EP3320975B1 - Vorrichtung zum bereitstellen von pipettenspitzen - Google Patents

Vorrichtung zum bereitstellen von pipettenspitzen Download PDF

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Publication number
EP3320975B1
EP3320975B1 EP16198650.0A EP16198650A EP3320975B1 EP 3320975 B1 EP3320975 B1 EP 3320975B1 EP 16198650 A EP16198650 A EP 16198650A EP 3320975 B1 EP3320975 B1 EP 3320975B1
Authority
EP
European Patent Office
Prior art keywords
lid
side wall
latching
lid side
perforated plate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP16198650.0A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3320975A1 (de
Inventor
Rethwisch Hanna
Frank Horstmann
Matthias Haak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eppendorf SE
Original Assignee
Eppendorf SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eppendorf SE filed Critical Eppendorf SE
Priority to EP16198650.0A priority Critical patent/EP3320975B1/de
Priority to PCT/EP2017/076998 priority patent/WO2018086850A1/de
Priority to US16/348,920 priority patent/US10654042B2/en
Priority to CN201780070565.9A priority patent/CN109952155B/zh
Priority to JP2019524975A priority patent/JP6857727B2/ja
Publication of EP3320975A1 publication Critical patent/EP3320975A1/de
Application granted granted Critical
Publication of EP3320975B1 publication Critical patent/EP3320975B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/54—Supports specially adapted for pipettes and burettes
    • B01L9/543—Supports specially adapted for pipettes and burettes for disposable pipette tips, e.g. racks or cassettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02—Internal fittings
    • B65D25/10—Devices to locate articles in containers
    • B65D25/108—Devices, e.g. plates, presenting apertures through which the articles project
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/043—Hinged closures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls

Definitions

  • Pipette tips are small plastic tubes that are used in the laboratory for dosing liquid samples preferably in the range of 0.1 ⁇ l to 100 ml. They have a lower through-opening for liquid and an upper through-opening for air, wherein the cross-section of the pipette tips usually increases from the lower to the upper average opening.
  • the top of the pipette tip is connected to a pipette so that the top port is connected to a pipette air displacement device.
  • the pipette tip is clamped with the passage opening on a neck of the pipette or clamped in a hole of the pipette.
  • the displacement device is a cylinder with a piston displaceable therein.
  • an air volume is displaced, so that a defined amount of liquid is taken up in the pipette tip and discharged from it.
  • Fixed volume pipettes with a constant dosing volume have a constant displacement and variable pipettes with adjustable dosing volume have an adjustable displacement.
  • a piston is integrated in the pipette tip, which is driven by the displacement device.
  • the pipette tip is separated from its seat on the pipette, for which the pipette may have an ejector which, when actuated, forces the pipette tip off its seat. After that, the pipette may have a new pipette tip take up. Carryover of sample liquid between successive dosages is thus avoided.
  • pipette tips are provided on pipette tip supply devices. These devices have a perforated plate, also referred to as a "tray” or "wafer”.
  • these devices comprise a lower part, which is designed as a bottom closed and open-topped box (also called “ box ”) or bottom and top open, rectangular frame (also called “ rack “).
  • An equipped with pipette tips perforated plate can be placed from above on a support edge of an insertion opening of the lower part, so that the pipette tips protrude into a receptacle in the lower part.
  • the pipette tips are removable by pressing the seat of a single-channel pipette or the seats of a multichannel pipette onto or into the upper ends of the pipette tips individually or simultaneously to several of a pipette tip supply apparatus.
  • the refill packs may include a plurality of perforated plates equipped with pipette tips.
  • refill packages are known in which one or more, filled with pipette tips perforated plates in cartons or frames made of cardboard or in simple plastic boxes or plastic frames are arranged.
  • a perforated plate equipped with pipette tips is releasably secured to the upper edge of a plastic shell, with the pipette tips protruding into the shell.
  • a further perforated plate is arranged, the pipette tips protrude into the pipette tips of the lower perforated plate and the edge is releasably secured to the lower perforated plate.
  • Further plates with pipette tips are correspondingly arranged above and above the arrangement is covered by a lid made of plastic, which is releasably attached to the uppermost perforated plate.
  • the lid may be used to transfer the perforated plates loaded with pipette tips from the refill stack into the holder and then placed on the top perforated plate of the refill stack to protect the opened refill pack.
  • sterile pipette tips are offered. Sterile applications should not be contaminated prior to use (or must be autoclaved prior to use). Filter pipette tips are typically offered sterile because the filter materials do not withstand autoclaving temperatures.
  • the EP 2 535 109 A2 describes an apparatus for providing pipette tips that includes a refill pack and a holder.
  • the refill pack has a perforated plate having a plurality of holes, pipette tips inserted into the holes, a cup covering the pipette tips at the bottom with a rigidity of up to 300 N / mm, and a cover covering the pipette tips at the top.
  • the holder has a receptacle for inserting the refill.
  • Refill pack and holder have means for supporting, which support the refill pack inserted in the receptacle. Through the shell and the cover, the pipette tips inserted into the perforated plate are covered at the top and bottom when refilling the holder and protected against contamination.
  • the shell has such a low rigidity that it is easy to produce with little use of materials.
  • the forces when picking up pipette tips by means of a pipette are dissipated via the means for supporting in the holder.
  • One embodiment has means for latching cover and shell.
  • the holder has a lower part with the receptacle and a refill pack inserted therein covering, which has a hinge connection with the lower part.
  • the cover of the holder and the cover of the refill have latching means which can be locked together by closing the lid when inserted into the receptacle refill.
  • the cover When opening the lid, the cover is opened with, as the force to release the latch between the lid and cover exceeds the force to release the locking between the cover and shell. Protection of the refill pack from contamination is improved and the pipette tips are protected from contact with the lid of the holder.
  • the disadvantage is that the user must engage in the lid before inserting a new refill by hand to release the catch with the cover. For this purpose, a relatively high force must be expended. This complicates the handling and can lead to contamination of the holder.
  • the object of the invention is to provide a device for providing pipette tips, which facilitates the replacement of refill packs and further reduces the risk of contaminations.
  • the unlock button is simply pressed.
  • the pressing element exerts a force on the outside of the first lid side wall, which has the first latching element.
  • the first lid side wall is bent inward, so that the locking between the first and second locking element is canceled.
  • the inner lid may fall out of the outer lid and into the pipette tips covering position to return. If, when the catch is released, the outer lid is arranged in the closed position, then it can then be pivoted into the open position, the inner lid remaining in the position covering the pipette tips.
  • the perforated plate is a plate-shaped carrier having a substantially rectangular base made of plastic with a plurality of holes in a matrix arrangement.
  • the perforated plate usually has 96 holes in eight rows and 12 columns. Pipette tips are inserted into the holes from above, but do not fall through the holes due to an upwardly broadening diameter or a collar at their upper end.
  • the bottom surface of the perforated plate and the arrangement of the holes of the 96-well plate substantially correspond to the bottom surface of a microtiter plate and the wells of a 96-well microtiter plate according to ANSI standard recommended by the Society for Biomolecular Screening (SBS).
  • SBS Society for Biomolecular Screening
  • a group of pipette tips picked up from the carrier by means of a multi-channel pipette adapted to this standard can be directed directly to a group of microtiter plate wells according to this standard.
  • the perforated plate thus has two long edges (long sides) and two short edges (transverse sides).
  • the inner lid and / or the shell in adaptation to conventional perforated plates with 96 holes in a horizontal section has a rectangular contour with two long sides and two short sides.
  • the outer shell and / or the receptacle in a horizontal section has a rectangular shape adapted thereto with two long sides and two short sides.
  • the first articulated connection is arranged on a long side of the receptacle.
  • the first latching element is arranged on a long first lid side wall and the second latching element is arranged on a long second lid side wall and the support element on an opposite long lid side wall.
  • two opposing first lid side walls are provided with a first latching element, so that the refill pack can be inserted into the holder in two different orientations.
  • the first latching element is a shoulder at the lower end of a first ramp on the outside of the first lid side wall, the distance of which increases from the first lid side wall with increasing distance from the lid bottom.
  • the first ramp makes it easier to lock the inner lid to the outer lid and the inner lid is held securely on the outer lid by the heel. By pressing the pressing element against the outside of the first ramp, a force pushing out the inner lid from the outer lid can additionally be generated.
  • the second locking element is the lower edge of the through-channel on the inside of the second cover side wall.
  • the unlocking button with the pressing element against the first locking element or next to the first locking element, preferably in the immediate vicinity of the first locking element, against the first lid side wall can be pressed, whereby the unlatching of the first is facilitated by the second locking element.
  • the second latching element is a second step on the upper side of the inside of the second cover side wall projecting second ramp whose distance from the second lid side wall increases with increasing distance from the lower edge of the second lid side wall. This facilitates the locking of the second locking element with the first locking element and the second paragraph causes a secure locking.
  • the support element is a rib projecting from the inside of the second cover side wall with a third shoulder at the upper end for supporting the lower edge of the first cover side wall.
  • the support element By pivoting the outer cover from the open position to the closed position, the support element is displaceable under the lower edge of the first cover side wall.
  • the support member is a third locking element which presses when pivoting the outer cover in the closed position against the outside of the adjacent elastic first cover side wall of the inner cover and this bends slightly inwards until it springs back above the third locking element.
  • the support member is pivoted below the lower edge of the first lid side wall without bending it inwardly. Instead, the first and second latching elements are formed so that when they latch the inner lid is pushed over the support member, so that when unfolding the outer lid, the support element engages under the lower edge of the adjacent first lid side wall.
  • the third locking element is a third paragraph at the upper end of a third ramp on the inside of the second lid side wall, the distance increases from the second lid side wall with increasing distance from the lower edge of the second lid side wall. This embodiment facilitates latching of the third latching element with the lower edge of the adjacent first lid side wall.
  • the unlocking button is a lever which is pivotally mounted on the outer cover via a second hinge connection, the actuating element on the outside of a first lever arm, the pressing element on the inside of the first lever arm and a latching nose on the inside of a second lever arm is locked in the closed position of the second cover with a locking edge on the outside of the holder.
  • the actuator By pressing the actuating element, the pressing element is pressed against the inner lid and thereby the latching between inner lid and outer lid repealed.
  • the unlocking button is a pin-shaped body which is displaceable in the passageway.
  • the passage can form a straight guide for the release button.
  • the unlocking button is formed so that the latching of the latching lug on the latching edge can be canceled by operating the actuating element about a first actuating travel and the locking of the inner lid with the outer lid can be canceled by operating the actuating element to an additional, second actuating.
  • This allows the user, by pressing the release button for a short actuation path to release the outer lid from the holder to swing open the outer lid together with the inner lid and remove pipette tips. Further, the user can by pressing the actuator to a longer actuation path to release the outer lid from the holder and discard the inner lid from the outer lid to remove or replace the refill.
  • the first hinge connection has a horizontal pivot axis for pivoting the outer cover onto the inner cover from above and pivoting it upwards away from the inner cover.
  • the pivot axis is aligned parallel to the second lid side wall with the second locking element.
  • the first hinge connection is arranged next to a second cover side wall, which is arranged opposite the second cover side wall with the second latching element. This also facilitates the latching of the first latching element with the second.
  • the inner lid has a latching connection or clamping connection with the perforated plate. As a result, the inner lid is secured to the refill pack so that it does not accidentally come off.
  • the holder has at least one unlocking element, which is designed to release the latching connection or clamping connection between the inner lid and the perforated plate during insertion of the refill pack into the holder.
  • This simplifies the use of the device because when opening the outer lid, the locking connection or clamping connection between inner lid and perforated plate does not need to be canceled to expose the pipette tips.
  • This locking connection or clamping connection between the inner lid and perforated plate can be resolved when the refill is inserted into the holder, because then the Inner lid can not unintentionally solve the refill.
  • the locking connection or clamping connection between the inner lid and perforated plate is released by opening the outer lid, but this requires a correspondingly strong locking connection between the outer lid and inner lid and an increased effort.
  • the shell has a latching connection or clamping connection with the perforated plate. This prevents unintentional loosening of the shell during transport of the refill pack and avoids contamination.
  • the shell has at the upper edge protruding latching hooks which latch on the edge of the perforated plate.
  • Possible embodiments of the shell are in the EP 2 535 109 A2 described.
  • the present invention also includes other trays, in particular trays having a higher rigidity than in the EP 2 535 109 A2 have described.
  • the perforated plate and / or the shell and / or the inner lid and / or the holder consists wholly or partly of polypropylene and / or polyethylene and / or polycarbonate and / or acrylonitrile-butadiene-styrene copolymers and / or polystyrene and / or Polyethylene terephthalate and / or biodegradable plastics and / or bio-based plastics and / or composite films of polyamide and polyethylene or polyethylene terephthalate and polyethylene.
  • the pipette tips are made of polypropylene or polyethylene.
  • top and bottom refer to an orientation of the device with horizontal perforated plate, wherein the shell is disposed substantially below the perforated plate, and the inner lid substantially above the perforated plate. Furthermore, the insertion opening is oriented horizontally, the outer cover is closed and arranged substantially above the lower part.
  • a device according to the invention for providing pipette tips 1 comprises a refill 2 and a holder 3, in which the refill 1 is used.
  • the refill pack 2 comprises a perforated plate 4, pipette tips 5 inserted into the perforated plate 4, a bowl 6 arranged below the perforated plate and an inner lid 7 arranged above the perforated plate 4.
  • the holder 3 has a lower part 8, an outer lid 9 and an unlocking button 10.
  • the perforated plate 4 is a substantially rectangular plate having a total of 96 circular holes 11 in eight rows and 12 columns.
  • the perforated plate 4 has a circumferential, downwardly projecting skirt 12. From the skirt 12 stand on the two longer longitudinal sides locking tabs 13 downwards. The locking tabs 13 are arranged approximately in the middle of the two longer edges of the perforated plate 4. The latching tabs 13 each have, in addition to their two lateral edges, first latching beads 14, 15.
  • the perforated plate 4 is made of an elastic plastic, so that the locking tabs 13 are elastically deformable.
  • the perforated plate 4 is preferably produced by injection molding.
  • pipette tips 5 are inserted into the holes. These have a tubular body 16 with a lower passage opening 17 and an upper passage opening 18. Further, they have a collar 19, with which they are supported on top of the perforated plate 4.
  • the shell 6 is substantially box-shaped.
  • the distance of opposing shell side walls 20, 21, 22, 23, starting from the shell bottom 24 to an upper shell opening 25 of the shell 6 increases slightly.
  • the longer shell side walls 20, 22 each have at the upper edge two pairs of upstanding centering projections 26.
  • the centering projections 26 are each connected to the outside of a longer side wall 20, 22, so that they are offset with respect to the side walls 20, 22 slightly outwards.
  • the shorter side walls 21, 23 have at the upper edge in each case two projecting latching hooks 27, wherein the hooked ends 28 are arranged on the side of the shell opening 25.
  • the latching hooks 27 are each on the outside of a shorter Side wall 21, 23 connected so that they are slightly offset with respect to the side walls 21, 23 to the outside.
  • the inner lid 7 is formed like a hood, starting from a first lid bottom 29, the distance between opposing first lid side walls 30, 31, 32, 33 widened to a first lid opening 34 of the inner lid 7 out.
  • the inner lid 7 has on the inner sides of the longer first lid side walls 30, 32 rib-shaped support members 35 for supporting on the upper edge of the perforated plate 4th
  • the inner lid 7 has outwardly projecting outer steps 36, 37.
  • an inwardly projecting clamping projection 38 is present in each case below an opening.
  • the inside of each clamping projection 38 is chamfered ramp-like, so that each clamping projection 38 projects further inwardly with increasing distance from the lower edge of the inner lid 7.
  • the inner lid 7 has two hood-shaped formations 39, 40th
  • each first latching element 41 has a first ramp 42 whose distance from the first cover side wall 30, 32 increases with increasing distance from the lid bottom 29 , Further, each locking element 41 has a first step 43 below.
  • the perforated plate 4 is placed on the shell 6, wherein the centering projections 26 rest against the inside of the skirt 12 and the latching hooks 27 overlap with the hook ends 28, the shorter edges of the perforated plate 4 outside.
  • the pipette tips 5 protrude into the shell 6 and project beyond the perforated plate 4 with the upper end.
  • the perforated plate 4 is equipped with 96 pipette tips, in the example, however, only four are shown.
  • the inner lid 7 With the clamping projections 38, the inner lid 7 is clamped onto the short edges of the perforated plate 4.
  • the inner lid 7 is supported with the rib-shaped support elements 35 and the outer steps 36, 37 on the edges of the perforated plate 4 and the latching hooks 27 engage in the hood-shaped formations 39, 40 a.
  • the lower part 8 of the holder 3 comprises a frame 44 and a trough 45.
  • the frame 44 includes a substantially horizontal, upper frame member 46.
  • a support frame 47 protrudes upward with a substantially horizontal upper support edge 48.
  • the support frame 48 and the trough 45 define a substantially cuboid receptacle 49.
  • the support edge 46 of the support frame 47 defines an insertion opening 50 of the receptacle 49th
  • the frame 44 includes a jacket 51 projecting downwardly from the outer edge of the upper frame member 46 and enclosing the trough 45.
  • the jacket 51 has four jacket walls 52, 53, 54, 55, wherein the distance between opposing jacket walls 52, 53, 54, 55 increases from each other downwards.
  • the jacket 51 protrudes the same distance or slightly further down from the upper frame part 46 than the trough 45.
  • the trough 45 is substantially cuboid. It has a substantially horizontal, rectangular trough bottom 56. From the edges of the trough bottom 56 are trough walls 57, 58, 59, 60 upwardly, whose upper edges are connected to the inner edge of the upper frame member 46. Starting from the trough bottom 56, the distance of opposing trough walls 57, 58, 59, 60 increases upwards.
  • the support frame 47 has at two long edges each center first recesses 61, 62 with a downwardly arched bottom.
  • the first recesses 61, 62 each have on the two upstanding lateral edges inwardly projecting second latching beads 63, 64 (FIG. Fig. 9 ).
  • the support frame 47 has at the two long edges respectively on both sides of the first recess 61, 62 a pair of centering pockets 65 which are open to the support edge 48 and the inside of the support frame 47 out.
  • a wedge-shaped projection 66, 67 is arranged centrally in each case, which tapers upwards, protrudes above the support edge 48 and protrudes laterally somewhat from the support frame 47.
  • the support frame 47 has at the short edges on both sides of the projection 66, 67 in the support edge 48 each have a rectangular second recess 68th
  • the upper frame part 46 has at the front adjacent to the first recess 61 has a substantially rectangular, third recess 69 with a flat first bottom 70.
  • the third recess 69 extends into a front shell wall 52 into it. There it has a second floor 71 bulging downwards.
  • the third one Recess 69 has at the front edge of the first bottom 70 a slightly in the continuation of the third recess 69 in the front shell wall 52 projecting locking edge 72 (FIG. Fig. 2 ).
  • Tray 45 and frame 44 are e.g. injection-molded separately and connected together, e.g. by latching, or produced in one piece by injection molding.
  • the outer lid 9 has a second lid bottom 73 and from the edges of the second lid bottom 73 downwardly projecting second lid side walls 74, 75, 76, 77 on.
  • the outer lid 9 is pivotally mounted on the lower part 8 via a first articulated connection 78.
  • the first articulated connection 78 comprises lug-shaped wall extensions 79, 80 projecting from the lower edges of the short second cover side walls 75, 77 next to a long second side wall 76 with first bearing lugs 81, 82 of the outer cover 9. Furthermore, they comprise at the upper edges of the two short jacket walls 53 , 55 next to the rear long shell wall 54 projecting first bearing pin 83, 84.
  • a fourth recess 85 which is open at the top of the second lid side wall 74 upwards and at the bottom edge downwards.
  • the fourth recess 85 is trapezoidal, widening from bottom to top.
  • the fourth recess 85 has a frame-shaped bottom portion 86.
  • the fourth recess 85 has second bearing bosses 87.
  • passageway 88 of approximately rectangular cross-section extending from the outside to the inside of the frame-shaped bottom portion 86.
  • the fourth recess 85 has an approximately rectangular, central floor area 90 in a rectangular recess 89 which is surrounded by the frame-shaped floor area 86.
  • the central floor area 90 is firmly connected to the frame-shaped floor area 86 only at the lower floor edge 91. He is elastically deflectable.
  • a second catch element 92 projects below the passage channel 88 with a second ramp 93, whose distance from the second lid side wall 74 increases with increasing distance from the lower edge of the second lid side wall 74.
  • the second latching element 92 has a second shoulder 94 (FIG. Fig. 15 ).
  • the outer lid 9 has from the inside of the other long second lid side wall 76 projecting support elements ( Fig. 11 ). These are arranged at the lower edge of the second cover side wall 76. They are formed as a third latching elements 95 each having a third shoulder 96 at the upper end and a third ramp 97 on the inside of the second cover side wall 76, whose distance from the second cover side wall 76 increases with increasing distance from the lower edge of the second cover side wall 76.
  • the outer cover 9 is preferably injection molded in one piece from plastic.
  • the release button 10 is a two-armed lever, wherein a first lever arm 98 on the outside has a barrel-shaped outwardly arched actuating element 99 and on the inside at the upper end a projecting pressing element 100.
  • the pressing member 100 is formed in the example of an incisor.
  • a second lever arm 101 is substantially plate-shaped and has at the lower end a projecting from the inside lug 102nd
  • two horizontal second bearing pins 103, 104 are arranged on the inside of the release button 10. These protrude from the ends of two parallel, laschenartiger bearing carrier 105, 106 in different directions, which are firmly connected at their other ends further down with the inside of the second lever arm 101.
  • the unlocking button 10 is preferably injection molded in one piece from a plastic.
  • the bearing carrier 105, 106 are elastically deformable.
  • the release button 10 is mounted with the second bearing pin 103, 104 in the second bearing eyes 87.
  • the actuator 99 is located at the top and the latch 102 below.
  • the unlocking button 10 is located with the inner side of the first lever arm 98 below the contact pressure element 100 at the central bottom portion 90 of the fourth recess 85 (FIG. Fig. 14 . 15 ) on.
  • the pressing member 100 passes through the through-channel 88.
  • the latching nose 102 locks with the latching edge 72.
  • the elastic deflection of the central bottom region 90 allows a deflection of the unlocking button 10 outwards until the latching lug 102 engages with the latching edge 72.
  • the contact pressure element 100 When pressed from the outside against the actuating element 99, the contact pressure element 100 protrudes further from the inside of the second cover side wall 74.
  • the central bottom portion 90 is deflected elastically inward, so that it returns the release button 10 after relieving the actuator 99 back to the starting position.
  • the device can be used as follows:
  • the refill 2 of Fig. 3 to 5 is inserted with the shell 6 ahead through the insertion opening 50 in the receptacle 49 until the lower edge of the perforated plate 4 is seated on the support edge 48. Then the insertion position is reached. Then the locking tabs 13 engage in the first recesses 61, 62, the first locking beads 14, 15 are locked to the second locking beads 63, 64, engage the centering projections 26 in the centering pockets 65 and engage the latching hooks 27 in the second recesses 68 a , Further, upon insertion of the refill pack 2, the wedge-shaped protrusions 66, 67 press from below against the clamping protrusions 38 and release the inner lid 7 from the perforated plate 4.
  • the first and second latching elements 41, 92 lock together and latch the third latching element 95 to the lower edge of the first cover side wall 32. Furthermore, the latching lug 102 locks with the latching edge 72. In this situation, the device is in the Fig. 1 and 14 shown.
  • the outer cover 9 By pressing the actuating element 99 for a short distance, the outer cover 9 can be unlatched and swung up together with the latched inner cover 7 in order to remove pipette tips 5.
  • Fig. 17 the device is shown opening. In Fig. 2 it is fully open and the outer lid 9 is in the insertion position. In the insertion position, the outer cover 9 is opened to the maximum extent and the wall extensions 79, 80 lie with their rear edges against the lower edges of the flattened regions around the first bearing pins 83, 84 of the short jacket walls 53, 55.
  • the actuator 99 is pressed deeper, so that the pressing member 100 presses from the outside against the first lid side wall 30 with the first locking element 41.
  • the first lid side wall 30 is bent inwards and the first latching element 41 comes free from the second latching element 92.
  • the inner lid 7 falls down, as in the Fig. 17 . 18 and 19 shown.
  • the user can press from above against the inner lid 7 to clamp it to the perforated plate 4. Then he can detent the locking tabs 13 by pressing inwards and remove the refill 2.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Packages (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Containers Having Bodies Formed In One Piece (AREA)
EP16198650.0A 2016-11-14 2016-11-14 Vorrichtung zum bereitstellen von pipettenspitzen Active EP3320975B1 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP16198650.0A EP3320975B1 (de) 2016-11-14 2016-11-14 Vorrichtung zum bereitstellen von pipettenspitzen
PCT/EP2017/076998 WO2018086850A1 (de) 2016-11-14 2017-10-23 Vorrichtung zum bereitstellen von pipettenspitzen
US16/348,920 US10654042B2 (en) 2016-11-14 2017-10-23 Device for providing pipette tips
CN201780070565.9A CN109952155B (zh) 2016-11-14 2017-10-23 用于提供移液针的装置
JP2019524975A JP6857727B2 (ja) 2016-11-14 2017-10-23 ピペット・チップ供給装置

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16198650.0A EP3320975B1 (de) 2016-11-14 2016-11-14 Vorrichtung zum bereitstellen von pipettenspitzen

Publications (2)

Publication Number Publication Date
EP3320975A1 EP3320975A1 (de) 2018-05-16
EP3320975B1 true EP3320975B1 (de) 2019-07-17

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EP16198650.0A Active EP3320975B1 (de) 2016-11-14 2016-11-14 Vorrichtung zum bereitstellen von pipettenspitzen

Country Status (5)

Country Link
US (1) US10654042B2 (ja)
EP (1) EP3320975B1 (ja)
JP (1) JP6857727B2 (ja)
CN (1) CN109952155B (ja)
WO (1) WO2018086850A1 (ja)

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US10137453B2 (en) * 2014-12-10 2018-11-27 Biotix, Inc. Static-defeating apparatus for pipette tips
JP6694486B2 (ja) * 2018-03-29 2020-05-13 バイオティクス， インコーポレイテッド 剛性を高められたピペットチップトレイ
USD954984S1 (en) 2019-11-26 2022-06-14 Integra Biosciences Ag Thermoformed container
USD973901S1 (en) 2019-11-26 2022-12-27 Integra Biosciences Ag Pipette tip dispenser
USD928343S1 (en) 2019-11-26 2021-08-17 Integra Biosciences Ag Thermoformed container
JP7462052B2 (ja) 2020-01-07 2024-04-04 インテグラ バイオサイエンシーズ アーゲー ピペットチップラックシステム
EP3978383A1 (de) * 2020-10-02 2022-04-06 Eppendorf AG Vorrichtung zum bereitstellen von autoklavierbaren reaktionsgefässen
CN112249482B (zh) * 2020-10-29 2022-08-09 江西立讯智造有限公司 一种充电盒前壳流转用载具
EP4019137A1 (de) * 2020-12-23 2022-06-29 TECAN Trading AG Aufnahmerahmen zum aufnehmen einer trägerplatte für pipettenspitzen
US20230158509A1 (en) * 2021-11-22 2023-05-25 Mettler-Toledo Rainin, LLC Biodegradable pipette tip rack
US11912477B2 (en) 2022-06-08 2024-02-27 Yeti Coolers, Llc Container with handle and latching system
USD1024557S1 (en) 2022-06-08 2024-04-30 Yeti Coolers, Llc Container

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Also Published As

Publication number Publication date
CN109952155B (zh) 2021-09-14
JP6857727B2 (ja) 2021-04-14
JP2019536619A (ja) 2019-12-19
EP3320975A1 (de) 2018-05-16
US10654042B2 (en) 2020-05-19
US20190275528A1 (en) 2019-09-12
WO2018086850A1 (de) 2018-05-17
CN109952155A (zh) 2019-06-28

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