ES2004472A4 - Metodo de sintesis de un peptido que contiene un enlace no peptido. - Google Patents

Metodo de sintesis de un peptido que contiene un enlace no peptido.

Info

Publication number
ES2004472A4
ES2004472A4 ES87305715T ES87305715T ES2004472A4 ES 2004472 A4 ES2004472 A4 ES 2004472A4 ES 87305715 T ES87305715 T ES 87305715T ES 87305715 T ES87305715 T ES 87305715T ES 2004472 A4 ES2004472 A4 ES 2004472A4
Authority
ES
Spain
Prior art keywords
peptide
features
synthesis
nacnbh3
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES87305715T
Other languages
English (en)
Other versions
ES2004472T3 (es
Inventor
David H Coy
Simon J Hocart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tulane University
Original Assignee
Tulane University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tulane University filed Critical Tulane University
Publication of ES2004472A4 publication Critical patent/ES2004472A4/es
Application granted granted Critical
Publication of ES2004472T3 publication Critical patent/ES2004472T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ESTA INVENCION CONFIGURA UN METODO PARA LA SINTESIS EN FASE SOLIDA DE ENLACES NO PEPTIDICOS (CH2-NH) EN CADENAS DE POLIPEPTIDOS. SE SINTETIZAN POR PROCEDIMIENTOS ESTANDAR Y EL ENLACE NO PEPTIDICO SE SINTETIZA HACIENDO REACCIONAR UN AMINOALDEHIDO Y UN AMINOACIDO EN PRESENCIA DE NACNBH3. ESTA INVENCION TAMBIEN SE REFIERE A ANALOGOS DE SOMATOSTATINA CON ENLACES NO PEPTIDICOS. LA INVENCION TAMBIEN SE REFIERE A UN METODO EN FASE SOLIDA PARA MODIFICAR QUIMICAMENTE UN PEPTIDO. EL METODO IMPLICA SINTETIZAR ALFA-N-R Y LOS ANALOGOS N-R DEL GRUPO LATERAL DE PEPTIDOS, DONDE R ES UN GRUPO ALQUILO O ARILO, HACIENDO REACCIONAR UN COMPUESTO QUE CONTENGA CARBONILO Y UN AMINOACIDO EN PRESENCIA DE NACNBH3
ES87305715T 1986-06-27 1987-06-26 Metodo de sintesis de un peptido que contiene un enlace no peptido. Expired - Lifetime ES2004472T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/879,348 US4803261A (en) 1986-06-27 1986-06-27 Method for synthesizing a peptide containing a non-peptide

Publications (2)

Publication Number Publication Date
ES2004472A4 true ES2004472A4 (es) 1989-01-16
ES2004472T3 ES2004472T3 (es) 1994-12-16

Family

ID=25373967

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87305715T Expired - Lifetime ES2004472T3 (es) 1986-06-27 1987-06-26 Metodo de sintesis de un peptido que contiene un enlace no peptido.

Country Status (8)

Country Link
US (1) US4803261A (es)
EP (1) EP0257742B1 (es)
JP (1) JP2679786B2 (es)
AT (1) ATE100815T1 (es)
CA (1) CA1307623C (es)
DE (2) DE257742T1 (es)
ES (1) ES2004472T3 (es)
GR (1) GR880300166T1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750646A (en) * 1987-09-24 1998-05-12 The Administrators Of The Tulane Educational Fund Bradykinin analogs with non-peptide bond
US5877277A (en) * 1987-09-24 1999-03-02 Biomeasure, Inc. Octapeptide bombesin analogs
US5410019A (en) * 1987-09-24 1995-04-25 The Administrators Of The Tulane-Educational Fund Therapeutic peptides
US5084555A (en) * 1989-08-21 1992-01-28 The Administrators Of The Tulane Educational Fund An octapeptide bombesin analog
US5162497A (en) * 1987-09-24 1992-11-10 The Administrators Of The Tulane Educational Fund Bradykinin analogs with non-peptide bond
GB8807921D0 (en) * 1988-04-05 1988-05-05 Fujisawa Pharmaceutical Co Ws-9326 & its derivatives
ES2108684T3 (es) * 1988-02-10 1998-01-01 Tap Pharmaceuticals Inc Analogo de la hormona de liberacion de la hormona luteinizante (lhrh).
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
US5059653A (en) * 1988-03-04 1991-10-22 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide bond
AU3428089A (en) * 1988-03-25 1989-10-16 The Administrators Of The Tulane Eductional Fund Therapeutic peptides
US5807979A (en) * 1988-04-08 1998-09-15 The Scripps Research Institute Synthetic, three-dimensionally stabilized polypeptide mimics of HIV
JPH03504496A (ja) * 1988-04-08 1991-10-03 スクリプス　クリニック　アンド　リサーチ　ファウンデーション 水素結合の共有結合置換により安定化されたポリペプチド
JP2919889B2 (ja) * 1988-10-14 1999-07-19 アドミニストレイターズ オブ ザ テューレイン エデュケイショナル ファンド 治療用ペプチド
IE77033B1 (en) * 1989-08-16 1997-11-19 Univ Tulane Substance P antagonists
JP2536110Y2 (ja) * 1990-01-05 1997-05-21 富士通テン株式会社 音場構成装置
JPH03103700U (es) * 1990-02-08 1991-10-28
JP2505588Y2 (ja) * 1990-02-15 1996-07-31 富士通テン株式会社 音場構成装置
US5767236A (en) * 1990-05-09 1998-06-16 Biomeasure, Inc. Linear therapeutic peptides
CA2081890A1 (en) * 1990-05-09 1991-11-10 David H. Coy Cyclized and linear therapeutic peptides
ATE193892T1 (de) * 1993-06-29 2000-06-15 Ferring Bv Synthese zyklischer peptide
SK281963B6 (sk) * 1993-12-23 2001-09-11 Novo Nordisk A/S Zlúčeniny ovplyvňujúce uvoľňovanie rastového hormónu, farmaceutické prostriedky s ich obsahom a ich použitie
US5854211A (en) * 1993-12-23 1998-12-29 Novo Nordisk A/S Compounds with growth hormone releasing properties
GB9727123D0 (en) * 1997-12-22 1998-02-25 Int Centre Genetic Eng & Bio Synthesis of diamines
US20070264229A1 (en) * 2004-09-13 2007-11-15 Strominger Jack L Peptides for Treatment of Autoimmune Disease
JP5352586B2 (ja) * 2007-07-27 2013-11-27 イマティクス バイオテクノロジーズ ゲーエムベーハー 腫瘍関連ペプチドおよび関連抗癌ワクチンの組成物
EP3473643A1 (en) 2008-06-12 2019-04-24 Ipsen Bioinnovation Limited Fusion proteins for use in the treatemnt of cancer
JP5728380B2 (ja) 2008-06-12 2015-06-03 シンタクシン リミテッドＳｙｎｔａｘｉｎ Ｌｉｍｉｔｅｄ 神経内分泌疾患の抑制
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
GB201900621D0 (en) 2019-01-16 2019-03-06 Ipsen Biopharm Ltd Labelled polypeptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
EP0088350B1 (en) * 1982-03-08 1985-02-20 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
CH655505B (es) * 1982-08-24 1986-04-30
US4569967A (en) * 1983-10-24 1986-02-11 The Salk Institute For Biological Studies Synthesis of N-substituted peptide amides

Also Published As

Publication number Publication date
DE257742T1 (de) 1988-12-15
JPS6322600A (ja) 1988-01-30
ATE100815T1 (de) 1994-02-15
DE3788910D1 (de) 1994-03-10
JP2679786B2 (ja) 1997-11-19
EP0257742A2 (en) 1988-03-02
GR880300166T1 (en) 1989-01-31
EP0257742A3 (en) 1990-03-21
US4803261A (en) 1989-02-07
DE3788910T2 (de) 1994-07-21
CA1307623C (en) 1992-09-15
EP0257742B1 (en) 1994-01-26
ES2004472T3 (es) 1994-12-16

Similar Documents

Publication Publication Date Title
ES2004472T3 (es) Metodo de sintesis de un peptido que contiene un enlace no peptido.
DE3373908D1 (en) Method for the solid-phase synthesis of retro-inverso polypeptides
AU564620B2 (en) Peptides and protein-peptide complexes
FI953525A0 (fi) Kemiskt syntetiseringsfoerfarande foer framstaellning av ett protein eller en polypeptid
DE3477004D1 (en) Process for the preparation of insuline derivatives
ES539382A0 (es) Procedimiento para la determinacion de fibrina
DK0418590T3 (da) Antistoffer, fremstilling deraf og anvendelse deraf
DK0465404T3 (da) Peptidylhydroxylglycin-N-C-lyase og DNA, som koder derfor
FABRY et al. Design and synthesis of a novel biotinylated photoreactive insulin for receptor analysis
FR2636643B1 (fr) Peptide-signal, sequences d'adn codant pour celui-ci, vecteurs d'expression portant l'une de ces sequences et procede de production periplasmique d'un polypeptide
DE69428401T2 (de) Verfahren zur Herstellung von alpha-Aminosäureamiden zur Verwendung in der Peptidsynthese

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 257742

Country of ref document: ES