EP3382002B1 - Composition for contact lens - Google Patents

Composition for contact lens Download PDF

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Publication number
EP3382002B1
EP3382002B1 EP17190771.0A EP17190771A EP3382002B1 EP 3382002 B1 EP3382002 B1 EP 3382002B1 EP 17190771 A EP17190771 A EP 17190771A EP 3382002 B1 EP3382002 B1 EP 3382002B1
Authority
EP
European Patent Office
Prior art keywords
composition
contact lens
algefacient
surfactant
lens according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP17190771.0A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3382002A1 (en
Inventor
Han-Yi Chang
Li-Ju Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pegavision Corp
Original Assignee
Pegavision Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pegavision Corp filed Critical Pegavision Corp
Publication of EP3382002A1 publication Critical patent/EP3382002A1/en
Application granted granted Critical
Publication of EP3382002B1 publication Critical patent/EP3382002B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02—Anionic compounds
    • C11D1/04—Carboxylic acids or salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02—Anionic compounds
    • C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
    • C11D1/14—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aliphatic hydrocarbons or mono-alcohols
    • C11D1/146—Sulfuric acid esters
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02—Anionic compounds
    • C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
    • C11D1/29—Sulfates of polyoxyalkylene ethers
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02—Anionic compounds
    • C11D1/34—Derivatives of acids of phosphorus
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/667—Neutral esters, e.g. sorbitan esters
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/72—Ethers of polyoxyalkylene glycols
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/18—Hydrocarbons
    • C11D3/188—Terpenes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C11D3/2006—Monohydric alcohols
    • C11D3/2024—Monohydric alcohols cyclic; polycyclic
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C11D3/2006—Monohydric alcohols
    • C11D3/2037—Terpenes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C11D3/2041—Dihydric alcohols
    • C11D3/2062—Terpene
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2093—Esters; Carbonates

Definitions

  • the instant disclosure relates to a composition for contact lenses; in particular, to a composition for contact lenses which can serve as a contact lens preservation solution.
  • Smartphones and computers are used frequently in today's information society, resulting in an increase in the population with myopia and a decrease in the age group of myopia.
  • it is generally a good choice for people with myopia to wear contact lenses.
  • most people with myopia need to wear contact lenses for extended periods of time.
  • the material of the conventional contact lenses have been constantly improved to meet various requirements such as high water content and high oxygen permeability, the wearers thereof would still suffer from eye dryness due to decreased water content and experience eye discomfort due to dirt or secretion. Therefore, there is an urgent need for a maintenance solution that can be used to clean, rehydrate and preserve contact lenses.
  • US2017056335 A1 discloses an ophthalmic composition comprising polysorbate 80 and a refreshing agent.
  • WO9603158 A1 and US 6 228 323 B1 disclose compositions for contact lenses which include sodium lauroyl lactylate.
  • One aspect of the instant disclosure relates to a composition for contact lens which allows a contact lens wearer's eyes to feel comfortable during the period of initial wear and extended periods of continuous wear.
  • the composition for contact lenses includes an algefacient and a surfactant, and a water soluble polymer, wherein the surfactant is sodium lauroyl lactylate, wherein the algefacient includes one or a combination of menthol, camphor, borneol, menthyl lactate, menthone glycerol ketal, monomethyl succinate, and p-menthane-3,8-diol; and wherein the water soluble polymer includes PEG 400 and MPC in a molar ratio of 1:20.
  • the surfactant is sodium lauroyl lactylate
  • the algefacient includes one or a combination of menthol, camphor, borneol, menthyl lactate, menthone glycerol ketal, monomethyl succinate, and p-menthane-3,8-diol
  • the water soluble polymer includes PEG 400 and MPC in a molar ratio of 1:20.
  • the algefacient and the surfactant wherein the surfactant is sodium lauroyl lactylate and the expression of the algefacient in the composition of a contact lens can be performed effectively. Therefore, the discomfort and foreign matter sensation in the eyes of contact lens wearers can be reduced or relieved, providing long-lasting cool and moist sensations to the eyes.
  • Fig. 1 is a perspective view showing a contact lens and a composition for contact lenses according to the instant disclosure in a container.
  • the instant disclosure provides a composition for contact lenses which can serve as a preservation solution and be hermetically sealed with the contact lenses in a container.
  • the contact lenses are immersed in direct contact with the composition.
  • the user takes the contact lens out of the composition and put the contact lenses on his/her eyes. More specifically, the ingredients of the composition absorb onto the surface of the contact lenses and then transfer into the user's eyes.
  • the composition according to the instant embodiment is intended for use in connection with soft and rigid contact lenses.
  • soft contact lens can refer to a hydrous soft contact lens made from hydrogels (i.e., hydrogel contact lenses) and a non-hydrous soft contact lens made from copolymers of butyl acrylate and butyl methacrylate.
  • the composition according to the instant embodiment is applicable to the soft contact lenses in U.S. FDA category Group I-IV.
  • Group I-IV lenses often contain materials identified in the market as: alphafilcon, asmofilcon, balafilcon, ethafilcon, hefilcon, hilafilcon, lidofilcon, lotrafilcon, methafilcon, nelfilcon, ocufilcon, omafilcon, phemfilcon, polymacon, tefilcon, tetrafilcon, vasurfilcon, vifilcon, senofilcon, galyfilcon, enfilcon, comfilcon, narafilcon, delefilcon, efrofilcon, and filicon II 3.
  • the composition according to the instant embodiment mainly includes a base solution, an algefacient, a surfactant, and a water soluble polymer.
  • the algefacient, the surfactant, and the water soluble polymer are uniformly dispersed in the base solution.
  • the base solution is a physiological saline solution with a buffer containing boric acid or phosphorous acid.
  • the buffer has a pH buffering capacity and is configured to adjust the pH of the composition to a pH between 6.8 and 7.6.
  • the base solution can include an appropriate amount of sodium chloride or potassium chloride to maintain the osmolality of the composition at a value between 250 Osmol/Kg and 350 Osmol/Kg.
  • the buffer can be selected from boric acid, borate (e.g., sodium tetraborate), phosphorous acid, or phosphate (e.g., sodium hydrogen phosphate and sodium dihydrogen phosphate). It should be noted that a buffer may be used alone or two or more different buffers may be used in combination in the base solution. In addition, the concentration of the buffer may be appropriately adjusted depending on its kind or the kind of the other ingredients.
  • the algefacient is added to reduce or relieve the discomfort and foreign matter sensation in the eyes and give the eyes a cool, fresh sensation.
  • the algefacient includes one or a combination of menthol, camphor, borneol, menthyl lactate, menthone glycerol ketal, monomethyl succinate, and p-menthane-3,8-diol.
  • the content of the algefacient is in the range between 0.001% (w/v) and 0.5 % (w/v), preferably between 0.001% (w/v) and 0.25 % (w/v), to avoid irritating the eye.
  • the surfactant is added to clean and moisturize a contact lens, in which protein and lipid deposits on the surfaces of the contact lens can be removed.
  • the surfactant is sodium lauroyl lactylate.
  • the content of the surfactant is in the range between 0.001% (w/v) and 2% (w/v), and preferably between 0.001% (w/v) and 0.5 % (w/v).
  • the expression of the algefacient in the composition for contact lenses can be performed effectively. Therefore, eye related symptoms such as eye fatigue, eye dryness, eye pruritus, and eye pain can be reduced or relieved, and a cool fresh sensation in the eyes can be maintained for a long period of time.
  • the water soluble polymer is added to moisten and lubricate the eyes, and also helps to keep the ingredients beneficial to the eyes in contact with the contact lens.
  • the composition for contact lenses includes one or more vitamins (e.g., A, B and E)
  • the vitamin(s) can be attached to the surface of the contact lens by interacting with the water soluble polymer.
  • the water soluble polymer includes PEG 400 and MPC in a molar ratio of 1:20.
  • the content of the water soluble polymer is in the range between 0.05% (w/v) and 5% (w/v).
  • Comparative Examples 1-5 and Comparative Examples 1-2 are shown in Table 1. Each of the compositions obtained respectively in Comparative Examples 1-5 and Comparative Examples 1-2 was used in full contact with the contact lenses. The contact lenses were then put on the user's eyes, and a VAS (Visual analogue scale) method was used to evaluate the sensations of lubrication, comfort, coolness, and moisture in the eyes during the period of initial wear (time 1) and after wearing for 30 minutes (time 2) and 60 minutes (time 3). The evaluation results of for the Comparative Examples 1-5 and the Comparative Examples 1-2 are shown in Table 2. Scores for each of the items, as shown in Table 2, are average scores calculated from three users (i.e., six eyes).
  • Table 1 unit g Examples Comparative ex 1 2 3 4 5 1 2 water 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 sodium chloride 10-20 10-20 10-20 10-20 10-20 10-20 boric acid 8-16 8-16 8-16 8-16 8-16 8-16 sodium tetraborate 0.5-4.5 0.5-4.5 0.5-4.5 0.5-4.5 0.5-4.5 0.5-4.5 TWEEN 80TM 0.01-5 0.01-5 - 0.01-5 0.01-5 - - PVP 0.01-5 0.01-5 0.01-5 0 0.01-5 - - GEROPONTM SBFA-30 0 0.01-5 0.01-5 0 0.01-5 - - polyoxyethylene hardened castor oil - - - 0.01-2.5 0.01-2.5 - - Hyaluronic acid (HA) 0-50 0-50 0-50 0-50 0-50 - 0-50 PEG400 0-50 0-50 0-50 0-50 0-50 - 0-50 MPC 0-50 0-50 0-50 0-50 0-50
  • composition for contact lenses in which the algefacient and the surfactant are cooperatively used and the surfactant is sodium lauroyl lactylate. Accordingly, the expression of the algefacient can be performed effectively, so that the discomfort and foreign matter sensation in the eyes of contact lens wearers can be reduced or relieved, and long-lasting cool and moist sensations can be provided to the eyes.

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Eyeglasses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
EP17190771.0A 2017-03-31 2017-09-13 Composition for contact lens Active EP3382002B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW106111144A TWI607768B (zh) 2017-03-31 2017-03-31 隱形眼鏡用組成物及隱形眼鏡的保養方法

Publications (2)

Publication Number Publication Date
EP3382002A1 EP3382002A1 (en) 2018-10-03
EP3382002B1 true EP3382002B1 (en) 2021-08-04

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP17190771.0A Active EP3382002B1 (en) 2017-03-31 2017-09-13 Composition for contact lens

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EP (1) EP3382002B1 (zh)
JP (1) JP6652530B2 (zh)
TW (1) TWI607768B (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI798452B (zh) * 2019-06-17 2023-04-11 晶碩光學股份有限公司 隱形眼鏡產品

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US5494937A (en) * 1994-07-22 1996-02-27 Alcon Laboratories, Inc. Saline solution for treating contact lenses
US6228323B1 (en) * 1996-12-13 2001-05-08 Alcon Laboratories, Inc. Multi-purpose compositions containing an alkyl-trypsin and methods of use in contact lens cleaning and disinfecting
JP5437350B2 (ja) * 2000-12-28 2014-03-12 ロート製薬株式会社 眼科用組成物
JP4135905B2 (ja) * 2003-03-17 2008-08-20 ロート製薬株式会社 清涼化剤を含有するコンタクトレンズ用点眼剤
JP2012072183A (ja) * 2004-06-08 2012-04-12 Rohto Pharmaceutical Co Ltd 眼科用清涼組成物
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JP4457237B1 (ja) * 2009-07-30 2010-04-28 株式会社シード コンタクトレンズ用溶液
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Also Published As

Publication number Publication date
EP3382002A1 (en) 2018-10-03
TWI607768B (zh) 2017-12-11
JP6652530B2 (ja) 2020-02-26
TW201836650A (zh) 2018-10-16
JP2018173618A (ja) 2018-11-08

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