ES2004340A6 - Procedimiento de obtencion de anticuerpos momoclonales para detectar celulas bacterianas y dispositivo de ensayo correspondiente. - Google Patents

Procedimiento de obtencion de anticuerpos momoclonales para detectar celulas bacterianas y dispositivo de ensayo correspondiente.

Info

Publication number
ES2004340A6
ES2004340A6 ES8602198A ES8602198A ES2004340A6 ES 2004340 A6 ES2004340 A6 ES 2004340A6 ES 8602198 A ES8602198 A ES 8602198A ES 8602198 A ES8602198 A ES 8602198A ES 2004340 A6 ES2004340 A6 ES 2004340A6
Authority
ES
Spain
Prior art keywords
monoclonal antibodies
negative bacteria
gram negative
lipopolysaccharide
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8602198A
Other languages
English (en)
Inventor
Lowell S Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/781,242 external-priority patent/US4777136A/en
Application filed by University of California filed Critical University of California
Publication of ES2004340A6 publication Critical patent/ES2004340A6/es
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56916—Enterobacteria, e.g. shigella, salmonella, klebsiella, serratia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/21—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Pseudomonadaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/50—Lipopolysaccharides; LPS
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/863—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgM
    • Y10S530/864—Monoclonal

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE ANTICUERPOS MONOCLONALES PARA DETECTAR CELULAS BACTERIANAS, EN EL QUE SE INMUNIZAN CELULAS INMUNES DE MAMIFERO CON UNA PREPARACION PROCEDENTE DE UNA CEPA DE BACTERIAS GRAM-NEGATIVAS, SE RETIRAN CELULAS INMUNES DE DICHO MAMIFERO Y SE HACE UNA SUSPENSION DE ELLAS, SE INMORTALIZA UNA PARTE SUSTANCIAL DE DICHAS CELULAS INMUNES, SE EVALUAN DICHAS CELULAS INMORTALIZADAS EN CUANTO A LA PRESENCIA DE ANTICUERPOS PARA DICHA CEPA DE BACTERIAS GRAM-NEGATIVAS, Y SE SELECCIONA Y CLONA UNA CELULA INMORTALIZADA QUE SECRETA ANTICUERPOS REACTIVOS CON BACTERIAS GRAM-NEGATIVAS Y GRAM-POSITIVAS, HACIENDO CRECER EL CLON Y RECOGIENDO DICHOS ANTICUERPOS PRODUCIDOS POR DICHO CLON. EL DISPOSITIVO DE ENSAYO COMPRENDE UN ANTICUERPO MONOCLONAL MARCADO O UN EQUIVALENTE FUNCIONAL DEL MISMO, PRODUCIDO POR UNA LINEA CELULAR SELECCIONADA DEL GRUPO CONSISTENTE EN XMMEN-J5D, XMMEN-OE5, XMMEN-LYL Y XMMEN-OPL. EL INVENTO ES ESPECIALMENTE UTIL EN RELACION CON INFECCIONES CAUSADAS POR BACTERIAS GRAM-NEGATIVAS.
ES8602198A 1985-09-27 1986-09-26 Procedimiento de obtencion de anticuerpos momoclonales para detectar celulas bacterianas y dispositivo de ensayo correspondiente. Expired ES2004340A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/781,242 US4777136A (en) 1985-09-27 1985-09-27 Monoclonal antibody reactive with Pseudomonas Aeruginosa
US06/855,878 US4918163A (en) 1985-09-27 1986-04-24 Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria

Publications (1)

Publication Number Publication Date
ES2004340A6 true ES2004340A6 (es) 1989-01-01

Family

ID=27119830

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8602198A Expired ES2004340A6 (es) 1985-09-27 1986-09-26 Procedimiento de obtencion de anticuerpos momoclonales para detectar celulas bacterianas y dispositivo de ensayo correspondiente.

Country Status (11)

Country Link
US (2) US4918163A (es)
EP (1) EP0217527B1 (es)
JP (1) JP2539797B2 (es)
KR (1) KR910002427B1 (es)
AU (1) AU606581B2 (es)
DE (1) DE3686931T2 (es)
ES (1) ES2004340A6 (es)
IE (1) IE59685B1 (es)
IL (1) IL79719A (es)
NZ (1) NZ217283A (es)
PH (1) PH26525A (es)

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PH26525A (en) 1992-08-07
EP0217527A2 (en) 1987-04-08
IL79719A0 (en) 1986-11-30
IL79719A (en) 1991-06-10
EP0217527B1 (en) 1992-10-07
AU6323686A (en) 1987-04-02
AU606581B2 (en) 1991-02-14
US4918163B1 (es) 1993-08-17
IE862546L (en) 1987-03-27
IE59685B1 (en) 1994-03-23
KR870003195A (ko) 1987-04-15
JPS62228295A (ja) 1987-10-07
EP0217527A3 (en) 1989-02-08
DE3686931T2 (de) 1993-04-29
NZ217283A (en) 1991-07-26
US4918163A (en) 1990-04-17
JP2539797B2 (ja) 1996-10-02
US5484591A (en) 1996-01-16
DE3686931D1 (de) 1992-11-12
KR910002427B1 (ko) 1991-04-22

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