CN108690740A - The maintenance method of contact lenses composition and contact lenses - Google Patents

The maintenance method of contact lenses composition and contact lenses Download PDF

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Publication number
CN108690740A
CN108690740A CN201710237450.6A CN201710237450A CN108690740A CN 108690740 A CN108690740 A CN 108690740A CN 201710237450 A CN201710237450 A CN 201710237450A CN 108690740 A CN108690740 A CN 108690740A
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Prior art keywords
contact lenses
composition
maintenance method
freshener
soluble polymer
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Inventor
张汉宜
陈莉茹
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Pegavision Corp
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Pegavision Corp
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Priority to CN201710237450.6A priority Critical patent/CN108690740A/en
Publication of CN108690740A publication Critical patent/CN108690740A/en
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66Non-ionic compounds
    • C11D1/825Mixtures of compounds all of which are non-ionic
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    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
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    • C11D1/83Mixtures of non-ionic with anionic compounds
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    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66Non-ionic compounds
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/86Mixtures of anionic, cationic, and non-ionic compounds
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005Other compounding ingredients characterised by their effect
    • C11D3/0078Compositions for cleaning contact lenses, spectacles or lenses
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02Inorganic compounds ; Elemental compounds
    • C11D3/04Water-soluble compounds
    • C11D3/046Salts
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2003Alcohols; Phenols
    • C11D3/2006Monohydric alcohols
    • C11D3/2024Monohydric alcohols cyclic; polycyclic
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    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2003Alcohols; Phenols
    • C11D3/2041Dihydric alcohols
    • C11D3/2051Dihydric alcohols cyclic; polycyclic
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    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
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    • C11D3/2072Aldehydes-ketones
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    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
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    • C11D3/2093Esters; Carbonates
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    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
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    • C11D3/2096Heterocyclic compounds
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    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/22Carbohydrates or derivatives thereof
    • C11D3/222Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
    • C11D3/227Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin with nitrogen-containing groups
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    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
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    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/37Polymers
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    • C11D3/3707Polyethers, e.g. polyalkyleneoxides
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    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02Anionic compounds
    • C11D1/12Sulfonic acids or sulfuric acid esters; Salts thereof
    • C11D1/28Sulfonation products derived from fatty acids or their derivatives, e.g. esters, amides
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    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/38Cationic compounds
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    • C11D1/66Non-ionic compounds
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    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66Non-ionic compounds
    • C11D1/74Carboxylates or sulfonates esters of polyoxyalkylene glycols

Abstract

The present invention discloses the maintenance method of a kind of contact lenses composition and contact lenses, contact lenses composition includes freshener and surfactant, and wherein surfactant includes one or more combinations in sodium lauroyl lactylate, polyoxyethylene lauryl alcohol polyethers sulfuric acid, polyoxypropylene diols, polyoxyethylene hardened castor oil, polyvinylpyrrolidone, lauryl sodium sulfate, polyoxyethylene sorbitan monooleate and alkyl sulfo succinate.Therefore, the present invention can effectively improve the wearing comfort level of contact lenses.

Description

The maintenance method of contact lenses composition and contact lenses
Technical field
The present invention relates to a kind of contact lenses composition, more particularly to a kind of for contact lenses preservation of packaged liquid Contact lenses composition.The invention further relates to a kind of maintenance methods of contact lenses.
Background technology
As the arriving of information age does not only result in compatriots' myopia due to largely using computer and smartphone Ratio constantly increases, and near-sighted age level also has downward trend year by year.In view of convenience and aesthetics, contact lenses are a kind of Very valuable selection, however the people of most of dysphotias has the custom of long-time contact lens wear, even if existing The materials of contact lenses have been subjected to continuous improvement to meet various demands (such as High water cut, high oxygen flow), user still can Moisture reduction due to contained by eyeglass feels that eyes are dry and astringent, and eyes discomfort is felt because of dirt and sediment on eyeglass (such as itching, shouting pain);Therefore, be badly in need of at present it is a kind of contact lenses can be cleaned, the maintenance solution of rewetting and preservation.
Invention content
Technical problem to be solved by the present invention lies in provide a kind of contact lenses combination in view of the deficiencies of the prior art User can be kept when just starting wearing and continuous contact lens wear for a long time for the maintenance method of object and contact lenses Ocular comfort.
In order to solve the above-mentioned technical problem, a technical solution of the present invention is to provide a kind of contact lenses use Composition, which is characterized in that contact lenses composition includes freshener and surfactant, and surfactant includes the moon Osmanthus acyl lactylate, polyoxyethylene lauryl alcohol polyethers sulfuric acid, polyoxypropylene diols, polyoxyethylene hardened castor oil, polyethylene One kind in pyrrolidones, lauryl sodium sulfate, polyoxyethylene sorbitan monooleate and alkyl sulfo succinate Or a variety of combination.
In order to solve the above-mentioned technical problem, another technical solution of the present invention is to provide a kind of contact lenses Maintenance method comprising following steps:Fluid composition is provided, it includes freshener and surfactant, wherein surface is lived Property agent include sodium lauroyl lactylate, polyoxyethylene lauryl alcohol polyethers sulfuric acid, polyoxypropylene diols, polyoxyethylene hardened castor-oil plant Oil, polyvinylpyrrolidone, lauryl sodium sulfate, polyoxyethylene sorbitan monooleate and alkyl sulfo succinate In one or more combinations;And the minute surface of fluid composition and contact lenses is come into full contact with.
Preferably, the content of surfactant is between 0.001% (w/v) to 0.5% (w/v).
Preferably, freshener includes menthol, camphor, borneol, menthyl lactate, menthone glycerol ketals, succinic acid Monomenthyl esters and to one or more combinations in terpane -3,8- glycol.
Preferably, freshener is menthol.
Preferably, the content of freshener is between 0.001% (w/v) to 0.25% (w/v).
Preferably, fluid composition further includes water-soluble polymer, the water-soluble polymer include polyethylene glycol, One or more combinations in methacrylate phosphoryl choline and sodium hyaluronate.
Preferably, water-soluble polymer includes polyethylene glycol (molecular weight PEG400) and methacrylate phosphoryl choline, and The weight ratio of polyethylene glycol and methacrylate phosphoryl choline is 1:20.
Preferably, the content of water-soluble polymer is between 0.05% (w/v) to 5% (w/v).
Preferably, fluid composition further includes buffer, and the buffer includes boric acid and sodium tetraborate.
The beneficial effects of the present invention are the contact lenses composition that technical scheme of the present invention is provided passes through The compatible use of freshener and surfactant, wherein surfactant are poly- comprising sodium lauroyl lactylate, polyoxyethylene lauryl alcohol Ether sulfuric ester salt, polyoxypropylene diols, polyoxyethylene hardened castor oil, polyvinylpyrrolidone, lauryl sodium sulfate, polyoxy One or more combinations in ethylene sorbitan monooleate and alkyl sulfo succinate can be played preferably refrigerant The using effect of agent, and the sense of discomfort for the contact lens wearers' eyes that can eliminate or releive and foreign body sensation and maintenance eyes for a long time In lubrication, moistening and refrigerant state.
For the enabled feature and technology contents for being further understood that the present invention, please refer to below in connection with the present invention specifically Bright and attached drawing, however the attached drawing provided is merely provided for reference and description, is not intended to limit the present invention.
Description of the drawings
Fig. 1 uses schematic diagram for contact lenses composition of the invention.
Fig. 2 is the flow diagram of the maintenance method of the contact lenses of the present invention.
Specific implementation mode
It is to be illustrated by particular specific embodiment presently disclosed related " contact lenses composition " below Embodiment, those skilled in the art can understand advantages of the present invention and effect by content disclosed in this specification.The present invention It can be implemented or be applied by other different specific embodiments, the various details in this specification may be based on different viewpoints With application, various modifications and change are carried out without departing from the spirit of the present invention.In addition, the attached drawing of the present invention is only simple signal Illustrate, not according to the description of actual size, states in advance.The correlation of the present invention will be explained in further detail in the following embodiments and the accompanying drawings Technology contents, but disclosure of that is not to limit the scope of the invention.
Referring to Fig.1, the contact lenses that the embodiment of the present invention is provided use composition can as contact lenses preserve liquid with it is hidden Shape glasses are loaded into sealed package together.In practical applications, contact lenses be impregnate in the composition with combine Object holding comes into full contact with, and when user is intended to contact lens wear, just takes out contact lenses from composition, and matched It is worn on eyeball.Furthermore, when contact lenses impregnate in the composition, the ingredient in composition will be adsorbed on hidden On shape glasses, once contact lenses are moved and are attached on eyeball, this ingredient will go into eyeball.
The contact lenses composition that the embodiment of the present invention is provided is suitable to Soft contact lens and hard contact lenses With wherein Soft contact lens can be the property of water-bearing Soft contact lens (hydrogel contact lens) using hydrogel, also may be used To be the non-aqueous Soft contact lens using butyl propyleneglycol acid esters and the copolymer of butyl methyl acrylate.Further Say that contact lenses of the invention are suitable for classifying according to Food and Drug Administration (FDA) with composition, belong to I to IV groups in ground Any one of:alphafilcon,asmofilcon,balafilcon,ethafilcon,hefilcon, hilafilcon,lidofilcon,lotrafilcon,methafilcon,nelfilcon,ocufilcon,omafilcon, phemfilcon,polymacon,tefilcon,tetrafilcon,vasurfilcon,vifilcon,senofilcon, galyfilcon,enfilcon,comfilcon,narafilcon,delefilcon,efrofilcon,FILICON II 3 Deng.
The contact lenses composition that the embodiment of the present invention is provided mainly comprising liquid matrix and is dispersed in liquid Freshener, surfactant in state matrix and water-soluble polymer.
In the present embodiment, the physiological saline of boronic acid containing buffer or phosphoric acid buffer agent, wherein boric acid can be selected in liquid matrix Buffer has pH cushioning effects with phosphoric acid buffer agent, and the pH value of the present composition is adjusted to about 6.8 to 7.6 range It is interior;In addition, liquid matrix may include suitable sodium chloride or potassium chloride, the osmotic pressure of the present composition is maintained about In the range of 250Osmol/Kg to 350Osmol/Kg.
Boric acid or borate (such as sodium tetraborate) can be selected in borate buffer, and phosphoric acid or phosphate can be selected in phosphoric acid buffer agent (such as disodium-hydrogen, sodium dihydrogen phosphate);It should be noted that a kind of buffer that can be used alone in liquid matrix, it also can group Close use two or more different buffer, and the concentration of buffer can according to the type of used buffer or its He makes the appropriate adjustments the type of gradation composition.
Freshener is added for eliminating or releive the sense of discomfort and foreign body sensation of eyes, and gives eyes refrigerant sense.It is refrigerant Agent includes menthol, camphor, borneol, menthyl lactate (menthyl lactate), menthone glycerol ketals (menthone- Glycerol ketal), monomenthyl succinate (monomethyl succinate) and to terpane -3,8- glycol (p- Menthane-3,8-doil) in one or more combinations, the content of freshener can be between 0.001% (w/v) to 0.5% (w/v) between, and between preferably 0.001% (w/v) to 0.25% (w/v), too aggressive eyeball is avoided.
Surfactant is added for cleaning contact lenses, to remove the grease on eyeglass, sediment etc., and Improve the lubricious and wettability of contact lenses.Surfactant includes sodium lauroyl lactylate (sodium lauroyl Lactylate), polyoxyethylene lauryl alcohol polyethers sulfuric acid (polyoxyethylene laureth sulfate), polyoxy third Enediol (polyoxypropylene glycol), polyoxyethylene hardened castor oil (polyoxyethylene hardened Castor oil), polyvinylpyrrolidone (PVP), lauryl sodium sulfate (SDS), polyoxyethylene sorbitol acid anhydride list oleic acid Ester (TWEEN80TM) and alkyl sulfo succinate (GEROPONTMSBFA-30 one or more combinations in), surface The content of activating agent can be between 0.001% (w/v) to 2% (w/v), and preferably 0.001% (w/v) to 0.5% (w/v) Between.
It is worth noting that the present invention selects specific surfactant and freshener compatible use, can preferably play The effect of freshener, for example, freshener can effectively relieving eye strain, it is dry and astringent, scratch the symptoms such as itching and pain, and can be for a long time Maintain the refrigerant sense of eyes.
The addition of water-soluble polymer contributes to lubrication and the moisturizing of contact lenses, in addition to this, water-soluble polymer Help ingredient beneficial to eyes in composition being retained on contact lenses, for example, if containing vitamin in composition (such as vitamin A, vitamine B group, vitamin E), then water-soluble polymer can with vitamin occur reciprocation, with increase dimension The adsorbance of raw element avoids vitamin from being lost in rapidly simultaneously.Water-soluble polymer includes polyethylene glycol (molecular weight PEG400), third One or more combinations in e pioic acid methyl ester phosphocholine (MPC) and sodium hyaluronate (hyaluronic acid), wherein and with Simultaneously using polyethylene glycol and methacrylate phosphoryl choline, and press 1:20 weight ratio is added to most preferably;Water-soluble polymer Content can be between 0.002% (w/v) to 10% (w/v), and between preferably 0.05% (w/v) to 5% (w/v).
With reference to Fig. 2, it is based on above-mentioned contact lenses composition, the present invention separately provides a kind of maintenance method of contact lenses. As shown in Fig. 2, step S102 is first carried out in the maintenance method S100 of contact lenses, fluid composition is provided, it includes fresheners And surfactant, wherein surfactant includes sodium lauroyl lactylate, polyoxyethylene lauryl alcohol polyethers sulfuric acid, polyoxy Propylene glycol, polyoxyethylene hardened castor oil, polyvinylpyrrolidone, lauryl sodium sulfate, polyoxyethylene sorbitol acid anhydride One or more combinations in monoleate and alkyl sulfo succinate.Then, step S104 is executed, by liquid compositions The minute surface of object and contact lenses comes into full contact with.
Term " contact " used herein, can be realized by contact lenses are soaked in fluid composition Contact, can also be the contact realized come rinse (rinsing) contact lenses using fluid composition.
Assessment item
Several representative embodiments and comparative example are listed in table 1, using embodiment and the contact lenses of comparative example with combining Object comes into full contact with contact lens respectively, and after just putting on contact lenses and putting on 30 minutes and 1 hour, uses VAS Method (Visual Analogue Scale:Visual evaluation scale) to projects such as lubrication sense, comfort, cool feeling and moist feelings It is evaluated, the score average of 3 (6) is calculated to each assessment item, is as a result shown in table 2.
Table 1
Table 2
The advantageous effect of embodiment
The contact lenses composition that the embodiment of the present invention is provided, is made by the compatibility of freshener and surfactant With wherein surfactant is poly- comprising sodium lauroyl lactylate (sodium lauroyl lactylate), polyoxyethylene lauryl alcohol Ether sulfuric ester salt (polyoxyethylene laureth sulfate), polyoxypropylene diols (polyoxypropylene Glycol), polyoxyethylene hardened castor oil (polyoxyethylene hardened castor oil), polyvinylpyrrolidine Ketone (PVP), lauryl sodium sulfate (SDS), polyoxyethylene sorbitan monooleate (TWEEN 80TM) and alkyl sulfobetaines Succinate (GEROPONTMSBFA-30 one or more combinations in) can preferably play the using effect of freshener, And the sense of discomfort and foreign body sensation for the contact lens wearers' eyes that can eliminate or releive with for a long time maintain eyes in lubrication, moistening with Refrigerant state.
Content disclosed above is only the preferred possible embodiments of the present invention, and the right for not thereby limiting to the present invention is wanted The protection domain of book, therefore the equivalence techniques variation done with description of the invention and accompanying drawing content are asked, this hair is both contained in In the protection domain of bright claims.

Claims (18)

1. a kind of contact lenses composition, it includes freshener and surfactants, which is characterized in that the surface-active Agent includes sodium lauroyl lactylate, polyoxyethylene lauryl alcohol polyethers sulfuric acid, polyoxypropylene diols, polyoxyethylene hardened castor-oil plant Oil, polyvinylpyrrolidone, lauryl sodium sulfate, polyoxyethylene sorbitan monooleate and alkyl sulfo succinate In one or more combinations.
2. contact lenses composition according to claim 1, which is characterized in that volume basis by weight, the surface The content of activating agent is between 0.001% to 0.5%.
3. contact lenses composition according to claim 1, which is characterized in that the freshener includes menthol, camphor tree Brain, borneol, menthyl lactate, menthone glycerol ketals, monomenthyl succinate and to one in terpane -3,8- glycol Kind or a variety of combinations.
4. contact lenses composition according to claim 3, which is characterized in that the freshener is the menthol.
5. contact lenses composition according to claim 3 or 4, which is characterized in that volume basis by weight is described clear Cool dose of content is between 0.001% to 0.25%.
6. contact lenses composition according to claim 1, which is characterized in that the contact lenses composition is into one Step includes water-soluble polymer, and the water-soluble polymer includes polyethylene glycol, methacrylate phosphoryl choline and sodium hyaluronate In one or more combinations.
7. contact lenses composition according to claim 6, which is characterized in that the water-soluble polymer includes described Polyethylene glycol and the methacrylate phosphoryl choline, the molecular weight of the polyethylene glycol are 400, and the polyethylene glycol with The weight ratio of the methacrylate phosphoryl choline is 1:20.
8. the contact lenses composition described according to claim 6 or 7, which is characterized in that volume basis by weight, the water The content of soluble polymer is between 0.05% to 5%.
9. contact lenses composition according to claim 1, which is characterized in that the contact lenses composition is into one Step includes buffer, and the buffer includes boric acid and sodium tetraborate.
10. a kind of maintenance method of contact lenses, which is characterized in that the maintenance method of the contact lenses includes the following steps:
Fluid composition is provided, it includes freshener and surfactants, wherein the surfactant includes lauroyl breast Sour sodium, polyoxyethylene lauryl alcohol polyethers sulfuric acid, polyoxypropylene diols, polyoxyethylene hardened castor oil, polyvinylpyrrolidine It is one or more in ketone, lauryl sodium sulfate, polyoxyethylene sorbitan monooleate and alkyl sulfo succinate Combination;And
The minute surface of the fluid composition and the contact lenses is come into full contact with.
11. the maintenance method of contact lenses according to claim 10, which is characterized in that volume basis by weight, it is described The content of surfactant is between 0.001% to 0.5%.
12. the maintenance method of contact lenses according to claim 10, which is characterized in that the freshener includes peppermint Alcohol, camphor, borneol, menthyl lactate, menthone glycerol ketals, monomenthyl succinate and to terpane -3,8- glycol In one or more combinations.
13. the maintenance method of contact lenses according to claim 12, which is characterized in that the freshener is the peppermint Alcohol.
14. the maintenance method of contact lenses according to claim 11 or 12, which is characterized in that volume basis by weight, The content of the freshener is between 0.001% to 0.25%.
15. the maintenance method of contact lenses according to claim 10, which is characterized in that the fluid composition is further Including water-soluble polymer, the water-soluble polymer includes in polyethylene glycol, methacrylate phosphoryl choline and sodium hyaluronate One or more combinations.
16. the maintenance method of contact lenses according to claim 15, which is characterized in that the water-soluble polymer includes The molecular weight of the polyethylene glycol and the methacrylate phosphoryl choline, the polyethylene glycol is 400, and the poly- second two The weight ratio of alcohol and the methacrylate phosphoryl choline is 1:20.
17. the maintenance method of contact lenses according to claim 15 or 16, which is characterized in that volume basis by weight, The content of the water-soluble polymer is between 0.05% to 5%.
18. the maintenance method of contact lenses according to claim 10, which is characterized in that the fluid composition is further Including buffer, the buffer includes boric acid and sodium tetraborate.
CN201710237450.6A 2017-04-12 2017-04-12 The maintenance method of contact lenses composition and contact lenses Pending CN108690740A (en)

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