EP3526342A1 - Composition detergente - Google Patents
Composition detergenteInfo
- Publication number
- EP3526342A1 EP3526342A1 EP18811851.7A EP18811851A EP3526342A1 EP 3526342 A1 EP3526342 A1 EP 3526342A1 EP 18811851 A EP18811851 A EP 18811851A EP 3526342 A1 EP3526342 A1 EP 3526342A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- bacterium
- detergent composition
- seq
- pathogenic
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 239000003599 detergent Substances 0.000 title claims abstract description 36
- 241000894006 Bacteria Species 0.000 claims abstract description 104
- 230000001717 pathogenic effect Effects 0.000 claims abstract description 33
- 239000007788 liquid Substances 0.000 claims abstract description 29
- 244000005700 microbiome Species 0.000 claims abstract description 23
- 244000052769 pathogen Species 0.000 claims description 27
- 239000003755 preservative agent Substances 0.000 claims description 27
- 239000002773 nucleotide Substances 0.000 claims description 18
- 125000003729 nucleotide group Chemical group 0.000 claims description 18
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 15
- 230000002335 preservative effect Effects 0.000 claims description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 241000193744 Bacillus amyloliquefaciens Species 0.000 claims description 10
- 241000588724 Escherichia coli Species 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 8
- 239000012228 culture supernatant Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 239000004094 surface-active agent Substances 0.000 claims description 7
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 6
- 230000003115 biocidal effect Effects 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 claims description 5
- DHVLDKHFGIVEIP-UHFFFAOYSA-N 2-bromo-2-(bromomethyl)pentanedinitrile Chemical compound BrCC(Br)(C#N)CCC#N DHVLDKHFGIVEIP-UHFFFAOYSA-N 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
- 241000191967 Staphylococcus aureus Species 0.000 claims description 5
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 5
- 125000003158 alcohol group Chemical group 0.000 claims description 5
- 150000001412 amines Chemical group 0.000 claims description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 5
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 5
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 5
- MGIYRDNGCNKGJU-UHFFFAOYSA-N isothiazolinone Chemical compound O=C1C=CSN1 MGIYRDNGCNKGJU-UHFFFAOYSA-N 0.000 claims description 5
- 239000011707 mineral Substances 0.000 claims description 5
- 108700019599 monomethylolglycine Proteins 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 229930195732 phytohormone Natural products 0.000 claims description 5
- 229940101011 sodium hydroxymethylglycinate Drugs 0.000 claims description 5
- CITBNDNUEPMTFC-UHFFFAOYSA-M sodium;2-(hydroxymethylamino)acetate Chemical compound [Na+].OCNCC([O-])=O CITBNDNUEPMTFC-UHFFFAOYSA-M 0.000 claims description 5
- 229940075554 sorbate Drugs 0.000 claims description 5
- 229940075582 sorbic acid Drugs 0.000 claims description 5
- 235000010199 sorbic acid Nutrition 0.000 claims description 5
- 239000004334 sorbic acid Substances 0.000 claims description 5
- 229960003500 triclosan Drugs 0.000 claims description 5
- 241000233866 Fungi Species 0.000 claims description 4
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 230000004060 metabolic process Effects 0.000 claims description 3
- 244000000010 microbial pathogen Species 0.000 claims description 3
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 3
- 238000012419 revalidation Methods 0.000 claims description 3
- 206010041925 Staphylococcal infections Diseases 0.000 claims 1
- 230000003042 antagnostic effect Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 claims 1
- 239000002609 medium Substances 0.000 description 18
- 241000222122 Candida albicans Species 0.000 description 10
- 229940095731 candida albicans Drugs 0.000 description 10
- 230000000694 effects Effects 0.000 description 8
- 230000003993 interaction Effects 0.000 description 7
- 238000009630 liquid culture Methods 0.000 description 6
- 239000003381 stabilizer Substances 0.000 description 6
- 229920001817 Agar Polymers 0.000 description 5
- 239000008272 agar Substances 0.000 description 5
- 239000003960 organic solvent Substances 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000193830 Bacillus <bacterium> Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 241001138501 Salmonella enterica Species 0.000 description 3
- 241000193996 Streptococcus pyogenes Species 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 238000003501 co-culture Methods 0.000 description 3
- 239000000645 desinfectant Substances 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 239000004382 Amylase Substances 0.000 description 2
- 102000013142 Amylases Human genes 0.000 description 2
- 108010065511 Amylases Proteins 0.000 description 2
- 241000062285 Bacillus amyloliquefaciens group Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- 235000019418 amylase Nutrition 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 2
- NKDDWNXOKDWJAK-UHFFFAOYSA-N dimethoxymethane Chemical compound COCOC NKDDWNXOKDWJAK-UHFFFAOYSA-N 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
- 125000001475 halogen functional group Chemical group 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 229960003085 meticillin Drugs 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- OAAZUWWNSYWWHG-UHFFFAOYSA-N 1-phenoxypropan-1-ol Chemical compound CCC(O)OC1=CC=CC=C1 OAAZUWWNSYWWHG-UHFFFAOYSA-N 0.000 description 1
- 108020004465 16S ribosomal RNA Proteins 0.000 description 1
- OAYXUHPQHDHDDZ-UHFFFAOYSA-N 2-(2-butoxyethoxy)ethanol Chemical compound CCCCOCCOCCO OAYXUHPQHDHDDZ-UHFFFAOYSA-N 0.000 description 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- PUSPAPGHKSLKKH-UHFFFAOYSA-N 2-methyl-1,2-thiazolidin-3-one Chemical compound CN1SCCC1=O PUSPAPGHKSLKKH-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- 108020005097 23S Ribosomal RNA Proteins 0.000 description 1
- XDMYYHWZRFUZSZ-UHFFFAOYSA-N 4-chloro-2-methyl-1,2-thiazolidin-3-one Chemical compound CN1SCC(Cl)C1=O XDMYYHWZRFUZSZ-UHFFFAOYSA-N 0.000 description 1
- 229940046305 5-bromo-5-nitro-1,3-dioxane Drugs 0.000 description 1
- 241000186046 Actinomyces Species 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- 241000223602 Alternaria alternata Species 0.000 description 1
- 241000266326 Alternaria botrytis Species 0.000 description 1
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 241000193755 Bacillus cereus Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000589972 Borrelia sp. Species 0.000 description 1
- LVDKZNITIUWNER-UHFFFAOYSA-N Bronopol Chemical compound OCC(Br)(CO)[N+]([O-])=O LVDKZNITIUWNER-UHFFFAOYSA-N 0.000 description 1
- 241000589562 Brucella Species 0.000 description 1
- 241000589876 Campylobacter Species 0.000 description 1
- 241000193464 Clostridium sp. Species 0.000 description 1
- 241000186249 Corynebacterium sp. Species 0.000 description 1
- 241000147019 Enterobacter sp. Species 0.000 description 1
- 241000589565 Flavobacterium Species 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 241000606841 Haemophilus sp. Species 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 241000588754 Klebsiella sp. Species 0.000 description 1
- 241000186780 Listeria ivanovii Species 0.000 description 1
- 241000186779 Listeria monocytogenes Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000187488 Mycobacterium sp. Species 0.000 description 1
- LGRAHSFRTOITOM-UHFFFAOYSA-N NC(=O)NC1=NNCC1 Chemical compound NC(=O)NC1=NNCC1 LGRAHSFRTOITOM-UHFFFAOYSA-N 0.000 description 1
- 241000588653 Neisseria Species 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 241000606580 Pasteurella sp. Species 0.000 description 1
- 241000228168 Penicillium sp. Species 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 241000588770 Proteus mirabilis Species 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- 241000194022 Streptococcus sp. Species 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 241000607734 Yersinia <bacteria> Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 229940065181 bacillus anthracis Drugs 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- DMSMPAJRVJJAGA-UHFFFAOYSA-N benzo[d]isothiazol-3-one Chemical compound C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- XVBRCOKDZVQYAY-UHFFFAOYSA-N bronidox Chemical compound [O-][N+](=O)C1(Br)COCOC1 XVBRCOKDZVQYAY-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- VXIVSQZSERGHQP-UHFFFAOYSA-N chloroacetamide Chemical compound NC(=O)CCl VXIVSQZSERGHQP-UHFFFAOYSA-N 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000001955 cumulated effect Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- -1 glycol ethers Chemical class 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 1
- 238000009343 monoculture Methods 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 235000010292 orthophenyl phenol Nutrition 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000003209 petroleum derivative Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/381—Microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
Definitions
- the present invention relates to detergent compositions having the property of specifically inhibiting the growth of pathogens or undesirable ones.
- Pathogenic bacteria are a health hazard. This danger, due to their pathogenicity, is amplified by their multi-resistance to antibiotics. In fact, the use or overuse of antibiotics has led to the emergence of multi-resistant pathogenic strains.
- Disinfectants may present a solution but with toxicological and ecotoxicological risks that these disinfectants present.
- Patent application WO 2014/079938 describes the addition of enzymes to detergent compositions for the treatment of biofilms resistant to conventional disinfectants and / or biocides.
- US patent application 2008/0233093 describes the use of very particulate strains of Bacillus ssp to reduce the formation of biofilms.
- US 2010/0028314 discloses the use of Bacillus amyloliquefaciens strain NRRL B-50154 in the treatment of biofilms and its use in several distinct embodiments, which are related to the secretion of amylase by this bacterial strain.
- US 2010/0008893 discloses the use of Bacillus velezensis strain NRRL B-50150 in the treatment of biofilms, here also thanks to the secretion of amylase by this bacterial strain.
- US 2011/0230345 describes the use of the strain NRRL B-50349 Bacillus amyloliquefaciens for phytosanitary use.
- the present invention relates to a method for identifying a bacterium capable of interacting with the growth of pathogenic or undesirable microorganisms comprising the following successive steps:
- one or more pathogenic or unwanted micro-organism (s) is taken;
- the culture conditions for the growth of both said pathogenic or undesirable microorganism (s) and said bacterium (to be tested) are determined and / or a culture supernatant of said bacterium (to be tested) is taken;
- a bacterium which causes a specific reduction in the growth of at least one of said pathogenic or unwanted microorganism (s).
- the pathogen (s) is (are) selected from Gram- bacteria, Gram + bacteria, molds and yeasts.
- At least 2, 3, 4 or 5 microorganisms are selected which are pathogenic (s) or undesirable (s).
- the pathogenic or undesirable microorganism include Escherichia coli, Staphylococcus aureus (eg MRSA), and another pathogen selected from Pseudomonas aeruginosa, a yeast and a fungus, preferably a , 2, or each of said pathogens is (are) resistant to antibiotic treatment.
- the growth of other pathogenic microorganisms, such as Salmonella enterica (Enterica subsp.) And Streptococcus pyogenes is also reduced by the composition of the present invention.
- the pathogens are known to cause diseases, for example nosocomial diseases.
- the bacterium (to be tested) is from the Bacillus amylollecaclens group.
- At least 100 contiguous nucleotides of the genome of the bacterium has at least 75% identity with at least 100 contiguous nucleotides of SEQ.ID.NO: 1, SEQ.ID.NO: 3, SEQ. ID.NO: 4 and / or SEQ.ID.NO: 5.
- a related aspect of the invention relates to the use of the bacterium obtainable by the above method (in particular a bacterium of the group Bacillus amylollquefaciens and / or a bacterium having at least 75% identity with at least 100 contiguous nucleotides of SEQ.ID.NO: 1, SEQ.ID.NO: 3, SEQ.ID.NO: 4 and / or SEQ.ID.NO: 5), in a detergent composition, intended preferably cleaning surfaces and / or floors and / or points of contact.
- Such use is advantageous for communities, such as hospitals, nurseries for young children, retirement homes for the elderly or in revalidation, department stores, canteens and kitchens.
- a liquid detergent composition of pH between 2.5 and 11.5 comprising (i) a bacterium, (ii) one or more molecule (s) having surface and / or surfactant and / or amphiphilic and (iii) a preservative for the reduction of pathogenic and / or nosocomial bacteria present on a surface and / or points of contact.
- the bacterium is likely to be obtained by the method described above (in particular the bacteria of the Bacillus amyloliquefaciens group and / or those having at least 75% identity with at least 100 contiguous nucleotides of SEQ.ID.NO: 1, SEQ.ID.NO: 3, SEQ.ID.NO: 4 and / or SEQ.ID.NO: 5).
- the preservative is preferably chosen from the group consisting of isothiazolinone, formaldehyde and its liberators, preservatives with an amine function, preservatives with an alcohol function, benzoate and its derivatives, parabens and derivatives, methyldibromoglutaronitrile, Sodium hydroxy methyl glycinate, triclosan and Sorbate (and / or sorbic acid).
- liquid detergent composition comprising one or more molecule (s) having surface and / or surface active and / or amphiphilic properties in an amount by weight of between 1% and 30%; one or more preservative agent (s) in an amount by weight of between 0.001% and 10% and a bacterium obtainable by the method described above (in particular a bacterium of the Bacillus amyloliquefaciens group and / or a bacterium having at least 75% identity with at least 100 contiguous nucleotides of SEQ.ID.NO: 1, SEQ.ID.NO: 3, SEQ.ID.NO: 4 and / or SEQ.ID.NO : 5).
- the preservative of the detergent composition is selected from the group consisting of isothiazolinone, formaldehyde and its liberators, preservatives with an amine function, preservatives with an alcohol function, benzoate and its derivatives, parabens and derivatives, quaternary ammoniums, methyldibromoglutaronitrile, Sodium hydroxy methyl glycinate, triclosan and Sorbate (and / or sorbic acid).
- the bacterium is present at a concentration of at least 200,000 cfu / ml, preferably at least 1000000 cfu / ml, more preferably at a concentration of at least 10,000,000 cfu / ml.
- the detergent composition further comprises one or more compound (s) selected from (mono-) nucleotides (or nucleosides), a phytohormone, mineral nitrogen and a carbon source.
- compound (s) selected from (mono-) nucleotides (or nucleosides), a phytohormone, mineral nitrogen and a carbon source.
- Another related aspect of the present invention is a liquid composition
- a liquid composition comprising at least 200,000 cfu / ml, preferably at least 1000000 cfu / ml, more preferably at least 10,000,000 cfu / ml of a bacterium of which at least 100 contiguous nucleotides of its genome has at least 75% identity with at least 100 contiguous nucleotides of SEQ.ID. NO: 1 or SEQ.ID. NO: 3 and / or SEQ.ID. NO: 4 and / or SEQ.ID. NO: 5.
- this liquid composition further comprises a preserving agent (selected from the group consisting of isothiazolinone, formaldehyde and its liberators, preservatives with an amine function, preservatives with an alcohol function, benzoate and its derivatives, parabens and derivatives, quaternary ammoniums, methyldibromoglutaronitrile, sodium hydroxy methyl glycinate, triclosan and sorbate (and / or sorbic acid) and / or one or more compounds selected from nucleotides, a phytohormone, mineral nitrogen and a source of carbon.
- a preserving agent selected from the group consisting of isothiazolinone, formaldehyde and its liberators, preservatives with an amine function, preservatives with an alcohol function, benzoate and its derivatives, parabens and derivatives, quaternary ammoniums, methyldibromoglutaronitrile, sodium hydroxy methyl glycinate, triclosan
- Figure 1 depicts the interaction between the bacterium of the invention (BS) and Candida albicans (CA) in liquid culture.
- Figure 2 depicts the interaction between the bacterium of the invention (BS) and Staphylococcus aureus (methicillin-resistant strain; MRSA) in liquid culture.
- BS bacterium of the invention
- MRSA methicillin-resistant strain
- Figure 3 depicts the interaction between the bacterium of the invention (BS) and Escherichia coli (EC) in liquid culture.
- the inventor has surprisingly noticed that the enrichment of bacteria specific to a detergent composition intended to be applied to a surface reduces the amount of pathogens on that surface without there being any biocidal or overall disinfecting effect.
- the inventor has succeeded in introducing this bacterium into detergent compositions which, in both their concentrated and diluted forms, are compatible with the metabolism of these bacteria.
- a first aspect of the invention is therefore a method for identifying a bacterium capable of interacting with the growth of pathogens (or harmful microorganisms) comprising the following successive stages:
- a bacterium to be tested (identified) or a collection of bacteria to be tested (identified) is sampled (selected);
- one or more pathogens are sampled (selected);
- the growth of the pathogen (s) (and / or microorganism) is determined (i) in the absence of this bacterium and (ii) in the presence of this bacterium and / or the growth of the pathogen is determined in the presence culture supernatant of this bacterium;
- a bacterium that causes a specific reduction in the growth of at least one of the pathogens.
- the terminology “reduction (specific) of growth” means that the amount of the pathogen in condition (ii), therefore in the presence of the bacterium to be tested or the culture supernatant of the bacterium to be tested, is less than in condition (i), so in the absence of the bacterium to be tested.
- the amount of the pathogen after culture in condition (ii) may also be less than the quantity seeded.
- the term "specific (growth) reduction” means that the bacterium does not have a general biocidal effect.
- the bacterium of the invention may, for example, act in competition with the pathogen (or microorganism), or produce a factor that specifically disrupts the metabolism of the pathogen (or microorganism).
- Measure (ii) above can be done in several ways that can be cumulated. In particular, it is possible to take a supernatant from a culture of the bacteria to be tested and measure the effect of this supernatant on the growth of pathogens or the microorganism (in monoculture).
- An alternative is to perform a co-culture test in which a pre-determined amount of the bacterium and the pathogen (or microorganism) are seeded.
- a pre-determined amount of the bacterium and the pathogen or microorganism
- different quantity ratios between the bacterium and the pathogen are tested.
- the pathogen is advantageously in culture on a surface (but preferably not as a biofilm). This makes it possible to demonstrate a possible phenomenon of competition for the substrate, or even the presence of an inhibitory factor that would be produced by the bacterium to be tested (eg presence of an inhibition halo).
- a preferred culture medium for co-cultivation includes yeast extracts, protein hydrolysates (peptone) and metabolizable sugars, e.g. glucose.
- the pH of the medium is controlled, and maintained during the culture.
- peptone protein hydrolysates
- metabolizable sugars e.g. glucose.
- the pH of the medium is controlled, and maintained during the culture.
- the bacteria to be tested may be any bacterium that does not adversely affect the properties of the detergent composition.
- these bacteria have no known toxicity to humans or animals and do not have a general biocidal effect.
- These bacteria are preferably natural, that is, they are not modified by genetic engineering.
- a preferred strain of these bacteria is to be found in the Bacillus subtilis complex.
- Bacillus amyloliquefaciens or Bacillus velezensis More preferably, the bacteria to be tested have an element of their genome having at least 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, (approximately) 95%, 96%, 97%, 98%, 99% or even 100% identity with at least 100 contiguous nucleotides of 16S or 23S ribosomal RNA from Bacillus amyloliquefaciens (eg ATCC strains 39374 and 39320, see SEQ.ID.Our: 1, 2) or
- Bacillus velezensis eg strain NRRL B-41580, SEQ.ID.NO: 3
- Bacillus velezensis eg strain NRRL B-41580, SEQ.ID.NO: 3
- a related aspect of the present invention is that of using the bacterium described above to reduce, for example on a surface, the amount of nosocomial bacteria, yeasts and / or fungi and / or which can cause diseases and / or or unwanted.
- yeast and / or nosocomial fungi and / or which can cause diseases we find in particular certain strains of Escherichia coli, Staphylococcus aureus, in particular meticillin-resistant strains (MRSA), Pseudomonas aeruginosa and Candida albicans or even Salmonella enterica (Enterica subsp.) and Streptococcus pyogenes.
- MRSA meticillin-resistant strains
- Pseudomonas aeruginosa and Candida albicans
- Salmonella enterica Enterica subsp.
- Streptococcus pyogenes Salmonella enterica
- Another related aspect of the present invention is the use (or incorporation) of the bacterium identified above in detergent compositions.
- the preferred detergent compositions are those for the treatment of surfaces, particularly surfaces of communities such as hospitals, nurseries for young children, nursing homes for elderly or revalidating, department stores (including the handles of caddies), canteens.
- the detergent compositions are not particularly limited.
- the detergent compositions are liquids. They preferably have pH (in general the detergent compositions contain water, which does not exclude the presence, even majority, of organic solvents) and the various compounds in concentration which are compatible with the life of the bacterium (described above) for a sufficiently long period (for example several weeks or more, in general, the compositions are stable for several months, for example 10 months or more).
- the bacterium of the invention may be formulated in an intermediate composition, preferably a liquid, which must be mixed just before use with the detergent composition, preferably in simple proportions (eg between 1: 100 and 100: 1, preferably between 1: 10 and 10: 1).
- the detergent composition is a liquid solution (aqueous and / or comprising one or more organic solvents) and this solution comprises (besides the bacterium described above) at least one molecule having surface properties and and / or surfactant and / or amphiphilic surfactants and soaps (preferably less than 30% by weight) and one (at least one) preservative (and / or stabilizing) agent (up to 10% by weight for total preservatives present).
- the detergent composition is aqueous, including a composition comprising one or more organic solvents
- its pH is set, preferably between 2.5 and 11.5, advantageously between 4 and 10, or even between 7 and 10.
- composition further comprises, advantageously, waxes and / or polymers (preferably less than 30% by weight), bleaching agents (preferably less than 15% by weight), acids, bases (preferred) or salts (preferably a total of less than 30% by weight), as well as one or more compounds selected from the group consisting of chelants, enzymes, thickeners and corrosion inhibitors.
- the detergent composition may optionally include one or more perfume (s) and / or one or more dyeing agent (s).
- Another related aspect of the present invention is the bacterium identified above in a liquid medium at a concentration of at least 200,000 cfu / ml, for example at least 500,000 cfu / ml, at least 1 million cfu / ml, at least 5 million cfu / ml, at least 10 million cfu / ml, for example about 40 to about 70 million cfu / ml.
- Cfu is the English acronym for "colony forming unit", which is the usual way of quantify the presence of a bacterium by its capacity to generate colonies, once this bacterium seeded on a suitable culture medium.
- this liquid medium further comprises at least one molecule having surface and / or surfactant and / or amphiphilic properties such as surfactants and soaps (preferably less than 30% by weight) and a preservative (stabilizing agent). ) (up to 10% by weight, preferably up to 1% by weight).
- a preservative stabilizing agent
- the liquid medium advantageously further comprises one or more compounds for promoting the growth of the bacterium of the invention (once placed on a surface to be cleaned), preferably chosen from nucleotides (eg, adenine, guanine, 0.1 to 1% by weight: weight of liquid medium ) / a phytohormone, for example 3-acetic indole (from 0.01% to 0.1% by weight, liquid medium ), mineral nitrogen (eg NH 4 S0 4 : 0, 1-1% by weight liquid miiieu) and a carbon source (eg. glucose).
- nucleotides eg, adenine, guanine, 0.1 to 1% by weight: weight of liquid medium
- a phytohormone for example 3-acetic indole (from 0.01% to 0.1% by weight, liquid medium ), mineral nitrogen (eg NH 4 S0 4 : 0, 1-1% by weight liquid miiieu) and a carbon source (eg. glucose).
- This compound for promoting the growth of the bacterium of the invention is particularly useful for formulations where the concentration of the bacterium of the invention is lower (eg 200,000 cfu / ml, 500,000 cfu / ml, 1000000 cfu / ml)
- the liquid medium may be aqueous, which means that it comprises water and may also include non-aqueous solvents.
- a preferred liquid medium comprises at least 50% by weight (organic solvent weight: weight of all solvents) of a solvent (i.e. a non-aqueous liquid at room temperature) selected from the group consisting of alcohols (eg benzyl, ethanol, isopropanol), glycol ethers (eg butyldiglycol, monopropylene glycol, dipropylene glycol), petroleum distillates (eg "white spirit", petroleum ether, paraffin oil), amino compounds (ex. monoethanolamine), ketone and aldehyde derivatives (eg methylal, dimethoxy methane).
- a solvent i.e. a non-aqueous liquid at room temperature
- the preservative (s) (stabilizer (s)) are present at concentrations of 10% by weight maximum, preferably between 0.001% and 10%, more preferably between 0.01% and 1%, of even more preferably, between 0.05% and 0.2% (weight of the preservative (s) present (s): weight of the composition).
- the preservative (s) are preferably selected from the group consisting of isothiazolinone (eg 1,2-benzisothiazol-3-one; 2-methyl-2H-isothiazol-3-one; Chloro-2-methyl-isothiazolin-3 (2H) -one (CMI) 2-methylisothiazolin-3 (2H) -one (MI)), formaldehyde and its liberators (eg glutaraldehyde, 2-bromo-2-nitropropane -1,3-diol; 5-bromo-5-nitro-1,3-dioxane), preservatives (stabilizers) with an amine function (eg Diazolinidylurea, Chloroacetamide), preservatives (stabilizers) with an alcohol function (ex: Phenoxypropanol, benzyl alcohol, o-phenylphenol, phenoxyethanol), benzoate and its derivatives, parabens and derivatives, methyldi
- Example 2 Development of a liquid medium common to the bacterium of the invention and SP.
- the inventor has noticed that all the SP strains above (same CA, whose culture is recommended rather at pH 5, 6), but also the bacterium of the invention, are capable of growing in medium A comprising an extract yeast, peptone and glucose at pH 7 and at room temperature.
- Example 3 Analysis of the interaction between the bacterium of the invention and SP in liquid culture.
- the starting inoculum of the strain of the bacterium of the invention was fixed at a high concentration.
- a colony of the bacterium of the invention is taken from an agar plate and inoculated into 10 ml of medium A in a vial.
- the number of CFU / ml is determined after a 24-hour incubation with the particle counter.
- the concentration of the starting inoculum of the SP strains is 5.10 2 CFU / ml.
- several colonies are removed from the agar plate and suspended in a precise volume of medium A. This culture is then counted on the particle counter and then diluted to the desired concentration.
- the bacterium of the invention reduced EC growth, greatly reduced AC growth and had an even stronger effect on
- the bacterium of the invention also greatly reduced the growth in liquid medium Salmonella enterica (subs Enterica) and Streptococcus pyogenes.
- the bacterium of the present invention did not have any significant effect in liquid culture on the growth of KP or PA, which shows that the bacterium of the invention does not have general biocidal properties, and suggests a specific effect.
- the interaction between the bacterium of the invention and each strain of SP was studied in agar medium: firstly, the effect of the culture supernatant was tested on an agar culture of each SP; on the other hand, the effect of the bacterium of the invention on the growth of SP strains was tested by streaking or by adding colonies of the bacterium of the invention to a SP carpet.
- CA and EC were cultured, and show carpet growth.
- Measurement of striated interactions showed significant growth of the bacterium of the invention, and a low number of CA colonies. The effect is even more dramatic in the case of MRSA, and also observable in the case of EC.
- the inventor also cultured the SPs on agar, and after drying, 3 colonies of the bacterium of the invention.
- the bacterium of the invention has had a significant growth, which covers CA.
- the inventor has observed that the bacterium of the invention, where it was seeded, caused MRSA growth inhibition halos. The effect is less pronounced for other SPs.
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Application Number | Priority Date | Filing Date | Title |
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BE2017/5916A BE1025305B1 (fr) | 2017-12-08 | 2017-12-08 | Composition détergente |
BE2018/5504A BE1025484B1 (fr) | 2017-12-08 | 2018-07-12 | Composition détergente |
PCT/EP2018/084001 WO2019110811A1 (fr) | 2017-12-08 | 2018-12-07 | Composition detergente |
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EP18811851.7A Withdrawn EP3526342A1 (fr) | 2017-12-08 | 2018-12-07 | Composition detergente |
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US (1) | US20210171877A1 (fr) |
EP (1) | EP3526342A1 (fr) |
BE (2) | BE1025305B1 (fr) |
CA (1) | CA3121541A1 (fr) |
WO (1) | WO2019110811A1 (fr) |
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FR3118058A1 (fr) | 2020-12-22 | 2022-06-24 | H T S Bio | Souche de bacillus pumilus presentant un fort antagonisme vis-a-vis de pathogenes de surface |
US20220206955A1 (en) * | 2020-12-26 | 2022-06-30 | Intel Corporation | Automated translation lookaside buffer set rebalancing |
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US4545991A (en) * | 1983-06-13 | 1985-10-08 | Merck & Co., Inc. | Difficidin and derivative antibacterials |
AU2007284126B2 (en) * | 2006-08-11 | 2013-12-19 | Novozymes Biologicals, Inc. | Bacteria cultures and compositions comprising bacteria cultures |
JP5427041B2 (ja) * | 2007-03-23 | 2014-02-26 | ノボザイムス バイオロジカルズ,インコーポレイティド | バイオフィルム形成及びプランクトン様増殖の予防及び低減 |
US20100008893A1 (en) * | 2008-07-11 | 2010-01-14 | Novozymes A/S | Bacillus velezensis strain |
WO2010014715A1 (fr) * | 2008-07-30 | 2010-02-04 | Novozymes A/S | Souche de bacillus amyloliquefaciens |
US9234251B2 (en) * | 2010-03-19 | 2016-01-12 | Novozymes Biologicals, Inc. | Bacillus amyloliquefaciens strain |
CA2892497A1 (fr) | 2012-11-26 | 2014-05-30 | Realco S.A. | Procede d'elimination de biofilms pour le nettoyage d'instruments medicaux, en particulier pour lutter contre les maladies nosocomiales |
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2017
- 2017-12-08 BE BE2017/5916A patent/BE1025305B1/fr active IP Right Grant
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2018
- 2018-07-12 BE BE2018/5504A patent/BE1025484B1/fr active IP Right Grant
- 2018-12-07 CA CA3121541A patent/CA3121541A1/fr active Pending
- 2018-12-07 EP EP18811851.7A patent/EP3526342A1/fr not_active Withdrawn
- 2018-12-07 US US16/768,732 patent/US20210171877A1/en not_active Abandoned
- 2018-12-07 WO PCT/EP2018/084001 patent/WO2019110811A1/fr unknown
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US20210171877A1 (en) | 2021-06-10 |
WO2019110811A1 (fr) | 2019-06-13 |
BE1025305B1 (fr) | 2019-01-11 |
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