JP6652530B2 - Composition for contact lens - Google Patents
Composition for contact lens Download PDFInfo
- Publication number
- JP6652530B2 JP6652530B2 JP2017164517A JP2017164517A JP6652530B2 JP 6652530 B2 JP6652530 B2 JP 6652530B2 JP 2017164517 A JP2017164517 A JP 2017164517A JP 2017164517 A JP2017164517 A JP 2017164517A JP 6652530 B2 JP6652530 B2 JP 6652530B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- contact lens
- lens according
- water
- soluble polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 31
- 239000002826 coolant Substances 0.000 claims description 14
- 239000004094 surface-active agent Substances 0.000 claims description 9
- 229920003169 water-soluble polymer Polymers 0.000 claims description 9
- 239000000872 buffer Substances 0.000 claims description 8
- LTNJYGRCMNQPFQ-UHFFFAOYSA-M sodium;2-dodecanoyloxypropanoate Chemical compound [Na+].CCCCCCCCCCCC(=O)OC(C)C([O-])=O LTNJYGRCMNQPFQ-UHFFFAOYSA-M 0.000 claims description 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 4
- OXJGJKIURHREKH-UHFFFAOYSA-O CC(=C)C(=O)OCCP(=O)=C(O)C[N+](C)(C)C Chemical compound CC(=C)C(=O)OCCP(=O)=C(O)C[N+](C)(C)C OXJGJKIURHREKH-UHFFFAOYSA-O 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 229920002674 hyaluronan Polymers 0.000 claims description 4
- 229960003160 hyaluronic acid Drugs 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 3
- 229940041616 menthol Drugs 0.000 claims description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 2
- MHXKJAQHDWBUAT-UHFFFAOYSA-N 4-methoxy-4-oxobutanoic acid 2-methylbutanedioic acid Chemical compound CC(C(=O)O)CC(=O)O.C(CCC(=O)O)(=O)OC MHXKJAQHDWBUAT-UHFFFAOYSA-N 0.000 claims description 2
- 241000723346 Cinnamomum camphora Species 0.000 claims description 2
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 claims description 2
- 229910021538 borax Inorganic materials 0.000 claims description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 2
- 239000004327 boric acid Substances 0.000 claims description 2
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims description 2
- 229940116229 borneol Drugs 0.000 claims description 2
- 229930008380 camphor Natural products 0.000 claims description 2
- 229960000846 camphor Drugs 0.000 claims description 2
- UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 claims description 2
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol Substances OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 2
- LMXFTMYMHGYJEI-UHFFFAOYSA-N p-menthane-3,8-diol Chemical compound CC1CCC(C(C)(C)O)C(O)C1 LMXFTMYMHGYJEI-UHFFFAOYSA-N 0.000 claims description 2
- 239000004328 sodium tetraborate Substances 0.000 claims description 2
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 2
- 210000001508 eye Anatomy 0.000 description 12
- -1 polyoxyethylene Polymers 0.000 description 9
- 229920001451 polypropylene glycol Polymers 0.000 description 9
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 7
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 7
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 7
- 239000004359 castor oil Substances 0.000 description 5
- 235000019438 castor oil Nutrition 0.000 description 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 4
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 4
- 238000005461 lubrication Methods 0.000 description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 4
- 229920000053 polysorbate 80 Polymers 0.000 description 4
- 230000035807 sensation Effects 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 2
- 206010013774 Dry eye Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000003761 preservation solution Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010047531 Visual acuity reduced Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003270 Vitamin B Chemical group 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical group OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 208000003464 asthenopia Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 125000006353 oxyethylene group Chemical group 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Chemical group 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/04—Carboxylic acids or salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/14—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aliphatic hydrocarbons or mono-alcohols
- C11D1/146—Sulfuric acid esters
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/29—Sulfates of polyoxyalkylene ethers
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/34—Derivatives of acids of phosphorus
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/667—Neutral esters, e.g. sorbitan esters
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/72—Ethers of polyoxyalkylene glycols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/18—Hydrocarbons
- C11D3/188—Terpenes
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2006—Monohydric alcohols
- C11D3/2024—Monohydric alcohols cyclic; polycyclic
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2006—Monohydric alcohols
- C11D3/2037—Terpenes
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2041—Dihydric alcohols
- C11D3/2062—Terpene
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2093—Esters; Carbonates
Description
本発明は、コンタクトレンズ用組成物に関し、特にコンタクトレンズ保存液に用いられるコンタクトレンズ用組成物に関する。 The present invention relates to a composition for contact lenses, and more particularly to a composition for contact lenses used in a contact lens preservation solution.
ところで、情報化社会が訪れた後、コンピュータとスマートフォンが多く用いられた結果、国民の近視の割合が高まっているだけでなく、近視年齢層も年々下がる傾向にある。利便性と美観性を考え、コンタクトレンズは非常に価値のある選択である。しかしながら、殆どの視力不良の人はコンタクトレンズを長時間装用する習慣を有する。種々の需要（例えば高含水性、高酸素透過性等）を満たすように従来のコンタクトレンズの材質が改良されたにもかかわらず、ユーザは依然としてレンズに含まれる水分が減少するためドライアイを感じ、及びレンズにおける汚物と堆積物のため目の不快感（例えば痒み、痛み等）を感じる。このため、現在、コンタクトレンズを洗浄し、再湿潤・保存する保存溶液が強く要望されている。 By the way, as a result of the use of computers and smartphones after the arrival of the information-oriented society, not only the ratio of myopia among the people has increased, but also the myopic age group has tended to decrease year by year. For convenience and aesthetics, contact lenses are a very valuable choice. However, most people with poor vision have the habit of wearing contact lenses for extended periods of time. Despite improvements in conventional contact lens materials to meet various demands (eg, high water content, high oxygen permeability, etc.), users still experience dry eye due to reduced water content in the lens. And eye discomfort (eg, itching, pain, etc.) due to dirt and deposits on the lens. For this reason, at present, there is a strong demand for a preservative solution for cleaning, rewetting and preserving contact lenses.
本発明が解決しようとする技術問題は、従来技術のデメリットについて、ユーザがコンタクトレンズを装用し始めたばかりの場合及び長時間装用し続ける場合にも、目の快適性を保持できるコンタクトレンズ用組成物を提供する。 The technical problem to be solved by the present invention is a disadvantage of the prior art, which is a composition for a contact lens that can maintain eye comfort even when a user has just started wearing a contact lens and continues to wear it for a long time. I will provide a.
上記の技術問題を解決するために、本発明に用いられる一つの技術方案は、清涼剤と、ラウロイル乳酸ナトリウム（ｓｏｄｉｕｍ ｌａｕｒｏｙｌ ｌａｃｔｙｌａｔｅ）、ポリオキシエチレンラウレス硫酸塩（ｐｏｌｙｏｘｙｅｔｈｙｌｅｎｅ ｌａｕｒｅｔｈ ｓｕｌｆａｔｅ）、ポリオキシプロピレングリコール（ｐｏｌｙｏｘｙｐｒｏｐｙｌｅｎｅ ｇｌｙｃｏｌ）、ポリオキシエチレン硬化ヒマシ油（ｐｏｌｙｏｘｙｅｔｈｙｌｅｎｅ ｈａｒｄｅｎｅｄ ｃａｓｔｏｒ ｏｉｌ）、ポリビニルピロリドン（ＰＶＰ）、ＳＤＳ、ＴＷＥＥＮ ８０ＴＭ及びＧＥＲＯＰＯＮＴＭ ＳＢＦＡ−３０の中の１種類又は２種類以上の組合せを含む界面活性剤と、を含むことを特徴とする、コンタクトレンズ用組成物を提供する。 In order to solve the above technical problems, one technical solution used in the present invention includes a cooling agent, sodium lauroyl lactate, polyoxyethylene laureth sulfate, and polyoxypropylene glycol. (Polyoxypropylene glycol), polyoxyethylene hardened castor oil (polyoxyethylene hardened castor oil), polyvinylpyrrolidone (PVP), SDS, TWEEN 80 TM and GEROPON TM SBFA-30. And a composition for contact lenses, comprising:
本発明の技術方案が提供するコンタクトレンズ用組成物は、清涼剤と、ラウロイル乳酸ナトリウム（ｓｏｄｉｕｍ ｌａｕｒｏｙｌ ｌａｃｔｙｌａｔｅ）、ポリオキシエチレンラウレス硫酸塩（ｐｏｌｙｏｘｙｅｔｈｙｌｅｎｅ ｌａｕｒｅｔｈ ｓｕｌｆａｔｅ）、ポリオキシプロピレングリコール（ｐｏｌｙｏｘｙｐｒｏｐｙｌｅｎｅ ｇｌｙｃｏｌ）、ポリオキシエチレン硬化ヒマシ油（ｐｏｌｙｏｘｙｅｔｈｙｌｅｎｅ ｈａｒｄｅｎｅｄ ｃａｓｔｏｒ ｏｉｌ）、ポリビニルピロリドン（ＰＶＰ）、ＳＤＳ、ＴＷＥＥＮ ８０ＴＭ及びＧＥＲＯＰＯＮＴＭ ＳＢＦＡ−３０の中の１種類又は２種類以上の組合せを含む界面活性剤との配合使用により、清涼剤の使用効果をよりよく発揮することができ、コンタクトレンズ装用者の目の不快感と異物感を解消又は軽減し、目を潤滑、湿潤と清涼の状態に長時間維持することができる。 The composition for contact lenses provided by the technical solution of the present invention comprises a cooling agent, sodium lauroyl lactate, polyoxyethylene laureth sulfate, polyoxypropylene glycol, polyoxypropylene glycol, and polyoxypropylene glycol. Oxyethylene hydrogenated castor oil (polyoxyethylene hardened castor oil), polyvinylpyrrolidone (PVP), SDS, TWEEN 80 TM and GEROPON TM SBFA-30 in combination with a surfactant containing one or more kinds of surfactants. , The effect of using a cooling agent can be better exhibited, and the discomfort of the eyes of contact lens wearers To eliminate or reduce the foreign body sensation, eye lubrication, it can be maintained for a long time in the state of wet and soft.
本発明の特徴及び技術内容がより一層分かるように、以下本発明に関する詳細な説明と添付図面を参照する。しかし、提供される添付図面は参考と説明のために提供するものに過ぎず、本発明を制限するためのものではない。 For a better understanding of the features and technical contents of the present invention, reference is made to the detailed description of the present invention and the accompanying drawings. However, the accompanying drawings provided are provided for reference and explanation only, and do not limit the present invention.
図１を参照する。本発明の実施例に係るコンタクトレンズ用組成物は、コンタクトレンズ保存液としてコンタクトレンズと共に密閉する包装容器に装入され得る。実際の応用では、ユーザがコンタクトレンズを装用しようとするまで、コンタクトレンズは組成物に浸漬され組成物と十分な接触が保持され、その場合になって始めて、コンタクトレンズを組成物から取り出し、眼球につける。更には、コンタクトレンズが組成物に浸漬される場合、組成物中の成分はコンタクトレンズに吸着し、コンタクトレンズが眼球に移動され貼りつけられると、これらの成分は眼球に入る。 Please refer to FIG. The composition for a contact lens according to the embodiment of the present invention can be placed in a packaging container that is hermetically sealed together with the contact lens as a contact lens preservation solution. In practical applications, the contact lens is immersed in the composition and remains in good contact with the composition until the user attempts to wear the contact lens, and only then is the contact lens removed from the composition and Attach to Furthermore, when the contact lens is immersed in the composition, the components in the composition adsorb to the contact lens, and when the contact lens is moved and adhered to the eye, these components enter the eye.
本発明の実施例に係るコンタクトレンズ用組成物はソフトコンタクトレンズにもハードコンタクトレンズにも適用され、また、ソフトコンタクトレンズはハイドロゲルを用いる含水性ソフトコンタクトレンズ（ハイドロゲルコンタクトレンズ）であってもよく、ブチルアクリレートとブチルメタクリレートの共重合体を用いる非含水性ソフトコンタクトレンズであってもよい。更には、本発明のコンタクトレンズ用組成物は、米国食品医薬品局（ＦＤＡ）による分類に適用され、Ｉ〜ＩＶグループ中の何れか１種類：ａｌｐｈａｆｉｌｃｏｎ、ａｓｍｏｆｉｌｃｏｎ、ｂａｌａｆｉｌｃｏｎ、ｅｔｈａｆｉｌｃｏｎ、ｈｅｆｉｌｃｏｎ、ｈｉｌａｆｉｌｃｏｎ、ｌｉｄｏｆｉｌｃｏｎ、ｌｏｔｒａｆｉｌｃｏｎ、ｍｅｔｈａｆｉｌｃｏｎ、ｎｅｌｆｉｌｃｏｎ、ｏｃｕｆｉｌｃｏｎ、ｏｍａｆｉｌｃｏｎ、ｐｈｅｍｆｉｌｃｏｎ、ｐｏｌｙｍａｃｏｎ、ｔｅｆｉｌｃｏｎ、ｔｅｔｒａｆｉｌｃｏｎ、ｖａｓｕｒｆｉｌｃｏｎ、ｖｉｆｉｌｃｏｎ、ｓｅｎｏｆｉｌｃｏｎ、ｇａｌｙｆｉｌｃｏｎ、ｅｎｆｉｌｃｏｎ、ｃｏｍｆｉｌｃｏｎ、ｎａｒａｆｉｌｃｏｎ、ｄｅｌｅｆｉｌｃｏｎ、ｅｆｒｏｆｉｌｃｏｎ、ＦＩＬＩＣＯＮ ＩＩ ３等に属する。 The composition for a contact lens according to the embodiment of the present invention is applicable to both a soft contact lens and a hard contact lens, and the soft contact lens is a hydrous soft contact lens using a hydrogel (a hydrogel contact lens). Alternatively, a non-water-containing soft contact lens using a copolymer of butyl acrylate and butyl methacrylate may be used. Furthermore, the composition for a contact lens of the present invention is applied to classification by the U.S. Food and Drug Administration (FDA), and any one of the groups I to IV: alphafilcon, asmofilcon, balafircon, ethafilcon, hefilcon, hilafilcon, lidofilcon. , Lotrafilcon, methafilcon, nelfilcon, ocufilcon, omafilcon, phemfilcon, polyconon, tefilcon, tetrafilcon, vasurcon, filfilcon, filfilcon, fenfilcon, fenfilcon, genficoncon Belonging to the CON II 3 and the like.
本発明の実施例に係るコンタクトレンズ用組成物は、主として液状の基質と、液状の基質に均一に分散される清涼剤と、界面活性剤と、水溶性重合体とを含む。 The composition for a contact lens according to an example of the present invention mainly includes a liquid substrate, a cooling agent uniformly dispersed in the liquid substrate, a surfactant, and a water-soluble polymer.
本実施例では、液状の基質は、ホウ酸緩衝剤又はリン酸緩衝剤を含む生理食塩水を選択してもよい。また、ホウ酸緩衝剤とリン酸緩衝剤はｐＨ緩衝作用を有し、本発明に係る組成物のｐＨを約６．８〜７．６の範囲に調整する。なお、本発明に係る組成物の浸透圧を約２５０Ｏｓｍｏｌ／Ｋｇ〜３５０Ｏｓｍｏｌ／Ｋｇの範囲に維持するように、液状の基質は適量の塩化ナトリウム又は塩化カリウムを含んでも良い。 In this embodiment, the liquid substrate may be a physiological saline containing a borate buffer or a phosphate buffer. Further, the borate buffer and the phosphate buffer have a pH buffering action, and adjust the pH of the composition according to the present invention to a range of about 6.8 to 7.6. The liquid substrate may contain an appropriate amount of sodium chloride or potassium chloride so as to maintain the osmotic pressure of the composition according to the present invention in the range of about 250 Osmol / Kg to 350 Osmol / Kg.
ホウ酸緩衝剤はホウ酸又はホウ酸塩（例えばテトラホウ酸ナトリウム）を選択してもよい。リン酸緩衝剤はリン酸又はリン酸塩（例えばリン酸水素二ナトリウム、リン酸二水素ナトリウム等）を選択してもよい。なお、液状の基質には１種類の緩衝剤を単独で用いてもよく、２種類以上の異なる緩衝剤を組み合わせて用いてもよい。緩衝剤の濃度は、用いられる緩衝剤の種類又は他の配合成分の種類により適当に調整されても良い。 The borate buffer may be selected from boric acid or borate (eg, sodium tetraborate). The phosphate buffer may be selected from phosphoric acid or phosphate (eg, disodium hydrogen phosphate, sodium dihydrogen phosphate, etc.). One type of buffer may be used alone for the liquid substrate, or two or more types of different buffers may be used in combination. The concentration of the buffer may be appropriately adjusted depending on the type of the buffer used or the type of other components.
清涼剤は、目の不快感と異物感を解消又は軽減し、目に清涼感を与えるために添加されるものである。清涼剤は、メントール、カンファ、ボルネオール、乳酸メンチルエステル（ｍｅｎｔｈｙｌ ｌａｃｔａｔｅ）、メントングリセリンケタール（ｍｅｎｔｈｏｎｅ−ｇｌｙｃｅｒｏｌ ｋｅｔａｌ）、コハク酸モノメチル（ｍｏｎｏｍｅｔｈｙｌ ｓｕｃｃｉｎａｔｅ）及びパラメンタン−３，８−ジオール（ｐ−ｍｅｎｔｈａｎｅ−３，８−ｄｉｏｌ）の中の１種類又は２種類以上の組合せを含み、その含有量は、０．００１％（ｗ／ｖ）〜０．５％（ｗ／ｖ）であってもよく、好ましくは０．００１％（ｗ／ｖ）〜０．２５％（ｗ／ｖ）である。これにより、眼球を刺激しすぎることを回避することができる。 Cooling agents are added to eliminate or reduce discomfort and foreign body sensation in the eyes and to provide a refreshing sensation to the eyes. Cooling agents include menthol, camphor, borneol, menthyl lactate, menthone-glycerol ketal, monomethyl succinate (monomethyl succinate) and paramenthane-3,8-diol (p-menthate). 8- diol ), and the content thereof may be 0.001% (w / v) to 0.5% (w / v), preferably It is 0.001% (w / v) to 0.25% (w / v). Thereby, it is possible to prevent the eyeball from being excessively stimulated.
界面活性剤は、コンタクトレンズを洗浄し、レンズにおける油脂、堆積物等を取り除き、コンタクトレンズの潤滑性と湿潤性を向上するために添加されるものである。界面活性剤は、ラウロイル乳酸ナトリウム（ｓｏｄｉｕｍ ｌａｕｒｏｙｌ ｌａｃｔｙｌａｔｅ）、ポリオキシエチレンラウレス硫酸塩（ｐｏｌｙｏｘｙｅｔｈｙｌｅｎｅ ｌａｕｒｅｔｈ ｓｕｌｆａｔｅ）、ポリオキシプロピレングリコール（ｐｏｌｙｏｘｙｐｒｏｐｙｌｅｎｅ ｇｌｙｃｏｌ）、ポリオキシエチレン硬化ヒマシ油（ｐｏｌｙｏｘｙｅｔｈｙｌｅｎｅ ｈａｒｄｅｎｅｄ ｃａｓｔｏｒ ｏｉｌ）、ポリビニルピロリドン（ＰＶＰ）、ＳＤＳ、ＴＷＥＥＮ ８０ＴＭ及びＧＥＲＯＰＯＮＴＭ ＳＢＦＡ−３０の中の１種類又は２種類以上の組合せを含み、その含有量は、０．００１％（ｗ／ｖ）〜２％（ｗ／ｖ）であってもよく、好ましくは０．００１％（ｗ／ｖ）〜０．５％（ｗ／ｖ）である。 The surfactant is added to clean the contact lens, remove fats and oils, deposits and the like from the lens, and improve the lubricity and wettability of the contact lens. The surfactants include sodium lauroyl lactate, polyoxyethylene laureth sulfate, polyoxypropylene glycol, polyoxyethylene propylene glycol, and polyoxyethylene hydrogenated epoxy oil. (PVP), SDS, TWEEN 80 ™ and GEROPON ™ SBFA-30, including one or a combination of two or more thereof, with a content of 0.001% (w / v) to 2% (w / v). ), Preferably from 0.001% (w / v) to 0.5% (w / v).
なお、本発明は所定の界面活性剤を選択し清涼剤と配合使用することで、清涼剤の効果をよりよく発揮することができる。例えば、清涼剤は目の疲れ、ドライアイ、痒みと痛み等の症状を効率的に軽減し、目に清涼感を長時間維持することができる。 In the present invention, by selecting a predetermined surfactant and using it in combination with a cooling agent, the effect of the cooling agent can be more effectively exerted. For example, a cooling agent can efficiently reduce symptoms such as eye fatigue, dry eye, itching and pain, and can maintain a refreshing sensation in the eyes for a long time.
水溶性重合体の添加は、コンタクトレンズの潤滑と保湿に寄与し、それに加えて、水溶性重合体は、組成物における目に有益な成分をコンタクトレンズに保留させることにも寄与する。例えば、組成物にはビタミン（例えばビタミンＡ、ビタミンＢ群、ビタミンＥ等）が含まれると、水溶性重合体はビタミンと相互作用し、ビタミンの吸着量を増加すると同時にビタミンが迅速に失うことを回避できる。水溶性重合体は、ポリエチレングリコール、メタクリロイルオキシエチルホスホリルコリン（ＭＰＣ）及びヒアルロン酸（ｈｙａｌｕｒｏｎｉｃ ａｃｉｄ）の中の１種類又は２種類以上の組合せを含み、最も好ましくは、同時にポリエチレングリコールとメタクリロイルオキシエチルホスホリルコリンを用いて、１：２０の重量比で添加する。水溶性重合体の含有量は、０．００２％（ｗ／ｖ）〜１０％（ｗ／ｖ）であってもよく、好ましくは０．０５％（ｗ／ｖ）〜５％（ｗ／ｖ）である。 The addition of a water-soluble polymer contributes to the lubrication and moisturization of the contact lens, and in addition, the water-soluble polymer also contributes to retaining the eye-friendly components of the composition in the contact lens. For example, if the composition contains vitamins (eg, vitamin A, vitamin B group, vitamin E, etc.), the water-soluble polymer will interact with the vitamin, increasing the amount of vitamin adsorption and simultaneously losing the vitamin quickly. Can be avoided. Water-soluble polymers may include one or combinations of two or more in a polyethylene glycol, methacryloyloxyethyl phosphorylcholine (MPC) and hyaluronic acid (hyaluronic acid), and most preferably, polyethylene glycol and methacryloyloxyethyl phosphorylcholine simultaneously With a 1:20 weight ratio. The content of the water-soluble polymer may be 0.002% (w / v) to 10% (w / v), preferably 0.05% (w / v) to 5% (w / v). ).
［評価項目］
表１には幾つかの代表的実施例と比較例が挙げられている。実施例と比較例のコンタクトレンズ用組成物を用いて、それぞれコンタクトレンズと十分に接触し、コンタクトレンズ装用直後、装用３０分間後及び１時間後、ＶＡＳ法（Ｖｉｓｕａｌ Ａｎａｌｏｇｕｅ Ｓｃａｌｅ：視覚アナログスケール）で潤滑感、快適感、クール感と湿潤感等の項目を評価し、各評価項目に対して、いずれも３名（６眼）の点数の平均値を計算し、結果を表２に示す。
[Evaluation item]
Table 1 lists some representative examples and comparative examples. Using the contact lens compositions of the examples and comparative examples, the compositions were sufficiently contacted with the contact lenses, respectively, and immediately after wearing the contact lenses, 30 minutes and 1 hour after wearing, by the VAS method (Visual Analog Scale: visual analog scale). Items such as lubrication, comfort, coolness and wetness were evaluated, and the average value of the scores of three persons (six eyes) was calculated for each evaluation item. The results are shown in Table 2.
［実施例の有益な効果］
本発明の実施例に係るコンタクトレンズ用組成物は、清涼剤と、ラウロイル乳酸ナトリウム（ｓｏｄｉｕｍ ｌａｕｒｏｙｌ ｌａｃｔｙｌａｔｅ）、ポリオキシエチレンラウレス硫酸塩（ｐｏｌｙｏｘｙｅｔｈｙｌｅｎｅ ｌａｕｒｅｔｈ ｓｕｌｆａｔｅ）、ポリオキシプロピレングリコール（ｐｏｌｙｏｘｙｐｒｏｐｙｌｅｎｅ ｇｌｙｃｏｌ）、ポリオキシエチレン硬化ヒマシ油（ｐｏｌｙｏｘｙｅｔｈｙｌｅｎｅ ｈａｒｄｅｎｅｄ ｃａｓｔｏｒ ｏｉｌ）、ポリビニルピロリドン（ＰＶＰ）、ＳＤＳ、ＴＷＥＥＮ ８０ＴＭ及びＧＥＲＯＰＯＮＴＭ ＳＢＦＡ−３０の中の１種類又は２種類以上の組合せを含む界面活性剤との配合使用により、清涼剤の使用効果をよりよく発揮することができ、コンタクトレンズ装用者の目の不快感と異物感を解消又は軽減し、目を潤滑、湿潤と清涼の状態に長時間維持することができる。
[Beneficial effects of the embodiment]
The composition for a contact lens according to an embodiment of the present invention comprises a cooling agent, sodium lauroyl lactate, polyoxyethylene laureth sulfate, polyoxypropylene glycol, polyoxypropylene glycol, and polyoxypropylene glycol. With the use of a combination of one or more of surfactants including ethyleneoxy hydrogenated castor oil, polyvinylpyrrolidone (PVP), SDS, TWEEN 80 ™ and GEROPON ™ SBFA-30, The effect of using the cooling agent can be better exhibited, and the discomfort and foreign matter in the eyes of contact lens wearers The eliminate or alleviate, eye lubrication, it can be maintained for a long time in the state of wet and soft.
以上に開示される内容は本発明の好ましい実施可能な実施例に過ぎず、これにより本発明の特許請求の範囲を制限するものではないので、本発明の明細書及び添付図面の内容に基づき為された等価の技術変形は、全て本発明の特許請求の範囲に含まれるものとする。 The contents disclosed above are merely preferred embodiments of the present invention, and do not limit the scope of the claims of the present invention. All such equivalent technical modifications are intended to be included in the scope of the claims of the present invention.
Claims (8)
ラウロイル乳酸ナトリウム（ｓｏｄｉｕｍ ｌａｕｒｏｙｌ ｌａｃｔｙｌａｔｅ）、ＳＤＳの中の１種類又は２種類の組合せを含む界面活性剤と、
ポリエチレングリコールとメタクリロイルオキシエチルホスホリルコリン（ＭＰＣ）を含む水溶性重合体と、
を含み、
前記ポリエチレングリコールと前記メタクリロイルオキシエチルホスホリルコリンの重量比が１：２０であることを特徴とする、コンタクトレンズ用組成物。 Freshener,
Sodium lauroyl lactate, a surfactant comprising one or a combination of two of SDS;
A water-soluble polymer comprising polyethylene glycol and methacryloyloxyethyl phosphorylcholine (MPC);
Only including,
A composition for contact lenses, wherein the weight ratio of the polyethylene glycol to the methacryloyloxyethyl phosphorylcholine is 1:20 .
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| TW106111144 | 2017-03-31 | ||
| TW106111144A TWI607768B (en) | 2017-03-31 | 2017-03-31 | Composition for contact lenses and method for caring contact lenses |
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| JP2018173618A JP2018173618A (en) | 2018-11-08 |
| JP6652530B2 true JP6652530B2 (en) | 2020-02-26 |
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| EP (1) | EP3382002B1 (en) |
| JP (1) | JP6652530B2 (en) |
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| TWI798452B (en) * | 2019-06-17 | 2023-04-11 | 晶碩光學股份有限公司 | Contact lens product |
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| WO1996003158A1 (en) * | 1994-07-22 | 1996-02-08 | Alcon Laboratories, Inc. | Use of low molecular weight amino acids in ophthalmic compositions |
| US5494937A (en) * | 1994-07-22 | 1996-02-27 | Alcon Laboratories, Inc. | Saline solution for treating contact lenses |
| US6228323B1 (en) * | 1996-12-13 | 2001-05-08 | Alcon Laboratories, Inc. | Multi-purpose compositions containing an alkyl-trypsin and methods of use in contact lens cleaning and disinfecting |
| JP5437350B2 (en) * | 2000-12-28 | 2014-03-12 | ロート製薬株式会社 | Ophthalmic composition |
| JP4135905B2 (en) * | 2003-03-17 | 2008-08-20 | ロート製薬株式会社 | Eye drops for contact lenses containing a cooling agent |
| JP2012072183A (en) * | 2004-06-08 | 2012-04-12 | Rohto Pharmaceutical Co Ltd | Refreshing composition for ophthalmology |
| JP2007297559A (en) * | 2006-05-02 | 2007-11-15 | Rohto Pharmaceut Co Ltd | AMINO ACID-MODIFIED-(gamma-POLYGLUTAMIC ACID) OR ITS SALT AND THEIR USES |
| US20080095754A1 (en) * | 2006-10-18 | 2008-04-24 | Burke Susan E | Ophthalmic compositions comprising diglycine |
| JP5401113B2 (en) * | 2008-02-07 | 2014-01-29 | ロート製薬株式会社 | Aqueous composition containing chlorous acid compounds containing menthols |
| JP4457237B1 (en) * | 2009-07-30 | 2010-04-28 | 株式会社シード | Contact lens solution |
| CN102548562B (en) * | 2009-09-30 | 2014-04-09 | 日本乐敦制药株式会社 | Ophthalmic composition |
| TWI480039B (en) * | 2011-03-10 | 2015-04-11 | Pegavision Corp | Aqueous composition for contact lens |
| KR102051174B1 (en) * | 2012-06-14 | 2019-12-02 | 노파르티스 아게 | Azetidinium-containing copolymers and uses thereof |
| JP6654340B2 (en) * | 2013-04-12 | 2020-02-26 | ロート製薬株式会社 | Contact lens composition and contact lens package using the same |
| KR101490344B1 (en) * | 2013-07-05 | 2015-02-11 | 마준오 | Contact lens with cooling coating layer |
| CN106163565A (en) * | 2014-04-09 | 2016-11-23 | 乐敦制药株式会社 | Ophthalmic composition |
| JP6616137B2 (en) * | 2015-09-15 | 2019-12-04 | 株式会社メニコン | Contact lens composition |
| US20170087199A1 (en) * | 2016-02-10 | 2017-03-30 | Senomyx, Inc. | Compositions for delivering a cooling sensation |
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| TW201836650A (en) | 2018-10-16 |
| TWI607768B (en) | 2017-12-11 |
| EP3382002A1 (en) | 2018-10-03 |
| EP3382002B1 (en) | 2021-08-04 |
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