EP4032824A1 - Logement pour un récipient souple - Google Patents

Logement pour un récipient souple Download PDF

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Publication number
EP4032824A1
EP4032824A1 EP22153960.4A EP22153960A EP4032824A1 EP 4032824 A1 EP4032824 A1 EP 4032824A1 EP 22153960 A EP22153960 A EP 22153960A EP 4032824 A1 EP4032824 A1 EP 4032824A1
Authority
EP
European Patent Office
Prior art keywords
housing
container
foam
flexible container
housing according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22153960.4A
Other languages
German (de)
English (en)
Inventor
Thomas Wurm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Single Use Support GmbH
Original Assignee
Single Use Support GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ATGM50100/2017U external-priority patent/AT15857U1/de
Application filed by Single Use Support GmbH filed Critical Single Use Support GmbH
Publication of EP4032824A1 publication Critical patent/EP4032824A1/fr
Pending legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02—Internal fittings
    • B65D25/10—Devices to locate articles in containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/14—Linings or internal coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/16—Holders for containers
    • A61J1/165—Cooled holders, e.g. for medications, insulin, blood, plasma
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
    • B65D77/02—Wrapped articles enclosed in rigid or semi-rigid containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
    • B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
    • B65D77/06—Liquids or semi-liquids or other materials or articles enclosed in flexible containers disposed within rigid containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
    • B65D81/022—Containers made of shock-absorbing material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
    • B65D81/05—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents
    • B65D81/107—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents using blocks of shock-absorbing material
    • B65D81/113—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents using blocks of shock-absorbing material of a shape specially adapted to accommodate contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers

Definitions

  • the present invention relates to a housing for a flexible container for transporting liquids, in particular medicines.
  • liquids in particular medicines.
  • other liquids that occur in the (bio)pharmaceutical production process can also be transported in such a housing using a flexible container.
  • Flexible containers with which medicines are transported in a housing are also referred to as “single use bags”. This is mostly done in the frozen state, with the flexible container being placed in the housing prior to freezing. The liquid is then frozen by cooling the assembly.
  • the volume expansion during freezing (about 8%) creates a pressure on the housing and the flexible container that should not be underestimated. This introduces the risk of mechanical damage and consequent leakage of the mechanical container.
  • the object of the present invention is to reduce the mechanical stress on the flexible container and the housing compared to the prior art when freezing.
  • an elastic foam in other words: by at least one body made of elastic foam - with which the housing is lined.
  • This can, in particular, at least partially—preferably essentially completely—compensate for the volume expansion of the container arranged in the housing that occurs during freezing. protection is sought also for an arrangement of a housing according to the invention and a flexible container arranged therein and filled with a liquid, in particular a drug.
  • a housing according to the invention in which a liquid, in particular a drug, is filled into the flexible container, the filled container is placed in the housing and the liquid is frozen by cooling the assembly of housing and container.
  • Liquids that can be transported in flexible containers are e.g. B. Protein solutions, end products of a purification, antibody solutions and other high-quality intermediate products in the pharmaceutical production cycle, as well as of course drugs themselves.
  • the foam has a decreasing elasticity with decreasing temperature below the freezing point. It can also be provided that the foam essentially hardens at a temperature between 0° C. and ⁇ 30° C., preferably between ⁇ 5° C. and ⁇ 25° C. and particularly preferably between ⁇ 10° C. and ⁇ 20° C . These measures can contribute to the flexible container lying in a precisely adapted "bed" in the housing. All of the forces acting on the flexible container and the housing are thus absorbed by larger surfaces. As a result, damage caused by jamming or the like is at least reduced, if not completely ruled out.
  • the foam is designed in such a way that the curing process is reversible.
  • the curing process is reversible.
  • the housing can in principle be reused if desired.
  • the curing of the foam can also be referred to as setting. It is not a question of hardening during the production of the foam, but of changing the elasticity properties under the influence of cold.
  • the housing is lined with the foam in such a way that the container—preferably including any add-on parts—is completely surrounded by the foam when the container is arranged in the housing. This means that not only the flexible container, but also the attachments can be better protected against damage.
  • attachment parts for such flexible containers are often of different shapes, for example because they consist of deformable hoses and the like, a foam block in the housing which can accommodate the attachment parts (by deformation) can be advantageous.
  • the housing can be essentially cuboid. This can facilitate easy stacking of the housing, for example.
  • the flexible container 2 is arranged inside the housing 1 .
  • the housing 1 is lined with foam 3 and a foam block 5 . If the liquid within the container 2 freezes, the container 2 expands. This expansion in volume is absorbed by the foam 3 and the foam block 5, so that between the container 2 and the housing 1 no tension—or at least an insignificant tension—is created.
  • Attachments 4, z. B. hoses and valves and the like are arranged above or within the foam block 5, which can accommodate them due to its elasticity or flexibility.
  • the housing 1 is designed to be completely enclosing.
  • the housing 1 can be made of plastic and/or metal.
  • the cover layers are each made of stainless steel and the side walls are made of polyethylene (specifically: high-density polyethylene, HDPE).
  • a closure or seal could also be attached, whereby manipulation during the transport process or in the warehouse can be ruled out or at least made visible.
  • the foam 3 can preferably be designed in such a way that it is relatively resilient and flexible at room temperature (and low negative temperatures) and hardens at lower temperatures ( ⁇ 15° C. and colder) and encloses the container 2 arranged in the housing 1 and protects it from relative movement .
  • the container 2 protected in this way cannot be bent or compressed because the movement relative to the housing 1 is prevented. As a result, breakage and leaks in the container 2 made of plastic, for example, can be prevented.
  • So-called visco-elastic foam for example, can be used as the foam, which hardens at certain negative temperatures.
  • housing 1 and filled container 2 can be frozen, for example, by contact cooling systems or circulating air cooling systems or in some other way.
  • contact cooling systems the top surfaces of the housing 1 (also referred to as the “shell”) lie on cooled surfaces.
  • circulating air cooling systems the housing 1 is flushed with cooled air.
  • the individual sides of the housing 1, in particular the cover surfaces (that is to say at the top and bottom), can be made of relatively thin material, in particular steel, in order to achieve rapid heat conduction (or cold conduction).
  • the housing 1 according to the invention can be reused, in particular if the foam 3 is designed in such a way that curing at low temperatures is reversible.
  • the housing 1 can be easily dismantled for simple recycling measures.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Buffer Packaging (AREA)
  • Packages (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
EP22153960.4A 2017-01-16 2018-01-15 Logement pour un récipient souple Pending EP4032824A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AT600042017 2017-01-16
ATGM50100/2017U AT15857U1 (de) 2017-01-16 2017-05-24 Gehäuse für einen flexiblen Behälter
EP18705541.3A EP3509956B1 (fr) 2017-01-16 2018-01-15 Logement pour contenant flexible
PCT/AT2018/060010 WO2018129576A1 (fr) 2017-01-16 2018-01-15 Logement pour contenant flexible

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP18705541.3A Division EP3509956B1 (fr) 2017-01-16 2018-01-15 Logement pour contenant flexible
EP18705541.3A Division-Into EP3509956B1 (fr) 2017-01-16 2018-01-15 Logement pour contenant flexible

Publications (1)

Publication Number Publication Date
EP4032824A1 true EP4032824A1 (fr) 2022-07-27

Family

ID=62839098

Family Applications (2)

Application Number Title Priority Date Filing Date
EP18705541.3A Active EP3509956B1 (fr) 2017-01-16 2018-01-15 Logement pour contenant flexible
EP22153960.4A Pending EP4032824A1 (fr) 2017-01-16 2018-01-15 Logement pour un récipient souple

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP18705541.3A Active EP3509956B1 (fr) 2017-01-16 2018-01-15 Logement pour contenant flexible

Country Status (5)

Country Link
US (3) US11207239B2 (fr)
EP (2) EP3509956B1 (fr)
CN (1) CN109890716B (fr)
DK (1) DK3509956T3 (fr)
WO (1) WO2018129576A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT521596A1 (de) 2018-09-05 2020-03-15 Single Use Support Gmbh Kühlplattenanordnung und Verfahren
EP3879978A1 (fr) 2018-11-12 2021-09-22 Smartfreez Lda Isolant pour empêcher des dommages et une rupture de récipient provoqués par la congélation de solutions aqueuses contenant des matériaux biologiques
EP3926277A1 (fr) 2020-06-19 2021-12-22 Single Use Support GmbH Congélateur à plaques
EP3964453A1 (fr) 2020-09-02 2022-03-09 Single Use Support GmbH Conteneur pour réception d'un sac, procédé et utilisation
EP4014947A1 (fr) 2020-12-16 2022-06-22 Single Use Support GmbH Procédé de protection de tubes
EP4166884A1 (fr) 2021-10-15 2023-04-19 Single Use Support GmbH Plaque de refroidissement et procédé de fabrication d'une plaque de refroidissement
EP4169499A1 (fr) 2021-10-19 2023-04-26 Single Use Support GmbH Procédé et dispositif de refroidissement ou de chauffage de fluides bio-pharmaceutiques

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2258163A1 (de) * 1972-11-28 1974-06-12 Fridolin Wais Vorrichtung zur sterilen fuellung, drucksicheren lagerung und fuer ebensolchen transport, sowie fuer beliebig haeufige entnahme, insbesondere von fluessigkeiten
NL8501555A (nl) * 1985-05-30 1986-12-16 Nutricia Nv Met sondevoeding gevulde verpakking.
EP1396440A1 (fr) * 2002-09-05 2004-03-10 The Procter & Gamble Company Produit emballé comprenant des poches flexibles remplies de liquide

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US4723974A (en) * 1985-07-26 1988-02-09 Ammerman Stephen W Transporting container for an amputated extremity
US4738364A (en) * 1987-03-24 1988-04-19 Medicool, Inc. Portable medicine protector
IT220372Z2 (it) * 1989-04-03 1993-09-20 Qts Srl Contenitore termico portatile per fiale di insulina ed altro materiale occorrente per iniezioni a diabetici e medicinali simili.
US6401484B2 (en) * 1999-09-30 2002-06-11 Gano, Iii John Henry Transport container
US6554133B1 (en) * 2000-07-11 2003-04-29 Hewlett-Packard Development Company, L.P. Container package for packaging electronic devices including multimedia devices such as entire computer system including a computer case, a monitor, and a printer
US6381981B1 (en) * 2001-05-02 2002-05-07 Advanced Tissue Sciences, Inc. Container for shipping and storing frozen products
GB2383402A (en) * 2001-08-10 2003-06-25 Adrian Peter Copeland Heat-insulated container
DE10155150C2 (de) 2001-11-12 2003-09-11 Ghassan Sowan Versandtasche für thermisch empfindliches Material und damit aufgebaute Transportverpackung
US7278278B2 (en) * 2003-06-12 2007-10-09 21St Century Medicine, Inc. Cryogenic storage system
US7240513B1 (en) * 2004-04-12 2007-07-10 Conforti Carl J Thermally-controlled package
US8146762B2 (en) * 2006-03-09 2012-04-03 Nalge Nunc International Corporation Flexible container handling system
US9950830B2 (en) * 2007-04-23 2018-04-24 Coldkeepers, Llc Insulated liners and containers
US8177123B2 (en) * 2008-09-24 2012-05-15 Sartorius Stedim North America Inc. Systems and methods for freezing, storing and thawing biopharmaceutical materials
US9301520B2 (en) * 2007-12-21 2016-04-05 Sartorius Stedim North America Inc. Systems and methods for freezing, storing and thawing biopharmaceutical materials
WO2014081839A2 (fr) * 2012-11-20 2014-05-30 Ohio State Innovation Foundation Dispositif d'isolation pour poche de sang
CN203959080U (zh) * 2014-05-22 2014-11-26 青岛市中心医院 恒温输液袋收集器

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2258163A1 (de) * 1972-11-28 1974-06-12 Fridolin Wais Vorrichtung zur sterilen fuellung, drucksicheren lagerung und fuer ebensolchen transport, sowie fuer beliebig haeufige entnahme, insbesondere von fluessigkeiten
NL8501555A (nl) * 1985-05-30 1986-12-16 Nutricia Nv Met sondevoeding gevulde verpakking.
EP1396440A1 (fr) * 2002-09-05 2004-03-10 The Procter & Gamble Company Produit emballé comprenant des poches flexibles remplies de liquide

Also Published As

Publication number Publication date
US20220047457A1 (en) 2022-02-17
US11207239B2 (en) 2021-12-28
EP3509956A1 (fr) 2019-07-17
CN109890716A (zh) 2019-06-14
CN109890716B (zh) 2022-04-26
US20190224074A1 (en) 2019-07-25
US20230157928A1 (en) 2023-05-25
WO2018129576A1 (fr) 2018-07-19
US11602487B2 (en) 2023-03-14
DK3509956T3 (da) 2022-04-11
EP3509956B1 (fr) 2022-03-09

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