EP3775120A2 - Solutions comprenant de l'huile ozonisée - Google Patents

Solutions comprenant de l'huile ozonisée

Info

Publication number
EP3775120A2
EP3775120A2 EP19819129.8A EP19819129A EP3775120A2 EP 3775120 A2 EP3775120 A2 EP 3775120A2 EP 19819129 A EP19819129 A EP 19819129A EP 3775120 A2 EP3775120 A2 EP 3775120A2
Authority
EP
European Patent Office
Prior art keywords
oil
ozone gas
ozonized
ozone
solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19819129.8A
Other languages
German (de)
English (en)
Other versions
EP3775120A4 (fr
Inventor
Ahmet Ümit SABANCI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/TR2019/050209 external-priority patent/WO2019240713A2/fr
Publication of EP3775120A2 publication Critical patent/EP3775120A2/fr
Publication of EP3775120A4 publication Critical patent/EP3775120A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/02—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by the production or working-up
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
    • A23B4/00—General methods for preserving meat, sausages, fish or fish products
    • A23B4/10—Coating with a protective layer; Compositions or apparatus therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
    • A23B7/00—Preservation or chemical ripening of fruit or vegetables
    • A23B7/14—Preserving or ripening with chemicals not covered by groups A23B7/08 or A23B7/10
    • A23B7/144—Preserving or ripening with chemicals not covered by groups A23B7/08 or A23B7/10 in the form of gases, e.g. fumigation; Compositions or apparatus therefor
    • A23B7/152—Preserving or ripening with chemicals not covered by groups A23B7/08 or A23B7/10 in the form of gases, e.g. fumigation; Compositions or apparatus therefor in a controlled atmosphere comprising other gases in addition to CO2, N2, O2 or H2O ; Elimination of such other gases
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
    • A23B7/00—Preservation or chemical ripening of fruit or vegetables
    • A23B7/16—Coating with a protective layer; Compositions or apparatus therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/003—Compositions other than spreads
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
    • A23D7/0053—Compositions other than spreads
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/01—Other fatty acid esters, e.g. phosphatides
    • A23D7/011—Compositions other than spreads
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
    • A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
    • A23D9/013—Other fatty acid esters, e.g. phosphatides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/90—Feeding-stuffs specially adapted for particular animals for insects, e.g. bees or silkworms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/54—Mixing with gases
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3409—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor
    • A23L3/3445—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor in a controlled atmosphere comprising other gases in addition to CO2, N2, O2 or H2O
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3481—Organic compounds containing oxygen
    • A23L3/3508—Organic compounds containing oxygen containing carboxyl groups
    • A23L3/3517—Carboxylic acid esters
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/358—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05F—ORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C, e.g. FERTILISERS FROM WASTE OR REFUSE
    • C05F11/00—Other organic fertilisers
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B5/00—Preserving by using additives, e.g. anti-oxidants
    • C11B5/0021—Preserving by using additives, e.g. anti-oxidants containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/006—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by oxidation
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
    • C11D17/0017—Multi-phase liquid compositions
    • C11D17/0021—Aqueous microemulsions

Definitions

  • the invention relates to solutions comprising ozonized oil, to their production methods and to the applications/uses of these solutions.
  • the invention relates in particular to solutions comprising ozonized oil in nano or micron scales, which comprising ozone in designated doses, to their methods of production and to the use of such solutions.
  • Ozone The allotrope of oxygen, ozone (03) is a compound of three oxygen atoms.
  • Ozone is a colorless, sharp-odorous gas with high oxidation power.
  • Ozone is used as a disinfectant and deodorant in water and air. Since the oxidation power is high, it removes the organic molecules and microorganisms that pollute the environment. Accordingly, it is used as a disinfectant in the food industry and for the long term storage of foods. It is used in a variety of fields such as for infections, circulatory disorders, joint diseases, intestinal diseases, skin diseases, etc.
  • Ozone occurs in nature through ultraviolet rays of sun or lightnings. In the current technique, ozone can be produced via various production technologies. Ozone generators are generally used for this purpose.
  • ozone therapy The use of ozone in the field of healthcare is called ozone therapy.
  • the main ozone therapy methods in the current technique are as follows: major autohemotherapy, minor autohemotherapy, ozone enriched water, ozone/oxygen gas mixture injection directly into the joints and tissues, rectal and vaginal applications, external therapy and ozone enriched oil applications.
  • Ozone Since ozone is an active molecule, it loses its effect in a short time and turns into oxygen. Ozone is a non-stable gas that must be used at a time because it cannot be stored and has a 40-minute half life at 20°C. Therefore, it is generally used where it is produced and in a short period of time. In addition, the usage areas of ozone therapy are limited and the costs are quite high due to the fact that it should be performed by experts and the environments such as hospitals or clinics are required for the application. Also, some of the disadvantages of the ozone therapy methods are that ozone therapy methods are not practical and cannot be applied by individuals in anytime, anywhere.
  • oils that are known as the best movers of ozone and as keeping it stable for a long time are used.
  • ozonized oils are obtained by passing the ozone gas through the oils.
  • Ozone gas is widely used in the petrochemical and pharmaceutical industries due to its high reactivity between organic bonds.
  • Ozone gas is called ozonide when it becomes unstable following the oleic acid reaction. In this reaction, defined as the Criegee reaction, ozonide is converted into trioxolane-like carbonyl fragments, aldehyde, and peroxides.
  • the use of herbal oils by ozonization is known in the prior art.
  • the document numbered as TR2010/02961 describes the water-based personal care and cleaning liquid comprising the ozone derivative of vegetable oils and the method for obtaining it.
  • the said personal care and cleaning fluid is derived from the addition and mixing of the vegetable oil ozone derivative into a mixture comprising water and at least one emulsifier.
  • ozonide, water and emulsifier are mixed between 35 to 55°C and petroleum derivatives are not used.
  • ozonized herbal oils are used to obtain the personal care and cleaning fluids of the invention.
  • the mixtures obtained with this method are used only for cosmetic purposes.
  • EP331 1800A1 discloses a composition comprising microstructures for the controlled release of active agents, in particular, ozonized oil. Said microstructures are coated with a cationic surfactant comprising ammonium group polysaccharide.
  • a cationic surfactant comprising ammonium group polysaccharide.
  • US4983637A refers to a method for treating a viral infection of HIV.
  • the use of ozonides of terpenes as antiviral agents is described. It is stated that the amount of ozone formed as a result of ozonization of terpene is 2-6% and it is said that it should be mixed with polyethylene glycol at certain rates and should not be combined with water. It is written that diluting the mixture with water would reduce the effectiveness and indicated that it should be mixed with the physiological saline solution at the application, but no amount of physiological saline solution was given. This does not explain the dose. However, in order to be injected as a drug, the amount of all the ingredients must be stated.
  • ozonide is an oil that must be used with caution because of its burning properties. This form can only be used uncontrollably on the skin. At the same time, the absence of nano and micron sizes will cause absorption disorders. Terpen ozonide is intended for use only for the virus treatments.
  • Ozonized oils facilitate topical application of ozone therapy.
  • ozone is a reactive molecule, it is very important to pay attention to the use of ozone for medical purposes.
  • the oils used should preferably be compatible with the tissue and contain the appropriate dose of ozone.
  • ozonized oils are generally applied epidermally (administrated cutaneously). Applications by injection are usually performed by mixing the appropriate mixtures of ozone/oxygen gases with the blood of the patient to be treated and then returning the blood mixture to the patient. Due to the invention, the mixtures/solutions obtained by the ozonization of the injectable oils can be used by injection.
  • the injectable oils have been used for years to inject fat-soluble vitamins A, D, E, K and steroids into the tissue. Due to the low side effects of injectable oils, with the ozonization of the same oils and the formation of ozonized oil or ozonides having water-soluble nano or micron particle size, these oils, which are easily injected and can be measured in milligrams, are intended to be widely used as they are sold in pharmacies without the need for an ozonizer. At the same time, with this application, new usage areas of ozone are created.
  • Plant spraying is costly and has a negative effect on both people and the environment due to the spread of chemical wastes to nature.
  • the application made with solutions comprising ozonized oil is completely natural, it does not harm the plant and prevents harmful bacteria and fungi from forming cavities.
  • the application of ozone comprising oil solutions to the leaves and the trunk/body provides an enhancing effect on plant health.
  • the invention is inspired by the existing circumstances and aims to solve the above- mentioned drawbacks.
  • the main purpose of the invention is to enable ozonized oils comprising ozone in designated doses to be used in many areas by making available their chemical degradation into nano or micron sizes in water. It is especially to overcome the problems of ozone concerning the use of it in designated doses to avoid damaging tissues and its absorption.
  • Another purpose of the invention is to prepare solutions comprising ozone or ozonized oil in nano or micron sizes obtained by ozonizing the oils used for injection purposes and to ensure that they can be injected into the tissues individually or within a mixture/solution prepared with the appropriate substances.
  • Another purpose of the invention is to reduce the side effects of each oil in mixtures comprising more than one oil (multiple mixtures) in the solutions comprising ozonized oil or ozonide.
  • the solutions comprising the ozonized oil or ozonide according to the invention can be used on an individual basis or as combinations by mixing.
  • Another purpose of the invention is to ensure the safe use of the methods of the invention due to the measurability of the amount of ozone obtained by measuring ozonized oil in grams. Because, as a result of ozonization, oils are increased by weights.
  • Another purpose of the invention is to dissolve ozonized oils or ozonides formed with injectable oils in water to increase the absorption of them in tissues, thereby making it possible to use ozonized oils or ozonides injectable in the form of degraded to 100 - 400 microns or to the particle size of 1 nanometer by using ultrasonic methods or using high speed motors without requiring heat treatment.
  • This new product is called solution with ozonized oil (or ozonide solution).
  • ozonized oil or ozonides can be degraded into particle sizes in a wide range from 1 nanometer to 400 micrometers.
  • Another purpose of the invention is to standardize the ozone machine for the amount of ozone that the oils obtain and to provide the use of devices that calculate the current and ozone-oxygen content, in order to generate ozone-oxygen in the amount of ozone.
  • ozone and oxygen amounts produced by ozone devices are in different doses, it is aimed to calculate the active substance in the ozonized solution precisely, based on the fact that the carrier is charged with more oxygen if the oxygen amount of the machine is more and with more ozone if the ozone amount of the machine is more.
  • Another purpose of the invention is to form ozonized oils or ozonides with high-resolution oil solutions in water, having a nano or micron particle size in the range of 1 nanometer to 400 micrometers.
  • These ozonized oil or ozonide solutions are used for intramuscular, intraarticular, local effect, as a solution in wound treatment by local injection, as a nasal spray, ear drops, eye drops, in intra-oral wounds, for rectal washing and ozonization, rectal suppository, in vagina cleaning and intrauterine injections, and as a vaginal ovule and suppository, as a lubricant for urinary catheter into the bladder, as a local injection for the purpose of mesotherapy, in injections for the development of hair, and also in order to combine the effects of all kinds of external use, it may be used as a mixture with one or more injectable ozone oil, either alone or in combination with other drugs.
  • Another purpose of the invention is to ensure the use of ozonized oils or ozonides obtained as a result of the ozonization of all vegetable and chemical oils in various ratios depending on solution concentration or ratios in the chemical, cosmetics, agriculture, livestock sectors due to the chemical degradation of them into nano or micron particles.
  • Another purpose of the invention is that it can be used together with the drugs that need a prolonged effect time such as the local anesthetics, or anti-inflammatory drugs.
  • the dense mixtures of ozonized oil solutions of the invention release ozone for times as long as 72 hours in intramuscular, intraarticular or local injections.
  • Another object of the invention is to provide the use of ozonized oils by allowing its combination with all fat-soluble vitamins and drugs.
  • the invention can be used to provide parenteral ozone when given slowly at low doses.
  • a further purpose of the invention is to provide high ozonization of fats such as cholesterol, triglyceride, phospholipid, to be administrated intraarterially in combination with vitamin K in arterial vein occlusion, and to open the vessel with the antioxidant effect of ozonized oil products adhering to the vessel wall.
  • fats such as cholesterol, triglyceride, phospholipid
  • Another purpose of the invention is to reduce the use of antibiotics in regional infections. Since the injection of solutions comprising ozonized oil will be released slowly, it increases oxygenation and reduces the use of antibiotics. It can be applied as an injection into the abscess and periphery of it. In order to speed up the postoperative wound healing, it can also be injected to the surgical region.
  • Another purpose of the invention is to ensure that solutions comprising ozonized oil are used in wound treatment both by local injection and epidermally.
  • Another purpose of the invention is to increase the effects of soybean lecithin, phosphatidylcholine, alpha lipoic acid, and soy lecithin, which are used in regional mesotherapy for slimming purposes, by providing the ozonization of fats in nano or micron sizes.
  • Another purpose of the invention is to ensure the use of solutions comprising ozonized oil in mesotherapy alone or combined with other drugs for preventing hair loss.
  • Another purpose of the invention is to use the solutions comprising ozonized oil or ozonide that are formed by the ozonization of silicone oil and other ozonized oils or ozonides in skin mesotherapy.
  • Another purpose of the invention is to provide the application of solutions comprising ozonized oil in nano or micron sizes in the form of local fistule injections and regional injections in the treatment of mastitis.
  • Another purpose of the invention is to provide an enhanced antioxidant effect through regular injections of solutions comprising ozonized oil, and area of use in addition to cancer prevention and chemotherapy.
  • Another purpose of the invention is to make cancer tissue hypoxic by administering it to the cancerous tissue and surrounding area locally at high concentrations and high doses in cancer treatment.
  • Another purpose of the invention is to provide the cancer cell with a combination of chemotherapy drugs with ozonized oil solution for the treatment of cancer and with the consideration that the cancer cell as capable of taking up oxygen, to make it a selective drug that introduces the chemotherapeutic agent into the cell.
  • Another purpose of the invention is to provide the effect of major therapy with ozone applied 2 - 3 times a week for general purposes with the intramuscular or subcutaneous application.
  • Another purpose of the invention is to dissolve the ozone without reaching the lung tissue by using nano or micron size ozonized oil particles in water and by providing quick dissolving of the ozone in small doses in the intravenous way of the solutions comprising ozonized oil or ozonide.
  • solutions comprising ozonized oil is provided instead of blood transfusion.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils for the injections in the joint.
  • Another purpose of the invention is to provide more effective use of solutions comprising nano or micron-sized ozonized oils for the cervical disc and spinal disc hernia.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils in fracture union and, in particular, in regional injections in fracture union.
  • Another purpose of the invention is to provide more effective use of solutions comprising nano or micron-sized ozonized oils in wound treatment and, in particular, in the regional injections or epidermal applications.
  • a further purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oil in all external forms and mucosal forms, together with silver nanoparticles or other metals that shows oligodynamic effects.
  • Another purpose of the invention is to provide more effective use of solutions comprising nano or micron-sized ozonized oils in the treatment of diseases such as injectable in the treatment of diseases such as tenosynovitis, fibromyalgia, myositis, plantar fasciitis.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils as a lubricant in catheter applications.
  • a further purpose of the invention is to provide the intravesical use of solutions comprising nano or micron-sized ozonized oil in the treatment of cystitis, urethritis, ureteritis.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils in the treatment of vulvovaginitis and vaginitis.
  • Another purpose of the invention is to provide the use of solutions particularly comprising nano or micron-sized ozonized poppy oil for infertility treatment.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils for the pelvic inflammatory diseases.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils for eye diseases.
  • the solutions comprising nano or micron sized ozonized oils can be used in eye infections, allergic eye diseases, autoimmune eye diseases, and similar eye diseases, preferably as eye drops or in different forms.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils for the diseases relating to ears.
  • the solutions comprising nano or micron-sized ozonized oils can be used in external, or middle ear infections and similar ear related diseases, preferably as ear drops or in different forms.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils for the diseases relating to the nose.
  • the solutions comprising nano or micron-sized ozonized oils can be used in sinusitis, colds, allergic rhinitis and similar nasal diseases, preferably as ear drops or in different forms.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils preferably as a spray or in different forms in the treatment of flu.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils preferably as a pastille or in different forms in the throat infections.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils in the treatment of oral and periodontal diseases.
  • the solutions comprising nano or micron-sized ozonized oils can be used in the treatment of diseases such as stomatitis, gingivitis.
  • the solutions comprising nano or micron-sized ozonized oils can be injected into the cavities in tooth decays.
  • the solutions comprising nano or micron-sized ozonized oils can be used together with a local anesthetic.
  • the solutions comprising nano or micron-sized ozonized oils can be used in the treatment of dental abscess through injection.
  • the solutions comprising nano or micron-sized ozonized oils can be used after tooth extraction and in the treatment of alveolitis.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils preferably as a stomach-dissolving capsule or in different forms in the treatment of gastric diseases, and in the eradication of Helicobacter pylori.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils that have a generalized systemic effect and solved in the intestine as capsules or in different forms.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils in the treatment of hemorrhoids, fistulas, fissures, anal abscesses, and similar diseases as suppositories or in different forms.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils in the treatment of colitis ulcerous, Crohn's diseases or in order to achieve the absorption of ozone from the intestine in general as suppositories or in different forms.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils for rectal washing and lavatory.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils as an intraperitoneal injection for peritonitis.
  • Another purpose of the invention is to provide the use of dilute solutions comprising nano or micron-sized ozonized oils for parenteral administration.
  • Another purpose of the invention is to increase the skin absorption of the products by using solutions comprising nano or micron-sized ozonized oils in cosmetic products.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils easily in the desired density in sensitive tissues such as intestine, bladder, vaginal tissue, rectal tissue, mouth and nasal mucosa, eye and ear.
  • Another purpose of the invention is to enable the preparation of mixtures with high water content at the desired dosage in intra-articular injections for medical use.
  • Another purpose of the invention is to provide efficient use of drugs that require slow absorption and long release by providing the solutions comprising nano or micron-sized ozonized oils of the invention.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils in veterinary medicine to replace antibiotics to prevent infections.
  • Another purpose of the invention is to provide the use of solutions by mixing it with feed and drinking water to improve the development of animal health.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils as a regional injection and for administration into the cavity in mastitis in veterinary medicine.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils as vaginal suppositories or in different forms in cases of vaginal infections in veterinary medicine.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils for the treatment of abscess or regional infections in veterinary medicine.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils for joint injuries or tendinitis in veterinary medicine.
  • Another purpose of the invention is to prepare products using solutions comprising nano or micron-sized ozonized oils in the cosmetics, food, veterinary medicine, medicine, and agricultural medicine, etc. at adjustable doses to be used in application areas.
  • Another purpose of the invention is to provide the production of disposable wet wipes from the solutions comprising nano or micron-sized ozonized oils.
  • Another purpose of the invention is to provide the production of disposable packaging solutions from the solutions comprising nano or micron-sized ozonized oils.
  • Another purpose of the invention is to provide the production of disposable hygienic vaginal mixtures from the solutions comprising nano or micron-sized ozonized oils.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils in the form of gargle (mouthwash).
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils for the elaboration of cosmetic preparations, in skin care and treatment.
  • Another purpose of the invention is to prepare disposable packages to ensure that solutions comprising ozonized oil in nano or micron sizes are used by mixing into drinks.
  • Another purpose of the invention is to prepare or produce drinks with solutions comprising nano or micron-sized ozonized oils.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils in combination with cleaning supplies.
  • Another purpose of the invention is to provide a brighter appearance to the fruits and vegetables and prolong their shelf life by spraying solutions comprising nano or micron sized ozonized oils on them.
  • Another purpose of the invention is to provide a prolonged shelf life of the food of animal origin such as meat, fish etc. by spraying solutions comprising nano or micron-sized ozonized oils on them.
  • a further purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oil in the spraying of plants or in the organic farming applications.
  • Another purpose of the invention is to provide the use of solutions comprising nano or micron-sized ozonized oils in chicken breeding.
  • Another purpose of the invention is to provide an effective solution for the elimination of endo and ectoparasites in the animals, humans, and plants.
  • Another purpose of the invention is to provide a solution for the destruction and degradation of pesticides and insecticides on fruits and vegetables.
  • Another purpose of the invention is to extend the shelf life of fruit and vegetable products by using an apparatus comprising the ozonized solution to the stems in order to increase the durability period in fruits and vegetables.
  • Another purpose of the invention is the use of the ozonized solution alone or in combination with auxiliary products such as thymol in bees to treat nosema disease, varroa, American rot disease, European rot disease, lime disease, as a hive disinfectant and to improve bee health.
  • auxiliary products such as thymol in bees to treat nosema disease, varroa, American rot disease, European rot disease, lime disease, as a hive disinfectant and to improve bee health.
  • a further purpose of the invention to prevent the production of dried apricot mites on the apricot and the resulting contamination by using ozone solutions by dipping and spraying methods.
  • a further purpose of the invention is to provide a solution with a repellant effect, which is found in studies to inhibit aphids, caterpillars and other insects from eating of leaves and expel them from the environment at the same time with the use of various doses.
  • Another purpose of the invention is the use of ozone solutions in the transport of liquid foods such as milk and to ensure the long-term durability of them without boiling.
  • Another purpose of the invention is to provide a solution with a repellant effect which acts both as a disinfectant and as a shaft louse and flea removing agent in poultry farms.
  • Another purpose of the invention is to provide a solution with an insect repellent effect in dry pulses.
  • Another purpose of the invention is the use of it to keep seeds in the soil and to prevent the formation of seed infections.
  • Another purpose of the invention is to provide a solution that prevents both infections and contributes to plant growth by applying them to the roots in greenhouse cultivation and soilless agriculture by mixing with water.
  • Another purpose of the invention is to provide a solution that allows the removal of parasites such as louse and fleas in pets in the form of sprays or shampoo.
  • Another purpose of the invention is to provide the ease of transport by removing the water by lyophilizing the ozonized solution. It can be used by re-dilution in this form.
  • Another purpose of the invention is to provide the use of it in space technology to produce plants in anaerobic environments. It provides benefits for plant development in the anaerobic environment in the form of a solution.
  • Another purpose of the invention is to provide an ozonized solution comprising saline water, which enhances the effect in products such as nasal drops, ear drops, eye drops.
  • Another purpose of the invention is to combine all vitamins and other anti-hair loss agents with ozonized solutions in order to increase efficacy in combinations preventing hair loss.
  • the use of fat-soluble vitamins in nanoparticles is a new form of use.
  • a further purpose of the invention is to provide a new method of use by injecting ozonized solutions with all vitamin combinations into the tissue in form of nanoparticles and to provide an enhancing effect to the tissue healing properties.
  • Another purpose of the invention is to provide ease of use in food supplement, toothpaste, mouthwash, animal food supplements by the formation of ozonized solutions with sugared water or sweetener.
  • a further object of the invention is the use of ozonized solutions in combination with oil or petroleum products as a fuel additive to improve engine performance.
  • Another purpose of the invention is to provide the fabric with antibacterial properties and to disinfect the fabric as a result of using solutions with ozone in the textile with washing, dipping, spraying methods or immersing the rope in solutions with ozone before the knitting.
  • the density of the solutions and ozone dosage can be increased.
  • Another purpose of the invention is to provide the digestive system preparations formed by the intensive doses of ozonized solutions in 3 different forms, namely, stomach-soluble capsules, small intestine-soluble capsules, and lower intestine-soluble capsules. It provides different advantages in each region.
  • Another purpose of the invention is to use it as an effective treatment method for oral infections such as stomatitis, gingivitis by applying directly to the gums or in the form of toothpaste.
  • the solutions comprising nano or micron-sized ozonized oils can be used in oral care products in various forms such as gargle (mouthwash), toothpaste additive.
  • a further purpose of the invention is to provide an effect to enhance fracture union by injection of the ozonized solution into and around the fracture hematoma.
  • the use of it in combination with vitamin K, vitamin D, calcium, etc. accelerate the fracture union.
  • Another purpose of the invention is the use of it in combination with hyaluronic acid in the intra-articular injection to benefit from its effect of increasing cartilage matrix. It is known that better results are obtained with the ozone treatment and hyaluronic acid combinations. In the studies of the invention, ozonide solutions in water are mixed at the ratio of 1 - 30% and the use of the effective solution in the joint with the addition of 1 - 2% hyaluronic acid increases the effect on cartilage healing.
  • Another purpose of the invention is to present an ozone solution comprising poppy oil.
  • the use of the poppy oil injection through the hepatic artery in liver tumors constitutes effective treatment.
  • Poppy oil is ozonized in nano or micron sizes, given in the same way, so that, its entry into the cancer cell is facilitated and its effect can be increased.
  • Another purpose of the invention is to present an ozone solution comprising St. John’s Wort oil (the extract of Hypericum perforatum obtained with olive oil).
  • St. John’s Wort oil the extract of Hypericum perforatum obtained with olive oil.
  • the effectiveness of ozone oil made with Hypericum perforatum (St Johns-wort) is known in the treatment of hemorrhoids.
  • the solutions comprising nano or micron-sized ozonized oil of Hypericum perforatum are used in the treatment of hemorrhoids in the form of suppositories.
  • the invention relates to the solutions comprising nano or micron-sized ozonized oils in designated ozone doses, comprising oil, ozone gas, water, and at least one emulsifier.
  • ozonized oil or ozonides are defined as for wound treatment, for skin diseases, for cosmetics, or for uses in the digestive system.
  • the application of ozone by parenteral means, the application of ozone by local injection, the application of rectal ozone, major therapy, minor therapy, regional ozone applications with bags and hearts are the main ozone application methods.
  • the targeted treatment method aims to ensure the widespread use of ozone by making it available in pharmacies with portable vials or ampoules.
  • it is to ensure the use of it in veterinary medicine, food industry, nutritional solutions, chemical industry, agriculture and to turn it into salable products in markets.
  • oils that are known as the best movers of ozone and as keeping it stable for a long time are ozonized.
  • the structures called ozonide are formed with the ozonization of oils. Basically, it is known that all oils can be ozonized.
  • the oils used in solutions comprising ozonized oil of the invention are divided into two as injectable oils and non-injectable oils.
  • Oils of vegetable origin used for injection purposes such as soybean oil, sesame oil, palm oil, poppy oil, soy lecithin, cholesterol, b-sterol, triglyceride, olive oil, fish oil, sunflower oil, castor oil, saffron oil (safflower), coconut oil, triglyceride derivatives, tributyrin, tricaprin, tricaprylin, and vegetable and animal fats for the purpose of feeding from the vascular way, for a person of 70 kg, adding up to 175 grams of fat emulsion to dietary solutions is a widespread method.
  • Ozonides formed by the ozone bubbles formed in the oil as a result of ozonization of all injectable oils such as paraffin (mineral oil), ethyl oleate, methyl oleate used in the chemical industry are used individually or as a combination in certain doses in order to get rid of the unique side effects of each oil.
  • Injectable oils are of vegetable and chemical origin. Oils of vegetable origin display exothermic reaction and give heat to the outside during the ozonization process. Therefore, during the ozonization of oils of vegetable origin, a cooling process should be applied. Long term ozonization of oils of vegetable origin causes their solidification. In this case, it is not possible to inject them. In the ozonization process of oils of chemical origin like petroleum derivatives such as paraffin, since they do not display exothermic reactions, their density remains almost stable. However, the injection of these oils of petroleum derivatives with intense ozone damage the tissues. In addition, oils and ozonides in the form of large particles make them difficult to absorb.
  • the solutions comprising ozonized oil comprises oil, ozone gas, distilled water, and emulsifier.
  • water used in solution making can be prepared with saline water, sugared water, mineral water, deionized water, demineralized water, spring water, saline solution or physiological saline solution according to the area of use instead of distilled water and this has perfected the invention.
  • the solutions prepared for the nasal drops that contain salt water or the ones used in the beekeeping industry that contain sugared water increased the efficacy.
  • solutions comprising ozonized oil may comprise additional substances such as water and/or oil-soluble vitamins, minerals, hyaluronic acid, plant extracts or active ingredients, essential oils, or thymol, in order to increase efficacy relative to the area of use.
  • additional substances such as water and/or oil-soluble vitamins, minerals, hyaluronic acid, plant extracts or active ingredients, essential oils, or thymol.
  • the doses determined in the solutions were ascertained to remain stable for 1 year at room temperature and it is predicted that in cold storage, for example at +4°C, it will extend over 10 years.
  • the content and usable quantity by weight/volume in the invention within these designated doses are indicated in Table 1. All samples which can be formed within Table 1 are within the scope of the invention.
  • the said solutions are the solutions comprising ozonized oil with a particle size range of 1 nanometer to 400 micrometers.
  • the oils that are used for injection and have been studied in terms of their damage to the body are ozonized.
  • the vegetable originated ones of these oils perform the exothermic reaction in the ozonization stage and their density increases.
  • hydrocarbon derivatives oils of chemical origin
  • Ozone generators are used as sources of ozone in the process of ozonization. Ozonization process is carried out with the use of ozone/oxygen mixture obtained from these devices.
  • Ozone/oxygen mixture obtained from these devices.
  • the density of ozone in vegetable oils is observed at 160 mg/gr, and in hydrocarbon oils at 120mg/gr. This constitutes a good and reliable measurement method for measuring the amount of ozone in the oil.
  • calculations are also made on micrograms. For example, in a session of major therapy, 100 ml (cc) ozone in a density of 30 micrograms is applied, so that a total of 3 mg of ozone is given mixed with oxygen.
  • tissue damage from 10 ppm to 500 ppm is minimal, with the increased doses also the damage increases, yet the amount of oxygen released increases and enhances the anti-bacterial effect and anti-inflammatory effects. It provides ease of use to be applied with local anesthetics in order to avoid the pain and feeling of burn that occurs during the application. These doses were applied as 0.5 ml in rats. The same dose will show the same local effect in humans. No significant side effects were observed in the studies. The pathological examinations reveal that it did not cause any damage to the liver, kidney or lung tissues. This situation showed that 3-4 ml of ozone solution can lead to good results and be used safely in intra-articular applications in combination with local anesthetics.
  • this dose is equivalent to 35-70 ml ozone for a 70 kg person compared to the treatment dose of 4 ml ozone applied to humans.
  • the safety interval will be very high as the application of 3-4ml ozone solution to 70 kg human will be effective.
  • the ozonides being a dense oil solution becomes an advantage. Subcutaneous and intramuscular applications of dense oils provide slow release of the drugs in the oil and form long-release drugs. The injection of bupivacaine in oil provides a local effect for 72 hours.
  • the ozone amount in 0.1 ml oil is about 1 mg.
  • the ozone/oxygen mixture made with ozonizer is given into the joint as 20 microgram of ozone in 20 ml (cc). 2.5 times the dose of 400 micrograms of ozone is provided with such a small amount of oil. It is also known that together with the ozone in ozonized oils or ozonides is measured in grams, and its interaction with the oils, it ensures that the oils become saturated and its structure is changed.
  • the mechanism of action oxidizes the area in which it is applied, causing damage in the tissue and therefore activates the repair mechanism of the body.
  • ozone is bound to the carbons as 02 and O- and both are transferred to the tissue. In high doses, it oxidizes the tissue and creates tissue damage. In low doses, it is released slowly from the oils and thus oxygen is released into the tissue as well as free oxygen. This enables tissue healing and provides bounding of free radicals.
  • the healing mechanism that is seen in wound treatment and the reactions seen in skin creams reveals the increase in oxygen transport to the tissues. When applied on the skin, the amount of oxygen absorbed into the subcutaneous tissues is increased and the color of skin is enlightened.
  • both the wound area and the repair mechanism is activated by oxidation and the free oxygen in the ozonized oil or ozonide is transferred to the tissue which resulted in an increase in the oxygenation of the tissue.
  • Its antibacterial, antiviral, antifungal properties and anti-inflammatory and analgesic effects are other wound healing effects. It is thought that these effects will also be activated in regional injection applications just as they are activated in epidermal applications. In studies conducted on rats, it is seen that subcutaneous injections of a high dose such as 1 mg/gr do not cause the death of rats, but cause skin necrosis together with regional hair loss and scar formation.
  • this injection dose is 70000 times more than the regional injection dose applied to human, it means to apply 70 grams of ozone injection to a person of 70 kg on the same area will be done 3 days in a row. With the use of these doses, rats were monitored for a month and no deaths occurred.
  • the density of ozonized oils or ozonides can make injection difficult and cause regional redness and necrosis. For this reason, the oil emulsions in the prepared water is another form of application.
  • Ozonized oil or ozonides are dissolved in water using many various methods (ie. with ultrasonic oil digesters, nanotechnological methods, etc.) to make solutions comprising ozonized oils or ozonides. In microscopic examination, ozonized oil or ozonides having a nano or micron particle sizes are suspended in water in a wide range from 1 nanometer to 400 microns. These solutions can optionally be prepared at concentrations ranging from 1 % to 90%.
  • the emulsifiers used to form oil emulsions (solutions) have been successfully used for years to form intravenously nutritional solutions.
  • the emulsifiers such as the lecithin formed from egg yolk, lysophospholipid (12), polyethylene glycol (PEG), phosphatidylethanolamine (PEG-PE), pluronic, Polysorbate 20, Polysorbate 80 are applied and currently marketed in the products. These are safely used emulsifiers. While one or more of these agents are used in human and animal health, emulsifiers for general use can also be preferred in other industries.
  • oil particles in nano or micron sizes can be done with various methods. Solutions comprising ozonized oil in nano or micron sizes of the invention are preferably made in two ways. In either way, preferably, the oil or oil mixtures that the application will be made are ozonized first, then nano or micron particle creation and emulsion process can be done. However, nano or micron particles can be created first and then ozonization can be applied. In this case, the particle size increases.
  • the production method of solutions comprising ozonized oil in nano or micron sizes of the invention comprises following process steps;
  • oils used in the process step A are preferably injectable oils.
  • oils of vegetable and animal origin such as soybean oil, sesame oil, palm oil, poppy oil, St. John’s Wort oil, soy lecithin, cholesterol, b-sterol, triglyceride, olive oil, fish oil, sunflower oil, castor oil, saffron oil (safflower), coconut oil, triglyceride derivatives, tributyrin, tricaproin, tricaprylin, or oils of chemical origin (hydrocarbon derivatives) such as paraffin (mineral oil), ethyl oleate, methyl oleate are used.
  • oils are subject to ozonization for preferably 10 days. The duration of the ozonation process depends on the type and quality of the oil used and the usage area.
  • Ozone generators are used as sources of ozone in the process of ozonization. Ozonization process is carried out with the use of ozone/oxygen mixture obtained from these devices.
  • the amount of ozone in the oil can be determined by measuring the mass of the oil that is subjected to the ozonization process before and after step A. Precision scales are used for the measurement process. In this way, the amount of ozone in the oil is determined in milligrams.
  • Ozonization process varies according to the intensity of the ozonizer.
  • oil is measured in grams with an industrial ozone generator having an ozone output of 100 grams per hour. After 3 - 4 hours 10-15% of ozonized oil is obtained. In this way, 10 kg of oil becomes 1 1 - 1 1 .5 kg in weight. This varies depending on the type of oil. If the volume of the ozonizer is reduced and the volume of oil is increased, the ozonization process time is extended. Usually over 10%, the ozonization process takes a long time.
  • ozone devices are not standard, the ozone and oxygen rates they contain cannot be fully determined. For example, not only the amount of ozone in the gas emitted from the ozone generating machine with a source comprising 90% oxygen is less, but also other foreign gas quantities mix into the oil. In this case, when we accept the oil as 15% ozonized, we calculate it wrong. When the oils are saturated only with oxygen, they are aggravated by oxygen up to 6%. At the same time, in the process performed by closing the oxygen supply, the oil does not receive any ozone from the air, but because the oxygen content is very low, nitrogen and other gases in the air are also loaded, and an ozonized oil with a much-altered standard is obtained.
  • Ozone bearing capacity of oil decreases over time.
  • the oil is saturated in a few days and became frozen while the ozonization process continues.
  • Saturated oil may be dissolved again and then subjected to ozonization.
  • this process is repeated several times and 1000 g olive oil increase by 160 g and becomes 1 160 g olive oil with ozone or ozonide in 8-10 days. This situation is usually valid for all vegetable oils. Since hydrocarbon oils such as paraffin do not freeze, heating is not required.
  • 1000 g of paraffin becomes 1 100 g when it is subjected to 3 days of ozonization. In such oils, ozonization as much as olive oil is not formed.
  • the high ozone process makes the oil more acidic.
  • the amount of ozone in the oil is calculated in grams and the amount of ozone to be added according to the amount of oil added to the mixture is determined. In other words, if 10% of ozonization is made in 10 grams of oil, 1 g of ozone will be present and 1000ppm of ozone will be found if this amount is to be completed in a liter of water. If ozonization is made by 15%, the rate will be 1500 ppm. This is important to produce pharmaceutical formulations. In the applications of the current technique, oils with ozone are emulsified but the amount of ozone gas in the oil is not specified. In order to determine the doses that perfected the invention, studies are carried out with the calculation of ozone in ozonized oil in all steps of product creation.
  • the temperature of the mixture comprising water and at least one emulsifier is 10 - 15°C above the melting temperature of the oil depending on the type of oil used.
  • distilled water is heated up to 70°C and at least one emulsifier is added at the process step B.
  • the temperature of the distilled water and emulsifier mixture is 70°C.
  • the water and emulsifier are mixed preferably at 1 1000 rpm for 5 min in process step B.
  • the emulsifiers such as the lecithin formed from egg yolk, glycerin, lysophospholipid (12), polyethylene glycol (PEG), phosphatidylethanolamine (PEG-PE), pluronic, Polysorbate 20, Polysorbate 80 or different substances can be used as emulsifiers.
  • Polysorbate 80 is used as an emulsifier. Due to the emulsifier, water and oil are mixed within each other.
  • the temperature of the mixture comprising water, at least one emulsifier and ozonized oil is 10 - 15°C above the melting temperature of the oil depending on the type of oil used.
  • ozonized oil (or ozonide) at 70°C is added to the distilled water and emulsifier mixture at 70°C in the process step C.
  • the mixture is blended at high speed within the mixer having the cutting blades. In a preferred embodiment of the invention, mixing is performed using speeds between 1 1000 to 13600 rpm.
  • solutions comprising disintegrated ozonized oil (or ozonide) having particle sizes of 1 nanometer to 400 micrometers are prepared.
  • An alternative method is the use of high-speed motors to create a nanoparticle.
  • the production made with these devices preferably at 36000rpm speed does not require heat treatment and then the cooling process will not be necessary.
  • the use of these devices allows both the degradation of oils in the medical field, the cosmetic industry and the chemistry, as well as the separation of extracts and powders, making the solution easier to obtain and obtaining nanoparticle solutions.
  • the use of this type of device is important in these applications as it is feared that the heat treatment may reduce the amount of ozone. This type of cold particle formation process should be standardized in the drugs with the ozone solution.
  • solutions comprising water, at least one emulsifier and ozonized oil (or ozonide) are cooled via the spraying process.
  • the resulting solution is allowed to cool suddenly by spraying to a cold area. Keeping the disintegrated oil warm for long time results in particle growth.
  • the cooling process is applied to prevent this.
  • cold homogenization devices are used for the cooling process.
  • solutions comprising ozonized oil in nano or micron sizes can be cooled to temperatures down to 4°C or lower. Although there is no specific temperature range for cooling, high temperatures can cause particle growth.
  • the particle sizes of the solution comprising ozonized oil are reduced down to 1 nanometer using ultrasonic cutting methods.
  • Ultrasonic cutting methods are carried out with pieces of equipment such as ultrasonic splitter or reactor etc.
  • solutions comprising ozonized oil with particle sizes within the range of 10 - 50 nanometers can be used.
  • the solutions of the invention include ozonized oil in the range of 1 nanometer to 400 microns.
  • nanotechnological methods such as high-pressure homogenizers, micro-fluidization, ultrasonic emulsification, electrolysis or zeta potential can be used as an alternative to form micro or nanoparticles in the production of the ozonized solution.
  • the oil to be used for the preparation of the solutions of the invention is weighed primarily through the precision scale and the result is recorded.
  • the oil is subject to the ozonization with the ozone/oxygen mixture obtained from the ozone generator. Following the ozonization process, the measurement is made again with the precision scale and the amount of ozone in the oil is obtained in milligrams.
  • ozonized oil (or ozonide) at 70°C is added to the mixture comprising distilled water and preferably polysorbate 80 at the same temperature and preferably mixed with the mixer comprising cutting blades at high speed such as 1 1000 to 13600 rpm.
  • the resulting solution consists of ozonized oil (or ozonide) particles at sizes between 1 nanometer to 400 micrometers. This solution is cooled down by spraying to a cold area. Finally, the solution to be prepared is packed according to the desired form, content and quantity.
  • the ozonization of the stable nano or micron-sized particles obtained by the rapid spraying of the nano-or micron-sized particles formed by mixing above 10°C of the melting point of the oil with a mixer of cutting blades at a speed of 1 1000 - 13600 rpm is another alternative method.
  • the hot environment may cause the ozonides to dissolve and may reduce the ozone levels in the oil.
  • Solutions comprising ozonized oil in nano or micron sizes of the invention can be produced by ultrasonic methods.
  • Ultrasonic oil shredders are used in these methods. Heat treatment is not used in the formation of particles in nano or micron size by the disintegration of the oils with ultrasonic methods. During the application, cooling can be applied. There is no need to use emulsifiers in this method. Because particles smaller than 1 micron can be formed. As the application time increases, the particle size is reduced. With this method, oil particles can be reduced from 1 nanometer to 400 micrometers.
  • the duration of stay in the tissue according to the intensity can be calculated and other drugs can be injected into the tissue together with ozone to provide long-acting.
  • Lidocaine which is normally effective for up to 2 hours in the injection zone, increases the duration of the effect compared to the injection of the oil.
  • the regional interactions of other drugs and the release time of systemic drugs can be calculated. It is especially important that the application of ozonized oil or ozonide to subcutaneous tissues should not be in intensive doses and should be in diluted solutions. In order not to have subcutaneous tissue necrosis, solutions in water comprising 1 - 10% ozonized oil or ozone are preferred.
  • ozone In the applications to deep tissue, muscle and adipose tissues, more intense doses should be taken. However, given that a regional injection dose of ozone is 3 - 5 mg, the application can be performed easily with 1 ml of the solution having 5% ozone. In wound treatments, creams of 10 - 15 gr with ozonized oil or ozonide comprising 160 mg/gr ozone are regionally applied. This intensive ozone dose is more effective in wound treatment, and that the low-dose ozone-comprising creams did not cure the wound quickly was observed in studies. Considering all these, it is thought that a higher dose of ozone should be given in regional injections yet ensuring that there are dilute doses.
  • the solution of ozonized oil or ozonides in the water is easy to apply at the rates that vary according to the region in dosage adjustment. It also facilitates regional absorption through the creation of nano or micron-sized particles, thereby allowing it to be absorbed from the region without causing tissue necrosis and allergic reactions.
  • Diluted ozone solutions can be prepared by adjusting the ozone dose in both ozonized oil and ozonide and by adjusting the density in solution in water. It is thought that there is a large amount of ozone in the low amount of oil in the injection of concentrated ozone or ozonides. The less oil is used in injection, the less the side effect of the oil experienced. For this reason, solutions of the oils with high-ozone in water are advantageous.
  • Dosage adjustment of the solutions comprising disintegrated ozonized oil in nano or micron sizes can be made and dilute solutions can be prepared. Thus, ozone is used more safely.
  • the solutions comprising ozonized oil in prepared nano or micron sizes are prepared in doses varying according to the usage areas and the apparatus used.
  • the formed mixture is cooled down by adding the substances such as Witepsol.
  • solutions comprising ozonized oils of the invention are combined with drugs such as insulin or local anesthetic drugs, they prolong the release and action times of these drugs and facilitate their absorption.
  • the intramuscular injection of the solution comprising ozonized oil of the invention mixed with 5 - 10 ml (cc) of venous blood is equivalent to the treatment method known as minor therapy.
  • the said solutions comprising ozonized oil can be used in all external forms and mucosal forms together with silver nanoparticles.
  • the solutions comprising nano or micron-sized ozonized oil of the invention can be used as combined with silver or similar other metals that shows oligodynamic effects.
  • solutions comprising ozonized oil can be combined with hyaluronic acid and fat-soluble vitamins.
  • the cause of regional pain is the decrease in tissue oxygenation due to muscle spasm and the increase in inflammation due to it.
  • ozone/oxygen gas is given to the pain zone as superficial and deep. 20 micrograms of ozone gas 40 - 50 ml (cc) is injected locally to provide an anti-inflammatory analgesic effect.
  • muscle relaxant effects are obtained.
  • Ozone oil in nanoparticles or micron sizes dissolved in water can be injected regionally by subcutaneous and intracellular ozonized oil or ozonide application. It is known that paraffin oil has muscle relaxant properties in the injection.
  • Ozone concentration used in regional applications is in doses of 1 - 2 (1000-2000ppm) mg with ozonized oils comprising preferably 10% ozone, yet, since the dissolution of ozone in oils can be prolonged up to 72 hours, it can be raised up to 5 - 6 mg doses.
  • This application can be done in the same area at most twice a week.
  • Local anesthetics lidocaine or bupivacaine, anti-inflammatory agents may be added to the solution.
  • Ozone gas injection may cause short-term burning and itching. However, this effect is rarely seen in intramuscular injections. For this reason, ozonide solutions comprising local anesthetic should be preferred especially if superficial injection will be performed.
  • ozonized oils comprising preferably 10% ozone
  • ozonized oils comprising preferably 10% ozone
  • it can be applied at most twice a week.
  • Vitamin E which becomes popular in experimental studies in recent years, can be applied together with oil solutions and anti-inflammatory drugs.
  • Hyaluronic acid is known to increase cartilage matrix in the intraarticular injection. It is known that better results are obtained with the ozone treatment and hyaluronic acid combinations.
  • ozonized oil or ozonide solutions in water are mixed at the ratio of 1 - 30% and the use of the effective solution in the joint with the addition of 1 - 2% hyaluronic acid increases the effect on cartilage healing.
  • Cervical disc and spinal disc hernias are one of the common health issues.
  • the pain score is evaluated according to the VAS in 1 month, 4 months and 1 year after the regional injections of 8 sessions of ozone, 2 sessions of PRP.
  • the pain score was 9.3 at the beginning, 6.9 in the first month, 4.8 in the 4th month and 3.6 at the end of the first year.
  • the regional injections of ozone are so effective.
  • the dosages of solutions of ozonized oil or ozonides in water in regional applications are also applicable here.
  • the ozonized oil or ozonide solution of 2 - 4 mg (2000-4000ppm), which is made with ozonides comprising 10% ozone may be injected into paravertebral muscles and subcutaneous tissue to be able to benefit from anti-inflammatory and analgesic effects.
  • tissue oxygenation, dissolution of muscle spasm, and increased blood supply to the hernia a long-acting treatment and shrinking of the hernia is provided.
  • Ozone application is one of the most effective methods in wound treatment. Wound treatments usually fail, and the organ loss is experienced. Both giving the ozone to the area of the wound with a bag in the region, and the major therapy with regional injection are known methods of ozone treatment. However, since ozone therapy is not very widespread and requires the ozonizer, it has a limited area of use.
  • the regional injection of solutions of ozonized oils or ozonides in water and the use of intensive doses of oils in combination are effective in wound healing. It plays an effective role in wound treatment due to the use of 4 - 5 mg ozonized oil or ozonide solution in water as a regional injection and the superficial (epidermal) use of 160 mg ozonized oil or ozonide.
  • the solutions of the invention can be used in wound treatment with silver nanoparticles.
  • Ozone therapy plays an effective role in the treatment of plantar fasciitis, tennis elbow, tendinitis and in the elimination of regional pain.
  • Application of ozonized oil or ozonide solutions of 1 - 2 mg (1000-2000 ppm) in water prepared with ozonized oil comprising preferably 10% ozone to the area is an effective treatment method.
  • lubricants comprising chlorhexidine and lidocaine used in catheter applications are preferred to prevent the penetration of bacteria into the probe.
  • the solutions of ozonized oil or ozonides in water are used as a true lubricant for both its nontoxic features and oil content. It is a highly effective lubricant when it is applied together with local anesthetic due to its long-term release of ozone in the oil and the longer lasting effect of local anesthetic release. Silicone probes should be preferred due to the negative interaction of ozone with plastic.
  • solutions of ozonized oil or ozonides with anti-inflammatory, analgesic, antibacterial effects in the treatment of cystitis and urethritis, even with ureteral catheter applications has a positive impact on tissue healing in this region.
  • the solutions of ozonized oil or ozonides can be applied daily into the bladder with the probe. Intake of plenty of fluids is recommended. The intravesical and urethral contact with the ozonide solution accelerates the recovery via antibacterial and anti-inflammatory effects. Treatment is provided with the use of solutions of ozonized oil or ozonides alone or in combination with antibiotics.
  • Genital area infections in women are viral, bacterial and fungal infections and are common and contagious diseases.
  • the use of ozonized oil or ozonide can be an effective method for the cleansing of the vulva, vagina, and perineum.
  • the use of disposable disinfectant wipes in order to facilitate disinfection is a practical method to avoid infections and unpleasant odors.
  • solutions of ozonized oil or ozonides in disposable packages which have both lubricating and disinfectant properties provides ease of use. Spraying of the disposable product into the vagina provides protection from the infections.
  • the solutions of the invention can be used in the form of a vaginal ovule or in different forms.
  • poppy oil in gynecological diseases and infertility treatment has been known for centuries.
  • the use of poppy oil as an intravenous washing solution can be an effective method for the treatment of infertility because of the anti-inflammatory effect of it in the tubal and uterus, the canals will remain open and the negative effects of the autoimmune system will be eliminated.
  • solutions comprising nano or micron-sized ozonized oil of the invention can be used in the form of an eye drop or in various forms.
  • the drops used in the external ear and middle ear infections and dermatitis cause the nesting of the fungal infection while eliminating the bacterial infection. If there is also dermatitis, a new preparation should be added to the treatment.
  • the use of solutions of ozonized oil or ozonides as an ear drop allows the application of these multiple treatment methods at the same time. Thus, the treatment with a single product is provided instead of the one using several products. Dosages can be adjusted according to the intensity of infection. Use of solutions of ozonized oil or ozonides twice a day may be sufficient. Treatment of chronic dermatitis can take longer periods such as 1 month.
  • Sinusitis is a disease that is characterized by pain and throbbing in the acute or chronic phase, which is not possible to treat as it is known. Despite many treatments with antibiotics, it cannot be cured. Because it is not possible to reach the focus of the infection. This leads to unnecessary use of antibiotics.
  • the studies carried on with the invention revealed that the regular use of ozonized oil or ozonide solution by reclining the head not only provides the removal of the infection but also activates the anti inflammatory and analgesic effects by reaching into the sinus. Also, the modulation of the immune system solves issues relating to allergic rhinitis and permanently eliminates the sinusitis problem.
  • the solutions of ozonized oil or ozonides at 40% concentration may be applied together with local anesthetics as it has a burning effect for the first 1 -2 minutes. They can be combined with the decongestant or anti-inflammatory nasal drops. However, these are not generally needed. Even the initial application plays an effective role in the treatment. In these forms, preferably the form of saline water is used. However, it is important to use it regularly for 1 month, once a day and wait for the solution to enter the sinuses by keeping the head behind for 15 minutes following the application. The inside of the sinuses is completely cleaned due to daily application. Since it will be effective for allergic rhinitis, thus opening the nasal passages.
  • Maintenance treatments include softening of the nasal mucosa, the use of nasal sprays comprising solutions of ozonized oil or ozonides which are prepared for anti-allergic and anti-inflammatory effects 2 - 3 times a day prevents the formation of infections by relieving the nasal mucosa.
  • nasal sprays comprising solutions of ozonized oil or ozonides which are prepared for anti-allergic and anti-inflammatory effects 2 - 3 times a day prevents the formation of infections by relieving the nasal mucosa.
  • saline water preferably the form of saline water is used.
  • solutions comprising nano or micron-sized ozonized oils can be used in the form of a drop, spray or in various forms for the treatment of otorhinolaryngologic diseases. It can also be combined with the appropriate substances.
  • solutions comprising ozonized oils into dental cavities daily in doses such as 40% eliminates the infection by treating the cavity in a short period of time.
  • solutions comprising ozonized oil or ozonide in tooth extractions and dental treatments together with local anesthetics eliminates the infection and accelerates the healing process by increasing regional oxygenation.
  • the injection of solutions comprising ozonized oil or ozonide into the abscess area prevents infection.
  • solutions comprising ozonized oil or ozonide into the tooth cavity prevents infection.
  • solutions comprising nano or micron-sized ozonized oils can be used in oral care products in various forms such as gargle (mouthwash), toothpaste additive.
  • ozone products in the form of pastilles are used as mouth and throat antiseptics.
  • the taste and effect of the pastille that contains ozonized oil or ozonide can be modified by adding antiseptics and sweeteners.
  • Pastilles can be used three to five times a day. Since it does not contain antibiotics, it is a safe product that does not include toxic substances to be used in esophageal diseases.
  • Pastilles comprising ozonized oil or ozonide doses of 5 - 10 (5000- 10000ppm) preferably made with ozonized oils comprising 15% ozone is suitable for the treatment.
  • Disposable packages with dilute solutions comprising ozonized oil or ozonides to be mixed in beverages can be prepared to be used by mixing into juices or other drinks.
  • beverages comprising ozonized oil or ozonides can be prepared.
  • ozone is absorbed from the intestine and increases the oxygenation in the blood by passing systematically to the circulatory system.
  • the capsules made with using injectable vegetable oils and dissolving in the intestine is used. Ozone is transported up to 160 mg with 1 gr oil.
  • These doses of capsules with ozone of vegetable origin constitute a treatment method which is effective in the systemic circulation and non tissue-damaging.
  • ozonized oil or ozonide capsules comprising 50 (50000 ppm) mg ozone made with ozonized oils comprising 15% ozone are used. 1 - 2 capsules per day is appropriate.
  • the suppository comprising ozonized oil or ozonide prepared for use in the treatment of colon infections, colitis ulcerous, and Chron's disease, as well as autoimmune diseases, contains 320 mg ozone in 2 gr oil.
  • the application of these suppositories 1 - 2 times a day reduces intestinal infections and increases intestinal oxygenation. It provides regulation of the immune system and heals autoimmune intestinal diseases. It also allows the passage of oxygen from the intestines to the bloodstream and creates systemic effects.
  • suppositories are effective in the treatment of hemorrhoids, rectal fistulas, and fissures.
  • the effectiveness of ozone oil made with Hypericum perforatum is known in the treatment of hemorrhoids.
  • the solutions comprising nano or micron-sized ozonized oil of Hypericum perforatum are used in the treatment of hemorrhoids in the form of suppositories.
  • the solutions comprising nano or micron-sized ozonized oils obtained by ozonization of these oils in the form of suppositories are effective in the treatment of hemorrhoids, fistulas, fissures.
  • the intraperitoneal injection of the solutions of ozonized oil or ozonide in peritonitis constitutes an effective method for the treatment of infection.
  • the daily administration of solutions of 2% ozonized oil or ozonide of 20 ml (cc) by intraperitoneal injection is used to eradicate the infection and to create tissue regeneration.
  • solutions comprising ozonized oil in nano or micron sizes of the invention can be produced in the form of capsules dissolving in different pH ranges, in suppository form or in various forms and in combinations with the appropriate substances.
  • streptokinase used for the opening of atheroma plaques in arteries also dissolves the thrombus plaque in the vessel in the acute phase.
  • solutions comprising ozonized oil formed as a result of ozonization of cholesterol
  • the atheroma plaque is dissolved, and the vessel is opened.
  • the administration of it with vitamin K or with other appropriate substances accelerates its effect.
  • ozonization of fats such as cholesterol, triglyceride, phospholipid
  • the arterial injection of the solutions obtained by the ozonization of cholesterol adhere to the atheroma plaque and dissolves the atheroma plaque.
  • Ozone administration to the parenteral circulation is known to break down the surfactant in the alveoli.
  • the use of particles of soybean oil in 100 - 150 micrometers in nutritional solutions ensures the intravenous use of oils.
  • the solutions of ozonized oil formed by ozonized soybean oil which is composed of ozonized oil or ozonide in small sizes up to 50 nanometers by ultrasonic digestion method, the slow release in parenteral solutions and the dissolution of ozone in the blood before it reaches the lung and is converted to free oxygen, a harmless agent is formed.
  • the administration of the solution of ozone oil comprising 100 mg ozone in 1 gram diluted preferably to 0,1 -1 % (100-1000ppm) in 500 ml serum in 6 to 8 hours constitutes an effective parenteral solution. It can be effective in cardiac diseases as it increases cardiac health and coronary oxygenation.
  • Ozone is widely used in skin diseases and cosmetics as ozone oil and ozonized water.
  • Ozone oils in various doses obtained by the ozonization of oils depending on the ozonization process are still used. Since the solutions comprising ozonized oil of the present invention contain ozonized oil in the range of 1 nanometer to 400 microns relative to other dense ozonized oils, preparations that are much faster to absorb from the skin are formed. Besides, it can be used together with vitamins A, D, E, K as particles in nanoscale or micron sizes and accordingly increase their absorption from the skin. Due to nano or micron-sized particles, it facilitates the absorption of many substances from the skin.
  • Solutions comprising ozonized oil in nano and micron sizes can be used for dermatitis, acne, allergic dermatitis, anti-aging and wrinkle prevention.
  • the subcutaneous administration of the injectable agents created as a result of the ozonization of soybean oils and alpha lipoic acid used for mesotherapy is a novel method of the invention.
  • the lipolytic properties of ozone are known.
  • Administration of ozone gas for mesotherapy is a fat-burning method.
  • Alpha lipoic acid is also used for the same purpose.
  • the efficiency of mesotherapy is increasing with the injection of nano or micron sized particles formed by the ozonization of alpha lipoic acid under the skin. It can also be combined with other mesotherapy agents such as phosphatidylcholine.
  • the fat transferred to the liver is ozonized and the effect of fat on the liver is reduced. Can be applied 1 to 2 times per week.
  • the subcutaneous application of the solutions of ozonized oil or ozonide increases regional oxygenation and increases the nourishment of hair follicles. It can be combined with other hair mesotherapy agents such as vitamin E and minoxidil. Can be applied 1 to 2 times per week.
  • the solutions of the present invention used for hair treatments in combination with fat-soluble vitamins, water-soluble vitamins, saw palmetto, ginseng combined with fat-soluble forms of vegetable extracts have been found to enhance the efficacy of the samples.
  • solutions comprising nano or micron-sized ozonized oils in facial mesotherapy increases collagen synthesis by increasing oxygenation under the skin. It increases the regeneration ability of the tissue and reduces the formation of wrinkles.
  • the solutions of the present invention used for skin treatments in combination with fat-soluble vitamins, water-soluble vitamins, hyaluronic acid, ginseng combined with fat-soluble forms of vegetable extracts have been found to enhance the efficacy of the samples.
  • the solutions comprising nano or micron-sized ozonized silicone oil and other solutions comprising ozonized oil are used for facial mesotherapy. Due to the invention, the formation of spots is reduced with the removal of the toxic substances accumulated in subcutaneous tissues from the environment by the oxidation of free radicals. Ozone gas injection into subcutaneous tissues is known to reduce blotches. The injection of solutions comprising ozonized oils into subcutaneous tissues 1 - 2 times a week constitutes an effective method of treatment.
  • the solutions comprising nano or micron-sized ozonized oils can be combined with other injectable products such as Vitamin E, Vitamin A, vitamin C, hyaluronic acid. The use of it combined with Vitamin K, with Vitamin C, and with hyaluronic acid constitutes an effective method in the treatment of purple eyes.
  • solutions comprising ozonized oil in nano or micron sizes can be used for the purposes of protecting animal health, for the eradication of bacteria, viruses, and fungi, as well as for increasing their healthy development and reproductive capabilities.
  • the intramuscular injection of solutions comprising ozonized oil once a week is an effective method in preventing animal diseases. It reduces costs by reducing the use of antibiotics.
  • solutions comprising nano or micron-sized ozonized oils can be used both inside the fistula and in the form of a regional injection for treating mastitis in veterinary medicine.
  • solutions comprising nano or micron-sized ozonized oils can be applied into the vagina in vaginal infections and applied to the oral areas in oral and nasal infections as effective treatment methods in veterinary medicine.
  • solutions comprising nano or micron-sized ozonized oils can be applied to the cavity and periphery of the abscess for the abscess treatment in veterinary medicine.
  • solutions comprising nano or micron-sized ozonized oils can be applied as intra- articular injections in the treatment of joint diseases and as regional injections in treating regional pain in veterinary medicine, just like humans.
  • 1 liter of ozonized oil or ozonide solution preferably made with ozonized oil comprising 10% ozone comprising 40 g ozone is mixed into 100 liters of water.
  • the mixing process conducted with a mixer ensures better dispersal of the solution.
  • spraying can be applied also on the line.
  • a group of fruits and vegetables were sprayed with a solution comprising preferably 1 % ozonized oil and another group of fruits and vegetables were not sprayed with a solution comprising ozonized oil.
  • These fruits and vegetables were kept at room temperature. 10 days later, it is observed that while the wrinkling and decay in the fruits and vegetables that are not sprayed is unacceptable, the fruit and vegetables sprayed with the solution comprising ozonized oil did not lose their healthy images.
  • the percentage of the solution comprising ozonized oil used in the study as %1 is not a limiting value. This ratio can be increased.
  • the packaging of meat by passing through the ozone gas is known to increase shelf life by two times.
  • Spraying of the solutions comprising ozonized oil in nano or micron sizes formed by ozonization of vegetable oils in a thin layer in dilute doses during the packaging of white meat and red meat ensures that the meats seem fresh and alive and prevents them from drying due to its water content. It also prevents bacterial, viral and fungal contamination. And thus, prolongs the shelf life. There is no harm in the consumption of these foods.
  • ozonized oils or ozonides have healing effects on the digestive system when swallowed.
  • the use of solutions comprising ozonized oil in nano or micron sizes as stabilizers in order to prevent decay of the packaged foods and beverages makes it both harmless and a useful additive for the digestive system and general body health.
  • ozone pills to human health are known and they have been used for many years. The effects are profound, especially in the treatment of stomach and intestinal infections. It is also effective in parasitic and fungal infections. It also improves health and provides oxygen to the body. The same applies to animal health. In particular, it is very common for chickens living in poultry farms with dense populations in congestion to infect each other and cause great outbreaks. This leads to mass deaths. Mixing the solutions comprising ozonized oil in nano or micron sizes to the drinking water of chicken prevents the infections as well as enhances the health of the chicken. The calculation of solutions comprising ozonized oil in nano or micron sizes that are added to the drinking water of chickens can be made according to the daily human dose/kilos.
  • ozone released into the environment helps eliminate the bad odors in the chicken farm and reduces the number of bacteria spread in the air.
  • the solution comprising ozonized oil comprising 40 g of ozone in 1 liter is 40000 mg, the solution comprising ozonized oil comprising 1 liter of ozone per day can be added to the amount of daily water needed by 40000 chickens. The mixing process conducted with a mixer ensures better dispersal of the solution.
  • solutions comprising ozonized oil in nano or micron sizes in chicken breeding allows chickens to produce healthier eggs and protects them from infectious diseases. In addition, it reduces the use of antibiotics is in chicken breeding.
  • a mask should be used during spraying. However, there is no harm in swallowing some.
  • solutions comprising diluted ozonized oil as a spray increases the lifetime of the plant due to its low oil ratio and its oxygen secretion ability, and with its small amount of oil content, it makes the leaf look brighter by creating a thin layer on it.
  • spraying at intervals of 10 days is sufficient for the plant to appear bright.
  • the solutions of 1 % (1 OOOppm) are sufficient. Solutions comprising ozonized oil in nano or micron sizes prevent fungus and bacteria formation on the plant.
  • ozone which is a powerful disinfectant, is used for water disinfection, in disinfection of storages and hygienic areas.
  • Solutions comprising ozonized oil in nano or micron sizes in combination with dishwasher detergents and cleaning agents increase the disinfectant effect of detergents and prevent the formation of contact dermatitis by reducing the toxic effects of the cleaning agents on the skin.
  • mixing solutions comprising 3 - 5% ozonized oil in a variety of doses of 1000-5000 ppm (mg/L) during the preparation of detergents increases the disinfectant effect of the detergent and provides therapeutic effects against the adverse effects of detergents on the skin. These ratios can also be changed according to the desired duration of efficacy.
  • Solutions comprising ozonized oil in nano or micron sizes can be added to cleaning materials and used in various forms and for various purposes.
  • Disposable wipes used for hygiene can be divided into groups such as baby wet wipes, daily wet wipes, intimate cleansing wipes, or wipes for wound care, makeup removal, face and skin care, or wipes created for the elimination of warts.
  • ozone as a disinfectant in the solutions of the invention, its tissue healing properties and its ability to keep the tissue moist via the oils provides the multi-purpose use of the solutions comprising ozonized oil in nano or micron sizes.
  • the solutions of the invention have no side effects compared to other products comprising toxic substances. On the contrary, it has tissue healing properties. Solutions comprising ozonized oil in nano or micron sizes can be used in disposable wipes alone, preferably at a rate of%1 - 5 (1000-5000ppm).
  • Solutions comprising ozonized oil in nano or micron sizes prevent rash formation on babies due to its oil content. Therefore, there is no need to use other creams. It can be used with other antibacterial agents.
  • solutions comprising ozonized oil in nano or micron size at the high rates such as %10 - 20 (10000-20000ppm) are used to prevent the formation of fungi and viruses.
  • %10 - 20 10000-20000ppm
  • solutions comprising ozonized oil in nano or micron size at the high rates such as %10 - 20 (10000-20000ppm) are used to prevent the formation of fungi and viruses.
  • the use of it before or after sexual intercourse prevent contaminations by contact. It also improves the healing of the tissue. It is also suitable to use intra-vaginal solutions in combination with solutions comprising ozonized oil in nano or micron sizes.
  • the invention relates to the use of solutions of ozonated oil comprising nano or micron sizes comprising 10 - 100 000 mg / L (ppm) ozone gas as a disinfectant, preservative or food supplement in the food industry; as a disinfectant, repellent, feed-fattening contribution in the livestock industry; in pharmaceutical compositions for treatment of diseases in the health industry, especially in dermatology, otorhinolaryngology, eye diseases, oral-dental diseases, digestive system, urology, gynecology, orthopedics, circulatory system diseases, ozone therapy and mesotherapy; in the production of personal care products used in the cosmetics industry, especially in the skin, mouth, hair care; in the production of detergents and disinfectant products in the chemical industry and as an additive for the petroleum products; in textile industry as bleach, disinfectant or anti-bacterial textile chemicals; as a preservative and repellent in end products in agricultural industry, as an insecticide, pesticide, fungicide, virucide, and bacteria killer in
  • 100 000 mg / L (ppm) ozone gas are within the scope of the invention:
  • a nasal solution comprising 10 to 5000 mg/L of ozone gas, preferably with ozonized oil comprising 5% ozone gas by weight, and preferably with physiological saline solution, having a greater oil density, to provide lubrication of the nasal mucosa.
  • ozonized oil comprising 5% ozone gas expression means that every 100 grams of ozonized oil used in the preparation of the solution comprise 5 grams of ozone gas.
  • solution comprising 10 to 5000mg/L of ozone gas means that each 1 -liter solution can contain ozone gases from 10 to 5000 mg.
  • a nasal solution comprising 500 to 20000 mg/L of ozone gas, preferably with ozonized oil comprising 15% ozone gas by weight, and preferably with physiological saline solution, having a lower oil density, to be used in the treatment of sinusitis.
  • physiological saline solution having a lower oil density
  • Other forms of water can also be used in this solution.
  • An injectable solution with ozonized oil comprising preferably 10% ozone gas by weigh and ozone gas from 10 to 10000 mg/L, preferably distilled water, provided in a ready-made glass injector, silicone lid, glass vial, silicone cap, ampoule, ozone- resistant serum bottles, and plastic bags due to the ozone interaction for subcutaneous, intraarticular, intramuscular, intra-peritoneal mesotherapy applications to ensure the standardization of these therapies.
  • An eye drop comprising a solution comprising ozone gas of 10-5000 mg/liter, obtained by ozonized oil comprising 10% ozone gas by weight to be used for eye health.
  • An eardrop comprising a solution comprising ozone gas of 1000-10000 mg/liter, prepared from ozonized oil comprising 5% ozone gas by weight to be used in the treatment of intensive fungal infections in ear health.
  • a dermatological solution comprising ozone gas of 100-30000 mg/liter, obtained by ozonized oil comprising 10% ozone gas by weight to be used in the treatment of dermatitis in allergic diseases.
  • An injectable solution with ozonized oil comprising preferably 10% ozone gas by weight in combination with fat-soluble vitamins, hyaluronic acid, and active ingredients and ozone gas from 10 to 5000 mg/L, provided in the form of an ampoule, vial and glass syringe for subcutaneous, intraarticular, intramuscular, intra-peritoneal mesotherapy applications.
  • a dermatological solution presented in the form of a spray comprising ozone gas of 2000-70000 mg/L, prepared from ozonized oil comprising 15% ozone gas by weight to be used in the treatment of wounds.
  • a dermatological solution presented in the form of a spray comprising ozone gas of 2000-70000 mg/L, prepared from ozonized oil comprising 15% ozone gas by weight in combination with disinfectants comprising iodine, betadine, silver ions to be used in the treatment of wounds.
  • a dermatological solution presented in the form of a spray comprising ozone gas of 100-70000 mg/L, obtained by ozonized oil comprising 15% ozone gas by weight to be used in skin rejuvenation.
  • a dermatological solution presented in the form of a spray comprising ozone gas of 100-10000 mg/L, prepared from ozonized oil comprising 15% ozone gas by weight in combination with skin rejuvenation and stain-free products to be used in skin rejuvenation and stain treatments.
  • a urological solution to be presented in the form of injection for an antiseptic bladder comprising ozone gas of 100-5000 mg/L, prepared from ozonized oil comprising 15% ozone gas by weight to be used in urology.
  • vaginal solution to be presented in the form of disposable packages, bags, or syringe, comprising ozone gas of 100-10000 mg/L, obtained by ozonized oil comprising 15% ozone gas by weight to be used in vaginal antisepsis.
  • An injectable solution to be presented in the form of injection for use in infertility tubs comprising ozone gas of 100-5000 mg/L, prepared from ozonized oil comprising 10% ozone gas by weight.
  • An injectable solution to be presented in the form of antiseptic ampoules, injections and vial forms comprising ozone gas of 100-10000 mg/L, prepared from ozonized oil comprising 10% ozone gas by weight to be used in-cavity and in canal treatment in dental health.
  • Stomach-soluble, small intestine-soluble, and lower intestine-soluble capsules or gels including the solution comprising ozone gas of 50000-70000 mg/L, prepared from ozonized oil comprising 15% ozone gas by weight to be used in digestive system health.
  • a single use rectal solution comprising ozone gas of 100-10000 mg/L, prepared from ozonized oil comprising 10% ozone gas by weight to be used in the treatment of lower intestine diseases.
  • T oothpaste including the solutions comprising ozone gas of 500-2000 mg/L, prepared from ozonized oil comprising 10% ozone gas.
  • Pastilles comprising solutions comprising ozone gas of 5000-7000 mg/L and preferably sweetener, prepared from ozonized oil comprising 15% ozone gas.
  • a single use rectal solution comprising ozone gas of 100-5000 mg/L, prepared from ozonized oil comprising 15% ozone gas by weight to be used to protect animal health.
  • Disposable wipes or wet wipes comprising the solutions of ozone gas by 500-100000 mg/L, preferably prepared from ozonized oil comprising 10-15% ozone gas.
  • a fertilizer solution comprising ozone gas of 100-10000 mg/L, prepared from ozonized oil comprising 10% ozone gas to be used in soilless agriculture.
  • a seed solution comprising ozone gas of 100-20000 mg/L, prepared from ozonized oil comprising 10% ozone gas to be used to improve seeds, to provide the anti bacterial effects in seed cultivation, and to remove soil pathogens for germination purposes in agriculture.
  • a solution for plants presented in the form of a spray comprising ozone gas of 100- 5000 mg/L, prepared from ozonized oil comprising 5% ozone gas to be used to provide both brightness in ornamental plants and increase plant health.
  • a fuel additive solution comprising ozone gas of 100-70000 mg/L, prepared from ozonized oil comprising 15% ozone gas to be used to improve vehicle performance when mixed in petroleum products.

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Abstract

L'invention concerne des solutions comprenant de l'ozone à des doses désignées, et de l'huile ozonisée à des échelles nanométriques ou microniques, leurs procédés de production et l'utilisation de telles solutions.
EP19819129.8A 2018-03-29 2019-03-29 Solutions comprenant de l'huile ozonisée Withdrawn EP3775120A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2018/04452A TR201804452A2 (tr) 2018-03-29 2018-03-29 Ozonlanmiş yağ i̇çeren solüsyonlar
PCT/TR2019/050209 WO2019240713A2 (fr) 2018-03-29 2019-03-29 Solutions comprenant de l'huile ozonisée

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EP3775120A2 true EP3775120A2 (fr) 2021-02-17
EP3775120A4 EP3775120A4 (fr) 2021-06-02

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116033824A (zh) * 2021-03-01 2023-04-28 艾哈迈德·于米特·萨班哲 脂质体臭氧纳米溶液

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3504038A (en) * 1966-06-24 1970-03-31 Us Agriculture Ozonization of vegetable oils in an improved aqueous medium
ES2162586B1 (es) * 1999-11-25 2002-07-01 Moraleda Manuel Gomez Composicion que comprende aceites ozonizados y/o otros productos naturales y/o sinteticos ozonizados, y su empleo en composiciones farmaceuticas, cosmeticas, dieteticas o de suplementos alimentarios, en los campos humano y veterinario
RU2322217C2 (ru) * 2006-01-23 2008-04-20 Валерий Викторович Педдер Способ озон/no-ультразвуковой терапии экссудативных синуситов
IT1398503B1 (it) * 2010-02-24 2013-03-01 Alderan S A S Di Alderano Mannozzi & C Ora Alderan S A S Di D Ottavi Adele & C Uso di sostanze tamponanti per rendere liscio il capello riccio, crespo od ondulato.
ITMI20110354A1 (it) * 2011-03-07 2012-09-08 Neovalis S R L Composizione a base di olio ozonizzato per uso topico
CN103430797B (zh) * 2013-08-13 2015-08-05 陕西省微生物研究所 一种防治黄瓜真菌病害的方法
EP3139738B1 (fr) * 2014-05-07 2019-11-27 Multiossigen S.P.A. Produit d'activation des mécanismes de défense chez les plantes
CN106560216A (zh) * 2015-09-30 2017-04-12 高晓峰 一种治疗妇科疾病的精油及制备方法
IT201600106992A1 (it) * 2016-10-24 2018-04-24 General Services Spain Italy Sl Composizione comprendente microstrutture per il rilascio controllato di olio ozonizzato.
CN107088185B (zh) * 2017-06-09 2020-07-17 甘肃新天马制药股份有限公司 一种臭氧化油双连续相乳剂及其制备方法与应用
CN107582472A (zh) * 2017-10-31 2018-01-16 山东朱氏堂医疗器械有限公司 一种护肤组合物、面膜液、面膜及其制备方法
IT201800009063A1 (it) * 2018-10-01 2020-04-01 Project & Communications Ltd Formulazione comprendente olio ozonizzato nel trattamento di un tumore

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116033824A (zh) * 2021-03-01 2023-04-28 艾哈迈德·于米特·萨班哲 脂质体臭氧纳米溶液

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