionering
US4228154A (en) * 1979-02-26 1980-10-14 Armour Pharmaceutical Company Purification of plasma albumin by ion exchange chromatography
IL66614A (en) * 1981-08-28 1985-09-29 Genentech Inc Method of constructing a dna sequence encoding a polypeptide,microbial production of human serum albumin,and pharmaceutical compositions comprising it

Also Published As

Publication number Publication date
EP0319067B1 (en) 1991-12-18
KR890007753A (ko) 1989-07-05
ATE70455T1 (de) 1992-01-15
KR970003053B1 (ko) 1997-03-14
DE3867046D1 (de) 1992-01-30
GR3003828T3 (es) 1993-03-16
IL88326A (en) 1993-03-15
DK639288A (da) 1989-05-19
AU2572688A (en) 1989-05-18
IE61423B1 (en) 1994-11-02
FI92404B (fi) 1994-07-29
CA1312031C (en) 1992-12-29
FI885341A (fi) 1989-05-19
AU620355B2 (en) 1992-02-20
JPH0231687A (ja) 1990-02-01
EP0319067A1 (en) 1989-06-07
FI885341A0 (fi) 1988-11-17
DK639288D0 (da) 1988-11-16
JP2562192B2 (ja) 1996-12-11
IE883435L (en) 1989-05-18
FI92404C (fi) 1994-11-10
IL88326A0 (en) 1989-06-30

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