ZA892871B - Microbeads of ditiazem a process for their manufacture and a sustained-release pharmaceutical composition containing them - Google Patents

Microbeads of ditiazem a process for their manufacture and a sustained-release pharmaceutical composition containing them

Info

Publication number
ZA892871B
ZA892871B ZA892871A ZA892871A ZA892871B ZA 892871 B ZA892871 B ZA 892871B ZA 892871 A ZA892871 A ZA 892871A ZA 892871 A ZA892871 A ZA 892871A ZA 892871 B ZA892871 B ZA 892871B
Authority
ZA
South Africa
Prior art keywords
membrane
core
sustained
microspheres
ditiazem
Prior art date
Application number
ZA892871A
Inventor
Henri Desmolin
Desmolin Henri
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of ZA892871B publication Critical patent/ZA892871B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Abstract

The microspheres are composed of a core containing the active principle and a microporous membrane which is insoluble in aqueous media, the membrane consisting of a film-forming polymer, a plasticiser and a filler. The membrane has a thickness such that, in vitro, the diltiazem is released at a substantially constant rate for at least 6 hours, after a latency time of less than 1 hour. The active principle may be mixed intimately with the core, or coated in a layer of polyvinylpyrrolidone surrounding a carrier particle. The sustained-release microspheres are formed by application to the core of a dispersion of the constituents of the membrane in a solvent, and evaporation of the solvent. The pharmaceutical compositions consist of hard gelatine capsules containing the microspheres. They are administered, according to the dose, once to twice a day orally for the treatment of angina or hypertension.
ZA892871A 1988-04-27 1989-04-19 Microbeads of ditiazem a process for their manufacture and a sustained-release pharmaceutical composition containing them ZA892871B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8805629A FR2630647B1 (en) 1988-04-27 1988-04-27 DILTIAZEM MICROBALLS, PROCESS FOR PRODUCING THE SAME, AND SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
ZA892871B true ZA892871B (en) 1990-12-28

Family

ID=9365751

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA892871A ZA892871B (en) 1988-04-27 1989-04-19 Microbeads of ditiazem a process for their manufacture and a sustained-release pharmaceutical composition containing them

Country Status (12)

Country Link
EP (1) EP0340105B1 (en)
JP (1) JPH01313431A (en)
AT (1) ATE72974T1 (en)
AU (1) AU614056B2 (en)
CA (1) CA1336326C (en)
DE (1) DE68900903D1 (en)
ES (1) ES2032125T3 (en)
FR (1) FR2630647B1 (en)
GR (1) GR3003988T3 (en)
MX (1) MX9203020A (en)
NZ (1) NZ228846A (en)
ZA (1) ZA892871B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288505A (en) * 1991-06-26 1994-02-22 Galephar P.R., Inc., Ltd. Extended release form of diltiazem
GB2258613B (en) * 1991-08-12 1996-01-10 Euro Celtique Sa Pharmaceutical diltiazem formulation
KR100221695B1 (en) * 1991-08-12 1999-09-15 그린 마틴, 브라이언 쥐 테슬리 Pharmaceutical spheroid formulation
JPH08143450A (en) * 1994-11-14 1996-06-04 Taiyo Yakuhin Kogyo Kk Sustained release preparation
FR2742660B1 (en) * 1995-12-22 1998-04-03 Ethypharm Lab Prod Ethiques NOVEL FORMS OF EXTENDED RELEASE MICROGRANULES CONTAINING DILTIAZEM AS ACTIVE INGREDIENT
ES2530450T3 (en) * 2008-10-02 2015-03-03 Eyesense Ag Implantable sensor element

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57120518A (en) * 1981-01-19 1982-07-27 Tanabe Seiyaku Co Ltd Preparation of microcapsule
JPS58116414A (en) * 1981-12-23 1983-07-11 Yamanouchi Pharmaceut Co Ltd Composition for pharmaceutical of prolonged release containing nicardipine and preparation thereof
JPS5916821A (en) * 1982-07-16 1984-01-28 Tanabe Seiyaku Co Ltd Preparation of nonflocculating microcapsule
IE56999B1 (en) * 1983-12-22 1992-03-11 Elan Corp Plc Pharmaceutical formulation
LU85943A1 (en) * 1985-06-12 1987-01-13 Galephar PHARMACEUTICAL TABLETS FOR THE EASY ADMINISTRATION OF PELLETS, THEIR PREPARATION AND THEIR USE
JPS6232166A (en) * 1985-08-06 1987-02-12 Mitsui Toatsu Chem Inc Adhesive for fabrication of foams
LU86077A1 (en) * 1985-09-18 1987-04-02 Pharlyse Sa NEW GALENIC FORMS OF VERAPAMIL, THEIR MANUFACTURE AND THE MEDICINAL PRODUCTS CONTAINING THESE NEW GALENIC FORMS

Also Published As

Publication number Publication date
FR2630647B1 (en) 1991-08-16
MX9203020A (en) 1992-07-01
CA1336326C (en) 1995-07-18
GR3003988T3 (en) 1993-03-16
JPH01313431A (en) 1989-12-18
ES2032125T3 (en) 1993-01-01
EP0340105A1 (en) 1989-11-02
AU614056B2 (en) 1991-08-15
AU3336389A (en) 1989-11-02
NZ228846A (en) 1991-06-25
DE68900903D1 (en) 1992-04-09
FR2630647A1 (en) 1989-11-03
EP0340105B1 (en) 1992-03-04
ATE72974T1 (en) 1992-03-15

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