EA201100665A1 - Способ получения бензонорборненов - Google Patents

Способ получения бензонорборненов

Info

Publication number
EA201100665A1
EA201100665A1 EA201100665A EA201100665A EA201100665A1 EA 201100665 A1 EA201100665 A1 EA 201100665A1 EA 201100665 A EA201100665 A EA 201100665A EA 201100665 A EA201100665 A EA 201100665A EA 201100665 A1 EA201100665 A1 EA 201100665A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
compound
chlorine
reaction
benzorobornenes
Prior art date
Application number
EA201100665A
Other languages
English (en)
Other versions
EA019039B1 (ru
Inventor
Денис Грибков
Бьёрн Антельманн
Фанни Жордано
Харальд Вальтер
Ален Де Месмакер
Original Assignee
Зингента Партисипейшнс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP08018721A external-priority patent/EP2181981A1/en
Application filed by Зингента Партисипейшнс Аг filed Critical Зингента Партисипейшнс Аг
Publication of EA201100665A1 publication Critical patent/EA201100665A1/ru
Publication of EA019039B1 publication Critical patent/EA019039B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
    • C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
    • C07C209/36—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/32—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by introduction of halogenated alkyl groups into ring compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/23—Preparation of halogenated hydrocarbons by dehalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/25—Preparation of halogenated hydrocarbons by splitting-off hydrogen halides from halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/266—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions of hydrocarbons and halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/06—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
    • C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
    • C07C209/36—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
    • C07C209/365—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst by reduction with preservation of halogen-atoms in compounds containing nitro groups and halogen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/57—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton
    • C07C211/61—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton with at least one of the condensed ring systems formed by three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C22/00—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom
    • C07C22/02—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C22/00—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom
    • C07C22/02—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings
    • C07C22/04—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C23/00—Compounds containing at least one halogen atom bound to a ring other than a six-membered aromatic ring
    • C07C23/02—Monocyclic halogenated hydrocarbons
    • C07C23/08—Monocyclic halogenated hydrocarbons with a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/66—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)

Abstract

В заявке описан новый способ получения 9-дихлорметилен-1,2,3,4-тетрагидро-1,4-метанонафталин-5-иламина, который включает: а) реакцию циклопентадиена в присутствии радикального инициатора и CXCl, где Х обозначает хлор или бром, с получением соединения формулы (II), или аа) реакцию циклопентадиена с CXCl, где Х обозначает хлор, в присутствии металлсодержащего катализатора с получением соединения формулы (II), в которой Х обозначает хлор, b) реакцию соединения формулы (II) с основанием в присутствии подходящего растворителя с получением соединения формулы (III), с) и превращение соединения формулы (III) в присутствии 1,2-дигидро-6-нитробензола в соединение формулы (IV) и d) гидрирование соединения формулы (IV) в присутствии металлсодержащего катализатора.
EA201100665A 2008-10-27 2009-09-28 Способ получения бензонорборненов EA019039B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08018721A EP2181981A1 (en) 2008-10-27 2008-10-27 Process for the preparation of benzonorbornenes
EP09161388 2009-05-28
PCT/EP2009/062525 WO2010049228A1 (en) 2008-10-27 2009-09-28 Process for the preparation of benzonorbornenes

Publications (2)

Publication Number Publication Date
EA201100665A1 true EA201100665A1 (ru) 2011-12-30
EA019039B1 EA019039B1 (ru) 2013-12-30

Family

ID=41175685

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100665A EA019039B1 (ru) 2008-10-27 2009-09-28 Способ получения бензонорборненов

Country Status (24)

Country Link
US (3) US9115043B2 (ru)
EP (1) EP2349975B1 (ru)
JP (1) JP5406302B2 (ru)
KR (1) KR101596814B1 (ru)
CN (2) CN102197016B (ru)
AR (1) AR075472A1 (ru)
AU (1) AU2009309884B2 (ru)
BR (1) BRPI0920833B1 (ru)
CA (1) CA2739656C (ru)
CO (1) CO6361987A2 (ru)
CR (1) CR20110208A (ru)
EA (1) EA019039B1 (ru)
EC (1) ECSP11011004A (ru)
EG (1) EG26332A (ru)
ES (1) ES2431818T3 (ru)
GE (1) GEP20135747B (ru)
IL (1) IL211975A (ru)
MX (1) MX2011003758A (ru)
MY (1) MY150841A (ru)
NZ (1) NZ591977A (ru)
TW (1) TWI438176B (ru)
UY (1) UY32195A (ru)
WO (1) WO2010049228A1 (ru)
ZA (1) ZA201102453B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8519151B2 (en) * 2010-04-20 2013-08-27 Syngenta Crop Protection Llc Process for the preparation of pyrazole carboxylic acid amides
EP2433922A1 (en) * 2010-08-25 2012-03-28 Syngenta Participations AG Process for the preparation of dichlorofulvene
TWI510472B (zh) * 2012-02-15 2015-12-01 Syngenta Participations Ag 立體選擇性製備吡唑羧醯胺之方法
EP3677572B1 (en) 2017-08-28 2023-06-07 Japan Finechem Company, Inc. Production method for pyrazole-4-carboxamide derivative
CN111454157B (zh) * 2020-05-14 2022-07-22 利民化学有限责任公司 一种3-硝基苯炔的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07291876A (ja) * 1994-03-03 1995-11-07 Ricoh Co Ltd シクロペンタジエン化合物及びそれを含有する電子写真感光体
JP4294129B2 (ja) * 1998-11-04 2009-07-08 旭化成ケミカルズ株式会社 シクロアルケンの塩素化法
JP5118043B2 (ja) * 2005-09-16 2013-01-16 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト アミドの生成方法
TWI374126B (en) * 2005-10-25 2012-10-11 Syngenta Participations Ag Novel microbiocides
EA014275B1 (ru) 2005-12-12 2010-10-29 Синджента Партисипейшнс Аг Способ получения производных 5-аминобензонорборнена
GEP20135771B (en) * 2007-04-25 2013-02-25 Syngenta Participations Ag Fungicidal compositions

Also Published As

Publication number Publication date
TW201016642A (en) 2010-05-01
CN103319305A (zh) 2013-09-25
MX2011003758A (es) 2011-04-27
CN103319305B (zh) 2015-04-08
TWI438176B (zh) 2014-05-21
US9115043B2 (en) 2015-08-25
WO2010049228A1 (en) 2010-05-06
CA2739656C (en) 2016-08-16
UY32195A (es) 2010-05-31
GEP20135747B (en) 2013-02-11
JP2012506842A (ja) 2012-03-22
US20180016211A1 (en) 2018-01-18
AU2009309884B2 (en) 2013-08-29
CO6361987A2 (es) 2012-01-20
US9796646B2 (en) 2017-10-24
US9878970B1 (en) 2018-01-30
EP2349975B1 (en) 2013-07-31
US20110207958A1 (en) 2011-08-25
EP2349975A1 (en) 2011-08-03
CA2739656A1 (en) 2010-05-06
BRPI0920833A2 (pt) 2015-12-22
CN102197016B (zh) 2013-12-18
IL211975A0 (en) 2011-06-30
MY150841A (en) 2014-02-28
US20150141712A1 (en) 2015-05-21
NZ591977A (en) 2012-08-31
EA019039B1 (ru) 2013-12-30
ES2431818T3 (es) 2013-11-28
JP5406302B2 (ja) 2014-02-05
AR075472A1 (es) 2011-04-06
KR101596814B1 (ko) 2016-02-23
ECSP11011004A (es) 2011-05-31
EG26332A (en) 2013-08-19
ZA201102453B (en) 2011-12-28
KR20110074982A (ko) 2011-07-05
AU2009309884A1 (en) 2010-05-06
CR20110208A (es) 2011-05-11
IL211975A (en) 2015-06-30
BRPI0920833B1 (pt) 2018-02-06
CN102197016A (zh) 2011-09-21

Similar Documents

Publication Publication Date Title
EA201100665A1 (ru) Способ получения бензонорборненов
EA201491289A1 (ru) Способ получения гексаметилендиамина из 5-гидроксиметилфурфурола
BR112016011986A2 (pt) Método de despolimerização de lignina
EA200800171A1 (ru) Способ превращения углеводородов в соксигенаты
AR067004A1 (es) Produccion de quimicos a partir de aceites de pirolisis
EA201000789A1 (ru) Улучшенный способ получения спирта из углеродсодержащего сырья
ECSP088268A (es) Procedimiento para la preparacion de compuestos ester oxazolidina y su conversion a florfenicol
EA201171461A1 (ru) Получение налмефена гидрохлорида из налтрексона
EP1967507A3 (en) An improved process for converting alkanes to unsaturated carboxylic acids
GEP20125512B (en) Process for synthesis of agomelatin
CY1111978T1 (el) Συζυγη μακρολιδων με αντιφλεγμονωδη δραση
BR112012015503A2 (pt) produção de hidrocarbonetos a partir de matérias-primas contendo ácido graxo superior livre.
UY33339A (es) Proceso para la preparación de amidas de ácido pirazol carboxílico
EA201071121A1 (ru) Способ получения бензопроизводных диоксина
EA201001010A1 (ru) Способ превращения спирта (спиртов) в спирт (спирты) с более длинной углеродной цепью
AR059286A1 (es) Proceso para preparar voriconazol, una forma polimorfica de un intermediario del mismo y su uso
CY1119573T1 (el) Διαδικασιες αναεροβιας επεξεργασιας λυματολασπης
DE502005010080D1 (de) Ingem chlorid-gehalt
EA200702419A1 (ru) Новые соединения как агонисты glp-1
AR080923A1 (es) Proceso para la preparacion de amidas del acido pirazolcarboxilico
CL2012003371A1 (es) Compuestos intermediarios de la síntesis de agomelatina; y el procedimiento de obtención de agomelatina a partir de dichos compuestos intermediarios
EA201270055A1 (ru) Катализатор для получения низших олефинов и способ получения низших олефинов с его использованием
UY33342A (es) Proceso para la preparación de amidas de ácido pirazol carboxílico
EA200801506A1 (ru) Способ получения 2-хлорэтоксиуксусной кислоты n,n-диметиламида
EA200800723A1 (ru) Способ получения анилинов

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KG TJ TM