ES2026851T3 - Tocoferol estabilizado en una forma seca, en particulas y libremente fluyente. - Google Patents

Tocoferol estabilizado en una forma seca, en particulas y libremente fluyente.

Info

Publication number
ES2026851T3
ES2026851T3 ES198787100296T ES87100296T ES2026851T3 ES 2026851 T3 ES2026851 T3 ES 2026851T3 ES 198787100296 T ES198787100296 T ES 198787100296T ES 87100296 T ES87100296 T ES 87100296T ES 2026851 T3 ES2026851 T3 ES 2026851T3
Authority
ES
Spain
Prior art keywords
particles
free flowing
dry form
tocopherol
stabilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787100296T
Other languages
English (en)
Inventor
Bruce E. Wenzel
James P. Clar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henkel Corp
Original Assignee
Henkel Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel Corp filed Critical Henkel Corp
Application granted granted Critical
Publication of ES2026851T3 publication Critical patent/ES2026851T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cosmetics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE ENCUENTRA SECO, EN PARTICULAS Y EN FORMA DE LIBRE-CIRCULADOR DE VITAMINA E ( -TOCOFEROL) Y TIENE UN ESTABILIZADOR DE FUERZA PARA LA VITAMINA E. LOS ESTABILIZADORES DE FUERZA SON HIDROXIACIDOS O AMINOACIDOS TALES COMO ACIDO ASCORBICO, ACIDO CITRICO, METIONINA Y CISTEINA.
ES198787100296T 1986-01-16 1987-01-13 Tocoferol estabilizado en una forma seca, en particulas y libremente fluyente. Expired - Lifetime ES2026851T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/819,779 US4711894A (en) 1986-01-16 1986-01-16 Stabilized tocopherol in dry, particulate, free-flowing form

Publications (1)

Publication Number Publication Date
ES2026851T3 true ES2026851T3 (es) 1992-05-16

Family

ID=25229038

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787100296T Expired - Lifetime ES2026851T3 (es) 1986-01-16 1987-01-13 Tocoferol estabilizado en una forma seca, en particulas y libremente fluyente.

Country Status (9)

Country Link
US (1) US4711894A (es)
EP (1) EP0229652B1 (es)
JP (1) JP2677554B2 (es)
AT (1) ATE68971T1 (es)
DE (1) DE3774137D1 (es)
DK (1) DK169230B1 (es)
ES (1) ES2026851T3 (es)
FI (1) FI87524C (es)
NO (1) NO173318C (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3820693A1 (de) * 1988-06-18 1989-12-21 Henkel Kgaa Topische kosmetische und pharmazeutische zubereitungen
US5120761A (en) * 1988-10-14 1992-06-09 Finnan Jeffrey L Method of making a free-flowing spray dried edible powder comprising an oil
FI901046A0 (fi) * 1989-03-17 1990-03-01 Eisai Co Ltd Stabilisering av polyprenylfoereningen.
US5292521A (en) * 1990-04-06 1994-03-08 Eisai Co., Ltd. Solid oral preparation containing a pyrrolidine derivative with a catechol group
US5234695A (en) * 1990-07-24 1993-08-10 Eastman Kodak Company Water dispersible vitamin E composition
US6020003A (en) * 1998-02-23 2000-02-01 Basf Corporation Method of making spray-dried powders with high edible-oil loadings based on non-hydrolyzed gelatin
US6613821B2 (en) * 1998-10-09 2003-09-02 Canon Kabushiki Kaisha Cloth treating agent, cloth, textile printing process and print
US6303167B1 (en) 1998-11-09 2001-10-16 Archer-Daniels-Midland Company Method of producing vitamin powders
US6716451B1 (en) * 1999-11-30 2004-04-06 Soft Gel Technologies, Inc. Formulation and delivery method to enhance antioxidant potency of vitamin E
GB0017060D0 (en) * 2000-07-11 2000-08-30 Hunter Fleming Ltd Production, stabilisation and use of reduced forms of pharmaceutical compounds
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US7329688B2 (en) * 2002-12-17 2008-02-12 Soft Gel Technologies, Inc. Natural vitamin E compositions with superior antioxidant potency
DE10311585A1 (de) 2003-03-14 2004-09-23 Basf Ag Wirkstoffhaltige Adsorbate
US20070237834A1 (en) * 2003-04-18 2007-10-11 Bioderm Research Zinc Zeolite for the Treatment for Diaper Rash (Diaper Dermatitis)
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US9247765B2 (en) 2004-01-14 2016-02-02 Omniactive Health Technologies Limited Stable beadlets of lipophilic nutrients
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20080293955A1 (en) * 2005-12-22 2008-11-27 Basf Se Method for Producing Vitamin E-Adsorbates
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
JP5774853B2 (ja) 2008-01-25 2015-09-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 医薬投薬形
CA2723438C (en) 2008-05-09 2016-10-11 Gruenenthal Gmbh Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
MX2012000369A (es) 2009-07-22 2012-02-01 Gruenenthal Gmbh Forma de dosificacion resistente a la manipulacion para opioides sensibles a la oxidacion.
MX2012000317A (es) 2009-07-22 2012-02-08 Gruenenthal Gmbh Forma de dosificacion de liberacion controlada extruida por fusion en caliente.
EP2531176B1 (en) 2010-02-03 2016-09-07 Grünenthal GmbH Preparation of a powdery pharmaceutical composition by means of an extruder
ES2487244T3 (es) 2010-09-02 2014-08-20 Grünenthal GmbH Forma de dosificación resistente a la manipulación que comprende un polímero aniónico
RU2604676C2 (ru) 2010-09-02 2016-12-10 Грюненталь Гмбх Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль
US20130028972A1 (en) 2011-07-29 2013-01-31 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
PT2736495T (pt) 2011-07-29 2017-11-30 Gruenenthal Gmbh Comprimido resistente à adulteração proporcionando libertação imediata de fármaco
BR112014019988A8 (pt) 2012-02-28 2017-07-11 Gruenenthal Gmbh Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico
JP6282261B2 (ja) 2012-04-18 2018-02-21 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 不正使用防止および過量放出防止医薬剤形
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
BR112015029616A2 (pt) 2013-05-29 2017-07-25 Gruenenthal Gmbh forma de dosagem resistente à adulteração com perfil de liberação bimodal
CA2907950A1 (en) 2013-05-29 2014-12-04 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
KR20160031526A (ko) 2013-07-12 2016-03-22 그뤼넨탈 게엠베하 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형
MX371372B (es) 2013-11-26 2020-01-28 Gruenenthal Gmbh Preparacion de una composicion farmaceutica en polvo por medio de criomolienda.
CA2947786A1 (en) 2014-05-12 2015-11-19 Grunenthal Gmbh Tamper resistant immediate release capsule formulation comprising tapentadol
WO2015181059A1 (en) 2014-05-26 2015-12-03 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping
CN107889459A (zh) 2015-04-24 2018-04-06 格吕伦塔尔有限公司 具有立即释放和对溶剂萃取的抗性的抗篡改剂型
AU2016319203A1 (en) 2015-09-10 2018-02-22 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3608083A (en) * 1968-06-05 1971-09-21 Hoffmann La Roche Vitamin e powder
US3655852A (en) * 1969-08-01 1972-04-11 Hoffmann La Roche Method of forming a stable vitamin e-c granulation
GB1444024A (en) 1973-07-20 1976-07-28 Passwaterr A Food and feed supplents
FR2244468A1 (en) * 1973-07-31 1975-04-18 Passwater Richard Anticarcinogenic food supplements - contg antioxidants and S-contg amino acids
US3873694A (en) * 1973-09-27 1975-03-25 Cpc International Inc Direct compression tabletting composition and pharmaceutical tablets produced therefrom
JPS5421403B2 (es) * 1974-01-18 1979-07-30
JPS53148546A (en) * 1977-05-31 1978-12-25 Asahi Denka Kogyo Kk Cosmetic base composition
JPS56164749A (en) * 1980-05-22 1981-12-17 Chubu Shiryo Kk Breeding method of livestock
US4395422A (en) * 1981-04-06 1983-07-26 Basf Wyandotte Corporation Spray dried vitamin E powder
EP0107885B1 (en) * 1982-10-29 1987-07-29 Crinos Industria Farmacobiologica S.p.A. Cosmetic preparations promoting the trophism of the skin and of the related hair follicles
JPS6025918A (ja) * 1983-07-25 1985-02-08 Ajinomoto Co Inc 脂溶性薬物含有水性液

Also Published As

Publication number Publication date
US4711894A (en) 1987-12-08
JPS62190181A (ja) 1987-08-20
EP0229652B1 (en) 1991-10-30
NO173318B (no) 1993-08-23
EP0229652A2 (en) 1987-07-22
EP0229652A3 (en) 1987-10-14
DE3774137D1 (de) 1991-12-05
NO870159D0 (no) 1987-01-15
FI870169A (fi) 1987-07-17
FI87524B (fi) 1992-10-15
NO173318C (no) 1993-12-01
ATE68971T1 (de) 1991-11-15
FI87524C (fi) 1993-01-25
DK25587A (da) 1987-07-17
NO870159L (no) 1987-07-17
JP2677554B2 (ja) 1997-11-17
DK169230B1 (da) 1994-09-19
FI870169A0 (fi) 1987-01-16
DK25587D0 (da) 1987-01-16

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