EP3555615A4 - Méthode de dosage par spectrométrie de masse permettant une détection et une quantification de métabolites de la fonction rénale - Google Patents
Méthode de dosage par spectrométrie de masse permettant une détection et une quantification de métabolites de la fonction rénale Download PDFInfo
- Publication number
- EP3555615A4 EP3555615A4 EP17885159.8A EP17885159A EP3555615A4 EP 3555615 A4 EP3555615 A4 EP 3555615A4 EP 17885159 A EP17885159 A EP 17885159A EP 3555615 A4 EP3555615 A4 EP 3555615A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- quantitation
- detection
- mass spectrometry
- assay method
- kidney function
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000003556 assay Methods 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 230000003907 kidney function Effects 0.000 title 1
- 238000004949 mass spectrometry Methods 0.000 title 1
- 239000002207 metabolite Substances 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/62—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving urea
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0009—Calibration of the apparatus
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0031—Step by step routines describing the use of the apparatus
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
- H01J49/005—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
- H01J49/145—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using chemical ionisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7057—(Intracellular) signaling and trafficking pathways
- G01N2800/7066—Metabolic pathways
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Diabetes (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662435967P | 2016-12-19 | 2016-12-19 | |
US201762526043P | 2017-06-28 | 2017-06-28 | |
US201762558014P | 2017-09-13 | 2017-09-13 | |
PCT/US2017/066364 WO2018118630A1 (fr) | 2016-12-19 | 2017-12-14 | Méthode de dosage par spectrométrie de masse permettant une détection et une quantification de métabolites de la fonction rénale |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3555615A1 EP3555615A1 (fr) | 2019-10-23 |
EP3555615A4 true EP3555615A4 (fr) | 2020-11-04 |
Family
ID=62627087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP17885159.8A Pending EP3555615A4 (fr) | 2016-12-19 | 2017-12-14 | Méthode de dosage par spectrométrie de masse permettant une détection et une quantification de métabolites de la fonction rénale |
Country Status (7)
Country | Link |
---|---|
US (1) | US11619636B2 (fr) |
EP (1) | EP3555615A4 (fr) |
JP (1) | JP7393206B2 (fr) |
CN (1) | CN110088615B (fr) |
AU (1) | AU2017382744B2 (fr) |
CA (1) | CA3045022C (fr) |
WO (1) | WO2018118630A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3045022C (fr) | 2016-12-19 | 2024-01-16 | Metabolon, Inc. | Methode de dosage par spectrometrie de masse permettant une detection et une quantification de metabolites de la fonction renale |
JP2022517161A (ja) * | 2018-09-11 | 2022-03-07 | メタボロン,インコーポレイテッド | マイクロバイオータ関連代謝物の検出および定量のための質量分析検定法 |
WO2020217333A1 (fr) * | 2019-04-24 | 2020-10-29 | 株式会社島津製作所 | Dispositif d'imagerie par spectrométrie de masse |
JP2022534369A (ja) * | 2019-05-31 | 2022-07-29 | メタボロン,インコーポレイテッド | 代謝物を検出するための質量分析アッセイ法 |
CN112946150B (zh) * | 2019-11-26 | 2024-06-18 | 深圳华大临床检验中心 | 一种快速检测人体尿液中高香草酸、香草扁桃酸、5-羟基吲哚乙酸及肌酐的方法及试剂盒 |
CN111007173A (zh) * | 2019-12-20 | 2020-04-14 | 辉源生物科技(上海)有限公司 | 吲哚胺2,3-二氧化酶抑制剂的筛选方法 |
CN114026427B (zh) * | 2020-05-19 | 2023-11-17 | 深圳市中医院 | 诊断肾病的标志物以及诊断方法 |
CN114518413A (zh) * | 2020-11-18 | 2022-05-20 | 江苏天士力帝益药业有限公司 | 一种卡托普利原料药中脯氨酸的含量测定方法 |
CN114216984B (zh) * | 2021-12-16 | 2023-10-13 | 川北医学院附属医院 | 一种骨质疏松症负离子诊断标志物及其检测方法 |
CN114414700A (zh) * | 2022-01-27 | 2022-04-29 | 重庆迪纳利医药科技有限责任公司 | 一种同时测定生物样品中多种内源性糖醇含量的方法和系统 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014186311A1 (fr) * | 2013-05-14 | 2014-11-20 | Metabolon, Inc. | Biomarqueurs liés à la fonction rénale et méthodes d'utilisation de ceux-ci |
WO2016025429A1 (fr) * | 2014-08-15 | 2016-02-18 | The Johns Hopkins University | Estimation précise du débit de filtration glomérulaire à partir de plusieurs biomarqueurs |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090194685A1 (en) | 2008-01-31 | 2009-08-06 | Mds Analytical Technologies | High-throughput screening of metabolic disorders using a laser desorption ion source coupled to a mass analyzer |
JP5624709B2 (ja) * | 2008-03-13 | 2014-11-12 | 大日本住友製薬株式会社 | 内因性代謝物の分析方法 |
JP5197846B2 (ja) * | 2009-04-30 | 2013-05-15 | 紀陽 田仲 | 腎疾患重篤度を判定する方法又は装置若しくはその作動方法 |
CN107064330B (zh) * | 2010-12-28 | 2022-02-25 | 探索诊断投资公司 | 通过质谱法定量胰岛素 |
EP2788763A4 (fr) * | 2011-12-09 | 2015-10-07 | Metabolon Inc | Biomarqueurs pour cancer rénal et leurs procédés d'utilisation |
CN102680599A (zh) * | 2012-05-11 | 2012-09-19 | 上海特敏生物医药科技有限公司 | 尿肌氨酸及肌酐测定试剂盒 |
WO2014120449A1 (fr) * | 2013-01-31 | 2014-08-07 | Metabolon, Inc. | Biomarqueurs associés à la progression de l'insulinorésistance et procédés d'utilisation associés |
US9252003B2 (en) * | 2013-06-07 | 2016-02-02 | Pierce Biotechnology, Inc. | Absolute quantitation of proteins and protein modifications by mass spectrometry with multiplexed internal standards |
ES2731678T3 (es) * | 2013-07-31 | 2019-11-18 | Pharnext | Herramientas de diagnóstico para la enfermedad de Alzheimer |
CN105738626B (zh) * | 2014-12-12 | 2017-07-14 | 中国科学院大连化学物理研究所 | 一种新的血清代谢物的组合及其作为肝癌诊断标志物的用途 |
WO2016160741A1 (fr) * | 2015-03-28 | 2016-10-06 | Quantalytical Labs Inc. | Extraction en phase solide, dérivatisation à l'aide d'éthers couronnes, et spectrométrie de masse, procédés, réactifs et kits associés |
CA2987323A1 (fr) * | 2015-05-27 | 2016-12-01 | Quest Diagnostics Investments Llc | Procedes de quantification par spectrometrie de masse d'analytes extraits d'un dispositif de micro-echantillonnage |
CN104897821A (zh) * | 2015-06-03 | 2015-09-09 | 福建中烟工业有限责任公司 | 提取样品中肌醇的方法、试剂盒及其用途 |
CA3045022C (fr) | 2016-12-19 | 2024-01-16 | Metabolon, Inc. | Methode de dosage par spectrometrie de masse permettant une detection et une quantification de metabolites de la fonction renale |
-
2017
- 2017-12-14 CA CA3045022A patent/CA3045022C/fr active Active
- 2017-12-14 AU AU2017382744A patent/AU2017382744B2/en active Active
- 2017-12-14 US US16/466,451 patent/US11619636B2/en active Active
- 2017-12-14 EP EP17885159.8A patent/EP3555615A4/fr active Pending
- 2017-12-14 CN CN201780078615.8A patent/CN110088615B/zh active Active
- 2017-12-14 WO PCT/US2017/066364 patent/WO2018118630A1/fr active Application Filing
- 2017-12-14 JP JP2019553158A patent/JP7393206B2/ja active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014186311A1 (fr) * | 2013-05-14 | 2014-11-20 | Metabolon, Inc. | Biomarqueurs liés à la fonction rénale et méthodes d'utilisation de ceux-ci |
WO2016025429A1 (fr) * | 2014-08-15 | 2016-02-18 | The Johns Hopkins University | Estimation précise du débit de filtration glomérulaire à partir de plusieurs biomarqueurs |
Non-Patent Citations (4)
Title |
---|
ANNA SOLINI ET AL: "Prediction of Declining Renal Function and Albuminuria in Patients With Type 2 Diabetes by Metabolomics", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 101, no. 2, 1 February 2016 (2016-02-01), US, pages 696 - 704, XP055699144, ISSN: 0021-972X, DOI: 10.1210/jc.2015-3345 * |
See also references of WO2018118630A1 * |
TAKAHASHI N ET AL: "Tandem mass spectrometry measurements of creatinine in mouse plasma and urine for determining glomerular filtration rate", KIDNEY INTERNATIONAL, NATURE PUBLISHING GROUP, LONDON, GB, vol. 71, no. 3, 1 February 2007 (2007-02-01), pages 266 - 271, XP008133184, ISSN: 0085-2538, [retrieved on 20061206] * |
VINCENT GUAY: "Material Safety Data Sheet", CDN ISOTOPES FLYER, 1 January 2014 (2014-01-01), pages 1 - 2, XP055699855, Retrieved from the Internet <URL:https://cymitquimica.com/products/3U-D7000/17093-74-2/n-acetyl-d3-l-threonine-23-d2/> [retrieved on 20200529] * |
Also Published As
Publication number | Publication date |
---|---|
JP7393206B2 (ja) | 2023-12-06 |
WO2018118630A1 (fr) | 2018-06-28 |
CA3045022A1 (fr) | 2018-06-28 |
US20190346455A1 (en) | 2019-11-14 |
US11619636B2 (en) | 2023-04-04 |
JP2020502544A (ja) | 2020-01-23 |
EP3555615A1 (fr) | 2019-10-23 |
CN110088615A (zh) | 2019-08-02 |
CN110088615B (zh) | 2023-08-22 |
CA3045022C (fr) | 2024-01-16 |
AU2017382744A1 (en) | 2019-06-13 |
AU2017382744B2 (en) | 2023-02-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3555615A4 (fr) | Méthode de dosage par spectrométrie de masse permettant une détection et une quantification de métabolites de la fonction rénale | |
EP3850359A4 (fr) | Procédé de dosage par spectrométrie de masse pour la détection et la quantification de métabolites liés aux microbiotes | |
EP3548652A4 (fr) | Procédés d'analyse de protéines | |
EP3465202A4 (fr) | Procédé de spectrométrie de masse destinée à la détection et la quantification de métabolites | |
EP3612509A4 (fr) | Procédé de dosage par spectrométrie de masse pour la détection et la quantification de métabolites d'acide organique | |
EP3443485A4 (fr) | Systèmes et procédés pour la détermination de point d'intérêt | |
EP3304064A4 (fr) | Procédés de quantification par spectrométrie de masse d'analytes extraits d'un dispositif de micro-échantillonnage | |
EP3661966A4 (fr) | Anticorps anti-cd39, compositions comprenant des anticorps anti-cd39 et méthodes d'utilisation d'anticorps anti-cd39 | |
EP3452615A4 (fr) | Procédés de capture d'adn méthylé acellulaire, et utilisations desdits procédés | |
EP3333192A4 (fr) | Anticorps dirigé contre le glypican-3 et application associée | |
EP3320347A4 (fr) | Systèmes, procédés et dispositifs de numérisation automatique d'échantillons | |
EP3552137A4 (fr) | Système et procédés de détection de logiciels malveillants avec chiffrement | |
EP3732463A4 (fr) | Détermination de caractéristiques structurales d'un objet | |
EP3341711A4 (fr) | Systèmes et procédés de détection multiplexée de biomarqueurs | |
EP3691626A4 (fr) | Méthodes de détection de la transthyrétine | |
EP3493198A4 (fr) | Procédé et dispositif de détermination de retard d'un élément audio | |
EP3562429A4 (fr) | Système et méthode de détermination de caractéristiques structurales d'un objet | |
EP3519572A4 (fr) | Composés et procédés pour réduire l'expression de tau | |
EP3452618A4 (fr) | Étalons analytiques et leurs procédés d'utilisation | |
EP3115778A4 (fr) | Procédé de spectrométrie de masse et spectromètre de masse | |
EP3299769B8 (fr) | Auto-étalonnage d'un système d'inertie | |
EP3436025A4 (fr) | Procédés de séparation et de détection d'un oxystérol | |
EP3458171A4 (fr) | Procédés permettant d'influer sur la séparation | |
EP3107114A4 (fr) | Spectromètre de masse et procédé de spectrométrie de masse | |
EP3676798A4 (fr) | Système de recherche pour extraction de biosignature et découverte de biomarqueurs |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20190711 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: G01N 33/68 20060101AFI20200629BHEP |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40014572 Country of ref document: HK |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R079 Free format text: PREVIOUS MAIN CLASS: G01N0030720000 Ipc: G01N0033680000 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20201005 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: G01N 33/68 20060101AFI20200929BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
R17P | Request for examination filed (corrected) |
Effective date: 20190711 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
17Q | First examination report despatched |
Effective date: 20220728 |
|
P01 | Opt-out of the competence of the unified patent court (upc) registered |
Effective date: 20230527 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: GRANT OF PATENT IS INTENDED |
|
INTG | Intention to grant announced |
Effective date: 20240524 |