EP3617710B1 - Probenanalysator und probenanalyseverfahren - Google Patents

Probenanalysator und probenanalyseverfahren Download PDF

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Publication number
EP3617710B1
EP3617710B1 EP19194330.7A EP19194330A EP3617710B1 EP 3617710 B1 EP3617710 B1 EP 3617710B1 EP 19194330 A EP19194330 A EP 19194330A EP 3617710 B1 EP3617710 B1 EP 3617710B1
Authority
EP
European Patent Office
Prior art keywords
sample
unit
container
suction
sample container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP19194330.7A
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English (en)
French (fr)
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EP3617710A1 (de
Inventor
Kohei Oda
Hironori Katsumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sysmex Corp
Original Assignee
Sysmex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sysmex Corp filed Critical Sysmex Corp
Priority to EP22203812.7A priority Critical patent/EP4163639A1/de
Publication of EP3617710A1 publication Critical patent/EP3617710A1/de
Application granted granted Critical
Publication of EP3617710B1 publication Critical patent/EP3617710B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/0092—Scheduling
    • G01N35/0095—Scheduling introducing urgent samples with priority, e.g. Short Turn Around Time Samples [STATS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G01N2035/00752—Type of codes bar codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N2035/00891—Displaying information to the operator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0412—Block or rack elements with a single row of samples
    • G01N2035/0413—Block or rack elements with a single row of samples moving in one dimension
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/046—General conveyor features
    • G01N2035/0465—Loading or unloading the conveyor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/046—General conveyor features
    • G01N2035/0467—Switching points ("aiguillages")
    • G01N2035/0468—Switching points ("aiguillages") converging, e.g. selecting carriers from multiple incoming streams
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/046—General conveyor features
    • G01N2035/0467—Switching points ("aiguillages")
    • G01N2035/0472—Switching points ("aiguillages") for selective recirculation of carriers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0496—Other details

Definitions

  • the present invention relates to a sample analyzer and a sample analyzing method.
  • Japanese Patent Application Publication No. 2011-179919 discloses a sample analyzer that irradiates light on a measurement sample prepared by adding a reagent to a plasma sample, and performs optical measurement of the plasma sample using a coagulation method, a synthetic substrate method, an immunoturbidimetric method, and an aggregation method, and analyzes the results thereof.
  • a sample rack 510 holding a sample container 520 is transported in the depth direction along a rack setting area 501, and is delivered to the right end of a transport area 502.
  • the sample rack 510 positioned at the right end of the transport area 502 is transported leftward along the transport area 502.
  • the sample container 520 is positioned at the sample suction position 531, the sample stored in the sample container 520 is suctioned by a sample dispensing unit 541.
  • a sample container 520 for performing urgent measurement is set in a sample holder 552 positioned at the right end position of a transport path 551.
  • the sample holder 552 is transported in the leftward direction.
  • the sample container 520 held by the sample holder 552 is positioned at a suction position 553, the sample stored in the sample container 520 is suctioned by the sample dispensing unit 541.
  • EP 3 176 587 A1 and CN 107144699 A also describe automated analyzers according to the prior art.
  • a first aspect of the present invention relates to a sample analyzer as defined in claim 1.
  • both the sample container transported by the rack transport unit and the sample container transported by the sample transport unit are positioned at the same suction position. Then, the sample is suctioned using a common suction unit which can penetrate the stopper at the suction position.
  • the suction unit can penetrate the stopper installed in the opening of the sample container and the sample can be suctioned from within the sample container with a simple configuration.
  • the sample analyzer (30) may be configured to include a pressing member (334) provided above the sample container (20) positioned at the suction position (301). In this way the sample container can be prevented from moving upward as the suction unit moves, and being pulled out from the sample rack or the sample transport unit when the suction unit that has penetrated the stopper is pulled out of the sample container.
  • the sample analyzer (30) may be configured to include a cleaning unit (335) provided on the pressing member (334) to clean the outer surface of the suction unit (411). In this way contamination of a sample can be prevented since the sample attached to the outer surface of the suction unit can be removed.
  • the sample transport unit (310) is configured to have a holding member (311) for holding the sample container (20), and a rotation drive unit (313) for rotating the holding member (311) in a horizontal direction to transport the sample container to the suction position.
  • the sample transport unit can smoothly transport the sample container installed in the sample transport unit from outside of the transport path to the suction position in the transport path.
  • the sample transport unit (310) comprises a rotation shaft (312) configured to rotate the holding member (311), and the holding member (311) may be formed on an opposite side of the rotation shaft (312) relative to the transport path. In this way it is possible to smoothly switch between a state in which the holding member is in the suction position and a state in which the holding member is not in the suction position according to the rotational position of the holding member.
  • the shape of the holding member (311) in plan view may be configured to include an arc centered on the rotation shaft (312). In this way the flat area required for the rotation of the holding member can be reduced.
  • the holding member (311) may be formed with a plurality of container holding parts (311a) for holding the sample container (20). In this way the operator can continuously analyze the plurality of samples through the sample transport unit by setting the plurality of sample containers in the container holding part.
  • the sample transport unit (310) is configured to include a detection unit (314) that detects that the sample container (20) is held by the holding member (311).
  • the sample transport unit (310) is configured to transport the sample container (20) which is held by the holding member (311) to the suction position (301) based on the detection that the sample container (20) is held by the holding member (311). In this way analysis of the sample via the sample transport unit can be smoothly started by setting the sample container in the holding member.
  • the sample analyzer (30) may be configured to include a cover (350) that covers the sample transport unit (310). In this way it is possible to prevent the operator from inadvertently touching the sample transport unit in operation.
  • the sample analyzer (30) may be configured to include a lock mechanism (370) that locks the cover (350). In this way it is possible to prevent the operator from accidentally opening the cover and touching the sample transport unit in operation.
  • the cover (350) may be configured to include a transparent member (351) which allows the operator to see the position of the sample container (20) installed in the sample transport unit (310). In this way the operator can visually determine whether the sample container is installed in the sample transport unit.
  • the sample analyzer (30) may be configured to include a notification unit (360) to notify that the sample transport unit (310) is in operation.
  • the notification unit is, for example, an indicator or a liquid crystal panel. In this way the operator can determine whether the sample transport unit is operating by referring to the notification unit.
  • the suction unit (411) may be a nozzle with a pointed tip (411a). In this way the suction unit can be easily penetrate through the stopper of the sample container.
  • the rack transport unit (42) is configured to transport the sample rack (10) holding the sample container (20) containing a normal sample along the transport path (42a), position the sample container (20) held in the sample rack (10) at the suction position (301) and the sample transport unit (10) is configured to transport a priority sample container (20) to the suction position (301) when a sample container containing a priority sample that requires analysis prior to normal sample (20) is installed in the sample transport unit (310).
  • the sample analyzer (30) When analyzing a priority sample, the sample analyzer (30) according to the present aspect is configured to transport the priority sample to the suction position (301) after retracting the sample rack (10) positioned at the suction position (301) from the suction position (301) by the rack transport unit (42). In this way priority sample suction can be performed prior to normal sample suction.
  • the sample analyzer (30) may be configured to include a reading unit (333) that reads sample information from the sample container (20) positioned at the suction position (301). In this way one reading unit can read sample information from each sample container positioned at the suction position through different paths.
  • a second aspect of the present invention relates to a sample analyzing method as defined in claim 15.
  • the priority sample also can be suctioned prior to the suction of the normal sample.
  • a third aspect of the present invention relates to a sample analyzer.
  • the sample analyzer includes: a suction unit configured to suction a sample in a sample container; a rack transport unit configured to transport a sample rack holding a sample container along a transport path, and position the sample container held by the sample rack at a suction position by the suction unit; a sample transport unit comprising a holding member configured to hold a sample container other than the sample container transported by the rack transport unit, and a rotation drive unit configured to rotate the holding member in a horizontal direction to transport the sample container held by the holding member to the suction position; a measurement unit configured to measure a sample suctioned by the suction unit from the sample container positioned at the suction position; and an analysis unit configured to analyze the sample based on the measurement result of the measurement unit, wherein a transport route of the sample container by the rack transport unit and a transport route of the sample container by a rotational operation of the rotation drive unit intersect at the suction position, and the holding member is arranged to hold the sample
  • the sample container is positioned at the same suction position by two different transport paths and the sample is suctioned using the shared suction unit at the same suction position while suppressing the complication of the analyzer. Therefore, even when a suction unit that can penetrate the stopper of the sample container is used as the shared suction unit, it is possible to prevent the analyzer from becoming complicated.
  • the suction unit is caused to penetrate the stopper attached to the opening of the sample container, and the sample is suctioned from the sample container by a simple configuration.
  • the sample analyzer 30 includes a transport unit 31 and a measurement unit 32.
  • the transport unit 31 transports the sample container 20 held by the sample rack 10 by transporting the sample rack 10 to the suction position 301 where the measurement unit 32 suctions the sample.
  • the transport unit 31 transports the sample container 20 held by the holding member 311 of the sample transport unit 310 to the suction position 301 by driving the sample transport unit 310.
  • the entire structure of the transport unit 31 will be described later with reference to FIG. 4 .
  • the structures of the sample analyzer 30 and the measurement unit 32 will be described later with reference to FIGS. 7 to 9 .
  • the XYZ axes are orthogonal to each other, and the X-axis direction and the Y-axis direction correspond to directions parallel to the horizontal plane.
  • the positive direction of the X axis corresponds to the left direction
  • the positive direction of the Y axis corresponds to the backward direction
  • the positive direction of the Z axis corresponds to the vertically downward direction. Note that in the other drawings, the XYZ axes are set the same as in FIG. 1 .
  • the transport unit 31 includes a rack transport unit 42 and a sample transport unit 310.
  • the rack transport unit 42 transports the sample rack 10 sent to the end on the X axis negative side of the rack transport unit 42 in the X axis direction along the transport path 42a, and the sample container 20 held by the sample rack 10 is positioned at the suction position 301.
  • the sample rack 10 includes a plurality of container holding parts 110.
  • the container holding part 110 is a hole formed downward from the upper surface of the sample rack 10.
  • the sample container 20 contains a sample therein, and the upper end of the sample container 20 is sealed by a stopper 210.
  • the operator causes the sample rack 10 to hold the sample container 20 containing a normal sample that does not need to be preferentially analyzed, and sets the sample rack 10 in the transport unit 31. Then, the operator starts measurement and analysis of the sample in the sample container 20 held in the sample rack 10.
  • normal samples which do not need to be analyzed preferentially will be referred to as "normal samples”.
  • the sample transport unit 310 includes a holding member 311 and a rotating shaft 312.
  • the holding member 311 rotates around a rotation axis 312 extending in the Z-axis direction.
  • the holding member 311 includes one container holding part 311a.
  • the container holding part 311a is a hole which can hold the sample container 20 in the state of standing upright in the Z-axis direction.
  • the sample transport unit 310 positions the sample container 20 held by the container holding part 311a at the suction position 301 by rotating the holding member 311 around the rotation shaft 312.
  • the operator causes the holding member 311 to hold the sample container 20 containing the sample requiring analysis in priority to the normal sample, and starts measurement and analysis of the sample in the sample container 20 held by the holding member 311.
  • a sample requiring analysis in preference to a normal sample is referred to as a "priority sample”.
  • Priority samples include those that need to be analyzed urgently.
  • the sample container 20 containing the priority sample is installed in the sample transport unit 310, and the sample transport unit 310 transfers the installed sample container 20 to the suction position 301.
  • the sample transport unit 310 receives the sample container 20 different from the sample container 20 transported by the rack transport unit 42, and transports the received sample container 20 to the suction position 301.
  • the measurement unit 32 includes a sample dispensing unit 410.
  • the sample dispensing unit 410 includes a suction unit 411, an arm 412, and a mechanical unit 413.
  • the suction unit 411 is installed at the tip of the arm 412.
  • the suction unit 411 is configured by a nozzle.
  • the tip of the suction unit 411 is pointed so as to be able to penetrate the stopper 210 of the sample container 20.
  • the mechanical unit 413 is configured to rotate the arm 412 in the circumferential direction and move the arm 412 in the vertical direction. In this way the suction unit 411 can move in the circumferential direction and in the vertical direction.
  • the sample dispensing unit 410 is lowered from above and penetrates the stopper 210 of the sample container 20 positioned at the suction position 301. Then, the sample dispensing unit 410 suctions the sample from the sample container 20 via the suction unit 411.
  • the measurement unit 32 measures the sample suctioned by the suction unit 411 from the sample container 20 positioned at the suction position 301, and transmits the measurement result of the sample to the analysis unit 33.
  • the analysis unit 33 analyzes the sample based on the measurement result of the measurement unit 32.
  • the rack transport unit 42 transports the sample container 20 held in the sample rack 10, that is, the sample container 20 containing a normal sample, along the transport path 42a, and positions the sample container 20 at the suction position 301 of the suction unit 411. Then, the suction unit 411 is lowered from directly above the sample container 20 positioned at the suction position 301 and penetrates the stopper 210 and suctions the normal sample from within the sample container 20.
  • the sample transport unit 310 rotates the sample container 20 held by the holding member 311, that is, the sample container 20 containing the priority sample, around the rotation shaft 312 via the holding member 311, and positions the sample container 20 at the suction position 301. Then, the suction unit 411 is lowered from directly above the sample container 20 positioned at the suction position 301 and penetrates the stopper 210 and suctions the priority sample from the inside of the sample container 20.
  • both the sample container 20 transported by the rack transport unit 42 and the sample container 20 transported by the sample transport unit 310 are positioned at the same suction position 301. Then, the sample is suctioned using the common suction unit 411 capable of penetrating the stopper 210 at the suction position 301. As described above, according to the first embodiment, the suction unit 411 penetrates the stopper 210 installed in the opening of the sample container 20 and suctions the sample from within the sample container 20 via a simple structure, regardless of which of the two paths the sample container 20 is transported.
  • the suction unit 411 penetrates the stopper 210, the normal sample can be suctioned from the inside of the sample container 20 containing the normal sample transported by the rack transport unit 42 and the priority sample can be suctioned from within the sample container 20 containing the priority sample transported by the transport unit 310.
  • the holding member 311 is formed on one side of the rotation shaft 312, that is, on the Y-axis negative side of the rotation shaft 312 in the state shown in FIG. 1 . In this way it is possible to smoothly switch between the state in which the holding member 311 is at the suction position 301 as shown in FIG. 2A and the state in which the holding member 311 is not at the suction position 301 as shown in FIG. 2B according to the rotation position of the holding member 311.
  • the holding member 311 has a circular arc shape wherein the arc is aligned with a circle centered on the rotation shaft 312 in plan view.
  • the shape in plan view of the holding member 311 includes an arc centered on the rotation shaft 312. In this way the planar area required for the rotation of the holding member 311 can be reduced in plan view.
  • the suction unit 411 is a nozzle with a pointed tip. In this way the suction unit 411 can easily penetrate the stopper 210 of the sample container 20.
  • the outer shape of the sample rack 10 is a substantially rectangular parallelepiped, and the width in the X-axis direction is longer than the width in the Y-axis direction.
  • the container holding unit 110 holds the sample container 20 in an upright state in the Z-axis direction.
  • the sample rack 10 includes a plurality of container holding units 110, a plurality of samples can be transported to the measurement unit 32 by transporting of a single sample rack 10.
  • the number of container holders 110 formed in the sample rack 10 is not limited to six, and may be another number.
  • the identification member 101 is attached to the Y-axis positive side of the sample rack 10.
  • the identification member 101 is a barcode label on which a barcode indicating rack information is printed.
  • the rack information is information that can individually identify the sample rack 10.
  • the sample container 20 includes an identification member 201, a stopper 210, a body 220, and a lid 230.
  • the body 220 is a blood collection tube made of translucent glass or synthetic resin, and accommodates a sample therein.
  • An opening 221 is formed at the upper end of the body 220.
  • the stopper 210 is made of an elastic synthetic resin or the like.
  • the stopper 210 seals the opening 221 at the upper end of the trunk 220 containing the sample.
  • the lid 230 is made of plastic and covers the stopper 210 attached to the body 220 from the upper side.
  • a hole 231 penetrating vertically is formed at the center of the lid 230.
  • the suction unit 411 of the measurement unit 32 penetrates the stopper 210 in the Z-axis direction via the hole 231.
  • the identification member 201 is attached to the side surface of the body 220.
  • the identification member 201 is a barcode label on which a barcode indicating sample information is printed.
  • the sample information is information that can individually identify the sample.
  • the transport unit 31 includes a rack storage unit 41, a rack transport unit 42, a rack collection unit 43, a sample transport unit 310, a shield member 340, a cover 350, and a notification unit 360.
  • the sample rack 10 is set in the rack storage unit 41.
  • the sample rack 10 set in the rack storage unit 41 is supported by the bottom surface 41a of the rack storage unit 41.
  • the feed member 41b of the rack storage unit 41 is a claw-shaped member provided at the end on the X-axis positive side and the end on the X-axis negative side of the rack storage unit 41.
  • the feed member 41b is movable in the Y-axis direction.
  • the feed member 41b pushes the side surface on the Y-axis negative side of the sample rack 10 in the Y-axis positive direction, whereby the sample rack 10 set in the rack storage unit 41 is transported from the rack storage unit 41 to the transport path 42a of the rack transport unit 42.
  • the rack transport unit 42 includes two belts 320, motors 331 and 332, a reading unit 333, a pressing member 334, a cleaning unit 335, and a pushing member 336.
  • the transport path 42a of the rack transport unit 42 is configured by the upper surfaces of the two belts 320.
  • the two belts 320 extend in the X-axis direction in parallel with each other, and are connected to the pulleys at the ends on the X-axis positive side and the X-axis negative side.
  • the motor 331 rotates a pulley to which the belt 320 on the Y-axis positive side is connected to drive the belt 320 on the Y-axis positive side.
  • the motor 332 rotates a pulley to which the belt 320 on the Y-axis negative side is connected to drive the belt 320 on the Y-axis negative side.
  • Each of the two belts 320 includes one protrusion 321 protruding in the Z-axis negative direction.
  • the sample rack 10 is transported in the X-axis direction in the transport path 42a by driving the belt 320 in a state in which the protrusion 321 is engaged with the notch provided on the lower surface of the sample rack 10.
  • the reading unit 333 is a bar code reader.
  • the reading unit 333 reads the barcode from the identification member 101 of the sample rack 10 transported by the rack transport unit 42 and the identification member 201 of the sample container 20 held by the sample rack 10.
  • the reading unit 333 is supported movably in the X-axis direction and moves in the X-axis direction on the Y-axis positive side of the transport path 42a by a drive unit (not shown), and reads the barcode from the identification members 101 and 201.
  • the reading unit 333 moves to the Y-axis positive side of the suction position 301 and reads the barcode from the identification member 201 of the sample container 20 positioned at the suction position 301.
  • the reading unit 333 reads the sample information by reading the barcode from the sample container 20 positioned at the suction position 301. In this way the sample information can be read by one reading unit 333 from both the sample container 20 containing the normal sample positioned at the suction position 301 and the sample container 20 containing the priority sample delivered through different paths.
  • the reading unit 333 may be an antenna for reading an RFID.
  • the identification member 101 attached to the sample rack 10 and the identification member 201 attached to the sample container 20 are RFID tags.
  • the pressing member 334 is provided above the sample container 20 positioned at the suction position 301.
  • the cleaning unit 335 is installed on the lower surface of the pressing member 334 above the sample container 20 positioned at the suction position 301.
  • the cleaning unit 335 cleans the outer surface of the suction unit 411 extracted from the sample container 20.
  • the pressing member 334 and the cleaning unit 335 will be described later with reference to FIG. 8 .
  • the sample rack 10 is transported in the X-axis direction so that the plurality of sample containers 20 being held are sequentially positioned at the suction position 301.
  • the sample rack 10 is positioned at the end on the X-axis positive side of the transport path 42a.
  • the pushing member 336 pushes the side surface on the Y-axis positive side of the sample rack 10 in the Y-axis negative direction, and the sample rack 10 is fed onto the bottom surface 43a of the rack collection unit 43. In this way the sample rack 10 is collected by the rack collection unit 43.
  • the shield member 340 is installed to cover the rack transport unit 42 on the Y-axis negative side near the center position of the rack transport unit 42 in the X-axis direction.
  • An opening 341 is provided in the shield member 340 at a position on the Y-axis negative side of the suction position 301.
  • the sample transport unit 310 is installed inside the opening 341.
  • the cover 350 is provided at the opening 341 and covers the sample transport unit 310. More specifically, the cover 350 switches between opening the inside of the opening 341 to the outside and shielding the opening from the outside. It is possible to prevent the operator from accidentally touching the sample transport unit 310 in operation by providing the cover 350.
  • the notification unit 360 is configured by an indicator provided on the outer surface of the shield member 340.
  • the notification unit 360 indicates that the sample transport unit 310 is in operation. Specifically, the notification unit 360 flashes during the operation of the sample transport unit 310, and lights continuously while the sample transport unit 310 is not in operation. In this way the operator can determine whether the sample transport unit 310 is in operation with reference to the notification unit 360.
  • the notification unit 360 is not limited to an indicator, and may be configured by a liquid crystal panel or the like.
  • the notification unit 360 is configured by a liquid crystal panel, characters such as "the sample transport unit for transporting a priority sample is in operation" are displayed on the notification unit 360 while the sample transport unit 310 is operating.
  • the sample transport unit 310 includes a holding member 311, a rotation shaft 312, a rotation drive unit 313, and a detection unit 314.
  • a container holding part 311a extending in the Z-axis direction is formed on the holding member 311.
  • the holding member 311 is fixed to a rotation shaft 312 extending in the Z-axis direction.
  • An opening 311 b is formed on the side of the container holding part 311a opposite to the rotation shaft 312.
  • the rotation drive unit 313 includes pulleys 313a and 313b, a belt 313c, and a motor 313d.
  • the pulley 313a is connected to the lower end of the rotation shaft 312.
  • the belt 313c is looped around pulleys 313a and 313b.
  • the pulley 313b is connected to the rotation shaft of the motor 313d. By driving the motor 313d, the rotation shaft 312 is rotated via the belt 313c.
  • the sample transport unit 310 positions the sample container 20 held by the container holding part 311a at the suction position 301 by rotating the holding member 311 around the rotation shaft 312, and the sample container 20 set in the container holding part 311a of the holding member 311 is positioned at the suction position 301.
  • the sample transport unit 310 smoothly moves the sample container 20 installed on the holding member 311 from the outside of the transport path 42a to the suction position 301 in the transport path 42a.
  • the detection unit 314 is a reflection type sensor, and is fixed in the transport unit 31.
  • the detection unit 314 detects that the sample container 20 is held in the container holding part 311a via the opening 311b.
  • the cover 350 includes a transparent member 351, a hole 352, a flange 353, a hole 354, and a shielding member 355.
  • the transport unit 31 also includes a lock mechanism 370 and a detection unit 380 near the cover 350.
  • the transparent member 351 is provided on the front surface of the cover 350, that is, the surface on the Y-axis negative side.
  • the transparent member 351 is provided on the front surface of the cover 350 so that the position of the sample container 20 installed in the sample transport unit 310 can be seen therethrough. In this way the operator can visually determine whether the sample container 20 is installed in the sample transport unit 310 even when the cover 350 is closed.
  • the holes 352 are provided one each in two planes parallel to the YZ plane of the cover 350.
  • the two holes 352 face each other in the X-axis direction.
  • the cover 350 can rotate around the X-axis via a rotation shaft (not shown) passing through the two holes 352 in the transport unit 31.
  • the sample transport unit 310 disposed inside the cover 350 is switched between the state of being opened to the outside and the state of being shielded from the outside.
  • the flange 353 is provided in the vicinity of the upper end of the cover 350. The operator changes the open/close state of the cover 350 by holding the flange 353 and moving the cover 350 along the thick arrow in FIG. 5B .
  • the shaft 371 of the lock mechanism 370 is attached to and detached from the hole 354.
  • the lock mechanism 370 includes a shaft 371 and a cylinder 372.
  • the shaft 371 moves in the X-axis direction by driving the cylinder 372.
  • the cover 350 can not rotate around the X-axis, and the cover 350 is locked by inserting the shaft 371 into the hole 354.
  • the removal of the shaft 371 from the hole 354 allows the cover 350 to rotate about the X-axis.
  • the cover 350 is locked.
  • the lock mechanism 370 can prevent the operator from accidentally opening the cover 350 and touching the sample transport unit 310 while in operation.
  • the shield member 355 is disposed on the X-axis negative side of the cover 350.
  • the detection unit 380 is a transmission sensor, and includes a light emitting unit and a light receiving unit.
  • the shield member 355 is positioned between the light emitting unit and the light receiving unit of the detection unit 380.
  • the shield member 355 is retracted from between the light emitting unit and the light receiving unit of the detection unit 380. In this way the open/close state of the cover 350 can be detected by to the detection unit 380.
  • FIG. 6 is a flowchart showing the transport control of a priority sample and a normal sample by the transport unit 31.
  • the transport control shown in FIG. 6 is performed by a control unit 32a of a measurement unit 32 described later. Note that the transport control also may be performed by the control unit 33a of the analysis unit 33 described later, or may be performed by an external device other than the sample analyzer 30.
  • the control unit of the transport unit 31 may perform transport control.
  • step S11 the control unit 32a determines whether the sample container 20 accommodating the unsuctioned priority sample is set in the container holding part 311a of the sample transport unit 310, and the cover 350 is closed.
  • the control unit 32a determines whether the sample container 20 is set in the container holding part 311a based on the output signal of the detection unit 314, and determines whether the cover 350 is closed based on the output signal of the detection unit 380. Note that the operator sets the measurement order of the priority sample in advance via the input unit 33d of the analysis unit 33 described later before setting the sample container 20 in the sample transport unit 310.
  • the controller 32a determines whether the sample rack 10 being processed is present at the suction position 301 in step S12.
  • the state in which the sample rack 10 is being processed at the suction position 301 is a state in which a part of the sample rack 10 overlaps the lower side of the suction position 301, that is, an unsuctioned sample container 20 remains in the sample rack 10.
  • the control unit 32a drives the rack transport unit 42 to move the sample rack 10 in the negative direction of the X axis to retract the sample rack 10 from the suction position 301.
  • the process of step S13 is skipped.
  • step S14 the control unit 32a drives the sample transport unit 310 to rotate the holding member 311 around the rotation shaft 312, and transports the sample container 20 containing the priority sample to the suction position 301.
  • step S15 the control unit 32a positions the reading unit 333 behind the suction position 301, and reads the barcode from the identification member 201 of the sample container 20 containing the priority sample positioned at the suction position 301.
  • step S16 the control unit 32a drives the sample dispensing unit 410 to suction the priority sample from the sample container 20 positioned at the suction position 301 via the suction unit 411.
  • the control unit 32a rotates the holding member 311 around the rotation shaft 312, and positions the holding member 311 at a position for installing the sample container 20 as shown in FIG. 4 .
  • the position of the holding member 311 shown in FIG. 4 is a position at which the sample container 20 is installed in the sample transport unit 310.
  • the operator opens the cover 350 and removes the sample container 20 for which suction has been completed from the holding member 311.
  • the temporarily retract sample rack 10 is again transported to the suction position 301 in step S18 described later, and a normal sample is suctioned from the sample container 20 held by the sample rack.
  • step S11 determines whether there is a normal sample to be analyzed in step S17.
  • the state in which a normal sample to be analyzed is present includes the state in which the sample rack 10 is set in the rack storage unit 41, and the state in which an unsuctioned sample container 20 is present in the sample rack 10 of the rack transport unit 42. If there is no normal sample to be analyzed, the process returns to step S11.
  • step S18 the control unit 32a drives the rack storage unit 41 and the rack transport unit 42 to transport the sample rack 10, and moves the sample container 20 accommodating the normal sample held in the sample rack 10 to the suction position 301.
  • control unit 32a performs the processes of steps S15 and S16 as in the case of the priority sample. That is, in step S15, the control unit 32a positions the reading unit 333 behind the suction position 301 and reads the barcode from the identification member 201 of the sample container 20 containing the normal sample positioned at the suction position 301. In step S16, the control unit 32a drives the sample dispensing unit 410 to suction the normal sample from the sample container 20 positioned at the suction position 301 via the suction unit 411.
  • step S11 the process is started again from step S11, and the transport control of FIG. 6 is repeatedly performed.
  • the sample container 20 held by the holding member 311 is transported to the suction position 301 based on the detection of the sample container 20 held by the holding member 311. In this way analysis of the priority sample can be smoothly started by setting the sample container 20 containing the priority sample in the holding member 311.
  • the priority sample When analyzing a priority sample, the priority sample is moved to the suction position 301 by the sample transport unit 310 after the sample rack 10 positioned at the suction position 301 is temporarily retracted from the suction position 301 by the rack transport unit 42. In this way the priority sample can be suctioned prior to the suction of the normal sample.
  • the measurement unit 32 is disposed behind the transport unit 31.
  • the measurement unit 32 performs measurement regarding a blood coagulation test. Therefore, in the first embodiment, the sample contained in the sample container 20 is plasma.
  • liquid stored as the sample in the sample container 20 is not limited to plasma.
  • the sample stored in the sample container 20 is not limited to plasma, and may be whole blood, serum, urine, lymph fluid, body cavity fluid, or the like.
  • the sample when the measurement unit 32 performs measurement related to blood tests on the sample, the sample may be whole blood.
  • the measurement unit 32 performs measurement of a sample such as a coagulation test, immunoassay test, or biochemical test
  • the sample when the measurement unit 32 performs measurement of a sample, such as a coagulation test, immunoassay test, or biochemical test, the sample may be plasma.
  • sample may be serum.
  • the measurement unit 32 includes a sample dispensing unit 410, a reaction container table 420, a heating table 430, a reagent table 440, reagent dispensing units 450 and 460, a transport unit 470, a detection unit 480, and a dispensing unit 490.
  • the sample dispensing unit 410 lowers the suction unit 411 from the upper side of the sample container 20 positioned at the suction position 301 to penetrate the stopper 210. Then, the sample dispensing unit 410 suctions the sample from the sample container 20 via the suction unit 411, and discharges the suctioned sample to the reaction container 422 held by the holding hole 421 of the reaction container table 420.
  • the sample dispensing unit 490 includes a suction unit 491, an arm 492, and a mechanical unit 493.
  • the suction unit 491 is installed at the tip of the arm 492.
  • the suction unit 491 is configured by a nozzle.
  • the sample dispensing unit 490 is used to suction a small amount of sample from the sample container 20 in which the opening 221 is opened, so the tip of the suction unit 411 has a flat shape.
  • the mechanical unit 493 is configured to rotate the arm 492 in the circumferential direction and to move the arm 492 in the vertical direction. In this way the suction unit 491 can move in the circumferential direction and in the vertical direction.
  • the sample dispensing unit 490 inserts the suction unit 491 into the sample container 20 by lowering the suction unit 491 from above relative to the sample container 20 positioned at the suction position 302 on the transport path 42a of the rack transport unit 42. Then, the sample dispensing unit 490 suctions the sample from the sample container 20 via the suction unit 491 and discharges the suctioned sample to the reaction container 422 held in the holding hole 421 of the reaction container table 420.
  • the reaction container table 420 has an annular shape in plan view, and is disposed outside the reagent table 440.
  • the reaction container table 420 is configured to be rotatable in the circumferential direction.
  • the reaction container table 420 has a plurality of holding holes 421 for holding the reaction container 422.
  • the heating table 430 includes a plurality of holding holes 431 for holding the reaction container 422, and a transport unit 432 for transporting the reaction container 422.
  • the heating table 430 has a circular outline in plan view, and is configured to be rotatable in the circumferential direction.
  • the heating table 430 heats the reaction container 422 set in the holding hole 431 to 37°C.
  • the reaction container table 420 When a sample is discharged to the reaction container 422 held on the reaction container table 420, the reaction container table 420 is rotated, and the reaction container 422 containing the sample is transported to the vicinity of the heating table 430. Then, the transport unit 432 of the heating table 430 holds the reaction container 422 and sets it in the holding hole 431 of the heating table 430.
  • the reagent table 440 is configured to accommodate a plurality of reagent containers 441 containing reagents used for measurement related to a blood coagulation test.
  • the reagent table 440 is configured to be rotatable in the circumferential direction.
  • a plurality of reagent containers 441 containing reagents used in measurement of measurement items are installed on the reagent table 440.
  • the reagent dispensing unit 450 includes a nozzle 451 and a mechanical unit 452.
  • the mechanical unit 452 is configured to move the nozzle 451 in the horizontal direction so as to transect the reagent table 440, and to move the nozzle 451 in the vertical direction.
  • the reagent dispensing unit 460 includes a nozzle 461 and a mechanical unit 462.
  • the mechanical unit 462 is configured to move the nozzle 461 in the horizontal direction so as to transect the reagent table 440, and to move the nozzle 461 in the vertical direction.
  • the reagent dispensing units 450 and 460 are installed below the upper surface of the measurement unit 32.
  • the reagent dispensing units 450 and 460 dispense the reagent into the reaction container 422 heated by the heating table 430.
  • the transport unit 432 or the transport unit 470 removes the reaction container 422 from the holding hole 431 of the heating table 430, and positions the reaction container 422 at a predetermined position near the heating table 430.
  • the reagent dispensing unit 450, 460 suctions the reagent from the reagent container 441 through the nozzles 451, 461, and discharges the suctioned reagent to the reaction container 422. In this way the reagent is mixed with the sample to prepare a measurement sample.
  • the transport unit 470 sets the reaction container 422 in the holding hole 481 of the detection unit 480.
  • the measurement principle of the detection unit 480 is, for example, a coagulation method, a synthetic substrate method, an immunoturbidimetric method, an agglutination method, or the like.
  • the detection unit 480 includes a plurality of holding holes 481.
  • the detection unit 480 irradiates light on the reaction container 422 set in the holding hole 481, receives the light transmitted through the measurement sample, and outputs a signal according to the intensity of the received light.
  • the control unit 32a of the measurement unit 32 stores the signal output from the detection unit 480 as a measurement result, and transmits the measurement result to the analysis unit 33.
  • the sample dispensing unit 410 includes a suction unit 411, an arm 412, and a mechanical unit 413.
  • the mechanical unit 413 includes a shaft 413a, a guide member 413b, and driving units 413c and 413d.
  • FIG. 8 also illustrates the sample container 20 positioned at the suction position 301, the sample rack 10 holding the sample container 20, the pressing member 334 provided immediately above the suction position 301, and the cleaning unit 335.
  • the suction unit 411 is a nozzle in which the tip 411a on the Z-axis positive side is pointed.
  • the drive unit 413c moves the shaft 413a in the Z-axis direction.
  • the drive unit 413d rotates the shaft 413a with the Z axis as the center of rotation.
  • the drive units 413c and 413d are configured by stepping motors.
  • the shaft 413a supports the arm 412.
  • the suction unit 411 is installed downward at the end of the arm 412.
  • the guide member 413b is rotatable in accordance with the rotation of the shaft 413a, and is installed relative to the shaft 413a so that the position in the Z-axis direction does not change.
  • a hole penetrating in the vertical direction is formed at the tip of the guide member 413b, and the suction unit 411 passes through the hole at the tip of the guide member 413b.
  • the pressing member 334 is attached to the transport unit 31.
  • a hole 334a which penetrates the pressing member 334 in the vertical direction is formed in the pressing member 334.
  • the cleaning unit 335 is installed on the lower surface of the pressing member 334.
  • a hole 335a penetrating the cleaning unit 335 in the vertical direction is formed in the cleaning unit 335.
  • Two flow paths (not shown) extending horizontally are formed in the hole 335a.
  • the pressing member 334 is provided above the sample container 20 positioned at the suction position 301. In this way, even when the sample container 20 moves upward in conjunction with the movement of the suction unit 411 when the suction unit 411 which has penetrated the stopper 210 is extracted from the sample container 20, the top end of the sample container 20 is pressed by the pressing member 334 through the cleaning unit 335. In this way it is possible to prevent the sample container 20 from moving upward with the movement of the suction unit 411 and being removed from the sample rack 10 or the sample transport unit 310.
  • the sample analyzer 30 includes a transport unit 31, a measurement unit 32, and an analysis unit 33.
  • the measurement unit 32 includes a control unit 32a, a storage unit 32b, and various mechanical units illustrated in FIGS. 7 and 8 .
  • Control unit 32a is, for example, a CPU.
  • the storage unit 32b is, for example, a ROM, a RAM, and a hard disk.
  • the control unit 32a controls each part in the measurement unit 32 and the transport unit 31 in accordance with a program and data stored in the storage unit 32b.
  • the control unit 32a suctions the sample supplied by the transport unit 31, performs measurements related to the blood coagulation test for the sample, and transmits the measurement results to the analysis unit 33.
  • the analysis unit 33 includes a control unit 33a, a storage unit 33b, a display unit 33c, and an input unit 33d.
  • Control unit 33a is, for example, a CPU.
  • the storage unit 33b is, for example, a ROM, a RAM, a hard disk.
  • the control unit 33a controls each unit in the analysis unit 33 and the measurement unit 32 according to a program or data stored in the storage unit 33b.
  • the display unit 33c is, for example, a liquid crystal display.
  • the input unit 33 d is, for example, a mouse or a keyboard.
  • the display unit 33c and the input unit 33d may be integrally configured by a touch panel display or the like.
  • the control unit 33a analyzes the blood coagulation test of a sample based on the measurement result received from the measurement unit 32. Specifically, the control unit 33a analyzes measurement items including PT, APTT, Fbg, extrinsic coagulation factor, intrinsic coagulation factor, coagulation factor XIII, HpT, TTO, FDP, D dimer, PIC, FM, ATIII, Pig, APL, PC, VWF: Ag, VWF: RCo, ADP, collagen, epinephrine.
  • the sample transport unit 310 also is provided at a suction position 302 at which the sample dispensing unit 490 of the measurement unit 32 suctions a sample from the transport path 42a, similarly to the suction position 301.
  • the shield member 340 extends to the X-axis negative side so as to protect the suction position 302 as compared with the first embodiment, and the cover 350 also is provided on the Y-axis negative side.
  • the pressing member 334 also extends in the X-axis direction so as to straddle above the suction positions 301 and 302.
  • a cleaning unit 335 is provided on the lower surface of the pressing member 334 immediately above the suction position 302.
  • a sample dispensing unit 410 also is disposed at the position of the sample dispensing unit 490 rather than the sample dispensing unit 490. That is, the measurement unit 32 according to the second embodiment includes two sample dispensing units 410 including the suction unit 411 which has a sharp tip 411a. In this way the sample dispensing unit 410 on the X-axis negative side can suction the sample from the inside of the sample container 20 by making the suction unit 411 penetrate the stopper 210 of the sample container 20 situated at the suction position 302. Other structures of the second embodiment are the same as those of the first embodiment.
  • the sample can be suctioned from the sample container 20 containing the normal sample and the sample container 20 containing the priority sample via the stopper 210 at the suction position 302, similarly to the suction position 301.
  • the reading unit 333 also is movable in the X-axis direction to the positions of the suction positions 301 and 302. In this way the barcode can be read by one reading unit 333 at the suction positions 301 and 302 from both the sample container 20 containing the normal sample and the sample container 20 containing the priority sample.
  • three container holding parts 311a are provided on the holding member 311 of the sample transport unit 310. All three container holding parts 311a are arranged on the circumference centering on the rotation shaft 312. Other structures of the third embodiment are the same as those of the first embodiment.
  • the operator sets the plurality of sample containers 20 containing the priority samples in the holding member 311 to continuously analyze the plurality of priority samples.
  • the number of objects of the container holding part 311a provided in the holding member 311 is not limited to three, and may be another number.
  • the holding member 311 of the sample transport unit 310 has an elliptical shape in plan view.
  • Other structures of the fourth embodiment are the same as those of the first embodiment.
  • the shape of the holding member 311 in plan view is a convex shape centered on the rotation shaft 312, and includes a curve. In this way, the planar area required for the rotation of the holding member 311 can be reduced as in the first embodiment.

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Claims (15)

  1. Probenanalysiergerät, umfassend:
    eine Saugeinheit (411), die so konfiguriert ist, dass sie eine Probe in einem Probenbehälter (20) durch einen Stopfen (210), der in einer Öffnung (221) des Probenbehälters (20) installiert ist, ansaugt;
    eine Gestell-Transporteinheit (42), die so konfiguriert ist, dass sie ein Probengestell (10), das einen Probenbehälter (20) hält, entlang eines Transportweges (42a) transportiert und den Probenbehälter (20), der von dem Probengestell (10) gehalten wird, an einer Ansaugposition (301) in der Nähe der Saugeinheit (411) positioniert;
    eine Probentransporteinheit (310), in der ein anderer Probenbehälter (20) als der von der Gestell-Transporteinheit (42) transportierte Probenbehälter (20) installiert ist und die so konfiguriert ist, dass sie den installierten Probenbehälter zu der auf dem Transportweg (42a) bereitgestellten Ansaugposition (301) transportiert;
    eine Messeinheit (32), die so konfiguriert ist, dass sie eine von der Saugeinheit (411) aus dem an der Ansaugposition (301) positionierten Probenbehälter (20) angesaugte Probe misst; und
    eine Analyseeinheit (33), die so konfiguriert ist, dass sie die Probe basierend auf dem Messergebnis der Messeinheit (32) analysiert, wobei
    die Gestell-Transporteinheit (42) so konfiguriert ist, dass sie das Gestell aus der Ansaugposition (301) zurückzieht, wenn ein anderer Probenbehälter (29) als der von der Gestell-Transporteinheit (42) transportierte Probenbehälter (20) in der Probentransporteinheit (310) installiert wird.
  2. Probenanalysiergerät nach Anspruch 1, weiter umfassend ein Druckelement (334), das oberhalb des an der Ansaugposition (301) positionierten Probenbehälters (20) bereitgestellt ist.
  3. Probenanalysiergerät nach Anspruch 2, weiter umfassend eine Reinigungseinheit (335), die an dem Druckelement (334) zum Reinigen einer Außenfläche der Ansaugeinheit (411) bereitgestellt ist.
  4. Probenanalysiergerät nach einem der Ansprüche 1 bis 3, wobei die Probentransporteinheit (310) ein Halteelement (311) umfasst, das so konfiguriert ist, dass es den Probenbehälter (20) hält, und eine Rotationsantriebseinheit (313), die so konfiguriert ist, dass sie das Halteelement (311) in einer horizontalen Richtung dreht, um den Probenbehälter zur Ansaugposition (301) zu transportieren.
  5. Probenanalysiergerät nach Anspruch 4, wobei die Probentransporteinheit (310) eine Drehwelle (312) umfasst, die so konfiguriert ist, dass sie das Halteelement (311) dreht; und das Halteelement (311) auf einer gegenüberliegenden Seite der Drehwelle (312) relativ zum Transportweg (42a) ausgebildet ist.
  6. Probenanalysiergerät nach Anspruch 5, wobei eine Form des Halteelements (311) in einer Draufsicht einen auf die Drehwelle (312) zentrierten Bogen einschließt.
  7. Probenanalysiergerät nach einem der Ansprüche 4 bis 6, wobei eine Vielzahl von Behälterhalteteilen (311a), die jeweils zum Halten eines Probenbehälters (20) konfiguriert sind, an dem Halteelement (311) ausgebildet sind.
  8. Probenanalysiergerät nach einem der Ansprüche 4 bis 7, wobei die Probentransporteinheit (310) eine Erkennungseinheit (314) einschließt, die erkennt, dass der Probenbehälter (20) von dem Halteelement (311) gehalten wird.
  9. Probenanalysiergerät nach Anspruch 8, wobei die Probentransporteinheit (310) den von dem Halteelement (311) gehaltenen Probenbehälter (20) in Reaktion auf eine Erkennung durch die Erkennungseinheit (314), dass der Probenbehälter (20) von dem Halteelement (311) gehalten wird, zu der Ansaugposition (301) transportiert.
  10. Probenanalysiergerät nach einem der Ansprüche 1 bis 9, weiter umfassend eine Abdeckung (350), die die Probentransporteinheit (310) abdeckt.
  11. Probenanalysiergerät nach Anspruch 10, weiter umfassend einen Verriegelungsmechanismus (370), der die Abdeckung (350) verriegelt.
  12. Probenanalysiergerät nach Anspruch 10 oder 11, wobei die Abdeckung (350) ein transparentes Element (351) einschließt, durch das eine Position des in der Probentransporteinheit (310) installierten Probenbehälters (20) sichtbar ist.
  13. Probenanalysiergerät nach einem der Ansprüche 1 bis 12, weiter umfassend eine Meldeeinheit (360), die meldet, dass die Probentransporteinheit (310) in Betrieb ist.
  14. Probenanalysiergerät nach einem der Ansprüche 1 bis 13, wobei die Ansaugvorrichtung (411) eine Düse umfasst, die eine spitz zulaufende Spitze (411a) aufweist.
  15. Probenanalysierverfahren, umfassend:
    falls ein Probenbehälter, der eine Prioritätsprobe enthält, in einem Probenanalysiergerät installiert ist, wenn ein Gestell (10), in dem ein Probenbehälter (20), der eine normale Probe enthält, entlang eines Transportweges (42a) zu einer Ansaugposition durch eine Saugeinheit (411) transportiert worden ist, Zurückziehen des Gestells (10) aus der Ansaugposition (301) und Transportieren des installierten Probenbehälters (20), der die Prioritätsprobe enthält, zu der Ansaugposition (301);
    Durchstoßen eines Stopfens (210), der in einer Öffnung (221) des an der Ansaugposition (301) positionierten Probenbehälters (20) installiert ist, durch die Saugeinheit (411), um die Prioritätsprobe in dem an der Ansaugposition (301) positionierten Probenbehälter (20) anzusaugen;
    Messen der Prioritätsprobe, die aus dem Probenbehälter (20) angesaugt wurde, der an der Ansaugposition (301) positioniert ist; und
    Analysieren der Prioritätsprobe auf der Grundlage eines Messergebnisses der Prioritätsprobe.
EP19194330.7A 2018-08-31 2019-08-29 Probenanalysator und probenanalyseverfahren Active EP3617710B1 (de)

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EP22203812.7A EP4163639A1 (de) 2018-08-31 2019-08-29 Probenanalysegerät und probenanalyseverfahren

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JP2018163501A JP6772227B2 (ja) 2018-08-31 2018-08-31 検体分析装置および検体分析方法

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EP3617710B1 true EP3617710B1 (de) 2022-11-02

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CN110873808A (zh) 2020-03-10
CN115219731A (zh) 2022-10-21
JP6772227B2 (ja) 2020-10-21
EP3617710A1 (de) 2020-03-04
US11680951B2 (en) 2023-06-20
EP4163639A1 (de) 2023-04-12
US20200072860A1 (en) 2020-03-05
JP2020034515A (ja) 2020-03-05

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