EP3382002A1 - Composition for contact lens - Google Patents

Composition for contact lens Download PDF

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Publication number
EP3382002A1
EP3382002A1 EP17190771.0A EP17190771A EP3382002A1 EP 3382002 A1 EP3382002 A1 EP 3382002A1 EP 17190771 A EP17190771 A EP 17190771A EP 3382002 A1 EP3382002 A1 EP 3382002A1
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EP
European Patent Office
Prior art keywords
composition
contact lens
lens according
algefacient
surfactant
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Granted
Application number
EP17190771.0A
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German (de)
French (fr)
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EP3382002B1 (en
Inventor
Han-Yi Chang
Li-Ju Chen
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Pegavision Corp
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Pegavision Corp
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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02—Anionic compounds
    • C11D1/04—Carboxylic acids or salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02—Anionic compounds
    • C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
    • C11D1/14—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aliphatic hydrocarbons or mono-alcohols
    • C11D1/146—Sulfuric acid esters
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02—Anionic compounds
    • C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
    • C11D1/29—Sulfates of polyoxyalkylene ethers
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02—Anionic compounds
    • C11D1/34—Derivatives of acids of phosphorus
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/667—Neutral esters, e.g. sorbitan esters
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/72—Ethers of polyoxyalkylene glycols
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/18—Hydrocarbons
    • C11D3/188—Terpenes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C11D3/2006—Monohydric alcohols
    • C11D3/2024—Monohydric alcohols cyclic; polycyclic
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C11D3/2006—Monohydric alcohols
    • C11D3/2037—Terpenes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C11D3/2041—Dihydric alcohols
    • C11D3/2062—Terpene
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2093—Esters; Carbonates

Definitions

  • the instant disclosure relates to a composition for contact lenses; in particular, to a composition for contact lenses which can serve as a contact lens preservation solution.
  • Smartphones and computers are used frequently in today's information society, resulting in an increase in the population with myopia and a decrease in the age group of myopia.
  • it is generally a good choice for people with myopia to wear contact lenses.
  • most people with myopia need to wear contact lenses for extended periods of time.
  • the material of the conventional contact lenses have been constantly improved to meet various requirements such as high water content and high oxygen permeability, the wearers thereof would still suffer from eye dryness due to decreased water content and experience eye discomfort due to dirt or secretion. Therefore, there is an urgent need for a maintenance solution that can be used to clean, rehydrate and preserve contact lenses.
  • One aspect of the instant disclosure relates to a composition for contact lens which allows a contact lens wearer's eyes to feel comfortable during the period of initial wear and extended periods of continuous wear.
  • the composition for contact lenses includes an algefacient and a surfactant, wherein the surfactant includes one or a combination of sodium lauroyl lactylate, polyoxyethylene laureth sulfate, polyoxyethylene hardened castor oil, polyvinylpyrrolidone (PVP), sodium dodecyl sulfate (SDS), TWEEN 80TM and GEROPONTM SBFA-30.
  • the surfactant includes one or a combination of sodium lauroyl lactylate, polyoxyethylene laureth sulfate, polyoxyethylene hardened castor oil, polyvinylpyrrolidone (PVP), sodium dodecyl sulfate (SDS), TWEEN 80TM and GEROPONTM SBFA-30.
  • the algefacient and the surfactant includes one or a combination of sodium lauroyl lactylate, polyoxyethylene laureth sulfate, polyoxyethylene hardened castor oil, polyvinylpyrrolidone (PVP), sodium dodecyl sulfate (SDS), TWEEN 80TM and GEROPONTM SBFA-30
  • the expression of the algefacient in the composition of a contact lens can be performed effectively. Therefore, the discomfort and foreign matter sensation in the eyes of contact lens wearers can be reduced or relieved, providing long-lasting cool and moist sensations to the eyes.
  • Fig. 1 is a perspective view showing a contact lens and a composition for contact lenses according to the instant disclosure in a container.
  • the instant disclosure provides a composition for contact lenses which can serve as a preservation solution and be hermetically sealed with the contact lenses in a container.
  • the contact lenses are immersed in direct contact with the composition.
  • the user takes the contact lens out of the composition and put the contact lenses on his/her eyes. More specifically, the ingredients of the composition absorb onto the surface of the contact lenses and then transfer into the user's eyes.
  • the composition according to the instant embodiment is intended for use in connection with soft and rigid contact lenses.
  • soft contact lens can refer to a hydrous soft contact lens made from hydrogels (i.e., hydrogel contact lenses) and a non-hydrous soft contact lens made from copolymers of butyl acrylate and butyl methacrylate.
  • the composition according to the instant embodiment is applicable to the soft contact lenses in U.S. FDA category Group I-IV.
  • Group I-IV lenses often contain materials identified in the market as: alphafilcon, asmofilcon, balafilcon, ethafilcon, hefilcon, hilafilcon, lidofilcon, lotrafilcon, methafilcon, nelfilcon, ocufilcon, omafilcon, phemfilcon, polymacon, tefilcon, tetrafilcon, vasurfilcon, vifilcon, senofilcon, galyfilcon, enfilcon, comfilcon, narafilcon, delefilcon, efrofilcon, and filicon II 3.
  • the composition according to the instant embodiment mainly includes a base solution, an algefacient, a surfactant, and a water soluble polymer.
  • the algefacient, the surfactant, and the water soluble polymer are uniformly dispersed in the base solution.
  • the base solution is a physiological saline solution with a buffer containing boric acid or phosphorous acid.
  • the buffer has a pH buffering capacity and is configured to adjust the pH of the composition to a pH between 6.8 and 7.6.
  • the base solution can include an appropriate amount of sodium chloride or potassium chloride to maintain the osmolality of the composition at a value between 250 Osmol/Kg and 350 Osmol/Kg.
  • the buffer can be selected from boric acid, borate (e.g., sodium tetraborate), phosphorous acid, or phosphate (e.g., sodium hydrogen phosphate and sodium dihydrogen phosphate). It should be noted that a buffer may be used alone or two or more different buffers may be used in combination in the base solution. In addition, the concentration of the buffer may be appropriately adjusted depending on its kind or the kind of the other ingredients.
  • the algefacient is added to reduce or relieve the discomfort and foreign matter sensation in the eyes and give the eyes a cool, fresh sensation.
  • the algefacient includes one or a combination of menthol, camphor, borneol, menthyl lactate, menthone glycerol ketal, monomethyl succinate, and p-menthane-3,8-doil.
  • the content of the algefacient is in the range between 0.001% (w/v) and 0.5 % (w/v), preferably between 0.001% (w/v) and 0.25 % (w/v), to avoid irritating the eye.
  • the surfactant is added to clean and moisturize a contact lens, in which protein and lipid deposits on the surfaces of the contact lens can be removed.
  • the surfactant includes one or a combination of sodium lauroyl lactylate, polyoxyethylene laureth sulfate, polyoxyethylene hardened castor oil, polyvinylpyrrolidone (PVP), sodium dodecyl sulfate (SDS), TWEEN 80TM and GEROPONTM SBFA-30.
  • the content of the surfactant is in the range between 0.001% (w/v) and 2% (w/v), and preferably between 0.001% (w/v) and 0.5 % (w/v).
  • the expression of the algefacient in the composition for contact lenses can be performed effectively. Therefore, eye related symptoms such as eye fatigue, eye dryness, eye pruritus, and eye pain can be reduced or relieved, and a cool fresh sensation in the eyes can be maintained for a long period of time.
  • the water soluble polymer is added to moisten and lubricate the eyes, and also helps to keep the ingredients beneficial to the eyes in contact with the contact lens.
  • the composition for contact lenses includes one or more vitamins (e.g., A, B and E)
  • the vitamin(s) can be attached to the surface of the contact lens by interacting with the water soluble polymer.
  • the water soluble polymer includes one or a combination of polyethylene glycol 400 (PEG 400), methacryloyloxyethyl phosphorylcholine (MPC), and hyaluronic acid.
  • the water soluble polymer includes PEG 400 and MPC in a molar ratio of 1:20.
  • the content of the water soluble polymer is in the range between 0.05% (w/v) and 5% (w/v).
  • Examples 1-5 and Comparative Examples 1-2 are shown in Table 1. Each of the compositions obtained respectively in Examples 1-5 and Comparative Examples 1-2 was used in full contact with the contact lenses. The contact lenses were then put on the user's eyes, and a VAS (Visual analogue scale) method was used to evaluate the sensations of lubrication, comfort, coolness, and moisture in the eyes during the period of initial wear (time 1) and after wearing for 30 minutes (time 2) and 60 minutes (time 3). The evaluation results of for the Examples 1-5 and the Comparative Examples 1-2 are shown in Table 2. Scores for each of the items, as shown in Table 2, are average scores calculated from three users (i.e., six eyes).
  • Table 1 unit g Examples Comparative ex 1 2 3 4 5 1 2 water 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 sodium chloride 10-20 10-20 10-20 10-20 10-20 10-20 boric acid 8-16 8-16 8-16 8-16 8-16 8-16 sodium tetraborate 0.5-4.5 0.5-4.5 0.5-4.5 0.5-4.5 0.5-4.5 0.5-4.5 TWEEN 80TM 0.01-5 0.01-5 - 0.01-5 0.01-5 - - PVP 0.01-5 0.01-5 0.01-5 0 0.01-5 - - GEROPONTM SBFA-30 0 0.01-5 0.01-5 0 0.01-5 - - polyoxyethylene hardened castor oil - - - 0.01-2.5 0.01-2.5 - - Hyaluronic acid (HA) 0-50 0-50 0-50 0-50 0-50 - 0-50 PEG400 0-50 0-50 0-50 0-50 0-50 - 0-50 MPC 0-50 0-50 0-50 0-50 0-50
  • composition for contact lenses in which the algefacient and the surfactant are cooperatively used and the surfactant includes one or a combination of sodium lauroyl lactylate, polyoxyethylene laureth sulfate, polyoxyethylene hardened castor oil, polyvinylpyrrolidone (PVP), sodium dodecyl sulfate (SDS), TWEEN 80TM and GEROPONTM SBFA-30. Accordingly, the expression of the algefacient can be performed effectively, so that the discomfort and foreign matter sensation in the eyes of contact lens wearers can be reduced or relieved, and long-lasting cool and moist sensations can be provided to the eyes.

Abstract

The present invention provides a composition for contact lenses. The composition includes an algefacient and a surfactant, wherein the surfactant includes one or a combination of sodium lauroyl lactylate, polyoxyethylene laureth sulfate, polyoxyethylene hardened castor oil, polyvinylpyrrolidone (PVP), sodium dodecyl sulfate (SDS), TWEEN 80™ and GEROPON™ SBFA-30.

Description

    BACKGROUND OF THE INVENTION 1. Field of the Invention
  • The instant disclosure relates to a composition for contact lenses; in particular, to a composition for contact lenses which can serve as a contact lens preservation solution.
    • 2. Description of Related Art
  • Smartphones and computers are used frequently in today's information society, resulting in an increase in the population with myopia and a decrease in the age group of myopia. In consideration of user convenience and aesthetics, it is generally a good choice for people with myopia to wear contact lenses. However, most people with myopia need to wear contact lenses for extended periods of time. Although the material of the conventional contact lenses have been constantly improved to meet various requirements such as high water content and high oxygen permeability, the wearers thereof would still suffer from eye dryness due to decreased water content and experience eye discomfort due to dirt or secretion. Therefore, there is an urgent need for a maintenance solution that can be used to clean, rehydrate and preserve contact lenses.
    • SUMMARY OF THE INVENTION
  • One aspect of the instant disclosure relates to a composition for contact lens which allows a contact lens wearer's eyes to feel comfortable during the period of initial wear and extended periods of continuous wear.
  • According to one of the embodiments of the instant disclosure, the composition for contact lenses includes an algefacient and a surfactant, wherein the surfactant includes one or a combination of sodium lauroyl lactylate, polyoxyethylene laureth sulfate, polyoxyethylene hardened castor oil, polyvinylpyrrolidone (PVP), sodium dodecyl sulfate (SDS), TWEEN 80™ and GEROPON™ SBFA-30.
  • Based on the above, by cooperatively using the algefacient and the surfactant, wherein the surfactant includes one or a combination of sodium lauroyl lactylate, polyoxyethylene laureth sulfate, polyoxyethylene hardened castor oil, polyvinylpyrrolidone (PVP), sodium dodecyl sulfate (SDS), TWEEN 80™ and GEROPON™ SBFA-30, the expression of the algefacient in the composition of a contact lens can be performed effectively. Therefore, the discomfort and foreign matter sensation in the eyes of contact lens wearers can be reduced or relieved, providing long-lasting cool and moist sensations to the eyes.
  • In order to further appreciate the characteristics and technical contents of the instant disclosure, references are hereunder made to the detailed descriptions and appended drawings in connection with the instant disclosure. However, the appended drawings are merely shown for exemplary purposes, rather than being used to restrict the scope of the instant disclosure.
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • Fig. 1 is a perspective view showing a contact lens and a composition for contact lenses according to the instant disclosure in a container.
    • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • The aforementioned illustrations and following detailed descriptions are exemplary for the purpose of further explaining the scope of the instant disclosure. Other objectives and advantages related to the instant disclosure will be illustrated in the subsequent descriptions and appended drawings.
  • Referring to FIG. 1, the instant disclosure provides a composition for contact lenses which can serve as a preservation solution and be hermetically sealed with the contact lenses in a container. In practice, the contact lenses are immersed in direct contact with the composition. When the user wishes to wear the contact lenses, the user takes the contact lens out of the composition and put the contact lenses on his/her eyes. More specifically, the ingredients of the composition absorb onto the surface of the contact lenses and then transfer into the user's eyes.
  • The composition according to the instant embodiment is intended for use in connection with soft and rigid contact lenses. The term "soft contact lens" can refer to a hydrous soft contact lens made from hydrogels (i.e., hydrogel contact lenses) and a non-hydrous soft contact lens made from copolymers of butyl acrylate and butyl methacrylate. Furthermore, the composition according to the instant embodiment is applicable to the soft contact lenses in U.S. FDA category Group I-IV. Group I-IV lenses often contain materials identified in the market as: alphafilcon, asmofilcon, balafilcon, ethafilcon, hefilcon, hilafilcon, lidofilcon, lotrafilcon, methafilcon, nelfilcon, ocufilcon, omafilcon, phemfilcon, polymacon, tefilcon, tetrafilcon, vasurfilcon, vifilcon, senofilcon, galyfilcon, enfilcon, comfilcon, narafilcon, delefilcon, efrofilcon, and filicon II 3.
  • The composition according to the instant embodiment mainly includes a base solution, an algefacient, a surfactant, and a water soluble polymer. The algefacient, the surfactant, and the water soluble polymer are uniformly dispersed in the base solution.
  • In the instant embodiment, the base solution is a physiological saline solution with a buffer containing boric acid or phosphorous acid. The buffer has a pH buffering capacity and is configured to adjust the pH of the composition to a pH between 6.8 and 7.6. In addition, the base solution can include an appropriate amount of sodium chloride or potassium chloride to maintain the osmolality of the composition at a value between 250 Osmol/Kg and 350 Osmol/Kg.
  • The buffer can be selected from boric acid, borate (e.g., sodium tetraborate), phosphorous acid, or phosphate (e.g., sodium hydrogen phosphate and sodium dihydrogen phosphate). It should be noted that a buffer may be used alone or two or more different buffers may be used in combination in the base solution. In addition, the concentration of the buffer may be appropriately adjusted depending on its kind or the kind of the other ingredients.
  • The algefacient is added to reduce or relieve the discomfort and foreign matter sensation in the eyes and give the eyes a cool, fresh sensation. The algefacient includes one or a combination of menthol, camphor, borneol, menthyl lactate, menthone glycerol ketal, monomethyl succinate, and p-menthane-3,8-doil. The content of the algefacient is in the range between 0.001% (w/v) and 0.5 % (w/v), preferably between 0.001% (w/v) and 0.25 % (w/v), to avoid irritating the eye.
  • The surfactant is added to clean and moisturize a contact lens, in which protein and lipid deposits on the surfaces of the contact lens can be removed. The surfactant includes one or a combination of sodium lauroyl lactylate, polyoxyethylene laureth sulfate, polyoxyethylene hardened castor oil, polyvinylpyrrolidone (PVP), sodium dodecyl sulfate (SDS), TWEEN 80TM and GEROPONTM SBFA-30. The content of the surfactant is in the range between 0.001% (w/v) and 2% (w/v), and preferably between 0.001% (w/v) and 0.5 % (w/v).
  • It should be noted that by cooperatively using the algefacient and the surfactant, the expression of the algefacient in the composition for contact lenses can be performed effectively. Therefore, eye related symptoms such as eye fatigue, eye dryness, eye pruritus, and eye pain can be reduced or relieved, and a cool fresh sensation in the eyes can be maintained for a long period of time.
  • The water soluble polymer is added to moisten and lubricate the eyes, and also helps to keep the ingredients beneficial to the eyes in contact with the contact lens. For example, if the composition for contact lenses includes one or more vitamins (e.g., A, B and E), the vitamin(s) can be attached to the surface of the contact lens by interacting with the water soluble polymer. The water soluble polymer includes one or a combination of polyethylene glycol 400 (PEG 400), methacryloyloxyethyl phosphorylcholine (MPC), and hyaluronic acid. Exemplarily, the water soluble polymer includes PEG 400 and MPC in a molar ratio of 1:20. The content of the water soluble polymer is in the range between 0.05% (w/v) and 5% (w/v).
  • Examples 1-5 and Comparative Examples 1-2 are shown in Table 1. Each of the compositions obtained respectively in Examples 1-5 and Comparative Examples 1-2 was used in full contact with the contact lenses. The contact lenses were then put on the user's eyes, and a VAS (Visual analogue scale) method was used to evaluate the sensations of lubrication, comfort, coolness, and moisture in the eyes during the period of initial wear (time 1) and after wearing for 30 minutes (time 2) and 60 minutes (time 3). The evaluation results of for the Examples 1-5 and the Comparative Examples 1-2 are shown in Table 2. Scores for each of the items, as shown in Table 2, are average scores calculated from three users (i.e., six eyes). Table 1
    unit: g
    Examples Comparative ex
    1 2 3 4 5 1 2
    water 2000 2000 2000 2000 2000 2000 2000
    sodium chloride 10-20 10-20 10-20 10-20 10-20 10-20 10-20
    boric acid 8-16 8-16 8-16 8-16 8-16 8-16 8-16
    sodium tetraborate 0.5-4.5 0.5-4.5 0.5-4.5 0.5-4.5 0.5-4.5 0.5-4.5 0.5-4.5
    TWEEN 80™ 0.01-5 0.01-5 - 0.01-5 0.01-5 - -
    PVP 0.01-5 0.01-5 0.01-5 0 0.01-5 - -
    GEROPON™ SBFA-30 0 0.01-5 0.01-5 0 0.01-5 - -
    polyoxyethylene hardened castor oil - - - 0.01-2.5 0.01-2.5 - -
    Hyaluronic acid (HA) 0-50 0-50 0-50 0-50 0-50 - 0-50
    PEG400 0-50 0-50 0-50 0-50 0-50 - 0-50
    MPC 0-50 0-50 0-50 0-50 0-50 - 0-50
    menthol 0-4 0-4 0-4 0-4 0-4 - 0-4
    camphor 0-4 0-4 0-4 0-4 0-4 - 0-4
    borneol 0-4 0-4 0-4 0-4 0-4 - 0-4
    menthyl lactate 0-4 0-4 0-4 0-4 0-4 - 0-4
    menthone-glycerol ketal 0-4 0-4 0-4 0-4 0-4 - 0-4
    monomethyl succinate 0-4 0-4 0-4 0-4 0-4 - 0-4
    p-menthane-3,8-doil 0-4 0-4 0-4 0-4 0-4 - 0-4
    Table 2
    evaluation items wear-in time self-feeling score
    Examples Comparative ex
    lubrication sensation immediately right after 7 8
    after 30 minutes 7 8
    after 60 minutes 6 8
    comfort sensation immediately right after 7 8
    after 30 minutes 7 8
    after 60 minutes 7 8
    coolness sensation immediately right after NA 9
    after 30 minutes NA 6
    after 60 minutes NA 4
    moisture sensation immediately right after 8 10
    after 30 minutes 8 9
    after 60 minutes 8 9
  • The composition for contact lenses in which the algefacient and the surfactant are cooperatively used and the surfactant includes one or a combination of sodium lauroyl lactylate, polyoxyethylene laureth sulfate, polyoxyethylene hardened castor oil, polyvinylpyrrolidone (PVP), sodium dodecyl sulfate (SDS), TWEEN 80™ and GEROPON™ SBFA-30. Accordingly, the expression of the algefacient can be performed effectively, so that the discomfort and foreign matter sensation in the eyes of contact lens wearers can be reduced or relieved, and long-lasting cool and moist sensations can be provided to the eyes.
  • The descriptions illustrated supra set forth simply the preferred embodiments of the instant disclosure; however, the characteristics of the instant disclosure are by no means restricted thereto. All changes, alternations, or modifications conveniently considered by those skilled in the art are deemed to be encompassed within the scope of the instant disclosure delineated by the following claims.

Claims (9)

  1. A composition for contact lenses which includes an algefacient and a surfactant, wherein the surfactant includes one or a combination of sodium lauroyl lactylate, polyoxyethylene laureth sulfate, polyoxyethylene hardened castor oil, polyvinylpyrrolidone (PVP), sodium dodecyl sulfate (SDS), TWEEN 80™ and GEROPON™ SBFA-30.
  2. The composition for contact lens according to claim 1, wherein the content of the surfactant is in the range between 0.001% (w/v) and 0.5% (w/v).
  3. The composition for contact lens according to claim 1, wherein the algefacient includes one or a combination of menthol, camphor, borneol, menthyl lactate, menthone glycerol ketal, monomethyl succinate, and p-menthane-3,8-doil.
  4. The composition for contact lens according to claim 3, wherein the algefacient is menthol.
  5. The composition for contact lens according to claim 3 or 4, wherein the content of the algefacient is in the range between 0.001% (w/v) and 0.25 % (w/v).
  6. The composition for contact lens according to claim 1, further including a water soluble polymer, wherein the water soluble polymer includes one or a combination of polyethylene glycol 400 (PEG 400), methacryloyloxyethyl phosphorylcholine (MPC), and hyaluronic acid.
  7. The composition for contact lens according to claim 6, wherein the water soluble polymer includes PEG 400 and MPC in a molar ratio of 1:20.
  8. The composition for contact lens according to claim 6 or 7, wherein the content of the water soluble polymer is in the range between 0.05% (w/v) and 5% (w/v).
  9. The composition for contact lens according to claim 1, further including a buffer, wherein the buffer includes boric acid and sodium tetraborate.
EP17190771.0A 2017-03-31 2017-09-13 Composition for contact lens Active EP3382002B1 (en)

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TW106111144A TWI607768B (en) 2017-03-31 2017-03-31 Composition for contact lenses and method for caring contact lenses

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Publication number Priority date Publication date Assignee Title
TWI798452B (en) * 2019-06-17 2023-04-11 晶碩光學股份有限公司 Contact lens product

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003158A1 (en) * 1994-07-22 1996-02-08 Alcon Laboratories, Inc. Use of low molecular weight amino acids in ophthalmic compositions
US6228323B1 (en) * 1996-12-13 2001-05-08 Alcon Laboratories, Inc. Multi-purpose compositions containing an alkyl-trypsin and methods of use in contact lens cleaning and disinfecting
US20080095754A1 (en) * 2006-10-18 2008-04-24 Burke Susan E Ophthalmic compositions comprising diglycine
US20170056335A1 (en) * 2014-04-09 2017-03-02 Rhoto Pharmaceutical Co., Ltd. Ophthalmic Composition
US20170087199A1 (en) * 2016-02-10 2017-03-30 Senomyx, Inc. Compositions for delivering a cooling sensation

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494937A (en) * 1994-07-22 1996-02-27 Alcon Laboratories, Inc. Saline solution for treating contact lenses
JP5437350B2 (en) * 2000-12-28 2014-03-12 ロート製薬株式会社 Ophthalmic composition
JP4135905B2 (en) * 2003-03-17 2008-08-20 ロート製薬株式会社 Eye drops for contact lenses containing a cooling agent
JP2012072183A (en) * 2004-06-08 2012-04-12 Rohto Pharmaceutical Co Ltd Refreshing composition for ophthalmology
JP2007297559A (en) * 2006-05-02 2007-11-15 Rohto Pharmaceut Co Ltd AMINO ACID-MODIFIED-(gamma-POLYGLUTAMIC ACID) OR ITS SALT AND THEIR USES
JP5401113B2 (en) * 2008-02-07 2014-01-29 ロート製薬株式会社 Aqueous composition containing chlorous acid compounds containing menthols
JP4457237B1 (en) * 2009-07-30 2010-04-28 株式会社シード Contact lens solution
WO2011040572A1 (en) * 2009-09-30 2011-04-07 ロート製薬株式会社 Ophthalmic composition
TWI480039B (en) * 2011-03-10 2015-04-11 Pegavision Corp Aqueous composition for contact lens
WO2013188274A2 (en) * 2012-06-14 2013-12-19 Novartis Ag Azetidinium-containing copolymers and uses thereof
JP6654340B2 (en) * 2013-04-12 2020-02-26 ロート製薬株式会社 Contact lens composition and contact lens package using the same
KR101490344B1 (en) * 2013-07-05 2015-02-11 마준오 Contact lens with cooling coating layer
JP6616137B2 (en) * 2015-09-15 2019-12-04 株式会社メニコン Contact lens composition

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003158A1 (en) * 1994-07-22 1996-02-08 Alcon Laboratories, Inc. Use of low molecular weight amino acids in ophthalmic compositions
US6228323B1 (en) * 1996-12-13 2001-05-08 Alcon Laboratories, Inc. Multi-purpose compositions containing an alkyl-trypsin and methods of use in contact lens cleaning and disinfecting
US20080095754A1 (en) * 2006-10-18 2008-04-24 Burke Susan E Ophthalmic compositions comprising diglycine
US20170056335A1 (en) * 2014-04-09 2017-03-02 Rhoto Pharmaceutical Co., Ltd. Ophthalmic Composition
US20170087199A1 (en) * 2016-02-10 2017-03-30 Senomyx, Inc. Compositions for delivering a cooling sensation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Algefacient | definition of algefacient by Medical dictionary", MEDICAL DICTIONARY, 6 April 2018 (2018-04-06), pages 1 - 2, XP055465196, Retrieved from the Internet <URL:https://medical-dictionary.thefreedictionary.com/algefacient> [retrieved on 20180406] *

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TW201836650A (en) 2018-10-16
EP3382002B1 (en) 2021-08-04
JP2018173618A (en) 2018-11-08
JP6652530B2 (en) 2020-02-26

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