EP4344738A3 - Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation - Google Patents

Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation Download PDF

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Publication number
EP4344738A3
EP4344738A3 EP23215091.2A EP23215091A EP4344738A3 EP 4344738 A3 EP4344738 A3 EP 4344738A3 EP 23215091 A EP23215091 A EP 23215091A EP 4344738 A3 EP4344738 A3 EP 4344738A3
Authority
EP
European Patent Office
Prior art keywords
fusion proteins
insulin
long acting
ultra
acting insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23215091.2A
Other languages
German (de)
English (en)
Other versions
EP4344738A2 (fr
Inventor
Thomas M. Lancaster
Todd C. Zion
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akston Biosciences Corp
Original Assignee
Akston Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akston Biosciences Corp filed Critical Akston Biosciences Corp
Publication of EP4344738A2 publication Critical patent/EP4344738A2/fr
Publication of EP4344738A3 publication Critical patent/EP4344738A3/fr
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Analytical Chemistry (AREA)
EP23215091.2A 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation Pending EP4344738A3 (fr)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US201862692507P 2018-06-29 2018-06-29
US201862692498P 2018-06-29 2018-06-29
US201862693814P 2018-07-03 2018-07-03
US201862696645P 2018-07-11 2018-07-11
US201862698648P 2018-07-16 2018-07-16
US201862702167P 2018-07-23 2018-07-23
US201862719347P 2018-08-17 2018-08-17
US201862740735P 2018-10-03 2018-10-03
US201862743358P 2018-10-09 2018-10-09
US201862774682P 2018-12-03 2018-12-03
US201862781378P 2018-12-18 2018-12-18
US201862781368P 2018-12-18 2018-12-18
US201962824176P 2019-03-26 2019-03-26
US201962827809P 2019-04-01 2019-04-01
US201962837188P 2019-04-22 2019-04-22
EP19826154.7A EP3655006B1 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation
PCT/US2019/040010 WO2020006529A1 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation
EP21207279.7A EP4011908B1 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation
EP22203969.5A EP4186920B1 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
EP21207279.7A Division EP4011908B1 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation
EP22203969.5A Division EP4186920B1 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation
EP19826154.7A Division EP3655006B1 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation

Publications (2)

Publication Number Publication Date
EP4344738A2 EP4344738A2 (fr) 2024-04-03
EP4344738A3 true EP4344738A3 (fr) 2024-05-22

Family

ID=68985236

Family Applications (5)

Application Number Title Priority Date Filing Date
EP21164434.9A Active EP3892628B1 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation
EP23215091.2A Pending EP4344738A3 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation
EP19826154.7A Active EP3655006B1 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation
EP22203969.5A Active EP4186920B1 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation
EP21207279.7A Active EP4011908B1 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP21164434.9A Active EP3892628B1 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation

Family Applications After (3)

Application Number Title Priority Date Filing Date
EP19826154.7A Active EP3655006B1 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation
EP22203969.5A Active EP4186920B1 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation
EP21207279.7A Active EP4011908B1 (fr) 2018-06-29 2019-06-28 Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation

Country Status (15)

Country Link
US (8) US10947292B2 (fr)
EP (5) EP3892628B1 (fr)
JP (2) JP7417277B2 (fr)
KR (1) KR20210029210A (fr)
CN (1) CN113038964A (fr)
AU (1) AU2019291945A1 (fr)
BR (1) BR112020026777A2 (fr)
CA (1) CA3104144A1 (fr)
DK (4) DK4186920T3 (fr)
FI (2) FI4011908T3 (fr)
HR (4) HRP20230991T1 (fr)
HU (3) HUE058005T2 (fr)
LT (4) LT3892628T (fr)
SI (4) SI3892628T1 (fr)
WO (1) WO2020006529A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3939605A1 (fr) 2016-12-09 2022-01-19 Akston Biosciences Corporation Fusions d'insuline-fc et méthodes d'utilisation
FI4011908T3 (fi) 2018-06-29 2023-08-04 Akston Biosciences Corp Ultrapitkävaikutteiset insuliini-Fc-fuusioproteiinit ja niiden käyttömenetelmät
US11267862B2 (en) 2018-06-29 2022-03-08 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
WO2021011827A1 (fr) * 2019-07-16 2021-01-21 Akston Biosciences Corporation Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation
CN114846025A (zh) 2019-12-19 2022-08-02 阿卡斯通生物科学公司 超长效胰岛素-Fc融合蛋白及其使用方法
US11186623B2 (en) 2019-12-24 2021-11-30 Akston Bioscience Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
US11192930B2 (en) 2020-04-10 2021-12-07 Askton Bioscences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
US11213581B2 (en) 2020-04-10 2022-01-04 Akston Biosciences Corporation Antigen specific immunotherapy for COVID-19 fusion proteins and methods of use
US11198719B2 (en) 2020-04-29 2021-12-14 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
CA3189527A1 (fr) * 2020-07-24 2022-01-27 Jiangsu Gensciences Inc. Proteine de fusion insuline-fc et son application
CA3202345A1 (fr) * 2020-12-14 2022-06-23 Eli Lilly And Company Methodes de traitement du diabete
EP4373861A2 (fr) 2021-07-23 2024-05-29 Akston Biosciences Corporation Protéines de fusion insuline-fc et méthodes d'utilisation pour traiter le cancer
WO2023064711A2 (fr) * 2021-10-14 2023-04-20 Akston Biosciences Corporation Protéines de fusion insuline-fc à action ultra-longue et méthodes d'utilisation
TW202339790A (zh) 2021-11-15 2023-10-16 美商美國禮來大藥廠 可保存之調配物
WO2023174370A1 (fr) * 2022-03-16 2023-09-21 北京拓界生物医药科技有限公司 Analogue de l'insuline humaine, sa protéine de fusion et son utilisation médicale
WO2023247640A1 (fr) * 2022-06-23 2023-12-28 Sanofi Insulines à chaîne unique et leurs conjugués fc

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010117760A2 (fr) * 2009-03-30 2010-10-14 Boehringer Ingelheim International Gmbh Protéines hybrides comprenant des portions fc d'anticorps canins
CN103509118A (zh) * 2012-06-15 2014-01-15 郭怀祖 胰岛素-Fc融合蛋白
WO2016044676A2 (fr) * 2014-09-18 2016-03-24 AskGene Pharma, Inc. Nouveaux agonistes du récepteur de l'érythropoïétine de félins
WO2016119023A1 (fr) * 2015-01-29 2016-08-04 Nexvet Australia Pty Ltd Agents diagnostiques et thérapeutiques
WO2016178905A1 (fr) * 2015-05-07 2016-11-10 Eli Lilly And Company Protéines de fusion
WO2018009921A1 (fr) * 2016-07-08 2018-01-11 AskGene Pharma, Inc. Protéine de fusion comprenant de la leptine et procédés de production et d'utilisation associés
WO2018073185A1 (fr) * 2016-10-17 2018-04-26 Vetoquinol Sa Région constante modifiée d'un anticorps
WO2018107117A1 (fr) * 2016-12-09 2018-06-14 Akston Biosciences Corporation Fusions d'insuline-fc et méthodes d'utilisation

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040601A1 (en) 2001-06-08 2003-02-27 Ivan Diers Method for making insulin precursors and insulin analog precursors
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
US20100143479A1 (en) 2008-12-04 2010-06-10 Oakwood Laboratories, Llc Method of making sustained release microparticles
WO2010107520A1 (fr) 2009-03-20 2010-09-23 Smartcells, Inc. Conjugués d'insulines non déposées solubles et leurs utilisations
CN101891823B (zh) 2010-06-11 2012-10-03 北京东方百泰生物科技有限公司 一种Exendin-4及其类似物融合蛋白
CA2805739A1 (fr) 2010-07-28 2012-02-02 Smartcells, Inc. Conjugues medicaments-ligands, leur synthese et intermediaires correspondants
AU2011282988A1 (en) * 2010-07-28 2013-01-31 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
AR087433A1 (es) 2011-08-08 2014-03-26 Merck Sharp & Dohme Analogos de insulina n-glicosilados
US20140302028A1 (en) 2011-11-18 2014-10-09 Merck Sharp & Dohme Corp. Fc containing polypeptides having increased anti-inflammatory properties and increased fcrn binding
KR102041412B1 (ko) 2011-12-30 2019-11-11 한미사이언스 주식회사 면역글로불린 Ｆｃ 단편 유도체
EP2885543B1 (fr) * 2012-08-17 2019-01-16 Dresser-Rand Company Système et procédé de détection de décrochage ou pompage dans des compresseurs radiaux
WO2014093387A1 (fr) * 2012-12-10 2014-06-19 Kindred Biosciences, Inc. Protéines hybrides du récepteur de vegf pour utilisation vétérinaire
SG10201907106VA (en) 2013-02-26 2019-09-27 Hanmi Pharmaceutical Co Ltd Novel insulin analog and use thereof
CA2961037A1 (fr) * 2014-10-06 2016-04-14 Case Western Reserve University Analogues de l'insuline a chaine unique biphasique
CA2964918A1 (fr) * 2014-10-20 2016-04-28 Case Western Reserve University Analogues d'insuline halogenes a activite biologique amelioree
US10822386B2 (en) 2014-12-24 2020-11-03 Case Western Reserve University Insulin analogues with enhanced stability and reduced mitogenicity
KR20170106373A (ko) * 2015-01-20 2017-09-20 케이스 웨스턴 리저브 유니버시티 선택적 신호전달 특성 및 감소된 유사분열촉진을 갖는 인슐린 유사체
KR20160101702A (ko) 2015-02-17 2016-08-25 한미약품 주식회사 지속형 인슐린 또는 이의 아날로그 결합체
WO2016164937A2 (fr) * 2015-04-10 2016-10-13 Amgen Inc. Mutéines de l'interleukine-2 pour l'expansion de lymphocytes t régulateurs
AU2016257000B2 (en) * 2015-05-04 2020-05-14 Apogenix Ag Single-chain CD40-receptor agonist proteins
WO2016193380A1 (fr) 2015-06-02 2016-12-08 Novo Nordisk A/S Insulines à extensions recombinées polaires
CN108699120B (zh) 2015-11-16 2022-05-13 Ubi蛋白公司 用于延长蛋白质半衰期的方法
AU2017298565B2 (en) * 2016-07-22 2021-08-19 The Walter And Eliza Hall Institute Of Medical Research Insulin analogs
JP7158378B2 (ja) 2016-09-23 2022-10-21 ハンミ ファーマシューティカル カンパニー リミテッド インスリン受容体との結合力が減少された、インスリンアナログ及びその用途
AR111122A1 (es) 2017-03-07 2019-06-05 Univ Case Western Reserve Análogos de insulina de cadena única estabilizados por un cuarto puente disulfuro
US10572594B2 (en) 2017-08-01 2020-02-25 Intuit Inc. Extracting domain-specific actions and entities in natural language commands recognized based on edition and recognition scores
WO2019035010A1 (fr) 2017-08-15 2019-02-21 Kindred Biosciences, Inc. Variants d'igg fc à usage vétérinaire
AU2019255611A1 (en) 2018-04-16 2020-11-12 University Of Utah Research Foundation Glucose-responsive insulin
US11267862B2 (en) 2018-06-29 2022-03-08 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
FI4011908T3 (fi) 2018-06-29 2023-08-04 Akston Biosciences Corp Ultrapitkävaikutteiset insuliini-Fc-fuusioproteiinit ja niiden käyttömenetelmät
CA3114395A1 (fr) 2018-09-25 2020-04-02 Absci, Llc Procedes de purification de proteines
EP3861017A1 (fr) 2018-10-05 2021-08-11 Novo Nordisk A/S Composés bifonctionnels comprenant des peptides d'insuline et des peptides d'egf(a)
JP2022507627A (ja) 2018-11-19 2022-01-18 ケース ウェスタン リザーブ ユニバーシティ ポリ－アラニンｃ－ドメインのサブセグメントを有する単鎖インスリンアナログ
AU2020279968A1 (en) 2019-05-17 2021-12-16 Case Western Reserve University Variant single-chain insulin analogues
WO2021011827A1 (fr) 2019-07-16 2021-01-21 Akston Biosciences Corporation Protéines de fusion insuline-fc à action ultra-longue et procédés d'utilisation
JP2022542301A (ja) 2019-07-31 2022-09-30 イーライ リリー アンド カンパニー リラキシン類似体およびその使用方法
CN114846025A (zh) 2019-12-19 2022-08-02 阿卡斯通生物科学公司 超长效胰岛素-Fc融合蛋白及其使用方法
US11186623B2 (en) 2019-12-24 2021-11-30 Akston Bioscience Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
US11192930B2 (en) 2020-04-10 2021-12-07 Askton Bioscences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
US11198719B2 (en) 2020-04-29 2021-12-14 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010117760A2 (fr) * 2009-03-30 2010-10-14 Boehringer Ingelheim International Gmbh Protéines hybrides comprenant des portions fc d'anticorps canins
CN103509118A (zh) * 2012-06-15 2014-01-15 郭怀祖 胰岛素-Fc融合蛋白
WO2016044676A2 (fr) * 2014-09-18 2016-03-24 AskGene Pharma, Inc. Nouveaux agonistes du récepteur de l'érythropoïétine de félins
WO2016119023A1 (fr) * 2015-01-29 2016-08-04 Nexvet Australia Pty Ltd Agents diagnostiques et thérapeutiques
WO2016178905A1 (fr) * 2015-05-07 2016-11-10 Eli Lilly And Company Protéines de fusion
WO2018009921A1 (fr) * 2016-07-08 2018-01-11 AskGene Pharma, Inc. Protéine de fusion comprenant de la leptine et procédés de production et d'utilisation associés
WO2018073185A1 (fr) * 2016-10-17 2018-04-26 Vetoquinol Sa Région constante modifiée d'un anticorps
WO2018107117A1 (fr) * 2016-12-09 2018-06-14 Akston Biosciences Corporation Fusions d'insuline-fc et méthodes d'utilisation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
STRIETZEL CATHERINE J ET AL: "In Vitrofunctional characterization of feline IgGs", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 158, no. 3, 5 February 2014 (2014-02-05), pages 214 - 223, XP028604528, ISSN: 0165-2427, DOI: 10.1016/J.VETIMM.2014.01.012 *
TERADA T ET AL: "A chimeric human-cat Fc@c-Fel d1 fusion protein inhibits systemic, pulmonary, and cutaneous allergic reactivity to intratracheal challenge in mice sensitized to Fel d1, the major cat allergen", CLINICAL IMMUNOLOGY, ACADEMIC PRESS, US, vol. 120, no. 1, 13 February 2006 (2006-02-13), pages 45 - 56, XP024911178, ISSN: 1521-6616, [retrieved on 20060701], DOI: 10.1016/J.CLIM.2005.12.010 *

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