EP2174880B1 - Dispositif de réception de récipients et conteneur correspondant - Google Patents

Dispositif de réception de récipients et conteneur correspondant Download PDF

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Publication number
EP2174880B1
EP2174880B1 EP08017605A EP08017605A EP2174880B1 EP 2174880 B1 EP2174880 B1 EP 2174880B1 EP 08017605 A EP08017605 A EP 08017605A EP 08017605 A EP08017605 A EP 08017605A EP 2174880 B1 EP2174880 B1 EP 2174880B1
Authority
EP
European Patent Office
Prior art keywords
walls
container
wall
compartment
another
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP08017605A
Other languages
German (de)
English (en)
Other versions
EP2174880A1 (fr
Inventor
Roger Seiler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeta Biopharma GmbH
Original Assignee
Zeta Biopharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeta Biopharma GmbH filed Critical Zeta Biopharma GmbH
Priority to AT08017605T priority Critical patent/ATE512894T1/de
Priority to DK08017605.0T priority patent/DK2174880T3/da
Priority to EP08017605A priority patent/EP2174880B1/fr
Priority to US12/552,344 priority patent/US20100084405A1/en
Publication of EP2174880A1 publication Critical patent/EP2174880A1/fr
Application granted granted Critical
Publication of EP2174880B1 publication Critical patent/EP2174880B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/16—Holders for containers
    • A61J1/165—Cooled holders, e.g. for medications, insulin, blood, plasma
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1894—Cooling means; Cryo cooling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above

Definitions

  • the invention relates to a device and a container for receiving, filling, temperature control, storage, emptying and transport of containers for biological, biochemical and biopharmaceutical substances, in particular liquids.
  • the US 2004/0134203 describes a container with a thermally insulated housing and a door for receiving a device with one or more compartments for transporting containers.
  • the US 5,614,412 has a device for receiving flexible containers to the subject, these containers absorb liquid substances.
  • the substances mentioned are in particular liquids such as protein solutions, protein mixtures, amino acid solutions, DNA solutions, nucleic acid solutions, blood plasma or the like.
  • Such substances and their packaging must be regularly sterile.
  • the substances are often preserved by freezing for storage and / or transport.
  • the substances frozen in containers are temporarily stored in cold stores or transported in a frozen state before the substances are thawed and processed in a further process stage. These process steps are also performed to influence the quality of the substances.
  • the substances are packaged in flexible plastic containers.
  • the filling stops as well as the emptying technical problem, on the one hand in terms of sterility, on the other hand with regard to the mechanical stability of the container.
  • the invention has for its object to offer an alternative way of packaging the container. As many of the following process and treatment steps should be optimized in comparison with the prior art:
  • the invention is based on the following considerations:
  • the containers are set in a receiving device.
  • This device contains several compartments, each compartment serving to hold one or more containers. Walls delimiting the compartments serve to temper the container contents.
  • the containers are placed in the compartments via a corresponding opening.
  • the containers can be filled after conditioning in the subjects, ie in the device, and then tempered.
  • temperature control for example, for freezing a liquid in the container, the walls of the compartments are formed so that they at least partially by a fluid (heat transfer medium) can be flowed through.
  • Such a device with containers can be used in an associated container, which serves as a transport or storage container for the device or the container.
  • the container has a tempered and / or insulated housing.
  • the latter is intended to ensure that the required temperature level is kept as long as possible without further active temperature control when the container is being transported, for example.
  • the container itself can be opened or closed via a door or a lid. Door or lid may be formed according to the walls of the device. In general, however, it will suffice to thermally insulate the cover (door, cover) in such a way that prevail in the interior, ie in the area of the device, the fan and the container, largely isothermal conditions over a certain period of time.
  • a heat transfer medium including coolant
  • a coolant is passed through the walls and transfers the temperature to the preferably flat against the walls of the container and thus to the liquid in the container.
  • the temperature effect is greater, the higher the contact surface wall / container.
  • the medium for temperature control can be provided by an arranged in or on the container or connectable to the container unit, such as a cooling unit.
  • the corresponding connections can be passed through a wall of the container, preferably thermally insulated again.
  • the removal of the container takes place in reverse as the insertion of the container.
  • the containers can with tempered content, in particular frozen liquid, removed and further processed.
  • defrosting can again take place in the device / container.
  • the walls of the fan can be flowed through, for example with a hot liquid.
  • the emptying of the container can also be done before removal from the device, preferably via a lower, outlet-side end, as will be explained in more detail below.
  • the design is chosen such that thermal expansions occurring during the freezing of liquids are compensated.
  • the subjects variable or the fan-limiting walls are designed to be movable, that is, they can increase the distance to each other during "growing" of the container contents and thus increase the fan volume.
  • spring element includes, according to the invention, all types of construction elements which are suitable for returning the walls of the device to the original position, for example when the container contents are thawed or removed.
  • the spring element therefore has the task of compensating for the displacement of the fan walls in situ due to thermal expansion of the container contents.
  • the walls are guided along rails which run in the direction perpendicular to the walls.
  • the rails can be passed through the walls, as shown below with reference to an embodiment. Other ways of guiding and supporting the walls are possible.
  • the spring element is usually fixed to a bearing with a first section. This may be, for example, a framework of the device. A second portion of the spring element then loosely supported against a corresponding abutment. This may be, for example, the outer surface of an outer wall of the device.
  • both end portions of the spring element would be fixed to corresponding wall sections.
  • Exemplary spring elements are components from the group: compression spring, tension spring, leaf spring, pneumatic spring, elastomer body, rubber body, rubber body, hydraulic ram, pneumatic ram.
  • At least one wall can limit two adjacent compartments. This is rational, since the temperature of the wall acts simultaneously on two compartments / chambers.
  • an embodiment of the invention provides, in addition, to delimit each compartment by at least two side surfaces which are at a distance from each other and substantially perpendicular to the walls. These side surfaces thus represent vertical boundary surfaces for the subjects and run accordingly in the edge region of the walls. As a result, this results in particular a cuboid space for each compartment, although other geometric shapes are possible.
  • side surfaces may be continued at their lower end in the operative position of the device to form at least a partial bottom surface for each compartment.
  • the bend can be made so that the bottom surface extends at least partially at an angle> 90 ° to a corresponding side surface.
  • the side surfaces In order to allow the variation of the distance of adjacent walls of a compartment, the side surfaces must either be elastic or oversized, ie have a width which corresponds at least to the expected maximum distance of the walls.
  • An alternative embodiment provides to guide the side surfaces in grooves of the walls and to form these grooves with a depth which is greater than an assumed maximum displacement of opposite walls of a compartment.
  • the side surfaces When increasing the distance between the walls, the side surfaces then at least partially detach from the grooves. They are returned to the grooves as soon as the walls move towards each other again under the influence of the spring element.
  • the proposed maximum depth is a safety measure.
  • a material based on polytetrafluoroethylene is suitable.
  • the Dimensiön ist the device is such that even larger containers can be included, for example, containers with a volume of well over 10 liters, with volumes of> 50 liters,> 100 liters,> 250 liters up to 1000 liters and beyond are possible ,
  • the cooling unit can be separated after the tempering of the device / the container, so that the container closing in a Cold store and / or can be provided for transport. Due to the separate cooling unit, the size of the container can be limited, which is particularly important for transport purposes.
  • an auxiliary unit for controlling the temperature of the housing enclosed cavity in the container is proposed to integrate an auxiliary unit for controlling the temperature of the housing enclosed cavity in the container. This can be helpful in long transport routes, if the insulating effect of the container is not sufficient to keep the temperature in the interior of the container, ie in the area of the device / container constant.
  • Such a tempering / cooling unit may have an electrical connection line, which is supplied for example in an aircraft transport from the on-board voltage of the aircraft. It is also possible to electrically connect the auxiliary temperature control unit via a battery. This battery can be integrally formed in the container. To generate electricity can also serve a generator.
  • FIG. 1 shows a device comprising the following components:
  • a fluid line 23 meanders from a terminal portion 23z at an upper portion of the corresponding wall to a terminal portion 23a at the lower portion of each wall.
  • the walls 22.1 ... 22.5 are slidably guided on rails 40.1, 40.2, 40.3, 40.4, in each case in the corner area.
  • a respective locking pin (not shown) is arranged, so that the wall 22.4 can not slip off.
  • each rail 42 On each projecting portion of each rail 42, each formed as a round rod, located at the free end a threaded portion with an attached nut 42.2, which is a solid bearing forms for a first end 42.1 of a compression spring 42 which abuts with its other end 42.3 against the wall 22.5.
  • each of side surfaces 44, 46 are limited, which lie in grooves 48 of the walls 22.1 ... 22.5 loose.
  • the side surfaces 44, 46 are made of polytetrafluoroethylene, a material which is dimensionally stable over a wide temperature range and exhibits low surface friction when the respective side surfaces 44, 46 are moved along the grooves 48, as discussed below.
  • the side surfaces 44, 46 are at their lower end, angled in front of the rails 40.3, 40.4 to the inside (against each other), wherein the respective angle: ⁇ is about 100 ° degrees, so that bottom-side portions 44b, 46b inclined and funnel-shaped to each other , forming a middle open bottom section 44o.
  • bottom portions 44b, 46b extending in corresponding grooves 48 of the walls 22.1 ... 22.5.
  • FIG. 3 results.
  • the container is to be opened / closed from above via a pivotally hinged lid 14.5.
  • the lid 14.5 and wall and bottom portions 14.1, 14.2, 14.3, 14.4, 14.6, 14.7 of the container are thermally insulated.
  • ten openings 15 are arranged, which are associated with the inlet and outlet fittings 23z, 23a of the walls 22.1 ... 22.5 and allow corresponding connections of fluid lines (not shown).
  • the device or the container for example, connected to a cooling unit (not shown), which transports a corresponding tempered heat transfer medium through the walls 22.1 ... 22.5.
  • a cooling unit (not shown), which transports a corresponding tempered heat transfer medium through the walls 22.1 ... 22.5.
  • the containers 24 are flexible plastic containers with an upper filling device 24.2 and a lower emptying device 24.1 in the region of the bottom opening 44.o.
  • the containers 24 After filling, the containers 24 fill the fan volume largely as far as possible, wherein usually both in the container 24 and in each compartment 16.1 ... 16.4 remains an unused residual volume.
  • the walls 22.1... 22.5 are then tempered. With aqueous liquids, the volumetric expansion of the water increases from 0 ° C to an increase in the substance volume. To compensate for this expansion, the device has the described adjustable walls 22.1 ... 22.5, which are now shifted against the action of the springs 42 along the rails 40.1 ... 40.4.
  • the side surfaces 44, 46 are led out of the grooves 48 in part, or are then guided deeply into the grooves 48 again.
  • FIG. 5 shows an auxiliary cooling unit 36, which is formed in a space 34 of the container.
  • the cooling unit 36 can be fluidically connected to the coolant lines to the walls 22.1 ... 22.5. It serves for longer storage or longer Transports ensure that the temperature in the container does not rise or fall below or above critical levels. This is important, for example, in the so-called cryo-preservation of liquids.
  • FIG. 5 also shows feet 32 of the container below the floor 14.7.
  • the width (in the longitudinal direction of the rails) of the side walls is chosen to be at least as wide as the expected maximum distance of corresponding walls.
  • the walls can then be firmly connected to the side surfaces. Normally, for example, when filling the container, the side surfaces then fold slightly; but they still provide a guide for the inserted into the subjects container.

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Packages (AREA)
  • Cooling Or The Like Of Electrical Apparatus (AREA)
  • Supplying Of Containers To The Packaging Station (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (15)

  1. Dispositif de réception et de transport de réservoirs (24) pour des substances biologiques, biochimiques et biopharmaceutiques, avec les attributs suivants:
    1.1. plusieurs compartiments (16.1, 16.2, 16.3, 16.4) disposés les uns à côté des autres pour la réception d'un réservoir (24) chacun,
    1.2. chaque compartiment (16.1, 16.2, 16.3, 16.4) est délimité par au moins deux parois s'étendant à la parallèle, avec un écart les unes par rapport aux autres (22.1, 22.2, 22.3, 22.4, 22.5),
    1.3. les parois (22.1, 22.2, 22.3, 22.4, 22.5) peuvent être au moins en partie traversées par un fluide et présentent des raccords correspondants (23z, 23a) pour des conduits à fluide,
    1.4. au moins une paroi (22.1, 22.2, 22.3, 22.4, 22.5) de chaque compartiment (16.1, 16.2, 16.3, 16.4) est déplaçable dans une direction à la perpendiculaire des parois (22.1, 22.2, 22.3, 22.4, 22.5),
    1.5. au moins une paroi (22.1, 22.2, 22.3, 22.4, 22.5) de l'installation est déplaçable dans une direction à la perpendiculaire des parois (22.1, 22.2, 22.3, 22.4, 22.5), contre l'action d'au moins un élément formant ressort (42).
  2. Installation selon la revendication 1, sur laquelle les parois (22.1, 22.2, 22.3, 22.4, 22.5) sont guidées le long de rails (40.1, 40.2, 40.3, 40.4) qui s'étendent dans la direction à la perpendiculaire des parois (22.1, 22.2, 22.3, 22.4, 22.5).
  3. Installation selon la revendication 1, sur lequel l'au moins un élément formant ressort (42) est fixé par une première partie (42.1) sur un palier (42.2).
  4. Installation selon la revendication 1, sur laquelle, par une deuxième partie (42.3), l'au moins un élément formant ressort (42) s'appuie de façon mobile contre une butée correspondante.
  5. Installation selon la revendication 1, sur laquelle l'élément formant ressort (42) est un composant du groupe : ressort de pression, ressort de traction, ressort à lame, ressort à air comprimé, corps en élastomère, corps en caoutchouc, corps en gomme, poinçon hydraulique, poinçon pneumatique.
  6. Installation selon la revendication 1, sur laquelle au moins une paroi (22.1, 22.2, 22.3, 22.4, 22.5) délimite deux compartiments (16.1, 16.2, 16.3, 16.4) voisins.
  7. Installation selon la revendication 1, sur laquelle chaque compartiment (16.1, 16.2, 16.3, 16.4) est délimité en supplément par au moins deux surfaces latérales (44, 46) qui s'étendent avec un écart les unes par rapport aux autres et sensiblement à la perpendiculaire des parois (22.1, 22.2, 22.3, 22.4, 22.5).
  8. Installation selon la revendication 7, dont les surfaces latérales (44, 46) forment des surfaces de délimitation verticales pour les compartiments (16.1, 16.2, 16.3, 16.4) et s'étendent dans la zone marginale des parois (22.1, 22.2, 22.3, 22.4, 22.5).
  9. Installation selon la revendication 7, sur laquelle, sur leur extrémité inférieure, dans une position de fonction de l'installation, des surfaces latérales (44, 46) correspondantes d'au moins un compartiment (16.1, 16.2, 16.3, 16.4) sont conçues en étant coudées les unes contre les autres, en formant une surface de fond (44b, 46b) au moins partielle.
  10. Installation selon la revendication 7, sur laquelle la surface de fond (44b, 46b) s'étend au moins partiellement sous un angle supérieur à 90 degrés vers une surface latérale (44, 46) correspondante.
  11. Installation selon la revendication 7, sur laquelle les surfaces latérales (44, 46) sont guidées dans des rainures 48 des parois (22.1, 22.2, 22.3, 22.4, 22.5).
  12. Installation selon la revendication 11, sur laquelle dans le prolongement de surfaces latérales (44, 46) correspondantes, les rainures (48) présentent une profondeur qui est supérieure à un déplacement maximale à supposer de parois (22.1, 22.2, 22.3, 22.4, 22.5) correspondantes d'un compartiment (16.1, 16.2, 16.3, 16.4) les unes par rapport aux autres.
  13. Conteneur avec une caisse thermiquement isolée, qui présente au moins une porte ou un couvercle (14.5) et une cavité qui entoure une installation selon l'une quelconque des revendications 1 à 12.
  14. Conteneur selon la revendication 13, avec au moins une ouverture de caisse côté paroi pour réceptionner au moins un conduit de transport de fluide pour le raccordement sur au moins un conduit de fluide d'au moins une paroi (22.1, 22.2, 22.3, 22.4, 22.5) de l'installation.
  15. Conteneur selon la revendication 13, avec un groupe auxiliaire (36) intégré, pour tempérer la cavité entourée par la caisse.
EP08017605A 2008-10-08 2008-10-08 Dispositif de réception de récipients et conteneur correspondant Not-in-force EP2174880B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AT08017605T ATE512894T1 (de) 2008-10-08 2008-10-08 Einrichtung zur aufnahme von behältern und zugehöriger container
DK08017605.0T DK2174880T3 (da) 2008-10-08 2008-10-08 Indretning til modtagelse og transport af beholdere og tilhørende container
EP08017605A EP2174880B1 (fr) 2008-10-08 2008-10-08 Dispositif de réception de récipients et conteneur correspondant
US12/552,344 US20100084405A1 (en) 2008-10-08 2009-09-02 Device for accommodating receptacles and associated container

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08017605A EP2174880B1 (fr) 2008-10-08 2008-10-08 Dispositif de réception de récipients et conteneur correspondant

Publications (2)

Publication Number Publication Date
EP2174880A1 EP2174880A1 (fr) 2010-04-14
EP2174880B1 true EP2174880B1 (fr) 2011-06-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP08017605A Not-in-force EP2174880B1 (fr) 2008-10-08 2008-10-08 Dispositif de réception de récipients et conteneur correspondant

Country Status (4)

Country Link
US (1) US20100084405A1 (fr)
EP (1) EP2174880B1 (fr)
AT (1) ATE512894T1 (fr)
DK (1) DK2174880T3 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10690574B2 (en) * 2016-05-11 2020-06-23 The Florida International University Board Of Trustees Chilling apparatus
US11287292B2 (en) * 2017-02-13 2022-03-29 Lockheed Martin Corporation Sensor system
AT521831B1 (de) * 2018-11-13 2021-02-15 Productbloks Gmbh Vorrichtung zum temperierten Lagern von Lagergütern
CN113978896A (zh) * 2021-09-24 2022-01-28 商智粱 一种具有高强度的瓦楞箱缓冲装置
CN113911506A (zh) * 2021-10-29 2022-01-11 常德市粉之源食品有限责任公司 一种具备防挤压功能的运输设备
USD1030606S1 (en) * 2022-07-01 2024-06-11 Oxford Instruments Nanotechnology Tools Limited Cryogenic cooling system

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US412A (en) 1837-09-28 Water-wheel aktd mode of letting the water ow the same
US5614A (en) 1848-06-06 Machinery for cutting cog-wheels
US4484448A (en) * 1983-07-25 1984-11-27 Growers Ice Company Liquid ice injection system
US5614412A (en) * 1995-09-08 1997-03-25 Smith; Stephen L. Apparatus for carrying flexible containers and method of transferring fluids to containers
US6684646B2 (en) 2001-05-22 2004-02-03 Integrated Biosystems, Inc. Systems and methods for freezing, storing and thawing biopharmaceutical material
ATE417002T1 (de) * 2001-10-10 2008-12-15 Delta T Ges Fuer Medizintechni System zum transport von gütern bei gleichbleibenden temperaturen
DE10332296B3 (de) * 2003-07-16 2005-04-28 Fraunhofer Ges Forschung Substratstapel, insbesondere für die Kryokonservierung biologischer Proben

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Publication number Publication date
EP2174880A1 (fr) 2010-04-14
ATE512894T1 (de) 2011-07-15
DK2174880T3 (da) 2011-07-18
US20100084405A1 (en) 2010-04-08

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