EP3369409A1 - Dispositif et procédé de dosage de matériaux de remplissage pulvérulents - Google Patents

Dispositif et procédé de dosage de matériaux de remplissage pulvérulents Download PDF

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Publication number
EP3369409A1
EP3369409A1 EP17000326.3A EP17000326A EP3369409A1 EP 3369409 A1 EP3369409 A1 EP 3369409A1 EP 17000326 A EP17000326 A EP 17000326A EP 3369409 A1 EP3369409 A1 EP 3369409A1
Authority
EP
European Patent Office
Prior art keywords
metering
tool
filling material
rotational movement
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP17000326.3A
Other languages
German (de)
English (en)
Other versions
EP3369409B1 (fr
Inventor
Marco Weigel
Florian Huhnen
Jonas Höpfer
Philipp GAUS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harro Hofliger Verpackungsmaschinen GmbH
Original Assignee
Harro Hofliger Verpackungsmaschinen GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harro Hofliger Verpackungsmaschinen GmbH filed Critical Harro Hofliger Verpackungsmaschinen GmbH
Priority to EP17000326.3A priority Critical patent/EP3369409B1/fr
Publication of EP3369409A1 publication Critical patent/EP3369409A1/fr
Application granted granted Critical
Publication of EP3369409B1 publication Critical patent/EP3369409B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074—Filling capsules; Related operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B1/30—Devices or methods for controlling or determining the quantity or quality or the material fed or filled
    • B65B1/36—Devices or methods for controlling or determining the quantity or quality or the material fed or filled by volumetric devices or methods
    • B65B1/38—Devices or methods for controlling or determining the quantity or quality or the material fed or filled by volumetric devices or methods by pistons co-operating with measuring chambers

Definitions

  • the invention relates to a device and a method by means of which a powdery filling material can be metered.
  • the pulverulent filling material can then be transferred, in particular, into hard gelatine capsules but also into other containers.
  • Such devices and methods are used in particular in the pharmaceutical industry for filling hard gelatin capsules with drugs.
  • the powder to be filled is filled into a metering chamber, for example into the bores of a metering disk.
  • the powder is then compacted by means of a punch in the metering chamber.
  • the stamp performs at least one stroke, so that a compact arises.
  • the finished compact is then expelled from the metering chamber by opening the metering chamber and ejecting the compact by means of a punch.
  • the present invention seeks to provide an improved device for Specify metering of powdery product, can be avoided by means of metering inaccuracies.
  • the device according to the invention for dosing powdery filling material has a product container in which the powdery filling material can be kept in stock. From this product container, a defined amount of the powdery filling material can be removed by means of a metering tool and into a container - for example, in the capsule lower part of a hard gelatin capsule - transferred.
  • the metering tool is designed to be movable in its longitudinal direction.
  • the metering tool can be offset by a drive unit in a rotational movement about its longitudinal axis. By means of this drive unit, a defined rotational movement can be carried out, which prevents adhesion of the pulverulent solid to the metering tool. As a result, dose inaccuracy can be avoided, which leads to a lower reject rate and thus to increased productivity.
  • the drive unit can allow both a clockwise rotational movement and a counterclockwise rotational movement.
  • a reciprocal rotation in a clockwise and counterclockwise direction in a particularly advantageous embodiment, a pendulum or shearing motion can be generated, by means of which adherence of solids to the metering tool can be prevented particularly effectively.
  • a first motor drive can be present, by means of which the metering tool can be moved along its longitudinal axis.
  • the rotation of the Dosing tool can be done by means of a separately formed drive unit. The rotational movement could be carried out in this way, regardless of the transport movement of the metering tool by means of the first motor drive.
  • several metering tools could be moved by means of a common motor drive in the longitudinal direction.
  • the metering tool can be designed as a stamp.
  • at least one metering chamber can be formed at the bottom of the product container into which a defined quantity of the product can be filled.
  • the contents in the metering chamber can first be compacted by the stamp into a compact. Subsequently, the ejection of the compact from the metering chamber can be effected by the punch.
  • the rotational movements of the stamp can be carried out during the compaction of the powdery contents in the metering chamber and / or during the ejection of the compact from the metering chamber.
  • Rotational movements during the compacting of the powdery filling material in the metering chamber can already prevent the adhesion of the compact to the stamp.
  • rotational movement during ejection of the compact from the metering chamber may provide easier release of the compact from the punch.
  • a rotational movement, or a combination It would also be possible to let the stamp perform a rotational movement throughout.
  • the metering tool can be designed as a jack.
  • the pipette can be immersed in the powder bed present in the product container to remove a defined amount of contents. Subsequently, the In the metering chamber of the riser existing amount of powder are transferred to a waiting container.
  • the rotational movements of the piercer may be performed during the immersion of the piercer into the powder bed and / or during the ejection of the powder from the metering chamber of the piercer.
  • Rotational movements during the immersion of the piercer in the powder bed can already prevent the early adhesion of powder to the inner walls of the metering chamber of the piercer and thus allow complete and accurate filling of the metering chamber.
  • rotational movement during ejection of the powder from the metering chamber of the piercer can provide complete and easy ejection of the powder.
  • a rotational movement, or a combination It would also be possible to have the piercer continuously perform a rotational movement.
  • At least one rotational movement of the metering piston should occur during a rotational movement of the piercer.
  • This rotational movement may already be sufficient to effectively prevent the adhesion of powder in the metering chamber.
  • the rotational movements of metering piston and metering sleeve can run in opposite directions, so that a shearing movement takes place.
  • FIG Fig. 1 and 2 A first embodiment of the device 10 according to the invention is shown in FIG Fig. 1 and 2 shown.
  • the device 10 has as a dosing a punch 20, which can be offset by means of a motor drive not shown here in a vertical lifting movement (arrow 22).
  • the punch 20 moves through the lifting movement 22 in the bore 24 of a metering disk 26.
  • Each bore 24 of the metering disk 26 forms a metering chamber.
  • Fig. 1 the bore 24 is closed by a plate 28 from the bottom.
  • the bore 24 can first be filled with a defined amount of filling material.
  • the punch 20, the powder present in the bore 24 then according to Fig. 1 compact to a compact 30.
  • a drive unit 32 in a rotational movement (arrow 34).
  • the rotation 34 of the punch 20 during the compacting of the filling material can ensure that the resulting compact 30 does not adhere to the underside of the punch 20.
  • the rotational movement 34 takes place at a constant speed in the clockwise direction.
  • the rotation 34 could also be counterclockwise.
  • the speed during the rotational movement 34 could be varied.
  • the rotational movement could consist of several smaller, jerky movements.
  • the direction of rotation could be changed at predetermined intervals, so that first clockwise and then rotated counterclockwise. This change of direction could then be repeated as often as desired.
  • the capsule base 40 of a hard gelatin capsule is positioned below the dosing chamber 24 by means of a receiving unit 42.
  • the capsule lower part 40 can be laterally removed by the receiving unit 42, so that a new capsule lower part can be positioned below the dosing chamber 24.
  • the filled capsule lower part 40 can then be provided in other processing stations with another compact or another product or even directly closed.
  • the feeding and removing the Capsule bases can be done in particular by a rotary indexing table, as he, for example, from the EP 1 415 637 A1 or the EP 2 135 810 A1 is known.
  • the punch 20 during the ejection of the compact 30 by the drive unit 32 in a rotational movement (arrow 44) is added.
  • the rotation 44 of the punch 20 during the ejection of the compact 30 the compact 30 is more easily released from the underside of the punch 20 and can fall safely and reliably into the capsule base 40.
  • the rotational movement 44 can be made comparable to the rotational movement 34 with a constant rotational speed and direction but also with varying rotational speed and / or rotational direction. It would be possible, both the rotational movement 34 during compacting ( Fig. 1 ) as well as the rotational movement 44 during ejection ( Fig. 2 ). In this case, the two rotational movements 34, 44 may be identical, but also adapted to the different situations adapted differently. Depending on the contents used, the speed of the rotary indexing table and / or the size of the compact 30, however, it may be sufficient to provide only the rotational movement 34 during the compacting of the product or the rotational movement 44 during the ejection of the compact 30 from the metering chamber 24.
  • FIG 3 and 4 A second embodiment of the device 12 according to the invention is shown in FIG 3 and 4 shown.
  • the device 12 has as a dosing a piercer 50, which can be offset by means of a motor drive, not shown here in a vertical stroke movement (arrow 52).
  • the jack 50 moves through the lifting movement 52 down in the present in a product container 54 filling material 56 and back up out of this.
  • the piercer 50 has an outer metering sleeve 60 and a metering piston 62 guided displaceably therein.
  • the metering piston 62 is retracted somewhat in relation to the free edge 64 of the metering sleeve 60, so that a metering chamber 66 is formed inside the metering sleeve 60.
  • the dosing sleeve 60 is in Fig. 3 with its free edge 64 in the present in the product container 54, a powder bed forming filling 56 dipped.
  • the metering chamber 66 is filled with the filling material 56.
  • the metering piston 62 of the piercer 50 is set in a rotational movement (arrow 72) by a drive unit 70 in the embodiment shown here.
  • This rotation 72 of the metering piston can ensure that the filling material 56 is uniformly distributed in the metering chamber 66, so that an optimal and reproducible filling of the metering chamber 66 is achieved.
  • the rotational movement 72 takes place at a constant speed in the clockwise direction.
  • the rotational motion 72 could also be counterclockwise.
  • the speed during the rotational movement 72 could be varied.
  • the rotational movement could consist of several smaller, jerky movements.
  • the direction of rotation could be changed at predetermined intervals, so that first clockwise and then rotated counterclockwise. This change of direction could then be repeated as often as desired.
  • the predetermined by the volume of the metering chamber 66 amount of powder remains when pulling the piercer 50 from the powder bed in the metering chamber 66 hang.
  • the powder can be transported in this way with the jack 50 and filled by means of the metering piston 62 from the metering chamber 66 out in a designated container (see Fig. 4 ).
  • this is the capsule lower part 40 of a hard gelatin capsule, the was positioned below the piercer 50 by means of a receiving unit 42.
  • the metering piston 62 of the piercer 50 is set into a rotational movement (arrow 74) by the drive unit 70 during the ejection of the powder present in the metering chamber 66.
  • the metering chamber 66 can be emptied quickly and completely.
  • the rotational movement 74 can be made comparable to the rotational movement 72 with a constant rotational speed and direction but also with varying rotational speed and / or rotational direction. It would be possible, both the rotational movement 72 during immersion of the piercer 50 in the filling 56 ( Fig. 3 ) as well as the rotational movement 74 during the ejection of the powder ( Fig. 2 ). In this case, the two rotational movements 72, 74 may be identical, but also adapted differently to the different situations. However, it may also be sufficient to provide only the rotational movement 72 during the immersion of the piercer 50 into the filling material 56 or the rotational movement 74 during the ejection of the powder from the metering chamber 66.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Basic Packing Technique (AREA)
EP17000326.3A 2017-03-02 2017-03-02 Dispositif et procédé de dosage de matériaux de remplissage pulvérulents Active EP3369409B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP17000326.3A EP3369409B1 (fr) 2017-03-02 2017-03-02 Dispositif et procédé de dosage de matériaux de remplissage pulvérulents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17000326.3A EP3369409B1 (fr) 2017-03-02 2017-03-02 Dispositif et procédé de dosage de matériaux de remplissage pulvérulents

Publications (2)

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EP3369409A1 true EP3369409A1 (fr) 2018-09-05
EP3369409B1 EP3369409B1 (fr) 2023-07-12

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114144153A (zh) * 2019-07-22 2022-03-04 I·M·A·工业机械自动装置股份公司 用于填充胶囊的机器和方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2050885A1 (en) * 1969-10-21 1971-04-29 Fratelh Zanasi SpA, Ozzano Emilia, Bologna (Italien) Syphon dosimeter for pharmaceutical powders
EP1415637A1 (fr) 2002-10-31 2004-05-06 Harro Höfliger Verpackungsmaschinen GmbH Table à transfert circulaire pour le remplissage de capsules avec de la poudre
DE69929633T2 (de) * 1998-12-03 2006-09-21 I.M.A. Industria Macchine Automatiche S.P.A., Ozzano Emilia Kapsel-Packungsmaschine mit Überwachungs- und Regelungsvorrichtung
WO2009007275A1 (fr) 2007-07-09 2009-01-15 Robert Bosch Gmbh Dispositif de dosage d'un produit poudreux
EP2135810A1 (fr) 2008-06-16 2009-12-23 Harro Höfliger Verpackungsmaschinen GmbH Table à transfert circulaire pouvant être entraînée de manière cadencée pour remplir des récipients avec de la poudre

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102015206407A1 (de) * 2015-04-10 2016-10-13 Robert Bosch Gmbh Vorrichtung zum Dosieren von pulverförmigem Füllgut

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2050885A1 (en) * 1969-10-21 1971-04-29 Fratelh Zanasi SpA, Ozzano Emilia, Bologna (Italien) Syphon dosimeter for pharmaceutical powders
DE69929633T2 (de) * 1998-12-03 2006-09-21 I.M.A. Industria Macchine Automatiche S.P.A., Ozzano Emilia Kapsel-Packungsmaschine mit Überwachungs- und Regelungsvorrichtung
EP1415637A1 (fr) 2002-10-31 2004-05-06 Harro Höfliger Verpackungsmaschinen GmbH Table à transfert circulaire pour le remplissage de capsules avec de la poudre
WO2009007275A1 (fr) 2007-07-09 2009-01-15 Robert Bosch Gmbh Dispositif de dosage d'un produit poudreux
EP2175825A1 (fr) 2007-07-09 2010-04-21 Robert Bosch GmbH Dispositif de dosage d'un produit poudreux
EP2135810A1 (fr) 2008-06-16 2009-12-23 Harro Höfliger Verpackungsmaschinen GmbH Table à transfert circulaire pouvant être entraînée de manière cadencée pour remplir des récipients avec de la poudre

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114144153A (zh) * 2019-07-22 2022-03-04 I·M·A·工业机械自动装置股份公司 用于填充胶囊的机器和方法
CN114144153B (zh) * 2019-07-22 2023-12-29 I·M·A·工业机械自动装置股份公司 用于填充胶囊的机器和方法
US11951076B2 (en) 2019-07-22 2024-04-09 I.M.A. Industria Macchine Automatiche S.P.A. Machine and method for filling capsules

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EP3369409B1 (fr) 2023-07-12

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