EP2174880A1 - Dispositif de réception de récipients et conteneur correspondant - Google Patents
Dispositif de réception de récipients et conteneur correspondant Download PDFInfo
- Publication number
- EP2174880A1 EP2174880A1 EP08017605A EP08017605A EP2174880A1 EP 2174880 A1 EP2174880 A1 EP 2174880A1 EP 08017605 A EP08017605 A EP 08017605A EP 08017605 A EP08017605 A EP 08017605A EP 2174880 A1 EP2174880 A1 EP 2174880A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- walls
- container
- wall
- compartment
- side surfaces
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/16—Holders for containers
- A61J1/165—Cooled holders, e.g. for medications, insulin, blood, plasma
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0858—Side walls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1894—Cooling means; Cryo cooling
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
Definitions
- the invention relates to a device and a container for receiving, filling, temperature control, storage, emptying and transport of containers for biological, biochemical and biopharmaceutical substances, in particular liquids.
- the substances mentioned are in particular liquids such as protein solutions, protein mixtures, amino acid solutions, DNA solutions, nucleic acid solutions, blood plasma or the like.
- Such substances and their packaging must be regularly sterile.
- the substances are often preserved by freezing for storage and / or transport.
- the substances frozen in containers are temporarily stored in cold stores or transported in a frozen state before the substances are thawed and processed in a further process stage. These process steps are also performed to influence the quality of the substances.
- the substances are packaged in flexible plastic containers.
- the filling stops as well as the emptying technical problem, on the one hand in terms of sterility, on the other hand with regard to the mechanical stability of the container.
- the invention is based on the following considerations:
- the containers are set in a receiving device.
- This device contains several compartments, each compartment serving to hold one or more containers. Walls delimiting the compartments serve to temper the container contents.
- the containers are placed in the compartments via a corresponding opening.
- the containers can be filled after conditioning in the subjects, ie in the device, and then tempered.
- temperature control for example, for freezing a liquid in the container, the walls of the compartments are formed so that they at least partially by a fluid (heat transfer medium) can be flowed through.
- Such a device with containers can be used in an associated container, which serves as a transport or storage container for the device or the container.
- the container has a tempered and / or insulated housing.
- the latter is intended to ensure that the required temperature level is kept as long as possible without further active temperature control when the container is being transported, for example.
- the container itself can be opened or closed via a door or a lid. Door or lid may be formed according to the walls of the device. In general, however, it will suffice to thermally insulate the cover (door, cover) in such a way that prevail in the interior, ie in the area of the device, the fan and the container, largely isothermal conditions over a certain period of time.
- a heat transfer medium including coolant
- a coolant is passed through the walls and transmits the temperature to the preferably flat against the walls of the container and thus to the liquid in the container.
- the temperature effect is greater, the higher the contact surface wall / container.
- the medium for temperature control can be provided by an arranged in or on the container or connectable to the container unit, such as a cooling unit.
- the corresponding connections can be passed through a wall of the container, preferably thermally insulated again.
- the removal of the container takes place in reverse as the insertion of the container.
- the containers can with tempered content, in particular frozen liquid, removed and further processed.
- defrosting can again take place in the device / container.
- the walls of the fan can be flowed through, for example with a hot liquid.
- the emptying of the container can also be done before removal from the device, preferably via a lower, outlet-side end, as will be explained in more detail below.
- the design is chosen such that thermal expansions occurring during the freezing of liquids are compensated.
- the subjects variable or the fan-limiting walls are designed to be movable, that is, they can increase the distance to each other during "growing" of the container contents and thus increase the fan volume.
- spring element includes according to the invention all types of construction elements which are suitable for returning the walls of the device to the original position, for example when the container contents are thawed or removed.
- the spring element therefore has the task of compensating for the displacement of the fan walls in situ due to thermal expansion of the container contents.
- the walls are guided along rails which run in the direction perpendicular to the walls.
- the rails can be passed through the walls, as shown below with reference to an embodiment. Other ways of guiding and supporting the walls are possible.
- the spring element is usually fixed to a bearing with a first section. This may be, for example, a framework of the device. A second portion of the spring element then loosely supported against a corresponding abutment. This may be, for example, the outer surface of an outer wall of the device.
- both end portions of the spring element would be fixed to corresponding wall sections.
- Exemplary spring elements are components from the group: compression spring, tension spring, leaf spring, pneumatic spring, elastomer body, rubber body, rubber body, hydraulic ram, pneumatic ram.
- At least one wall can limit two adjacent compartments. This is rational, since the temperature of the wall acts simultaneously on two compartments / chambers.
- an embodiment of the invention provides, in addition, to delimit each compartment by at least two side surfaces which are at a distance from each other and substantially perpendicular to the walls. These side surfaces thus represent vertical boundary surfaces for the subjects and run accordingly in the edge region of the walls. As a result, this results in particular a cuboid space for each compartment, although other geometric shapes are possible.
- side surfaces may be continued at their lower end in the operative position of the device to form at least a partial bottom surface for each compartment.
- the bend can be made so that the bottom surface extends at least partially at an angle> 90 ° to a corresponding side surface.
- the side surfaces In order to allow the variation of the distance of adjacent walls of a compartment, the side surfaces must either be elastic or oversized, ie have a width which corresponds at least to the expected maximum distance of the walls.
- An alternative embodiment provides to guide the side surfaces in grooves of the walls and to form these grooves with a depth which is greater than an assumed maximum displacement of opposite walls of a compartment.
- the side surfaces When increasing the distance between the walls, the side surfaces then at least partially detach from the grooves. They are returned to the grooves as soon as the walls move towards each other again under the influence of the spring element.
- the proposed maximum depth is a safety measure.
- a material based on polytetrafluoroethylene is suitable.
- the dimensioning of the device is such that even larger containers can be accommodated, for example containers with a volume of well over 10 liters, wherein volumes of> 50 liters,> 100 liters,> 250 liters up to 1000 liters and beyond are possible ,
- the cooling unit can be separated after the tempering of the device / the container, so that the container closing in a Cold store and / or can be provided for transport. Due to the separate cooling unit, the size of the container can be limited, which is particularly important for transport purposes.
- an auxiliary unit for controlling the temperature of the housing enclosed cavity in the container is proposed to integrate an auxiliary unit for controlling the temperature of the housing enclosed cavity in the container. This can be helpful in long transport routes, if the insulating effect of the container is not sufficient to keep the temperature in the interior of the container, ie in the area of the device / container constant.
- Such a tempering / cooling unit may have an electrical connection line, which is supplied for example in an aircraft transport from the on-board voltage of the aircraft. It is also possible to electrically connect the auxiliary temperature control unit via a battery. This battery can be integrally formed in the container. To generate electricity can also serve a generator.
- FIG. 1 shows a device comprising the following components:
- a fluid line 23 meanders from a terminal portion 23z at an upper portion of the corresponding wall to a terminal portion 23a at the lower portion of each wall.
- the walls 22.1 ... 22.5 are slidably guided on rails 40.1, 40.2, 40.3, 40.4, in each case in the corner area.
- a respective locking pin (not shown) is arranged, so that the wall 22.4 can not slip off.
- each rail 42 On each projecting portion of each rail 42, each formed as a round rod, located at the free end a threaded portion with an attached nut 42.2, which is a solid bearing forms for a first end 42.1 of a compression spring 42 which abuts with its other end 42.3 against the wall 22.5.
- each of side surfaces 44, 46 are limited, which lie in grooves 48 of the walls 22.1 ... 22.5 loose.
- the side surfaces 44, 46 are made of polytetrafluoroethylene, a material which is dimensionally stable over a wide temperature range and exhibits low surface friction when the respective side surfaces 44, 46 are moved along the grooves 48, as discussed below.
- the side surfaces 44, 46 are at their lower end, in front of the rails 40.3, 40.4 angled inward (against each other), wherein the respective angle ⁇ is in each case about 100 ° degrees, so that bottom-side sections 44b, 46b are inclined and funnel-shaped, forming a central open bottom section 440.
- bottom portions 44b, 46b extending in corresponding grooves 48 of the walls 22.1 ... 22.5.
- FIG. 3 results.
- the container is to be opened / closed from above via a pivotally hinged lid 14.5.
- the lid 14.5 and wall and bottom portions 14.1, 14.2, 14.3, 14.4, 14.6, 14.7 of the container are thermally insulated.
- ten openings 15 are arranged, which are associated with the inlet and outlet fittings 23z, 23a of the walls 22.1 ... 22.5 and allow corresponding connections of fluid lines (not shown).
- the device or the container for example, connected to a cooling unit (not shown), which transports a corresponding tempered heat transfer medium through the walls 22.1 ... 22.5.
- a cooling unit (not shown), which transports a corresponding tempered heat transfer medium through the walls 22.1 ... 22.5.
- the containers 24 are flexible plastic containers with an upper filling device 24.2 and a lower emptying device 24.1 in the region of the bottom opening 44.0.
- the containers 24 After filling, the containers 24 fill the fan volume largely as far as possible, wherein usually both in the container 24 and in each compartment 16.1 ... 16.4 remains an unused residual volume.
- the walls 22.1... 22.5 are then tempered. With aqueous liquids, the volumetric expansion of the water increases from 0 ° C to an increase in the substance volume. To compensate for this expansion, the device has the described adjustable walls 22.1 ... 22.5, which are now shifted against the action of the springs 42 along the rails 40.1 ... 40.4.
- the side surfaces 44, 46 are led out of the grooves 48 in part, or are then guided deeply into the grooves 48 again.
- FIG. 5 shows an auxiliary cooling unit 36, which is formed in a space 34 of the container.
- the cooling unit 36 can be fluidically connected to the coolant lines to the walls 22.1 ... 22.5. It serves for longer storage or longer Transports ensure that the temperature in the container does not rise or fall below or above critical levels. This is important, for example, in the so-called cryo-preservation of liquids.
- FIG. 5 also shows feet 32 of the container below the floor 14.7.
- the width (in the longitudinal direction of the rails) of the side walls is chosen to be at least as wide as the expected maximum distance of corresponding walls.
- the walls can then be firmly connected to the side surfaces. Normally, for example, when filling the container, the side surfaces then fold slightly; but they still provide a guide for the inserted into the subjects container.
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Clinical Laboratory Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Packages (AREA)
- Cooling Or The Like Of Electrical Apparatus (AREA)
- Supplying Of Containers To The Packaging Station (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08017605A EP2174880B1 (fr) | 2008-10-08 | 2008-10-08 | Dispositif de réception de récipients et conteneur correspondant |
DK08017605.0T DK2174880T3 (da) | 2008-10-08 | 2008-10-08 | Indretning til modtagelse og transport af beholdere og tilhørende container |
AT08017605T ATE512894T1 (de) | 2008-10-08 | 2008-10-08 | Einrichtung zur aufnahme von behältern und zugehöriger container |
US12/552,344 US20100084405A1 (en) | 2008-10-08 | 2009-09-02 | Device for accommodating receptacles and associated container |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08017605A EP2174880B1 (fr) | 2008-10-08 | 2008-10-08 | Dispositif de réception de récipients et conteneur correspondant |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2174880A1 true EP2174880A1 (fr) | 2010-04-14 |
EP2174880B1 EP2174880B1 (fr) | 2011-06-15 |
Family
ID=40565027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP08017605A Not-in-force EP2174880B1 (fr) | 2008-10-08 | 2008-10-08 | Dispositif de réception de récipients et conteneur correspondant |
Country Status (4)
Country | Link |
---|---|
US (1) | US20100084405A1 (fr) |
EP (1) | EP2174880B1 (fr) |
AT (1) | ATE512894T1 (fr) |
DK (1) | DK2174880T3 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10690574B2 (en) * | 2016-05-11 | 2020-06-23 | The Florida International University Board Of Trustees | Chilling apparatus |
US11287292B2 (en) * | 2017-02-13 | 2022-03-29 | Lockheed Martin Corporation | Sensor system |
AT521831B1 (de) * | 2018-11-13 | 2021-02-15 | Productbloks Gmbh | Vorrichtung zum temperierten Lagern von Lagergütern |
CN113978896A (zh) * | 2021-09-24 | 2022-01-28 | 商智粱 | 一种具有高强度的瓦楞箱缓冲装置 |
CN113911506A (zh) * | 2021-10-29 | 2022-01-11 | 常德市粉之源食品有限责任公司 | 一种具备防挤压功能的运输设备 |
USD1042297S1 (en) * | 2022-07-01 | 2024-09-17 | Oxford Instruments Nanotechnology Tools Limited | Cryogenic cooling system |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US412A (en) | 1837-09-28 | Water-wheel aktd mode of letting the water ow the same | ||
US5614A (en) | 1848-06-06 | Machinery for cutting cog-wheels | ||
US5614412A (en) * | 1995-09-08 | 1997-03-25 | Smith; Stephen L. | Apparatus for carrying flexible containers and method of transferring fluids to containers |
EP1302410A1 (fr) * | 2001-10-10 | 2003-04-16 | delta T Gesellschaft für Medizintechnik GmbH | Système pour le transport de marchandises à température constante |
US20040134203A1 (en) | 2001-05-22 | 2004-07-15 | Integrated Biosystems, Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical material |
WO2005007290A1 (fr) * | 2003-07-16 | 2005-01-27 | Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. | Empilement de supports, notamment pour la cryoconservation d'echantillons biologiques |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4484448A (en) * | 1983-07-25 | 1984-11-27 | Growers Ice Company | Liquid ice injection system |
-
2008
- 2008-10-08 EP EP08017605A patent/EP2174880B1/fr not_active Not-in-force
- 2008-10-08 AT AT08017605T patent/ATE512894T1/de active
- 2008-10-08 DK DK08017605.0T patent/DK2174880T3/da active
-
2009
- 2009-09-02 US US12/552,344 patent/US20100084405A1/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US412A (en) | 1837-09-28 | Water-wheel aktd mode of letting the water ow the same | ||
US5614A (en) | 1848-06-06 | Machinery for cutting cog-wheels | ||
US5614412A (en) * | 1995-09-08 | 1997-03-25 | Smith; Stephen L. | Apparatus for carrying flexible containers and method of transferring fluids to containers |
US20040134203A1 (en) | 2001-05-22 | 2004-07-15 | Integrated Biosystems, Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical material |
EP1302410A1 (fr) * | 2001-10-10 | 2003-04-16 | delta T Gesellschaft für Medizintechnik GmbH | Système pour le transport de marchandises à température constante |
WO2005007290A1 (fr) * | 2003-07-16 | 2005-01-27 | Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. | Empilement de supports, notamment pour la cryoconservation d'echantillons biologiques |
Also Published As
Publication number | Publication date |
---|---|
DK2174880T3 (da) | 2011-07-18 |
EP2174880B1 (fr) | 2011-06-15 |
US20100084405A1 (en) | 2010-04-08 |
ATE512894T1 (de) | 2011-07-15 |
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