EP3565812C0 - Tubulin-bindende substanzen und therapeutische verwendung davon - Google Patents

Tubulin-bindende substanzen und therapeutische verwendung davon

Info

Publication number
EP3565812C0
EP3565812C0 EP18735991.4A EP18735991A EP3565812C0 EP 3565812 C0 EP3565812 C0 EP 3565812C0 EP 18735991 A EP18735991 A EP 18735991A EP 3565812 C0 EP3565812 C0 EP 3565812C0
Authority
EP
European Patent Office
Prior art keywords
tubulin
therapeutic use
binding substances
substances
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP18735991.4A
Other languages
English (en)
French (fr)
Other versions
EP3565812A4 (de
EP3565812A1 (de
EP3565812B1 (de
Inventor
Lan Huang
Santosh Ambadas Khedkar
Michel O Steinmetz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BeyondSpring Pharmaceuticals Inc
Original Assignee
BeyondSpring Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BeyondSpring Pharmaceuticals Inc filed Critical BeyondSpring Pharmaceuticals Inc
Publication of EP3565812A1 publication Critical patent/EP3565812A1/de
Publication of EP3565812A4 publication Critical patent/EP3565812A4/de
Application granted granted Critical
Publication of EP3565812C0 publication Critical patent/EP3565812C0/de
Publication of EP3565812B1 publication Critical patent/EP3565812B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Indole Compounds (AREA)
EP18735991.4A 2017-01-06 2018-01-05 Tubulin-bindende substanzen und therapeutische verwendung davon Active EP3565812B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762443247P 2017-01-06 2017-01-06
PCT/US2018/012668 WO2018129381A1 (en) 2017-01-06 2018-01-05 Tubulin binding compounds and therapeutic use thereof

Publications (4)

Publication Number Publication Date
EP3565812A1 EP3565812A1 (de) 2019-11-13
EP3565812A4 EP3565812A4 (de) 2020-08-19
EP3565812C0 true EP3565812C0 (de) 2023-12-27
EP3565812B1 EP3565812B1 (de) 2023-12-27

Family

ID=62790877

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18735991.4A Active EP3565812B1 (de) 2017-01-06 2018-01-05 Tubulin-bindende substanzen und therapeutische verwendung davon

Country Status (5)

Country Link
US (2) US11633393B2 (de)
EP (1) EP3565812B1 (de)
JP (2) JP2020503363A (de)
CN (1) CN110431135A (de)
WO (1) WO2018129381A1 (de)

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CN110431135A (zh) 2017-01-06 2019-11-08 大连万春布林医药有限公司 微管蛋白结合化合物及其治疗用途
CN110381938A (zh) 2017-02-01 2019-10-25 大连万春布林医药有限公司 减少中性粒细胞缺乏症的方法
CA3089226A1 (en) 2018-01-24 2019-08-01 Beyondspring Pharmaceuticals, Inc. Composition and method for reducing thrombocytopenia via the administration of plinabulin
CN111954532A (zh) * 2018-04-13 2020-11-17 上海交通大学医学院附属瑞金医院 杂芳基酰胺类化合物的抗肿瘤多药耐药性、治疗癌症的用途和蛋白质-药物分子复合物
US20210177952A1 (en) * 2018-08-16 2021-06-17 Beyondspring Pharmaceuticals, Inc. Method and composition for stimulating immune response
US20220226335A1 (en) * 2019-04-24 2022-07-21 The Governors Of The University Of Alberta Non-Peptidic Heterocycle-Containing Compounds for the Treatment of Alzheimer?s Disease
MX2022002720A (es) * 2019-09-05 2022-08-10 Lunan Pharmaceutical Group Corp Inhibidor de magl, procedimiento de preparacion y uso del mismo.
KR102304026B1 (ko) * 2020-02-03 2021-09-23 순천대학교 산학협력단 세포자멸사를 유도하는 치환된 아릴사이클로프로필우레아 화합물 및 이를 포함하는 항암용 조성물
WO2021221445A1 (ko) * 2020-04-27 2021-11-04 주식회사 오토텍바이오 Ubr 박스 도메인 리간드로의 화합물
AU2021359129A1 (en) * 2020-10-16 2023-06-01 Proxygen Gmbh Heterocyclic cullin ring ubiquitin ligase compounds and uses thereof
EP4319751A4 (de) 2021-04-09 2025-02-26 Beyondspring Pharmaceuticals, Inc. Therapeutische zusammensetzungen und verfahren zur behandlung von tumoren
CN113750088B (zh) * 2021-09-16 2024-05-28 中国人民解放军海军特色医学中心 杂环化合物在制备治疗溃疡性结肠炎药物中的应用
WO2023203174A1 (en) * 2022-04-20 2023-10-26 Proxygen Gmbh Heterocyclic cullin ring ubiquitin ligase compounds and uses thereof

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EP3565812A4 (de) 2020-08-19
US20240082243A1 (en) 2024-03-14
US11633393B2 (en) 2023-04-25
US12458639B2 (en) 2025-11-04
WO2018129381A1 (en) 2018-07-12
JP2023027366A (ja) 2023-03-01
EP3565812A1 (de) 2019-11-13
EP3565812B1 (de) 2023-12-27
JP2020503363A (ja) 2020-01-30
US20200237754A1 (en) 2020-07-30

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