EP3435951A1 - Installation et procédé pour produire une préparation médicamenteuse et canule pour une installation de production d'une préparation médicamenteuse - Google Patents

Installation et procédé pour produire une préparation médicamenteuse et canule pour une installation de production d'une préparation médicamenteuse

Info

Publication number
EP3435951A1
EP3435951A1 EP17713701.5A EP17713701A EP3435951A1 EP 3435951 A1 EP3435951 A1 EP 3435951A1 EP 17713701 A EP17713701 A EP 17713701A EP 3435951 A1 EP3435951 A1 EP 3435951A1
Authority
EP
European Patent Office
Prior art keywords
channel
cannula
container
valve
pharmaceutical preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17713701.5A
Other languages
German (de)
English (en)
Inventor
Martin Biehl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Kabi Deutschland GmbH
Original Assignee
Fresenius Kabi Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Kabi Deutschland GmbH filed Critical Fresenius Kabi Deutschland GmbH
Publication of EP3435951A1 publication Critical patent/EP3435951A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2037—Separating means having valve means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2072—Venting means for internal venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2082—Filtering means for gas filtration

Definitions

  • the invention relates to a system for automated
  • the invention relates to a plant, by means of drugs, in particular cytostatics, from a drug
  • the invention further relates to a method for
  • Preparing a pharmaceutical preparation and a cannula for a plant for producing a pharmaceutical preparation Preparing a pharmaceutical preparation and a cannula for a plant for producing a pharmaceutical preparation.
  • Plant is the plant, which is sold under the trade name PHARMAHELP® Compounder. Such plants are used in particular to cytostatics in
  • Transfer infusion bag which are then provided in particular directly for use on a patient.
  • Such a system may comprise a movable device in which one actuated by means of an actuator
  • Syringe is arranged.
  • the drug from a reservoir, which comprises a septum removed in portions by being pierced by means of a cannula into the septum and the drug by pulling the syringe into the movable device is transferred.
  • the movable device moves to a designated infusion bag and also transferred by means of the cannula drug on a
  • Connect e.g., a port to the infusion bag.
  • the reservoirs are usually made of glass vials and must usually be vented during the removal of the drug to prevent the formation of a negative pressure, which prevents drug delivery or reduces the dosing accuracy.
  • Agent container is ventilated via a second cannula.
  • a ventilation system is available on the market under the trade name PHARMAVENT® and comprises a 90 ° angled cannula, which is placed before the
  • Ventilation cannula requires further work steps.
  • the object of the invention is to reduce the aforementioned disadvantages of the prior art. It is a particular object of the invention, the
  • the object of the invention is already achieved by a plant for producing a pharmaceutical preparation, by a process for producing a pharmaceutical preparation, and by a cannula for a plant for producing a
  • the invention initially relates to a system for, in particular automated, producing a pharmaceutical preparation.
  • infusion bags are filled with a pharmaceutical preparation.
  • the pharmaceutical preparation may be, for example, a cytostatic drug formulation.
  • the system includes a movable device for
  • the movable device comprises a syringe with a cannula to puncture the septum of the first container in which the medicament is stored.
  • the first container is a non-collapsible container, in particular a vial.
  • the syringe is preferably actuated via an actuator arranged in the movable device.
  • the movable device is movable in at least two spatial directions, preferably in a horizontal and a vertical spatial direction. So can by means of
  • movable means the cannula are pushed through the septum and the drug are removed by operating the syringe.
  • the movable device can then approach the second container, in particular the infusion bag, in order to release the medicament again by actuating the syringe.
  • the first container is in particular not collapsible, preferably formed as a glass vial, and may have a virtually arbitrary design.
  • the design of the septum is arbitrary. In particular, the septum
  • the septum can comprise a polymer layer, which automatically closes again when the cannula is withdrawn. But it is also possible to use a septum, which is already slotted.
  • the movable device can also comprise several syringes, each with a cannula.
  • Pharmaceutical preparation include a carousel with multiple syringes, by means of which a plurality of different syringes can be selected by the movable device to remove various drugs.
  • the first container or the first container are usually in an overhead position, so with the septum down, inserted in a holding device of the system and is or are pierced from below by the cannula.
  • the cannula comprises a first channel for removal of the
  • the movable means for transferring the drug comprises a second channel for
  • Invention is a pressure equalization, so that it is also conceivable to use a different gas.
  • the cannula comprises both the first channel for withdrawing the drug and the second channel for ventilating the first container.
  • a separate cannula is used for ventilation, which is pushed over the movable device together with the cannula for taking the drug into the septum.
  • This second cannula can in particular be moved synchronously with the cannula for removing the medicament, in particular by arranging the first and the second cannula on a common carrier.
  • the first channel comprises a valve which is open only when the medicine is in transit. About such a valve, the leakage of residual amounts of the drug in the system can continue
  • Container sealed valve this be disposed together with the first container, i.
  • the cannula does not need to be disposed of separately from the container.
  • the first container can be removed after emptying together with the cannula and disposed of.
  • the container and the cannula form a closed system.
  • the locking may be manual or automatic, e.g. by means of an actuating element.
  • the valve comprises a float or float, which at Floating drug floats and releases the first channel.
  • the float sits for this purpose on a valve seat and has a collar with an oversize fit, so that the collar, for example, during transport of the cannula, does not slip through a bottom, which forms the valve seat.
  • the float closes the valve with emptying of the first container.
  • the interference fit is dimensioned so that then due to the example of the syringe applied suction and the collar of the float is pulled through the floor.
  • valve is now due to the underlying collar, or, as it is provided in a further embodiment of the invention, due to a locking means in addition to the present in the closed position
  • the movable device can drive to
  • the valve is arranged in the first channel, in particular in the cannula, and is located between an inlet opening of the cannula and an outlet, in particular a connection for a syringe.
  • the valve is such an integral part of the cannula, which in turn no plant
  • a float As a valve, in particular a float can be used, which floats by incoming drug and thus releases the first channel for removal of the drug.
  • a float In addition to reducing the possibility of leakage of
  • Residuals is through a valve, which only at
  • Removal device in particular the syringe of the movable device is blocked for transferring the drug, which means that it can be easily detected that the first container is emptied.
  • a valve which comprises a float, which in turn actuates a lid.
  • the second channel so the channel for ventilation, is
  • a gas-permeable barrier in particular with a filter membrane, closed.
  • the gas-permeable barrier may in particular be designed such that it is liquid-tight, that is, does not allow the drug to pass.
  • the second channel comprises a
  • the medicament passes through the second channel and in particular penetrates as far as the aforementioned filter membrane.
  • the cannula preferably consists essentially of metal. However, it can also be used in accordance with the invention, a plastic cannula.
  • the second venting channel may be provided by a tube inserted into the cannula. It is also conceivable that the cannula has a partition wall.
  • the second channel or the dividing wall may also be formed by an injection-molded component guided into a metal cannula
  • the cannula preferably has an outer diameter of less than 2 mm.
  • the cannula preferably has an outer diameter of less than 2 mm.
  • a lower edge of an inlet opening of the first channel is at a distance from the adjacent septum
  • the lower edge of the inlet opening is preferably spaced less than 0.5 mm from the adjacent septum, so that not too large residual quantities remain in the first container.
  • the distance of the lower edge of the inlet opening of the first channel from a connecting piece, by means of which the cannula a syringe can be attached is preferably between 1.5 and 3 mm.
  • the inlet opening of the first channel should be from a
  • Inlet opening of the first channel are sucked.
  • the inlet opening of the first channel is arranged on an opposite side of the inflow opening of the second channel.
  • the total length of the cannula to a sprue area is preferably between 15 and 25 mm.
  • Inlet opening from the septum in the connected state to the distance from inlet opening and inlet opening is preferably more than 5, more preferably more than 8.
  • the distance from inlet opening and inlet opening is defined by the shortest distance between an edge of the two openings, ie in particular between the upper edge of the inlet opening and the lowest edge of the inlet opening.
  • the invention further relates to a, preferably
  • composition wherein in particular a plant described above or cannula described below is used or can be used.
  • a drug from a first container taken by pushing into a septum by means of the cannula.
  • the drug is received via a first channel in the cannula of the movable device, in particular by means of a syringe in the movable
  • the cannula has a second channel over which the first container is vented while the drug is being withdrawn.
  • the movable device is moved to a second container.
  • the movable device is moved downwards, whereby the cannula is pulled out of the septum of the first container.
  • a second container in particular a
  • Infusion bag a syringe or an elastomer pump, started with a connection and moves the movable device back up so that the cannula is pushed into the connection of the second container.
  • the drug is dispensed into the second container by actuating the syringe by means of the actuator.
  • the cannula comprises a valve and is removed together with the emptied first container.
  • the valve comprises a floating body, which floats in an open position by the drug entering an inlet opening of the cannula and, after emptying the first container, closes the valve, in particular again.
  • the float locks the valve in the closed position.
  • the lock can in particular due to a applied suction.
  • the suction can be generated, for example, by the aspirating syringe.
  • the invention further relates to a cannula for a
  • the cannula comprises a first channel having an inlet opening for taking out a medicament, and a second channel, which is separate from the first channel, with an inflow opening for ventilating a container.
  • the inflow opening is spaced from the inlet opening in a main direction of extent.
  • Inlet opening and / or inlet opening are preferably arranged laterally on the cannula in order to prevent the punching of a part of the septum.
  • the first channel comprises a valve which is arranged between the inlet opening and an outlet
  • connection for a syringe is arranged.
  • the valve reduces the risk of leakage from the system during operation.
  • valve may be a slotted membrane.
  • the valve is designed in such a way that it is only opened when the medicine is in transit.
  • This can be realized in particular by a float, which floats in an open position through the drug entering the inlet opening.
  • the float locks in the closed position of the valve after the emptying of the first container.
  • the second channel preferably comprises one
  • Backflow preventer in particular a check valve, in order to prevent, in particular during piercing of the septum, that drug passes through the second channel.
  • the cannula may be designed in such a way as has already been described in connection with the system and / or the method for producing a pharmaceutical preparation.
  • Fig. 1 shows a schematic representation of a first embodiment of a cannula, as it may be part of a plant for producing a pharmaceutical preparation.
  • Fig. 2 shows another embodiment of a cannula, which is provided with a valve.
  • Fig. 3 shows schematically a plant for producing a pharmaceutical preparation. Referring to Fig. 4, the configuration of a check valve in the ventilation duct will be explained.
  • Fig. 5 is a detailed view of an embodiment of the valve mechanism of the first channel in the open state.
  • Fig. 1 shows schematically a first embodiment of a cannula 3, as it may be part of a plant for producing a pharmaceutical preparation (Fig. 3).
  • the cannula 3 comprises a tip 6 with which it can be pushed through a septum 16. Furthermore, the cannula 3 comprises a connection 8 for attaching the cannula to a syringe.
  • the cannula 3 is sectionally divided into two channels.
  • a first channel 1 serves for the removal of the drug.
  • the first channel 1 is separated by a partition 9 of a second channel 2, which the ventilation of a
  • At least the cannula 3 is formed with the exception of the metal connection. It is also conceivable, however, the use of plastic.
  • First and second channel can by introducing a
  • Partition 9 are provided in a tube.
  • the partition wall 9 can also zgussteil as Kunststoffsprit
  • the first channel 1 comprises an inlet opening 4, through which the drug leaves the cannula 3 via the connection 8 in the connected state.
  • the second channel 2 Arranged above the first channel 1 is the second channel 2, which serves to ventilate the first container 17 and has an inflow opening 5.
  • the inflow opening 5 and the inlet opening 4 should be spaced so far apart that there is no danger that inflowing gas bubbles through the inlet opening. 4
  • the inflow opening 5 and the inlet opening 4 are therefore also arranged on opposite sides of the cannula 3.
  • Both the inlet opening 4 and the inflow opening 5 are arranged in this embodiment on the side of the cannula 3 in order to prevent punching of a piece of material of the septum 16 of the first container 17.
  • the second channel 2 for ventilation of the first container 17 leads to the connecting piece 8 and allows an air supply through a filter membrane 7, which is arranged laterally to the connection 8. Between the filter membrane 7 and the inflow 5 is a check valve 12, which prevents the drug from the second channel 2 to
  • Filter membrane 7 can happen.
  • the check valve 12 may also be arranged in the immediate vicinity of the inflow opening 5 (not shown).
  • the inflow opening 5 may also be provided with a hydrophobic membrane (not shown). This can further reduce the risk of liquid entering the second channel 2.
  • Fig. 2 shows another embodiment of a
  • Cannula 3 according to the invention in a schematic view.
  • the cannula 3 in the first channel 1 has a valve 10 which is only opened when liquid or drug passes through the first channel 1.
  • the valve 10 in this embodiment comprises a floating body 11 seated on a valve seat, which may be part of the neck of the cannula 3, and which is formed in particular by a bottom of the neck.
  • the valve 10 is therefore arranged between the inlet opening 4 and the connection 8 for a syringe 15.
  • the floating body 11 has a density selected to be at influx of drug flows and so the first channel 1 releases.
  • the density of the floating body 11 is in particular between 0.95 and 1 g / cm 3 .
  • the float 11 comprises a foot part 21, which by means of a pin 22 with the
  • the foot part 21 may be formed of a material of higher density relative to the rest of the float 11, so that the foot part 21 aligns the float 11.
  • Containers take place.
  • the second channel 2 for ventilating the first container 17 comprises a check valve 12, and a filter membrane 7, through which air can flow into the second channel 2.
  • Fig. 3 shows a schematic representation of the essential components of a system 13 for producing a
  • a plurality of first containers 17 can be used in an overhead position in a holder, which serve as a source container.
  • the system 13 further comprises a movable
  • the movable device 14 includes a syringe 15 and an actuator (not shown) to the syringe 15 to
  • a cannula 3 for example a cannula according to FIG. 1 or FIG. 2, is attached to the syringe 15.
  • the system 13 comprises holders for at least one second container 18, preferably for a plurality of second containers 18, which serve as target containers.
  • the second containers 18 are preferably infusion bags, which also called a port
  • Port 19 for introducing a drug include.
  • the port 19 is preferably closed with a septum. It is understood that in this schematic representation possible further ports for removing the infusion solution are not shown. Even syringes or elastomer pumps can serve as a target container.
  • the syringe 15 which is preferably designed as a syringe, operated and removed a predetermined amount of a drug.
  • Fig. 4 shows a schematic view of a possible
  • the check valve 12 is designed here as a diaphragm valve made of an elastic material and comprises a flap 20 which rests on the membrane such that the flap 20 opens only in one direction.
  • Fig. 5 shows a detailed view of the first channel 1 for withdrawing the drug in the connected state.
  • Liquid can now pass through the inlet opening 4, the channel 1.
  • a further, preferably smaller opening 34 is provided above the inlet opening 4, which causes drugs above the
  • Inlet opening 4 enters the channel 1.
  • Fig. 6 shows, schematically illustrated, an alternative
  • valve 10 With reference to FIG. 6, an embodiment of a valve 10 will be explained based on a schematically illustrated embodiment, which automatically locks when the cannula 3 is turned over onto the head.
  • the valve 10 like the valve shown in Fig. 2, a float 11.
  • the floating body 11 sits on the valve seat 25 and thus seals off the first channel 1.
  • the valve seat 25 According to the illustration of FIG. 2 floats the
  • Float 11 at inflowing drug so that the float 11 lifts off the valve seat 25 and a channel 1 releases.
  • at least two arms 26 are attached to the floating body 11.
  • the arms 26 are movably connected to the float 11.
  • a ring 27 for example, a metal ring, made of a heavier material than the float 11 is placed.
  • the ring 27 rests on the hook-shaped ends of the arms 26 and the arms 26 can pass through the channel during the floating of the float 11, through the
  • Float 11 is arranged.
  • Cannula 3 reduced. Further, after locking, the emptied first container 17 may be safely disposed of together with the cannula 3.
  • FIG. 8 shows, schematically illustrated, a further variant of a valve 10 which automatically locks after emptying of the first container 17.
  • this valve 10 comprises a float 11, which floats when the drug enters and releases the first channel 1.
  • the float 11 is seated on a valve seat which is formed by the bottom 31 surrounding the opening of the cannula 3.
  • the float 11 has a collar 28, with respect to the
  • the float 11 closes the valve 10 with emptying of the first container 17, since this drops to the bottom after the drug has drained.
  • the float 11 further comprises at least one catch hook 31, which is also pulled through the opening in the bottom 31.
  • the latching hook 31 springs in this case.
  • FIG. 9 shows, again schematically shown, another embodiment of a valve 10, in which the floating body 11 has a preferably circular cylindrical lower part 24 which comprises a collar 30 which rests in the delivery state on the bottom 31, which is part of the valve 10 ,
  • the collar 30 is formed like a hook and so on
  • the collar 30 thus has both the function of forming a stop against the bottom 31 prior to the use of the cannula 3, as well as after emptying of the first container 17, the valve 10 to lock.
  • FIG. 1 shows, schematically illustrated, a further embodiment of a valve 10, which likewise comprises a floating body 11.
  • the float 11 is connected via a connecting rod 33 with a flap 32 which at the opening of a
  • Valve seat is struck. Floats now the

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne une installation de production automatisée d'une préparation médicamenteuse, comprenant un dispositif mobile horizontalement et verticalement pour transférer un médicament d'un premier contenant source fermé au moyen d'un septum à un deuxième contenant cible. Le dispositif mobile pour transférer le médicament comprend une canule présentant un premier canal pour prélever le médicament, ainsi qu'un deuxième canal pour aérer le premier contenant.
EP17713701.5A 2016-04-01 2017-03-31 Installation et procédé pour produire une préparation médicamenteuse et canule pour une installation de production d'une préparation médicamenteuse Withdrawn EP3435951A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16163544 2016-04-01
PCT/EP2017/057742 WO2017167986A1 (fr) 2016-04-01 2017-03-31 Installation et procédé pour produire une préparation médicamenteuse et canule pour une installation de production d'une préparation médicamenteuse

Publications (1)

Publication Number Publication Date
EP3435951A1 true EP3435951A1 (fr) 2019-02-06

Family

ID=55699444

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17713701.5A Withdrawn EP3435951A1 (fr) 2016-04-01 2017-03-31 Installation et procédé pour produire une préparation médicamenteuse et canule pour une installation de production d'une préparation médicamenteuse

Country Status (2)

Country Link
EP (1) EP3435951A1 (fr)
WO (1) WO2017167986A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2298270A1 (fr) * 2009-03-31 2011-03-23 Panasonic Corporation Dispositif de mélange de médicaments et procédé de mélange de médicaments
US20140020790A1 (en) * 2011-03-25 2014-01-23 Yuyama Mfg. Co., Ltd. Co-infusion apparatus
US20140311621A1 (en) * 2012-04-18 2014-10-23 Panasonic Corporation Medicine transfusion apparatus and medicine transfusion method

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Publication number Priority date Publication date Assignee Title
US4396016A (en) * 1977-09-07 1983-08-02 Becker Karl E Intravenous solution flow regulator
US4959053A (en) * 1988-01-08 1990-09-25 Jang Cheng Houng Automatic stopping device for the intravenous drip
DE29512323U1 (de) * 1995-07-31 1996-12-05 Ohmeda GmbH & Co KG, 91054 Erlangen Infusionsgerät
AU5816796A (en) * 1995-05-10 1996-11-29 Ohmeda Gmbh & Co. Kg Infusion device
DE29520388U1 (de) * 1995-12-22 1997-04-24 Frör, Werner, 91052 Erlangen Rohrförmiges Leitungsteil mit einem Schwimmerventil und Formwerkzeug zum Herstellen desselben
WO2014116602A1 (fr) * 2013-01-23 2014-07-31 Icu Medical, Inc. Adaptateurs pour flacon à régulation de pression

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2298270A1 (fr) * 2009-03-31 2011-03-23 Panasonic Corporation Dispositif de mélange de médicaments et procédé de mélange de médicaments
US20140020790A1 (en) * 2011-03-25 2014-01-23 Yuyama Mfg. Co., Ltd. Co-infusion apparatus
US20140311621A1 (en) * 2012-04-18 2014-10-23 Panasonic Corporation Medicine transfusion apparatus and medicine transfusion method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2017167986A1 *

Also Published As

Publication number Publication date
WO2017167986A1 (fr) 2017-10-05

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