ES2037833T3 - 2-amino-5-hidroxi-4-pirimidonas. - Google Patents

2-amino-5-hidroxi-4-pirimidonas.

Info

Publication number
ES2037833T3
ES2037833T3 ES198888306000T ES88306000T ES2037833T3 ES 2037833 T3 ES2037833 T3 ES 2037833T3 ES 198888306000 T ES198888306000 T ES 198888306000T ES 88306000 T ES88306000 T ES 88306000T ES 2037833 T3 ES2037833 T3 ES 2037833T3
Authority
ES
Spain
Prior art keywords
substituted
phenyl
alkyl
phenylalkyl
fenylalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888306000T
Other languages
English (en)
Spanish (es)
Inventor
Frederick Judson Walker
Brian Thomas O'neill
John Lawrence Lamattina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2037833T3 publication Critical patent/ES2037833T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Hydrogenated Pyridines (AREA)
ES198888306000T 1987-07-09 1988-07-01 2-amino-5-hidroxi-4-pirimidonas. Expired - Lifetime ES2037833T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1987/001608 WO1989000423A1 (en) 1987-07-09 1987-07-09 2-amino-5-hydroxy-4-pyrimidones

Publications (1)

Publication Number Publication Date
ES2037833T3 true ES2037833T3 (es) 1993-07-01

Family

ID=22202454

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888306000T Expired - Lifetime ES2037833T3 (es) 1987-07-09 1988-07-01 2-amino-5-hidroxi-4-pirimidonas.

Country Status (12)

Country Link
EP (1) EP0303348B1 (Direct)
JP (1) JPH0629264B2 (Direct)
AT (1) ATE71370T1 (Direct)
CA (1) CA1310642C (Direct)
DE (1) DE3867563D1 (Direct)
DK (1) DK381188A (Direct)
ES (1) ES2037833T3 (Direct)
FI (1) FI883285A7 (Direct)
GR (1) GR3003908T3 (Direct)
IE (1) IE60210B1 (Direct)
PT (1) PT87944B (Direct)
WO (1) WO1989000423A1 (Direct)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201111705D0 (en) * 2011-07-07 2011-08-24 Takeda Pharmaceutical Compounds and their use
JO3115B1 (ar) 2011-08-22 2017-09-20 Takeda Pharmaceuticals Co مركبات بيريدازينون واستخدامها كمثبطات daao
US9221809B2 (en) 2011-10-31 2015-12-29 Merck Sharp & Dohme Corp. Aminopyrimidinones as interleukin receptor-associated kinase inhibitors
AP2014007637A0 (en) 2011-11-15 2014-05-31 Takeda Pharmaceutical Dihydroxy aromatic heterocyclic compound
GB201222711D0 (en) 2012-12-17 2013-01-30 Takeda Pharmaceutical Novel compounds
WO2020163689A1 (en) 2019-02-08 2020-08-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education 20-hete formation inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB756189A (en) 1954-02-01 1956-08-29 Ici Ltd New pyrimidine derivatives
US4153793A (en) * 1973-05-03 1979-05-08 Smith Kline & French Laboratories Limited Imidazo alkylamino pyrimidones
IN153791B (Direct) * 1979-03-10 1984-08-18 Soc D Etudes Prod Chimique
FR2503162A1 (fr) 1981-04-07 1982-10-08 Pharmindustrie Nouveaux derives de piperazino-2 pyrimidine, procedes pour leur preparation et leur utilisation comme medicaments ou comme intermediaires pour la fabrication de medicaments
US4554276A (en) * 1983-10-03 1985-11-19 Pfizer Inc. 2-Amino-5-hydroxy-4-methylpyrimidine derivatives
GB8421427D0 (en) 1984-08-23 1984-09-26 Smith Kline French Lab Chemical compounds
DE3436380A1 (de) * 1984-10-04 1986-04-10 Bayer Ag, 5090 Leverkusen Selektiv-fungizide mittel auf pyrimidin-derivat-basis
JPS61205260A (ja) * 1985-03-08 1986-09-11 Zeria Shinyaku Kogyo Kk 新規な２−置換アミノ−６−（２−メトキシフエニ−ル）−４（３ｈ）−ピリミドン誘導体及びその製造法

Also Published As

Publication number Publication date
PT87944B (pt) 1995-03-01
CA1310642C (en) 1992-11-24
JPH0629264B2 (ja) 1994-04-20
IE60210B1 (en) 1994-06-15
GR3003908T3 (Direct) 1993-03-16
ATE71370T1 (de) 1992-01-15
FI883285A7 (fi) 1989-01-10
EP0303348B1 (en) 1992-01-08
JPS6429367A (en) 1989-01-31
DK381188D0 (da) 1988-07-08
DK381188A (da) 1989-02-21
IE882107L (en) 1989-01-09
DE3867563D1 (en) 1992-02-20
WO1989000423A1 (en) 1989-01-26
FI883285A0 (fi) 1988-07-08
EP0303348A1 (en) 1989-02-15
PT87944A (pt) 1989-06-30

Similar Documents

Publication Publication Date Title
PE31691A1 (es) Procedimiento para la preparacion de nuevos compuestos fungicidas
CO4970728A1 (es) 2-aminopiridinas que contienen sustituyentes de anillos condensados
ATE40994T1 (de) L-n-n-propylpipekolsaeure-2,6-xylidid und dessen herstellung.
ES8104203A1 (es) Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol
EA199800664A1 (ru) Замещенные производные 4-гидрокси-фенилалкановой кислоты с агонистической активностью по отношению к ppar-гамма
ES8706684A1 (es) Un procedimiento para preparar derivados del acido 1-arabiciclo (3,2,0) hept 2-en-7-ona-2-carboxilico.
DE68920654D1 (de) 4-Oxochinolin-3-carbonsäure-Derivate, ihre Herstellung und ihre Verwendung.
ES2117249T3 (es) Derivados de 2,6-diaminopurina.
ES2038188T3 (es) Un procedimiento para preparar nuevas tienopiridinonas.
ES2007543A6 (es) Procedimiento de preparacion de 1,4-dihidropiridinas.
FI811373L (fi) Substituerade fenyletrar
ES2114277T3 (es) Un compuesto eventualmente bajo la forma de isomero optico puro o mezcla de tales isomeros, su procedimiento de preparacion, medicamento y composicion farmaceutica a base del mismo.
ES2029003T3 (es) Un procedimiento para la preparacion de nuevos derivados de heteroaril 3-oxo-propanamida.
ES2059416T3 (es) 1,4-dihidropiridina-enantiomeros.
ES2103820T3 (es) Piperazinas 1,4-disustituidas.
ES470916A1 (es) Ÿun procedimiento para la preparacion de derivados de acidos4-hidroxi-2-quinolinon-3-carboxilicosŸ
ES8705370A1 (es) Un procedimiento para la preparacion de nuevos derivados del acido 3-axa-14-oxo-carbatron-52 enoico.
ATE71370T1 (de) 2-amino-5-hydroxy-4-pyrimidone.
ATE29024T1 (de) Bicyclooctanderivate, ihre herstellung und ihre verwendung.
FI871316A0 (fi) Foerfarande foer framstaellning av acymmetriska esterderivat av 1,4-dihydropyridin-3,5-dikarboxylsyra.
ES438757A1 (es) Un procedimiento de obtencion de las meta-trifluormetilben- cilaminas sustituidas al nitrogeno.
ES8504680A1 (es) Un procedimiento para la preparacion de derivados de benzamida
DE69011714D1 (de) Kalziumantagonisten.
ES2063157T3 (es) Nuevos derivados del indol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES8103725A1 (es) Procedimiento de preparacion de derivados del acido p-bife- nil-4-metil-2-buten-3-oico

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 303348

Country of ref document: ES