ES2006418A4 - Nuevo procedimiento para la sintesis del alfa-(1-metil-etil)-3,4-dimetoxi-benceno-aceto-nitrilo. - Google Patents

Nuevo procedimiento para la sintesis del alfa-(1-metil-etil)-3,4-dimetoxi-benceno-aceto-nitrilo.

Info

Publication number
ES2006418A4
ES2006418A4 ES88104469T ES88104469T ES2006418A4 ES 2006418 A4 ES2006418 A4 ES 2006418A4 ES 88104469 T ES88104469 T ES 88104469T ES 88104469 T ES88104469 T ES 88104469T ES 2006418 A4 ES2006418 A4 ES 2006418A4
Authority
ES
Spain
Prior art keywords
nitrile
dimetoxi
aceto
benzene
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES88104469T
Other languages
English (en)
Other versions
ES2006418T3 (es
Inventor
Vincenzo Cannata
Giancarlo Tamerlani
Garziano Zagnoni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Chemicals Italiana SpA
Original Assignee
Alfa Chemicals Italiana SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Chemicals Italiana SpA filed Critical Alfa Chemicals Italiana SpA
Publication of ES2006418A4 publication Critical patent/ES2006418A4/es
Application granted granted Critical
Publication of ES2006418T3 publication Critical patent/ES2006418T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

NUEVO PROCESO PARA LA SINTESIS DEL ALFA-(1-METILETIL)-3,4 -DIMETOXIACETONITRILO DE FORMULA (I) QUE ES UN INTERMEDIARIO EN LA SINTESIS DE LA DROGA INTERNACIONALMENTE CONOCIDO COMO VERAPAMIL.EL PROCESO COMIENZA A PARTIR DEL ISOBUTIRIL-3,4-DIMETOXIBENCENO DE FORMULA (II) LA CUAL, POR MEDIO DE LA CONDENSACION DARZENS, DA UN EXPOSIESTER, EL CUAL POR HIDROLISIS ALCALINA Y SUBSECUENTEMENTE DE CARBOXILACION, DA EL ALFA-(1-METILETIL) -3,4-DIMETOXIBENCENO ACETALDEHIDO.ESTE PRODUCTO SE SOMETE A REACCION CON HIDROXILAMINA PARA OBTENER LA CORRESPONDIENTE OXINA, QUE POR DESHIDRATACION DA EL NITRILO DE FORMULA (I).
ES88104469T 1987-04-08 1988-03-21 Nuevo procedimiento para la sintesis del alfa-(1-metil-etil)-3,4-dimetoxi-benceno-aceto-nitrilo. Expired - Lifetime ES2006418T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8720019A IT1215409B (it) 1987-04-08 1987-04-08 Processo per la sintesi dell'alfa-(1-metiletil)-3,4-dimetossibenzeneacetonitrile.

Publications (2)

Publication Number Publication Date
ES2006418A4 true ES2006418A4 (es) 1989-05-01
ES2006418T3 ES2006418T3 (es) 1994-07-16

Family

ID=11163169

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88104469T Expired - Lifetime ES2006418T3 (es) 1987-04-08 1988-03-21 Nuevo procedimiento para la sintesis del alfa-(1-metil-etil)-3,4-dimetoxi-benceno-aceto-nitrilo.

Country Status (23)

Country Link
US (1) US5097058A (es)
EP (1) EP0285890B1 (es)
JP (1) JPH0717592B2 (es)
KR (1) KR940011907B1 (es)
AR (1) AR243158A1 (es)
AT (1) ATE82566T1 (es)
AU (1) AU605571B2 (es)
CA (1) CA1327048C (es)
DD (1) DD273250A5 (es)
DE (2) DE285890T1 (es)
DK (1) DK189088A (es)
ES (1) ES2006418T3 (es)
FI (1) FI93950C (es)
GR (2) GR880300180T1 (es)
IE (1) IE62321B1 (es)
IL (1) IL85836A (es)
IT (1) IT1215409B (es)
NO (1) NO168032C (es)
NZ (1) NZ223966A (es)
PL (1) PL152661B1 (es)
PT (1) PT87187B (es)
YU (1) YU47119B (es)
ZA (1) ZA881961B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1229214B (it) * 1989-03-31 1991-07-25 Alfa Wassermann S P A Contrada Processo per la sintesi della n metil 3,4 dimetossifeniletilamina
ATE106186T1 (de) * 1990-12-28 1994-06-15 Unilever Nv Verbesserter, tiefgefrorener, vorgegärter teig.
US5457222A (en) * 1991-07-25 1995-10-10 Kao Corporation Process for producing nitrile
US7164047B2 (en) 2001-11-12 2007-01-16 Kuraray Co., Ltd. Processes for preparation of cyclopropylethanol, cyclopropylacetonitorile and intermediates of both
JP2010180142A (ja) * 2009-02-03 2010-08-19 Kuraray Co Ltd シクロヘキサンカルボニトリルの製造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1154810B (de) * 1961-04-01 1963-09-26 Knoll Ag Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
US3435075A (en) * 1965-06-15 1969-03-25 Merck & Co Inc Process for preparing (halophenyl) alkyl ketone compounds
US3415866A (en) * 1966-03-14 1968-12-10 Colgate Palmolive Co alpha-alkylidene-3,4-disubstituted-phenylacetonitriles
JPS5118940B2 (es) * 1971-12-25 1976-06-14
US3997608A (en) * 1973-07-05 1976-12-14 Richardson-Merrell Inc. N-substituted-dihydroxyphenethylamines
US4235807A (en) * 1979-07-02 1980-11-25 Thompson-Hayward Chemical Company Synthesis of 2,6-disubstituted benzonitriles
US4456562A (en) * 1981-12-02 1984-06-26 Sumitomo Chemical Company, Limited Process for producing nitriles
EP0165322B1 (de) * 1984-06-15 1988-01-20 LUDWIG HEUMANN & CO GMBH Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
US4593042A (en) * 1985-10-18 1986-06-03 G. D. Searle & Co. Bicyclo-substituted phenylacetonitrile derivatives

Also Published As

Publication number Publication date
FI93950C (fi) 1995-06-26
JPH0717592B2 (ja) 1995-03-01
YU69688A (en) 1989-10-31
AR243158A1 (es) 1993-07-30
IE62321B1 (en) 1995-01-25
IE881033L (en) 1988-10-08
PL152661B1 (en) 1991-01-31
DK189088D0 (da) 1988-04-07
GR3006382T3 (es) 1993-06-21
KR940011907B1 (ko) 1994-12-27
FI93950B (fi) 1995-03-15
KR880012533A (ko) 1988-11-28
NO881487D0 (no) 1988-04-07
DD273250A5 (de) 1989-11-08
PL271678A1 (en) 1989-05-16
ZA881961B (en) 1988-12-28
AU605571B2 (en) 1991-01-17
IL85836A (en) 1991-11-21
DK189088A (da) 1988-10-09
DE3875996D1 (de) 1992-12-24
US5097058A (en) 1992-03-17
FI881611A0 (fi) 1988-04-07
DE3875996T2 (de) 1993-04-22
NO168032C (no) 1992-01-08
PT87187B (pt) 1992-07-31
NO168032B (no) 1991-09-30
GR880300180T1 (en) 1989-06-22
IT8720019A0 (it) 1987-04-08
ES2006418T3 (es) 1994-07-16
PT87187A (pt) 1988-05-01
NZ223966A (en) 1990-03-27
DE285890T1 (de) 1989-03-30
YU47119B (sh) 1994-12-28
EP0285890B1 (en) 1992-11-19
NO881487L (no) 1988-10-10
EP0285890A3 (en) 1990-04-18
AU1437588A (en) 1988-10-13
IL85836A0 (en) 1988-09-30
ATE82566T1 (de) 1992-12-15
JPS63267753A (ja) 1988-11-04
FI881611A (fi) 1988-10-09
CA1327048C (en) 1994-02-15
IT1215409B (it) 1990-02-08
EP0285890A2 (en) 1988-10-12

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