ES2108684T3 - Analogo de la hormona de liberacion de la hormona luteinizante (lhrh). - Google Patents

Analogo de la hormona de liberacion de la hormona luteinizante (lhrh).

Info

Publication number
ES2108684T3
ES2108684T3 ES89902885T ES89902885T ES2108684T3 ES 2108684 T3 ES2108684 T3 ES 2108684T3 ES 89902885 T ES89902885 T ES 89902885T ES 89902885 T ES89902885 T ES 89902885T ES 2108684 T3 ES2108684 T3 ES 2108684T3
Authority
ES
Spain
Prior art keywords
hormone
lhrh
analog
luteinizing
epsilon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89902885T
Other languages
English (en)
Inventor
Fortuna Haviv
Jonathan Greer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tap Pharmaceuticals Inc
Original Assignee
Tap Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tap Pharmaceuticals Inc filed Critical Tap Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2108684T3 publication Critical patent/ES2108684T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un procedimiento para la preparación del compuesto N-Ac-D-2-Nal-D-4-Cl-Phe-D-3-Pal-Ser-N-Me-Tyr-D-Lys(N-épsilon-nicotinoil)-Leu-Lys(N-épsilon-isopropil)-Pro-D-AlaNH2 o una sal del mismo farmacéuticamente aceptable, comprendiendo dicho procedimiento acoplar secuencialmente aminoácidos o análogos de aminoácidos adecuadamente protegidos, seguido por la eliminación de los grupos protectores.
ES89902885T 1988-02-10 1989-02-09 Analogo de la hormona de liberacion de la hormona luteinizante (lhrh). Expired - Lifetime ES2108684T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15468188A 1988-02-10 1988-02-10

Publications (1)

Publication Number Publication Date
ES2108684T3 true ES2108684T3 (es) 1998-01-01

Family

ID=22552310

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89902885T Expired - Lifetime ES2108684T3 (es) 1988-02-10 1989-02-09 Analogo de la hormona de liberacion de la hormona luteinizante (lhrh).

Country Status (5)

Country Link
EP (2) EP0328090A3 (es)
DE (1) DE68928278T2 (es)
ES (1) ES2108684T3 (es)
GR (1) GR3025403T3 (es)
WO (1) WO1989007450A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935491A (en) * 1987-08-24 1990-06-19 Board Of Regents, The University Of Texas System Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
US5656727A (en) * 1992-09-15 1997-08-12 The Administrators Of The Tulane Educational Fund Antagonists of LHRH
US5480969A (en) * 1992-09-15 1996-01-02 The Administrators Of The Tulane Educational Fund Antagonists of LHRH
US5843901A (en) 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
CA2257381C (en) 1996-06-21 2007-08-21 Takeda Chemical Industries, Ltd. Method for producing peptides
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
EP0882736A1 (en) * 1997-06-02 1998-12-09 Laboratoire Theramex S.A. LH-RH peptide analogues, their uses and pharmaceutical compositions containing them
US6455499B1 (en) 1999-02-23 2002-09-24 Indiana University Foundation Methods for treating disorders associated with LHRH activity
DE19911771B4 (de) 1999-03-17 2006-03-30 Zentaris Gmbh LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung
DE60226419D1 (de) 2001-03-08 2008-06-19 Univ Tulane Somatostatin-antagonisten
US7098305B2 (en) 2001-09-06 2006-08-29 Ardana Bioscience Limited Sustained release of microcrystalline peptide suspensions
JP4407322B2 (ja) * 2004-03-09 2010-02-03 味の素株式会社 ペプチドの製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU497512B2 (en) * 1975-04-15 1978-12-14 Ici Australia Limited Nona and deca-peptides
NZ188987A (en) * 1977-11-30 1982-02-23 Salk Inst For Biological Studi Peptide analogues of luteinizing hormone releasing factor
IT1149971B (it) * 1979-06-11 1986-12-10 Syntex Inc Derivati nonapeptide e decapeptide dell'ormone che rilascia l'ormone luteinizzante
US4581169A (en) * 1982-12-21 1986-04-08 Syntex (U.S.A.) Inc. Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH antagonists
US4444759A (en) * 1982-07-26 1984-04-24 The Salk Institute For Biological Studies GnRH Antagonists II
US4504414A (en) * 1983-03-28 1985-03-12 Board Of Regents, The University Of Texas System Synthetic pyridyl-alanyl decapeptides having antiovulatory activity
US4547370A (en) * 1983-11-29 1985-10-15 The Salk Institute For Biological Studies GnRH Antagonists
US4632979A (en) * 1984-06-18 1986-12-30 Tulane Educational Fund Therapeutic LHRH analogs
US4642332A (en) * 1985-04-26 1987-02-10 The Board Of Regents, The University Of Texas System Effective hormonal peptides: D-3-Pal6 -LHRH
US4803261A (en) * 1986-06-27 1989-02-07 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide
EP0480918A1 (en) * 1988-02-10 1992-04-22 Abbott Laboratories Reduced size lhrh analogs

Also Published As

Publication number Publication date
DE68928278T2 (de) 1998-03-12
GR3025403T3 (en) 1998-02-27
DE68928278D1 (en) 1997-10-02
EP0328090A2 (en) 1989-08-16
EP0400065A4 (en) 1991-03-13
EP0328090A3 (en) 1990-08-16
EP0400065A1 (en) 1990-12-05
EP0400065B1 (en) 1997-08-27
WO1989007450A1 (en) 1989-08-24

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