ES2039202T3 - Una composicion adaptada para ser aplicada topicamente a un mamifero para el tratamiento de la ulcera peptica de mamiferos. - Google Patents

Una composicion adaptada para ser aplicada topicamente a un mamifero para el tratamiento de la ulcera peptica de mamiferos.

Info

Publication number
ES2039202T3
ES2039202T3 ES198686308333T ES86308333T ES2039202T3 ES 2039202 T3 ES2039202 T3 ES 2039202T3 ES 198686308333 T ES198686308333 T ES 198686308333T ES 86308333 T ES86308333 T ES 86308333T ES 2039202 T3 ES2039202 T3 ES 2039202T3
Authority
ES
Spain
Prior art keywords
hydroxyl
hydrogen
group
mammal
composition adapted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686308333T
Other languages
English (en)
Inventor
Marvin E. Rosenthale
Laurence B. Katz
David A. Shriver
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Application granted granted Critical
Publication of ES2039202T3 publication Critical patent/ES2039202T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Medicinal Preparation (AREA)
  • Ticket-Dispensing Machines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Transplanting Machines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UNA COMPOSICION ADAPTADA PARA SER APLICADA TOPICAMENTE A UN MAMIFERO PARA TRATAMIENTO DE TRASTORNOS DE ULCERA PEPTICA EN MAMIFEROS, QUE CONTIENE UNA CANTIDAD EFICAZ DE UN ANALOGO DE PROSTAGLANDINA EN UN SOPORTE FARMACEUTICO ADECUADO PARA ADMINISTRAR A LA PIEL DEL MAMIFERO A TRATAR, TENIENDO DICHO ANALOGO DE PROSTAGLANDINA UNA ESTRUCTURA QUE CORRESPONDE A LA FORMULA (I), EN LA QUE: R TIENE LA FORMULA -CH2-Y-(CH2)2-Z; -Y- SE SELECCIONA DEL GRUPO QUE CONSTA DE -(CH2)3-, CIS-HC=CHCH2-, Y CIS,CIS-HC=C=CH-; -Z SE SELECCIONA DEL GRUPO QUE CONSTA DE -CH2OH, Y -CO2X, DON DE X ES HIDROGENO, UN CATION FISIOLOGICAMENTE COMPATIBLE O ALQUILO C1-C6; R1 ES N-BUTILO O FENOXI; R2 SE SELECCIONA DEL GRUPO QUE CONSTA DE HIDROGENO, METILO O HIDROXILO; R3 SE SELECCIONA DEL GRUPO QUE CONSTA DE HIDROGENO, METILO O HIDROXILO, CON LA CONDICION DE QUE R2 Y R3 NO PUEDEN SER AMBOS HIDROGENO O AMBOS HIDROXILO; Y R4 Y R5 SON EL MISMO O DIFERENTE Y SE SELECCIONAN DEL GRUPO QUE CONSTA DE HIDROGENO E HIDROXILO, PERO NOSON AMBOS HIDROXILO.
ES198686308333T 1985-10-28 1986-10-27 Una composicion adaptada para ser aplicada topicamente a un mamifero para el tratamiento de la ulcera peptica de mamiferos. Expired - Lifetime ES2039202T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/791,673 US4707495A (en) 1985-10-28 1985-10-28 Peptic ulcer treatment method

Publications (1)

Publication Number Publication Date
ES2039202T3 true ES2039202T3 (es) 1993-09-16

Family

ID=25154441

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686308333T Expired - Lifetime ES2039202T3 (es) 1985-10-28 1986-10-27 Una composicion adaptada para ser aplicada topicamente a un mamifero para el tratamiento de la ulcera peptica de mamiferos.

Country Status (17)

Country Link
US (1) US4707495A (es)
EP (1) EP0225044B1 (es)
JP (1) JPS62106020A (es)
AT (1) ATE66606T1 (es)
AU (1) AU579497B2 (es)
CA (1) CA1291709C (es)
DE (1) DE3681128D1 (es)
DK (1) DK513486A (es)
ES (1) ES2039202T3 (es)
GR (1) GR3002938T3 (es)
HK (1) HK21192A (es)
HU (1) HU199293B (es)
IL (1) IL80424A0 (es)
NO (1) NO864289D0 (es)
NZ (1) NZ217925A (es)
PH (1) PH23466A (es)
PT (1) PT83624B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219885A (en) * 1987-02-16 1993-06-15 Froelich Juergen Prostaglandin E1 derivatives as pharmaceutically active agents, and pharmaceutical compositions containing these compounds, especially for transcutaneous administration
DE3704825A1 (de) * 1987-02-16 1988-08-25 Froelich Juergen Prostaglandin e1-derivate als pharmazeutische wirkstoffe und diese verbindungen enthaltende arzneimittel insbesondere zur transkutanen anwendung
DK0527887T3 (da) * 1990-05-03 1995-07-03 Searle & Co Farmaceutisk præparat
WO1992006684A1 (en) * 1990-10-18 1992-04-30 Syntex (Usa) Inc. A new use of enprostil
US5324746A (en) * 1993-02-12 1994-06-28 Mckee Rex N Method of treating damaged mucosal and epithelial tissues with misoprostol
JPH06297379A (ja) * 1993-04-16 1994-10-25 Fanuc Ltd 産業用ロボットのオーバートラベル検出装置
US5380760A (en) * 1993-11-19 1995-01-10 Minnesota Mining And Manufacturing Company Transdermal prostaglandin composition
US5994399A (en) * 1997-03-27 1999-11-30 Mckee; Rex N. Method of regenerating collagen-containing tissues with misoprostol
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
US7241746B2 (en) * 2003-08-06 2007-07-10 Regena Therapeutics, Lc Method and composition for treating periodontal disease
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198521A (en) * 1976-07-19 1980-04-15 American Cyanamid Company 15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners
GB1595119A (en) * 1977-05-31 1981-08-05 Sumitomo Chemical Co 2-hydroxycyclopentaneacetic acid y-lactones and processes for producing them
US4097603A (en) * 1977-09-06 1978-06-27 The Upjohn Company Gastric cytoprotection with non-antisecretory doses of prostaglandins
US4254145A (en) * 1978-08-16 1981-03-03 American Cyanamid Company Topical application of prostaglandin hypotensive agents
NL8104929A (nl) * 1980-11-12 1982-06-01 Alza Corp Anticholinergische preparaten, alsmede de bereiding en de toepassing ervan.
JPS595155A (ja) * 1982-06-30 1984-01-12 Ono Pharmaceut Co Ltd プロスタグランジンｄ類似化合物
AU2064783A (en) * 1982-11-05 1984-05-10 Procter & Gamble Company, The Cytoprotective prostoglandins and histamine-2-receptor blocking actents
US4515810A (en) * 1983-10-06 1985-05-07 American Cyanamid Company Composition of matter

Also Published As

Publication number Publication date
JPS62106020A (ja) 1987-05-16
ATE66606T1 (de) 1991-09-15
GR3002938T3 (en) 1993-01-25
DK513486D0 (da) 1986-10-27
IL80424A0 (en) 1987-01-30
HK21192A (en) 1992-03-27
DE3681128D1 (de) 1991-10-02
US4707495A (en) 1987-11-17
HUT42325A (en) 1987-07-28
AU6444686A (en) 1987-04-30
EP0225044B1 (en) 1991-08-28
NZ217925A (en) 1988-10-28
HU199293B (en) 1990-02-28
CA1291709C (en) 1991-11-05
PT83624A (en) 1986-11-01
EP0225044A1 (en) 1987-06-10
NO864289D0 (no) 1986-10-27
DK513486A (da) 1987-04-29
PT83624B (pt) 1989-05-31
AU579497B2 (en) 1988-11-24
PH23466A (en) 1989-08-07

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