ES2004472A4 - Metodo de sintesis de un peptido que contiene un enlace no peptido. - Google Patents

Metodo de sintesis de un peptido que contiene un enlace no peptido.

Info

Publication number
ES2004472A4
ES2004472A4 ES87305715T ES87305715T ES2004472A4 ES 2004472 A4 ES2004472 A4 ES 2004472A4 ES 87305715 T ES87305715 T ES 87305715T ES 87305715 T ES87305715 T ES 87305715T ES 2004472 A4 ES2004472 A4 ES 2004472A4
Authority
ES
Spain
Prior art keywords
peptide
features
synthesis
nacnbh3
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES87305715T
Other languages
English (en)
Other versions
ES2004472T3 (es
Inventor
David H Coy
Simon J Hocart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tulane University
Original Assignee
Tulane University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tulane University filed Critical Tulane University
Publication of ES2004472A4 publication Critical patent/ES2004472A4/es
Application granted granted Critical
Publication of ES2004472T3 publication Critical patent/ES2004472T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ESTA INVENCION CONFIGURA UN METODO PARA LA SINTESIS EN FASE SOLIDA DE ENLACES NO PEPTIDICOS (CH2-NH) EN CADENAS DE POLIPEPTIDOS. SE SINTETIZAN POR PROCEDIMIENTOS ESTANDAR Y EL ENLACE NO PEPTIDICO SE SINTETIZA HACIENDO REACCIONAR UN AMINOALDEHIDO Y UN AMINOACIDO EN PRESENCIA DE NACNBH3. ESTA INVENCION TAMBIEN SE REFIERE A ANALOGOS DE SOMATOSTATINA CON ENLACES NO PEPTIDICOS. LA INVENCION TAMBIEN SE REFIERE A UN METODO EN FASE SOLIDA PARA MODIFICAR QUIMICAMENTE UN PEPTIDO. EL METODO IMPLICA SINTETIZAR ALFA-N-R Y LOS ANALOGOS N-R DEL GRUPO LATERAL DE PEPTIDOS, DONDE R ES UN GRUPO ALQUILO O ARILO, HACIENDO REACCIONAR UN COMPUESTO QUE CONTENGA CARBONILO Y UN AMINOACIDO EN PRESENCIA DE NACNBH3
ES87305715T 1986-06-27 1987-06-26 Metodo de sintesis de un peptido que contiene un enlace no peptido. Expired - Lifetime ES2004472T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/879,348 US4803261A (en) 1986-06-27 1986-06-27 Method for synthesizing a peptide containing a non-peptide

Publications (2)

Publication Number Publication Date
ES2004472A4 true ES2004472A4 (es) 1989-01-16
ES2004472T3 ES2004472T3 (es) 1994-12-16

Family

ID=25373967

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87305715T Expired - Lifetime ES2004472T3 (es) 1986-06-27 1987-06-26 Metodo de sintesis de un peptido que contiene un enlace no peptido.

Country Status (8)

Country Link
US (1) US4803261A (es)
EP (1) EP0257742B1 (es)
JP (1) JP2679786B2 (es)
AT (1) ATE100815T1 (es)
CA (1) CA1307623C (es)
DE (2) DE3788910T2 (es)
ES (1) ES2004472T3 (es)
GR (1) GR880300166T1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750646A (en) * 1987-09-24 1998-05-12 The Administrators Of The Tulane Educational Fund Bradykinin analogs with non-peptide bond
US5877277A (en) * 1987-09-24 1999-03-02 Biomeasure, Inc. Octapeptide bombesin analogs
US5410019A (en) * 1987-09-24 1995-04-25 The Administrators Of The Tulane-Educational Fund Therapeutic peptides
US5162497A (en) * 1987-09-24 1992-11-10 The Administrators Of The Tulane Educational Fund Bradykinin analogs with non-peptide bond
US5084555A (en) * 1989-08-21 1992-01-28 The Administrators Of The Tulane Educational Fund An octapeptide bombesin analog
GB8807921D0 (en) * 1988-04-05 1988-05-05 Fujisawa Pharmaceutical Co Ws-9326 & its derivatives
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
EP0328090A3 (en) * 1988-02-10 1990-08-16 Abbott Laboratories Lhrh analogs
US5059653A (en) * 1988-03-04 1991-10-22 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide bond
AU3428089A (en) * 1988-03-25 1989-10-16 The Administrators Of The Tulane Eductional Fund Therapeutic peptides
US5807979A (en) * 1988-04-08 1998-09-15 The Scripps Research Institute Synthetic, three-dimensionally stabilized polypeptide mimics of HIV
WO1989009783A1 (en) * 1988-04-08 1989-10-19 Scripps Clinic And Research Foundation Polypeptides stabilized by covalent hydrogen bond replacements
MC2144A1 (fr) * 1988-10-14 1992-02-19 Univ Tulane Peptides therapeutiques
IE77033B1 (en) * 1989-08-16 1997-11-19 Univ Tulane Substance P antagonists
JP2536110Y2 (ja) * 1990-01-05 1997-05-21 富士通テン株式会社 音場構成装置
JPH03103700U (es) * 1990-02-08 1991-10-28
JP2505588Y2 (ja) * 1990-02-15 1996-07-31 富士通テン株式会社 音場構成装置
US5767236A (en) * 1990-05-09 1998-06-16 Biomeasure, Inc. Linear therapeutic peptides
JPH05506862A (ja) * 1990-05-09 1993-10-07 ジ・アドミニストレイターズ・オブ・ザ・トゥーラン・エデュケイショナル・ファンド 環状および鎖状の治療用ペプチド
PT710243E (pt) * 1993-06-29 2000-11-30 Ferring Bv Sintese melhorada de peptidos ciclicos.
CN1052730C (zh) * 1993-12-23 2000-05-24 诺沃挪第克公司 具有生长激素释放特性的化合物
WO1995017423A1 (en) * 1993-12-23 1995-06-29 Novo Nordisk A/S Compounds with growth hormone releasing properties
GB9727123D0 (en) * 1997-12-22 1998-02-25 Int Centre Genetic Eng & Bio Synthesis of diamines
US20070264229A1 (en) * 2004-09-13 2007-11-15 Strominger Jack L Peptides for Treatment of Autoimmune Disease
SI2567707T1 (sl) * 2007-07-27 2017-01-31 Immatics Biotechnologies Gmbh Sestava s tumorjem povezanih peptidov in zadevnih cepiv proti raku
JP5799397B2 (ja) 2008-06-12 2015-10-28 イプセン・バイオイノベーション・リミテッドＩｐｓｅｎ Ｂｉｏｉｎｎｏｖａｔｉｏｎ Ｌｉｍｉｔｅｄ 癌の抑制
EP2719392B1 (en) 2008-06-12 2019-07-24 Ipsen Bioinnovation Limited Fusion proteins for use in the treatment of acromegaly
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
GB201900621D0 (en) 2019-01-16 2019-03-06 Ipsen Biopharm Ltd Labelled polypeptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
EP0088350B1 (en) * 1982-03-08 1985-02-20 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
CH655505B (es) * 1982-08-24 1986-04-30
US4569967A (en) * 1983-10-24 1986-02-11 The Salk Institute For Biological Studies Synthesis of N-substituted peptide amides

Also Published As

Publication number Publication date
EP0257742A3 (en) 1990-03-21
JPS6322600A (ja) 1988-01-30
ES2004472T3 (es) 1994-12-16
JP2679786B2 (ja) 1997-11-19
DE3788910D1 (de) 1994-03-10
ATE100815T1 (de) 1994-02-15
DE3788910T2 (de) 1994-07-21
GR880300166T1 (en) 1989-01-31
US4803261A (en) 1989-02-07
EP0257742A2 (en) 1988-03-02
EP0257742B1 (en) 1994-01-26
CA1307623C (en) 1992-09-15
DE257742T1 (de) 1988-12-15

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