ES2038215T3 - Medicamentos. - Google Patents

Medicamentos.

Info

Publication number
ES2038215T3
ES2038215T3 ES198787900101T ES87900101T ES2038215T3 ES 2038215 T3 ES2038215 T3 ES 2038215T3 ES 198787900101 T ES198787900101 T ES 198787900101T ES 87900101 T ES87900101 T ES 87900101T ES 2038215 T3 ES2038215 T3 ES 2038215T3
Authority
ES
Spain
Prior art keywords
amino
alkyl
alkyl group
hydroxy
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787900101T
Other languages
English (en)
Spanish (es)
Inventor
Hansjorg Eibl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Application granted granted Critical
Publication of ES2038215T3 publication Critical patent/ES2038215T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Electrically Operated Instructional Devices (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
  • Steroid Compounds (AREA)
ES198787900101T 1985-12-04 1986-12-04 Medicamentos. Expired - Lifetime ES2038215T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3542893 1985-12-04
DE3606631 1986-02-28

Publications (1)

Publication Number Publication Date
ES2038215T3 true ES2038215T3 (es) 1993-07-16

Family

ID=25838509

Family Applications (2)

Application Number Title Priority Date Filing Date
ES198787900101T Expired - Lifetime ES2038215T3 (es) 1985-12-04 1986-12-04 Medicamentos.
ES198686906829T Expired - Lifetime ES2032755T3 (es) 1985-12-04 1986-12-04 Medicamentos conteniendo hexadecil-fosfocolina con efecto antitumoral.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES198686906829T Expired - Lifetime ES2032755T3 (es) 1985-12-04 1986-12-04 Medicamentos conteniendo hexadecil-fosfocolina con efecto antitumoral.

Country Status (15)

Country Link
US (2) US4837023A (enExample)
EP (4) EP0225608A3 (enExample)
JP (2) JPH0637393B2 (enExample)
AT (2) ATE64529T1 (enExample)
CA (2) CA1338627C (enExample)
DE (4) DE3679908D1 (enExample)
DK (2) DK172954B1 (enExample)
ES (2) ES2038215T3 (enExample)
FI (2) FI873363A7 (enExample)
GR (2) GR3002487T3 (enExample)
HU (2) HU203201B (enExample)
IE (2) IE59778B1 (enExample)
NO (2) NO174877C (enExample)
PT (2) PT83872B (enExample)
WO (2) WO1987003478A2 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916884A (en) * 1985-12-04 1999-06-29 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften Compositions containing a mixture of phosphorus compounds and alkylglycerols
CA2001401A1 (en) * 1988-10-25 1990-04-25 Claude Piantadosi Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
DK0412941T3 (da) * 1989-08-10 1996-06-24 Sandoz Ag Phospholipider til behandling af dissemineret sklerose
US5182271A (en) * 1989-08-10 1993-01-26 Sandoz Ltd. Thioether, keto-ester and alkyl phospholipids useful in treating multiple sclerosis
US5290769A (en) * 1989-09-27 1994-03-01 Asta Pharma Aktiengesellschaft Use of hexadecylphosphocholine for the treatment of psoriasis
EP0916343A1 (de) * 1989-09-27 1999-05-19 ASTA Medica Aktiengesellschaft Verwendung von Alkylphosphorsäure-Verbindungen zur Bekämpfung von Psoriasis-Erkrankungen
DE4111105A1 (de) * 1991-04-05 1992-10-08 Max Planck Gesellschaft Neue erucyl-, brassidyl- und nervonylderivate
US5506217A (en) * 1991-04-25 1996-04-09 The University Of British Columbia Phosphonates as anti-cancer agents
US5369097A (en) * 1991-04-25 1994-11-29 The University Of British Columbia Phosphonates as anti-cancer agents
DK0521297T3 (da) * 1991-07-04 1998-05-04 Asta Medica Ag Fremgangsmåde til fremstilling af alkylphosphocholiner og rensning heraf
US6254879B1 (en) 1991-09-27 2001-07-03 Max-Planck-Gessellschaft zun Förderung der Wissenschaften e.V. Methods of treating protozoal diseases
DE4132344A1 (de) * 1991-09-27 1993-04-01 Max Planck Gesellschaft Verfahren zur herstellung eines arzneimittels zur oralen oder topischen verabreichung bei der behandlung von leishmaniasis
US5298655A (en) * 1991-09-27 1994-03-29 Merck & Co., Inc. Farnesyl pyrophosphate analogs
DE4222910A1 (de) * 1992-07-11 1994-01-13 Asta Medica Ag Neue Phospholipidderivate
US6172050B1 (en) 1992-07-11 2001-01-09 Asta Medica Aktiengesellschaft Phospholipid derivatives
DE4235911A1 (de) * 1992-10-23 1994-04-28 Asta Medica Ag Stabilisierte Hexadecylphosphocholinlösungen in Glycerinalkylethern
ATE226437T1 (de) * 1993-06-10 2002-11-15 Univ Wake Forest (phospho)lipide zum bekämpfen einer hepatitis b- infektion
FI961109L (fi) 1993-09-09 1996-05-06 Imutec Corp Sapesta valmistettuja immunomodulointikoostumuksia
US6551623B1 (en) 1993-09-09 2003-04-22 Lorus Therapeutics Inc. Immunomodulating compositions from bile
AU3216695A (en) * 1994-08-29 1996-03-22 University Of North Carolina At Chapel Hill, The Lipid analogs for treating viral infections
US7135584B2 (en) * 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
US5574025A (en) * 1994-10-26 1996-11-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferases
AU1573495A (en) * 1995-02-10 1996-08-27 University Of British Columbia, The {4-hexadecyl-3-methoxy-butyl} phosphonic acid and its protienconjugates useful as anti-cancer agents
KR19980703088A (ko) 1995-03-16 1998-09-05 라카일레 지, 필리페 신규의 침전탄산칼슘 안료를 포함하는 잉크젯 기록지
KR100499190B1 (ko) * 1996-03-29 2006-04-17 교와 핫꼬 고교 가부시끼가이샤 육모제
US20040101569A1 (en) * 1996-05-16 2004-05-27 Lorus Therapeutics Inc. Immunomodulating compositions from bile
US6121245A (en) * 1997-01-29 2000-09-19 Firshein; Richard N. Method of treating cancer using alkylglycerols in conjunction with chemotherapy
SE9701912D0 (sv) * 1997-05-22 1997-05-22 Interhealth Ab Pharmaceutical composition and use thereof
US7582678B2 (en) * 1997-07-09 2009-09-01 D-Pharm Limited Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
CN100413492C (zh) * 1998-01-22 2008-08-27 赞塔里斯有限公司 口服给药治疗利什曼病的含有米替福星的固体药物组合物
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
IL137672A0 (en) * 2000-08-03 2001-10-31 Dpharm Ltd Derivatives of branched-chain lipophilic molecules and uses thereof
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
CN1486289A (zh) * 2001-05-29 2004-03-31 皇家菲利浦电子有限公司 金属-陶瓷的结合
IL160080A0 (en) * 2001-08-31 2004-06-20 Thomson Licensing Sa Sequence counter for an audio visual stream
AU2002346284A1 (en) * 2002-04-26 2003-11-10 Rudolf Perl Pharmaceutical compositions of phospholipid derivatives
US20050187191A1 (en) * 2004-02-20 2005-08-25 Kucera Louis S. Methods and compositions for the treatment of respiratory syncytial virus
AU2006328479B2 (en) 2005-12-19 2012-03-08 Aeterna Zentaris Gmbh Alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof
US8637688B2 (en) * 2006-12-20 2014-01-28 Julia Diederichs Topical dosage form comprising tri-substituted glycerol compounds
JP2011057647A (ja) * 2009-09-14 2011-03-24 Adeka Corp 化粧料
EP3616701A1 (en) 2011-06-24 2020-03-04 GRI Bio, Inc. Prevention and treatment of inflammatory conditions
CN102491994B (zh) * 2011-12-07 2014-10-15 宁波九胜创新医药科技有限公司 一种胆碱磷酸烷基酯的制备方法
AU2015360945B2 (en) * 2014-12-09 2021-07-29 Gri Bio, Inc. Prevention and treatment of inflammatory conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225227A1 (de) * 1982-07-06 1984-01-12 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Derivate des n.n-bis-(2-chlor-aethyl)-phosphorsaeureamids
JPS5984824A (ja) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd 抗腫瘍剤
US4690935A (en) * 1983-03-31 1987-09-01 Wayne State University Inhibition of tumor growth and metastasis with calcium channel blocker compounds
JPS60184092A (ja) 1984-03-01 1985-09-19 Kao Corp リン酸エステルおよびその製法

Also Published As

Publication number Publication date
WO1987003478A3 (en) 1987-09-24
HUT44441A (en) 1988-03-28
ES2032755T3 (es) 1993-03-01
WO1987003478A2 (en) 1987-06-18
EP0230575A3 (de) 1987-12-02
DK393187D0 (da) 1987-07-28
DK398587D0 (da) 1987-07-30
JPS63501719A (ja) 1988-07-14
DK172954B1 (da) 1999-10-18
DE3679908D1 (de) 1991-07-25
DE3641491A1 (de) 1987-09-17
GR3002487T3 (en) 1992-12-30
ATE75608T1 (de) 1992-05-15
FI873364A7 (fi) 1987-08-03
IE863177L (en) 1987-06-04
NO175620B (enExample) 1994-08-01
PT83872A (de) 1987-01-01
EP0225608A2 (de) 1987-06-16
DE3641379A1 (de) 1987-09-03
GR3005168T3 (enExample) 1993-05-24
IE863176L (en) 1987-06-04
DK393187A (da) 1987-07-28
PT83872B (pt) 1989-01-17
JPH0637393B2 (ja) 1994-05-18
EP0225608A3 (de) 1987-10-28
WO1987003480A3 (en) 1988-02-25
NO873244L (no) 1987-10-01
HU203201B (en) 1991-06-28
NO873243L (no) 1987-10-02
WO1987003480A2 (en) 1987-06-18
NO174877C (no) 1994-07-27
FI873363L (fi) 1987-08-03
US4837023A (en) 1989-06-06
ATE64529T1 (de) 1991-07-15
IE59778B1 (en) 1994-04-06
NO174877B (no) 1994-04-18
DE19375061I2 (de) 2008-11-20
NO175620C (no) 1994-11-09
EP0248062A1 (de) 1987-12-09
HU208143B (en) 1993-08-30
PT83873B (pt) 1989-01-17
NO873243D0 (no) 1987-08-03
EP0230575A2 (de) 1987-08-05
DK398587A (da) 1987-07-30
US5049552A (en) 1991-09-17
JPH0859677A (ja) 1996-03-05
EP0248047A1 (de) 1987-12-09
CA1280369C (en) 1991-02-19
HUT44431A (en) 1988-03-28
JP2857084B2 (ja) 1999-02-10
NO873244D0 (no) 1987-08-03
EP0248062B1 (de) 1992-05-06
PT83873A (de) 1987-01-01
CA1338627C (en) 1996-10-01
FI873363A0 (fi) 1987-08-03
FI873364A0 (fi) 1987-08-03
IE59777B1 (en) 1994-04-06
FI873363A7 (fi) 1987-08-03
EP0248047B1 (de) 1991-06-19

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