ATE68971T1 - Stabilisiertes tocopherol in trockenener freifliessender partikelform. - Google Patents
Stabilisiertes tocopherol in trockenener freifliessender partikelform.Info
- Publication number
- ATE68971T1 ATE68971T1 AT87100296T AT87100296T ATE68971T1 AT E68971 T1 ATE68971 T1 AT E68971T1 AT 87100296 T AT87100296 T AT 87100296T AT 87100296 T AT87100296 T AT 87100296T AT E68971 T1 ATE68971 T1 AT E68971T1
- Authority
- AT
- Austria
- Prior art keywords
- particle form
- dry free
- flowing particle
- tocopherol
- stabilized
- Prior art date
Links
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title abstract 5
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 title abstract 3
- 239000002245 particle Substances 0.000 title 1
- 229960001295 tocopherol Drugs 0.000 title 1
- 229930003799 tocopherol Natural products 0.000 title 1
- 235000010384 tocopherol Nutrition 0.000 title 1
- 239000011732 tocopherol Substances 0.000 title 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- 229930003427 Vitamin E Natural products 0.000 abstract 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract 2
- 239000003381 stabilizer Substances 0.000 abstract 2
- 229940046009 vitamin E Drugs 0.000 abstract 2
- 235000019165 vitamin E Nutrition 0.000 abstract 2
- 239000011709 vitamin E Substances 0.000 abstract 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- 229940087168 alpha tocopherol Drugs 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 150000001261 hydroxy acids Chemical class 0.000 abstract 1
- 235000006109 methionine Nutrition 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 229960000984 tocofersolan Drugs 0.000 abstract 1
- 239000002076 α-tocopherol Substances 0.000 abstract 1
- 235000004835 α-tocopherol Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polyurethanes Or Polyureas (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/819,779 US4711894A (en) | 1986-01-16 | 1986-01-16 | Stabilized tocopherol in dry, particulate, free-flowing form |
| EP87100296A EP0229652B1 (de) | 1986-01-16 | 1987-01-13 | Stabilisiertes Tocopherol in trockenener freifliessender Partikelform |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE68971T1 true ATE68971T1 (de) | 1991-11-15 |
Family
ID=25229038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87100296T ATE68971T1 (de) | 1986-01-16 | 1987-01-13 | Stabilisiertes tocopherol in trockenener freifliessender partikelform. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4711894A (de) |
| EP (1) | EP0229652B1 (de) |
| JP (1) | JP2677554B2 (de) |
| AT (1) | ATE68971T1 (de) |
| DE (1) | DE3774137D1 (de) |
| DK (1) | DK169230B1 (de) |
| ES (1) | ES2026851T3 (de) |
| FI (1) | FI87524C (de) |
| NO (1) | NO173318C (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3820693A1 (de) * | 1988-06-18 | 1989-12-21 | Henkel Kgaa | Topische kosmetische und pharmazeutische zubereitungen |
| US5120761A (en) * | 1988-10-14 | 1992-06-09 | Finnan Jeffrey L | Method of making a free-flowing spray dried edible powder comprising an oil |
| FI901046A7 (fi) * | 1989-03-17 | 1990-09-18 | Eisai Co Ltd | Polyprenyyliyhdisteen stabiloiminen |
| DE69121225T2 (de) * | 1990-04-06 | 1997-02-06 | Eisai Co Ltd | Feste orale zubereitung mit einer catecholverbindung |
| US5234695A (en) * | 1990-07-24 | 1993-08-10 | Eastman Kodak Company | Water dispersible vitamin E composition |
| US6020003A (en) * | 1998-02-23 | 2000-02-01 | Basf Corporation | Method of making spray-dried powders with high edible-oil loadings based on non-hydrolyzed gelatin |
| US6613821B2 (en) | 1998-10-09 | 2003-09-02 | Canon Kabushiki Kaisha | Cloth treating agent, cloth, textile printing process and print |
| US6303167B1 (en) | 1998-11-09 | 2001-10-16 | Archer-Daniels-Midland Company | Method of producing vitamin powders |
| US6716451B1 (en) * | 1999-11-30 | 2004-04-06 | Soft Gel Technologies, Inc. | Formulation and delivery method to enhance antioxidant potency of vitamin E |
| GB0017060D0 (en) * | 2000-07-11 | 2000-08-30 | Hunter Fleming Ltd | Production, stabilisation and use of reduced forms of pharmaceutical compounds |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| US7329688B2 (en) * | 2002-12-17 | 2008-02-12 | Soft Gel Technologies, Inc. | Natural vitamin E compositions with superior antioxidant potency |
| DE10311585A1 (de) | 2003-03-14 | 2004-09-23 | Basf Ag | Wirkstoffhaltige Adsorbate |
| US20070237834A1 (en) * | 2003-04-18 | 2007-10-11 | Bioderm Research | Zinc Zeolite for the Treatment for Diaper Rash (Diaper Dermatitis) |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| US9247765B2 (en) | 2004-01-14 | 2016-02-02 | Omniactive Health Technologies Limited | Stable beadlets of lipophilic nutrients |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| JP2010512142A (ja) * | 2005-12-22 | 2010-04-22 | ビーエーエスエフ ソシエタス・ヨーロピア | ビタミンｅ吸着物の製造方法 |
| DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| JP5774853B2 (ja) | 2008-01-25 | 2015-09-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 医薬投薬形 |
| MX2010012039A (es) | 2008-05-09 | 2010-11-30 | Gruenenthal Gmbh | Proceso para la preparacion de una formulacion de polvo intermedia y una forma de dosificacion solida final bajo el uso de un paso de congelacion por rocio. |
| ES2428938T3 (es) * | 2009-07-22 | 2013-11-12 | Grünenthal GmbH | Forma de dosificación resistente a la manipulación y estabilizada frente a la oxidación |
| BR112012001547A2 (pt) | 2009-07-22 | 2016-03-08 | Gruenenthal Gmbh | forma de dosagem farmacêutica extrusada por fusão a quente |
| CN102821757B (zh) | 2010-02-03 | 2016-01-20 | 格吕伦塔尔有限公司 | 通过挤出机制备粉末状药物组合物 |
| CN103179954A (zh) | 2010-09-02 | 2013-06-26 | 格吕伦塔尔有限公司 | 包含阴离子聚合物的抗破碎剂型 |
| CA2808219C (en) | 2010-09-02 | 2019-05-14 | Gruenenthal Gmbh | Tamper resistant dosage form comprising inorganic salt |
| CA2839123A1 (en) | 2011-07-29 | 2013-02-07 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
| PL2736497T3 (pl) | 2011-07-29 | 2018-01-31 | Gruenenthal Gmbh | Tabletka odporna na ingerencję, zapewniająca natychmiastowe uwalnianie leku |
| MX356421B (es) | 2012-02-28 | 2018-05-29 | Gruenenthal Gmbh | Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico. |
| PL2838512T3 (pl) | 2012-04-18 | 2018-12-31 | Grünenthal GmbH | Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| MX371432B (es) | 2013-05-29 | 2020-01-30 | Gruenenthal Gmbh | Forma de dosificacion resistente al uso indebido que contiene una o mas particulas. |
| WO2014191396A1 (en) | 2013-05-29 | 2014-12-04 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
| US10624862B2 (en) | 2013-07-12 | 2020-04-21 | Grünenthal GmbH | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
| WO2015078891A1 (en) | 2013-11-26 | 2015-06-04 | Farmaceutici Formenti S.P.A. | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
| US20150320690A1 (en) | 2014-05-12 | 2015-11-12 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
| EP3148512A1 (de) | 2014-05-26 | 2017-04-05 | Grünenthal GmbH | Gegen entsorgung von ethanolischer dosis gesicherte mehrfachpartikel |
| BR112017021475A2 (pt) | 2015-04-24 | 2018-07-10 | Gruenenthal Gmbh | forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente |
| AU2016319203A1 (en) | 2015-09-10 | 2018-02-22 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3608083A (en) * | 1968-06-05 | 1971-09-21 | Hoffmann La Roche | Vitamin e powder |
| US3655852A (en) * | 1969-08-01 | 1972-04-11 | Hoffmann La Roche | Method of forming a stable vitamin e-c granulation |
| GB1444024A (en) | 1973-07-20 | 1976-07-28 | Passwaterr A | Food and feed supplents |
| FR2244468A1 (en) * | 1973-07-31 | 1975-04-18 | Passwater Richard | Anticarcinogenic food supplements - contg antioxidants and S-contg amino acids |
| US3873694A (en) * | 1973-09-27 | 1975-03-25 | Cpc International Inc | Direct compression tabletting composition and pharmaceutical tablets produced therefrom |
| JPS5421403B2 (de) * | 1974-01-18 | 1979-07-30 | ||
| JPS53148546A (en) * | 1977-05-31 | 1978-12-25 | Asahi Denka Kogyo Kk | Cosmetic base composition |
| JPS56164749A (en) * | 1980-05-22 | 1981-12-17 | Chubu Shiryo Kk | Breeding method of livestock |
| US4395422A (en) * | 1981-04-06 | 1983-07-26 | Basf Wyandotte Corporation | Spray dried vitamin E powder |
| DE3372703D1 (en) * | 1982-10-29 | 1987-09-03 | Crinos Industria Farmaco | Cosmetic preparations promoting the trophism of the skin and of the related hair follicles |
| JPS6025918A (ja) * | 1983-07-25 | 1985-02-08 | Ajinomoto Co Inc | 脂溶性薬物含有水性液 |
-
1986
- 1986-01-16 US US06/819,779 patent/US4711894A/en not_active Expired - Fee Related
-
1987
- 1987-01-13 DE DE8787100296T patent/DE3774137D1/de not_active Expired - Lifetime
- 1987-01-13 ES ES198787100296T patent/ES2026851T3/es not_active Expired - Lifetime
- 1987-01-13 EP EP87100296A patent/EP0229652B1/de not_active Expired - Lifetime
- 1987-01-13 AT AT87100296T patent/ATE68971T1/de not_active IP Right Cessation
- 1987-01-15 NO NO870159A patent/NO173318C/no unknown
- 1987-01-16 FI FI870169A patent/FI87524C/fi not_active IP Right Cessation
- 1987-01-16 DK DK025587A patent/DK169230B1/da not_active IP Right Cessation
- 1987-01-16 JP JP62008862A patent/JP2677554B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NO870159L (no) | 1987-07-17 |
| US4711894A (en) | 1987-12-08 |
| FI870169A0 (fi) | 1987-01-16 |
| FI870169L (fi) | 1987-07-17 |
| EP0229652A2 (de) | 1987-07-22 |
| JPS62190181A (ja) | 1987-08-20 |
| EP0229652B1 (de) | 1991-10-30 |
| DK25587A (da) | 1987-07-17 |
| JP2677554B2 (ja) | 1997-11-17 |
| DK25587D0 (da) | 1987-01-16 |
| EP0229652A3 (en) | 1987-10-14 |
| ES2026851T3 (es) | 1992-05-16 |
| DK169230B1 (da) | 1994-09-19 |
| FI87524C (fi) | 1993-01-25 |
| NO870159D0 (no) | 1987-01-15 |
| FI87524B (fi) | 1992-10-15 |
| NO173318B (no) | 1993-08-23 |
| DE3774137D1 (de) | 1991-12-05 |
| NO173318C (no) | 1993-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |