DE68900903D1 - Diltiazem-mikrokugeln, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen mit gesteuerter abgabe. - Google Patents

Diltiazem-mikrokugeln, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen mit gesteuerter abgabe.

Info

Publication number
DE68900903D1
DE68900903D1 DE8989401180T DE68900903T DE68900903D1 DE 68900903 D1 DE68900903 D1 DE 68900903D1 DE 8989401180 T DE8989401180 T DE 8989401180T DE 68900903 T DE68900903 T DE 68900903T DE 68900903 D1 DE68900903 D1 DE 68900903D1
Authority
DE
Germany
Prior art keywords
membrane
diltiazem
core
microspheres
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989401180T
Other languages
English (en)
Inventor
Henri Desmolin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of DE68900903D1 publication Critical patent/DE68900903D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE8989401180T 1988-04-27 1989-04-25 Diltiazem-mikrokugeln, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen mit gesteuerter abgabe. Expired - Fee Related DE68900903D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8805629A FR2630647B1 (fr) 1988-04-27 1988-04-27 Microbilles de diltiazem, leur procede de fabrication et compositions pharmaceutiques a liberation prolongee les contenant

Publications (1)

Publication Number Publication Date
DE68900903D1 true DE68900903D1 (de) 1992-04-09

Family

ID=9365751

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989401180T Expired - Fee Related DE68900903D1 (de) 1988-04-27 1989-04-25 Diltiazem-mikrokugeln, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen mit gesteuerter abgabe.

Country Status (12)

Country Link
EP (1) EP0340105B1 (de)
JP (1) JPH01313431A (de)
AT (1) ATE72974T1 (de)
AU (1) AU614056B2 (de)
CA (1) CA1336326C (de)
DE (1) DE68900903D1 (de)
ES (1) ES2032125T3 (de)
FR (1) FR2630647B1 (de)
GR (1) GR3003988T3 (de)
MX (1) MX9203020A (de)
NZ (1) NZ228846A (de)
ZA (1) ZA892871B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288505A (en) * 1991-06-26 1994-02-22 Galephar P.R., Inc., Ltd. Extended release form of diltiazem
KR100221695B1 (ko) * 1991-08-12 1999-09-15 그린 마틴, 브라이언 쥐 테슬리 약학적 구상 제형
GB2258613B (en) * 1991-08-12 1996-01-10 Euro Celtique Sa Pharmaceutical diltiazem formulation
JPH08143450A (ja) * 1994-11-14 1996-06-04 Taiyo Yakuhin Kogyo Kk 徐放化製剤
FR2742660B1 (fr) * 1995-12-22 1998-04-03 Ethypharm Lab Prod Ethiques Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif
EP2174586B1 (de) 2008-10-02 2014-12-10 EyeSense AG Implantierbares Sensorelement

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57120518A (en) * 1981-01-19 1982-07-27 Tanabe Seiyaku Co Ltd Preparation of microcapsule
JPS58116414A (ja) * 1981-12-23 1983-07-11 Yamanouchi Pharmaceut Co Ltd ニカルジピン持続性製剤用球形顆粒およびその製造法
JPS5916821A (ja) * 1982-07-16 1984-01-28 Tanabe Seiyaku Co Ltd 非凝集性マイクロカプセルの製法
IE56999B1 (en) * 1983-12-22 1992-03-11 Elan Corp Plc Pharmaceutical formulation
LU85943A1 (fr) * 1985-06-12 1987-01-13 Galephar Comprimes pharmaceutiques permettant l'administration aisee de pellets, leur preparation et leur utilisation
JPS6232166A (ja) * 1985-08-06 1987-02-12 Mitsui Toatsu Chem Inc 発泡体加工用粘着剤
LU86077A1 (fr) * 1985-09-18 1987-04-02 Pharlyse Sa Nouvelles formes galeniques du verapamil,leur fabrication et medicaments contenant ces nouvelles formes galeniques

Also Published As

Publication number Publication date
EP0340105A1 (de) 1989-11-02
JPH01313431A (ja) 1989-12-18
EP0340105B1 (de) 1992-03-04
NZ228846A (en) 1991-06-25
AU614056B2 (en) 1991-08-15
ES2032125T3 (es) 1993-01-01
FR2630647A1 (fr) 1989-11-03
FR2630647B1 (fr) 1991-08-16
AU3336389A (en) 1989-11-02
CA1336326C (en) 1995-07-18
ATE72974T1 (de) 1992-03-15
GR3003988T3 (de) 1993-03-16
MX9203020A (es) 1992-07-01
ZA892871B (en) 1990-12-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8328 Change in the person/name/address of the agent

Free format text: TER MEER STEINMEISTER & PARTNER GBR PATENTANWAELTE, 81679 MUENCHEN

8339 Ceased/non-payment of the annual fee