ES2032125T3 - Forma galenica para la liberizacion prolongada del diltiazem. - Google Patents
Forma galenica para la liberizacion prolongada del diltiazem.Info
- Publication number
- ES2032125T3 ES2032125T3 ES198989401180T ES89401180T ES2032125T3 ES 2032125 T3 ES2032125 T3 ES 2032125T3 ES 198989401180 T ES198989401180 T ES 198989401180T ES 89401180 T ES89401180 T ES 89401180T ES 2032125 T3 ES2032125 T3 ES 2032125T3
- Authority
- ES
- Spain
- Prior art keywords
- membrane
- core
- microspheres
- diltiazem
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
LAS MICROBOLAS ESTAN FORMADAS POR UN NUCLEO CON EL PRINCIPIO ACTIVO Y UNA MEMBRANA MICROPOROSA VISOLUBLE EN MEDIO ACUOSO CONSTITUIDA POR UN POLIMERO FILMOGENO, UN PLASTIFICANTE Y UNA CARGA. LA MEMBRANA TIENE UN ESPESOR TAL QUE "IN VITRO" EL DILTIAZEM SE LIBERA A VELOCIDAD SENSIBLEMENTE CONSTANTE DURANTE AL MENOS 6 HORAS, DESPUES DE UN PERIODO DE LATENCIA INFERIOR A UNA HORA. EL PRINCIPIO ACTIVO PUEDE SER MEZCLADO INTIMAMENTE AL NUCLEO O RECUBIERTO POR UNA CAPA DE POLIVINILPIRROLIDONA RODEANDO UN GRANO SOPORTE. LAS MICROBOLAS DE LIBERACION PROLONGADA ESTAN FORMADAS POR APLICACION SOBRE EL NUCLEO DE LA DISPERSION DE LOS CONSTITUYENTES DE LA MEMBRANA EN UN DISOLVENTE Y EVAPORACION DEL DISOLVENTE. LAS COMPOSICIONES FARMACEUTICAS ESTAN CONSTITUIDAS, POR CAPSULAS CONTENIENDO LAS MICROBOLAS. SE ADMINISTRAN 1 A 2 VECES POR DIA POR VIA ORAL PARA TRATAR LA HIPERTENSION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8805629A FR2630647B1 (fr) | 1988-04-27 | 1988-04-27 | Microbilles de diltiazem, leur procede de fabrication et compositions pharmaceutiques a liberation prolongee les contenant |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2032125T3 true ES2032125T3 (es) | 1993-01-01 |
Family
ID=9365751
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198989401180T Expired - Lifetime ES2032125T3 (es) | 1988-04-27 | 1989-04-25 | Forma galenica para la liberizacion prolongada del diltiazem. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0340105B1 (es) |
JP (1) | JPH01313431A (es) |
AT (1) | ATE72974T1 (es) |
AU (1) | AU614056B2 (es) |
CA (1) | CA1336326C (es) |
DE (1) | DE68900903D1 (es) |
ES (1) | ES2032125T3 (es) |
FR (1) | FR2630647B1 (es) |
GR (1) | GR3003988T3 (es) |
MX (1) | MX9203020A (es) |
NZ (1) | NZ228846A (es) |
ZA (1) | ZA892871B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5288505A (en) * | 1991-06-26 | 1994-02-22 | Galephar P.R., Inc., Ltd. | Extended release form of diltiazem |
KR100221695B1 (ko) * | 1991-08-12 | 1999-09-15 | 그린 마틴, 브라이언 쥐 테슬리 | 약학적 구상 제형 |
GB2258613B (en) * | 1991-08-12 | 1996-01-10 | Euro Celtique Sa | Pharmaceutical diltiazem formulation |
JPH08143450A (ja) * | 1994-11-14 | 1996-06-04 | Taiyo Yakuhin Kogyo Kk | 徐放化製剤 |
FR2742660B1 (fr) * | 1995-12-22 | 1998-04-03 | Ethypharm Lab Prod Ethiques | Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif |
EP2174586B1 (de) * | 2008-10-02 | 2014-12-10 | EyeSense AG | Implantierbares Sensorelement |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57120518A (en) * | 1981-01-19 | 1982-07-27 | Tanabe Seiyaku Co Ltd | Preparation of microcapsule |
JPS58116414A (ja) * | 1981-12-23 | 1983-07-11 | Yamanouchi Pharmaceut Co Ltd | ニカルジピン持続性製剤用球形顆粒およびその製造法 |
JPS5916821A (ja) * | 1982-07-16 | 1984-01-28 | Tanabe Seiyaku Co Ltd | 非凝集性マイクロカプセルの製法 |
IE56999B1 (en) * | 1983-12-22 | 1992-03-11 | Elan Corp Plc | Pharmaceutical formulation |
LU85943A1 (fr) * | 1985-06-12 | 1987-01-13 | Galephar | Comprimes pharmaceutiques permettant l'administration aisee de pellets, leur preparation et leur utilisation |
JPS6232166A (ja) * | 1985-08-06 | 1987-02-12 | Mitsui Toatsu Chem Inc | 発泡体加工用粘着剤 |
LU86077A1 (fr) * | 1985-09-18 | 1987-04-02 | Pharlyse Sa | Nouvelles formes galeniques du verapamil,leur fabrication et medicaments contenant ces nouvelles formes galeniques |
-
1988
- 1988-04-27 FR FR8805629A patent/FR2630647B1/fr not_active Expired - Fee Related
-
1989
- 1989-04-13 CA CA000596597A patent/CA1336326C/en not_active Expired - Fee Related
- 1989-04-19 ZA ZA892871A patent/ZA892871B/xx unknown
- 1989-04-21 NZ NZ228846A patent/NZ228846A/en unknown
- 1989-04-24 AU AU33363/89A patent/AU614056B2/en not_active Ceased
- 1989-04-25 ES ES198989401180T patent/ES2032125T3/es not_active Expired - Lifetime
- 1989-04-25 DE DE8989401180T patent/DE68900903D1/de not_active Expired - Fee Related
- 1989-04-25 EP EP89401180A patent/EP0340105B1/fr not_active Expired - Lifetime
- 1989-04-25 AT AT89401180T patent/ATE72974T1/de active
- 1989-04-26 JP JP1107115A patent/JPH01313431A/ja active Pending
-
1992
- 1992-03-05 GR GR920400339T patent/GR3003988T3/el unknown
- 1992-06-19 MX MX9203020A patent/MX9203020A/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP0340105A1 (fr) | 1989-11-02 |
MX9203020A (es) | 1992-07-01 |
AU3336389A (en) | 1989-11-02 |
CA1336326C (en) | 1995-07-18 |
ATE72974T1 (de) | 1992-03-15 |
GR3003988T3 (es) | 1993-03-16 |
ZA892871B (en) | 1990-12-28 |
AU614056B2 (en) | 1991-08-15 |
EP0340105B1 (fr) | 1992-03-04 |
FR2630647B1 (fr) | 1991-08-16 |
JPH01313431A (ja) | 1989-12-18 |
DE68900903D1 (de) | 1992-04-09 |
FR2630647A1 (fr) | 1989-11-03 |
NZ228846A (en) | 1991-06-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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