EP3122310B1 - Transfervorrichtung für medien mit unlösbar verrastbarem adapter - Google Patents

Transfervorrichtung für medien mit unlösbar verrastbarem adapter Download PDF

Info

Publication number
EP3122310B1
EP3122310B1 EP15712326.6A EP15712326A EP3122310B1 EP 3122310 B1 EP3122310 B1 EP 3122310B1 EP 15712326 A EP15712326 A EP 15712326A EP 3122310 B1 EP3122310 B1 EP 3122310B1
Authority
EP
European Patent Office
Prior art keywords
adapter
adapter part
transfer device
adapter component
section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP15712326.6A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3122310A2 (de
Inventor
Sonja Schuldt-Lieb
Friedrich Pipelka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medac Gesellschaft fuer Klinische Spezialpraeparate mbH
Original Assignee
Medac Gesellschaft fuer Klinische Spezialpraeparate mbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medac Gesellschaft fuer Klinische Spezialpraeparate mbH filed Critical Medac Gesellschaft fuer Klinische Spezialpraeparate mbH
Priority to PL15712326T priority Critical patent/PL3122310T3/pl
Priority to EP21176118.4A priority patent/EP3895680A1/de
Publication of EP3122310A2 publication Critical patent/EP3122310A2/de
Application granted granted Critical
Publication of EP3122310B1 publication Critical patent/EP3122310B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/16—Holders for containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends

Definitions

  • the dry substance is usually supplied in an injection bottle, a so-called vial.
  • a connector transfer device
  • the other container can, for.
  • these connectors also known as adapters and composed of adapter parts
  • the puncture needle starts from the bottom wall of the collar, in particular in the form of the steel cannula, and extends in the longitudinal direction of the hollow cylindrical body.
  • Such a release leads to exposure of staff, patients and the environment. This enables the released substances to be absorbed via inhalation, the skin or orally.
  • the release itself can e.g. B. via the formation of aerosols, splashes during preparation, leakage of the adapter, when removing the adapter or possibly caused by broken glass, as well as by injury from a contaminated cannula.
  • the second reason is that the closure of the puncture needle has to be punctured centrally in order to ensure a leak-tight connection of the vial.
  • vial adapters used according to the prior art, however, there is the risk that the vial will tilt when it is snapped into the collar. This results in a primarily eccentric puncture of the closure.
  • the vial is then fully pushed in, the cannula is then forced into a central position. This leads to tension in the closure of the vial, which leads to Leaks next to the cannula can result. This can happen in the case of toxic substances such as B. cytostatics, lead to the endangerment of staff and patients.
  • the corresponding adapters generally do not offer any aerosol or leak tightness.
  • a transfer device consists of a cap-like outer guide part and a tubular inner guide part, which are telescopically displaceable with respect to one another.
  • the origins of the inner guide part snap into recesses on the inside of the outer guide part. If the transfer device is pushed onto a vial, tongue-like elements extending from the inner guide part are bent outwards, with the result that the outer guide part is adjusted outward in the region of the recesses, so that the locking between the inner and outer guide parts is canceled. It is also disadvantageous that the transfer device can be removed from the vial after use without any problems, so that there is again a risk of injury to the user.
  • a transfer device which comprises a needle holder with a transfer needle which is axially adjustable in a hollow cylindrical structure.
  • the structure has a wall-shaped stop which can be placed on the opening of a storage container to be pierced and which is penetrated by the transfer needle when the transfer device is actuated.
  • a transfer device after the DE 698 08 432 T2 has an actuator in order to be able to axially adjust a first part having a mandrel to a second part surrounding a closure of a bottle by turning.
  • a fluid transfer device which comprises a sleeve-shaped guide structure with a needle holder with a puncture needle surrounded by this.
  • the sleeve-shaped guide structure has a Embodiment axially extending movable sleeve strips, which have clamping elements for gripping a bead-like edge of a vial.
  • a transfer device after the WO 2009/029390 A1 has an inner and an outer adapter part which are ultrasonically welded in the flange-like edge area.
  • the transfer device surrounds a vial, which in turn is surrounded by an envelope with which the transfer device latches.
  • the vial and connector can be separated, there is also the disadvantage of the risk of contamination by e.g. B. inhalation or through the skin or the formation of aerosols when removing the needle from the vial.
  • the U.S. 5,364,386 A relates to an infusion device which has a first adapter part which surrounds a bottle, and a second adapter part which is displaceable along the first adapter part and which has a transfer element in the form of a cannula. There is the possibility that the first adapter part is connected to the second adapter part in two different positions.
  • Subject of WO 2007/101798 A2 is a transfer device with a cylindrical first part and a cap-shaped second part which is displaceable relative to the first part.
  • the first part surrounds a vial.
  • Projections extend from the first and second parts and cooperate to hold the parts in a desired position relative to one another. There is the possibility that the projections can be brought into grip.
  • Subject of EP 0 335 378 A2 is a liquid container comprising a tubular capsule with a cap which in turn houses a pressing element which is at Rotation of the cap causes a vial to be adjustable in the direction of a control device having a cannula in order to enforce the closure of the vial.
  • Another transfer device is in DE6503460 A1 described.
  • the present invention is inter alia.
  • the underlying task is to provide a transfer device, i.e. a vial connector or adapter, which offers increased exposure security.
  • One aspect is aimed at avoiding a hazardous leakage after the closure has been pierced.
  • Another aspect of the invention is that an injury after the use of the transfer device by the transfer element such as needle, cannula, spike, perforation device is excluded.
  • the invention provides that the first adapter part is permanently fixed to the bottle or around the bottle after the second adapter part has been moved along the first adapter part in the direction of the closure and the second adapter part is locked, and that the second adapter part has a hood or pot geometry with a cylindrical circumferential wall and an inner hollow cylindrical section running coaxially to this and surrounded by it, from which a sealing element extends, which seals the second adapter part against the first adapter part when the first and second adapter parts are assembled.
  • Radially adjustable fixing elements can extend from the first adapter part, via which the first adapter part is permanently fixed to the bottle after the second adapter part has been moved along the first adapter part in the direction of the closure and the second adapter part locked if the transfer device is properly handled.
  • the invention is characterized in that the first and second adapter parts surround the bottle in such a way that a closed envelope results, so that aerosol-tightness and leakage security is provided.
  • the first adapter part is cup-shaped and receives the bottle body.
  • the second adapter part, from which the transition element extends, likewise has a hood-shaped or pot-shaped geometry that can latch with the first adapter part.
  • a seal can extend from the second adapter part in order to seal the first and second adapter parts with respect to the bottle.
  • a transfer device is made available which, after use, that is to say after the closure has been pierced, can no longer be detached from the bottle, which is mainly referred to as a vial below. It can be provided that, before the transfer device is used, unintentional touching of the tip of the transfer element is excluded, so that the risk of injury is avoided.
  • transition element is, for. B. can be a needle, a cannula, a spike or some other perforation device. So far is one There is no limitation of the invention. Rather, the term transfer element is intended to cover any suitable element that enables a medium transfer. Various terms are therefore also used, in particular puncture needle or cannula, without thereby restricting the teaching according to the invention.
  • the invention is characterized in that the first adapter part comprises a shell section surrounding the bottle circumferentially and having a hollow cylinder geometry with an end edge running on the bottle closure side - also called a shell wall - a bottom section that at least partially covers the bottom of the bottle, preferably completely, and a holding section running at the front edge, from which the fixing elements, which can be tongue-like or web-like, extend, which can be pivoted, bent or spread in the radial direction of the first adapter part and which extend in the direction of the longitudinal axis of the first adapter part.
  • the fixing elements can consequently be supported at the transition between the bottle neck and the bottle body, with the result that the first adapter part can no longer be detached from the vial.
  • the holding section is a ring section running in the end edge region of the casing section, which z. B. can be fixed as clamped or glued to the edge of the jacket wall, which extends at least in sections along the inside of the jacket section and has first projections which extend in the axial direction and extend over the end edge.
  • first projections which extend in the axial direction and extend over the end edge.
  • second projections proceed from the outside of the jacket wall, which can be locked or locked in guides such as link slots of the second adapter part when the adapter parts are locked. The second projections cannot then be removed from the guides during normal handling of the transfer device.
  • the second adapter part have an outer hollow cylindrical section and a boundary wall running transversely to its longitudinal axis, from which the puncture needle - i.e. the transfer element - starts or which is penetrated by the puncture needle.
  • Each guide for one projection has a first section starting from the free end edge of the outer cylinder section and running in its longitudinal direction, which merges into a second section running transversely to the first section, in which the second projection guided in this can be fixed and locked , which protrudes radially from the outside of the jacket wall of the holding section of the first adapter part.
  • the second section of the guide has a cross-sectional reduction in the axial direction, the axial extent of which is smaller than the axial extent between the maximum distance between the first and second protrusions.
  • the axial extent between the boundary wall and the edge of the second section of the guide facing away from it should be at least equal to the maximum distance between distant sections of the first and second projections in the axial direction.
  • the second adapter part must first be guided in the axial direction, i.e. in the longitudinal direction of the vial in the first section of the guide, i.e.
  • At least the delimitation of the second section of the guide facing away from the delimitation wall, i.e. on the bottle side, forming the inner edge in the direction of the delimitation wall should run at least partially inclined to the longitudinal axis of the first adapter part and thus the transfer device and enclose an obtuse angle to the longitudinal axis.
  • a proposal of the invention provides that the inner cross section of the hollow cylindrical section of the second adapter part corresponds to the outer cross section of the jacket section of the first adapter part.
  • Safe guidance is also ensured by the overlapping of the adapter parts or by the previously explained axially extending guides such as link slots or by z. B. ensures long ribs that extend from one of the adapter parts or a sealing element connected to this, in particular from the second adapter part.
  • an inner hollow cylindrical section runs coaxially to the outer hollow cylinder-shaped section of the second adapter part, with the one referred to as the first protective element preferably being arranged in a displaceable manner, with the tip of the when the first adapter part is not connected to the second adapter part Puncture needle runs between the protective element and the boundary wall of the outer hollow cylindrical section.
  • the invention further provides that the second projection in the projection of the outside of the jacket section has a rectangular or trapezoidal geometry with a corner, which when the first and second adapter parts are fixed to one another interacts with a cross-sectional reduction of the second portion of the guide causing step to prevent loosening.
  • a further embodiment of a transfer device which is no longer detachable from the vial after the closure has been pierced, provides that the first adapter part of the transfer device has a first, outer hollow cylindrical section extending on the bottle side and a first, extending from this inner hollow cylindrical section of smaller cross-section, that the first outer hollow cylindrical section axially extending the fixing elements forming tongue-shaped sections with radially inward projections in the respective free end area for gripping a section of the bottle, in particular its bead-like edge, and the second adapter part a second outer hollow cylindrical Has portion which is displaceable along the outside of the first outer hollow cylindrical portion of the first adapter part, that with the first outer hollow cylindrical portion of the first adapter part surrounded by the second outer hollow cylindrical portion an outwardly directed radial adjustment of the tongue-shaped portions is prevented or substantially prevented, and that from the second outer hollow cylindrical section of the second adapter part a third outer hollow cylindrical section of smaller cross section starts, within which a second inner hollow cylindrical section can be
  • a transfer device which consists of the first adapter part, which can be fixed to a bottle or its neck, and a two-part second adapter part, which are axially displaceable to one another and to the first adapter part.
  • the outer part of the second adapter part has the effect that when the hollow cylindrical section of larger cross section covers the first outer hollow cylindrical section of the first adapter part over a defined axial length, the tongue-shaped sections, in particular engaging behind the bead-like edge of the bottle, can no longer be adjusted outwards with the result that loosening from the bottle is impossible.
  • the adapter parts lock in place in order to prevent the second adapter part from being pulled back.
  • the outer part of the second adapter part latches to the first adapter part.
  • a projection protruding radially inward from the second outer hollow cylindrical section of the second adapter part acts like a rib with a recess or step or an equivalent change in the geometry of the first hollow cylindrical section of the first Adapter part together in such a way that an axial displacement of the second adapter part to the first adapter part against the direction of penetration is prevented.
  • the first and second adapter parts consequently form a rigid unit - viewed in the axial direction. If the first fuse is removed after the transfer device has been pushed onto a vial, the second adapter part can be shifted as a sub-unit in the direction of penetration, whereby the desired locking between the first and second adapter part takes place with the result that the tongue-shaped, the radially after inwardly protruding projections having fixing elements are no longer adjustable to the outside, so that a detachment from the bottle is excluded.
  • the penetration needle cannot be adjusted relative to the outer part of the second adapter part. If the transfer device is fixed to the bottle by adjusting the second adapter part, i.e. after removing the first securing device, the second securing device is removed so that the second inner section is axially in the direction of the outer part of the second adapter part, which has the second and third outer hollow cylindrical section of the bottle is displaceable so that the cannula extending from the inner part of the second adapter part can pierce the closure.
  • a protective element referred to as a second protective element, extends from the first inner section of the first adapter part, between the and the second inner section of the second adapter part when the transfer device is not in use the tip of the penetration needle runs.
  • the adapter parts or their sections should be geometrically designed such that when the second adapter part is axially displaced to the first adapter part, the third outer section is guided on the outside and the second inner section of the second adapter part is guided along the first inner section of the first adapter part on the inside.
  • the first fuse should have a geometry of a ring section which, when the transfer device is not in use, penetrates a slot running in the third outer section of the second adapter part and engages in a recess such as a groove in the outer wall of the first inner section of the first adapter part.
  • the second inner section of the second adapter part has, on the puncture needle tip side, a base wall penetrated by the puncture needle and, facing away from the puncture needle tips, a preferably encircling flange section directed radially outward from its peripheral wall, in particular from the outer end region of the second inner section of the second adapter part, whose effective radial Extension is at least the same, preferably greater than the outer cross section of the third outer section of the second adapter part.
  • This flange section serves as a handle in order to be able to axially adjust the second adapter part relative to the first adapter part or the inner section of the second adapter part relative to its outer section.
  • the second securing device can also have a geometry of a second ring section, which is fixed between the free end edge of the third outer section and the flange section of the second inner section of the second adapter part when axially immovable between the first and second adapter parts.
  • the first and / or second protective element by means of which the puncture needle tip, when the transfer device is not in use, against a unwanted contact is protected, is a disk element, wherein the first, preferably both the first and the second protective element, are axially displaceable in the first and second adapter part.
  • first and second adapter parts are put together, they cannot be detached from one another when used properly, even if they have not yet been fixed on a bottle.
  • a further development of the invention provides that with the first outer hollow cylindrical section of the first adapter part latched to the second outer hollow cylindrical section of the second adapter part in the use position of the transfer device between the second and third outer hollow cylindrical section of the second adapter part, the intermediate wall extending between the first outer hollow cylindrical section and the first inner hollow cylindrical section of the first adapter part extending intermediate wall rests.
  • the second securing element remains between the third outer section and the second inner section of the second adapter part.
  • the invention is characterized in that when the second part is adjusted in the penetration direction of the puncture needle, the second adapter part interacts with the first adapter part in such a way that adjustment of the second adapter part to the first adapter part against the penetration direction is prevented.
  • the first and second adapter parts are designed in such a way that when they surround the bottle, they form a closed container, through which an escape of aerosol or, after piercing the closure, an escape of the medium present in the bottle to the outside is excluded, so that contamination z. B. by inhalation, through the skin, possibly. Oral, can not be done.
  • the second element having the transition element can have a seal by means of which the second adapter part is sealed off from the bottle, in particular from both the bottle and the first adapter part.
  • the invention is also characterized by a transfer device for removing or transferring a medium from or into a bottle with a bottle neck, which can be closed via a closure, comprising a first adapter part that can be positioned on the bottle and a first adapter part that interacts with the first adapter part
  • a second adapter part which is displaceable in the longitudinal direction of the bottle and has a transition element for protruding through the closure, wherein when the first and second adapter parts are pushed into one another, they form a closed container surrounding the bottle.
  • the second adapter part has a seal by means of which the second adapter part is sealed off from the first adapter part.
  • the adapter parts are also inseparable.
  • the insolubility of the adapter parts is achieved by the engagement of projections in recesses, which can only be displaced relative to one another in the direction of penetration of the transfer element such as cannula and can no longer be separated in the opposite direction.
  • the latching can be done by tongue-like elements that have latching hooks, which in turn interact with corresponding elements.
  • the tongue-like elements can have different lengths.
  • the invention also includes sealing elements that prevent liquids, dusts, aerosols or the like from escaping from a closed space.
  • These sealing elements can seal the adapter parts to one another or to one another.
  • sealing elements are possible which have recesses, depressions, projections, which can also be circumferential and ring-shaped, or the like, in order to close off the space from the surroundings.
  • the sealing elements can lie between the outer parts of the adapter, between the inner or the inner and outer parts of the adapter.
  • the sealing elements can optionally also seal directly with respect to the bottle.
  • the sealing elements can also be designed in such a way that guide channels are formed so that the adapter parts can be shifted into one another or bottles into the adapter parts more easily.
  • the teaching according to the invention results, inter alia. the advantage that aerosol-tightness is already provided when the vial, i.e. the bottle, is pierced.
  • the invention also enables a leakage leading to a hazard to be avoided after the closure has been pierced.
  • the adapter remains in place prevents aerosols from occurring on the vial or around the vial, which result from the separation process. Aerosol-tightness is also ensured during use.
  • Another advantage of the invention to be emphasized is that an injury after the use of the transfer device by the transfer element such as needle, cannula, spike, perforation device is excluded.
  • the invention also relates to a kit consisting of a container with a medical agent, a bag with solvent for dissolving the medical agent and a transfer device for mixing the solvent with the medical agent.
  • transfer devices are shown by means of which from a bottle or a bottle, a so-called vial, fluids such as dry substances or liquids such as water or solvents that are mixed for infusion or injection purposes before their use or administration. It can also be used for instillation or for solvent bags.
  • fluids such as dry substances or liquids such as water or solvents that are mixed for infusion or injection purposes before their use or administration. It can also be used for instillation or for solvent bags.
  • the application cases are given purely by way of example.
  • Corresponding transfer devices are also referred to as connectors or adapters.
  • a corresponding transfer device is required in order to perforate the closure of the bottle by means of a transfer element such as a puncture needle - such as a steel cannula.
  • a transfer element such as a puncture needle - such as a steel cannula.
  • the transfer devices shown in the figures have parts which are arranged telescopically and can be adjusted relative to one another and are also referred to as the first and second adapter parts.
  • the transfer device is hereinafter referred to as the connector and the vial to be connected to this is referred to as the vial.
  • the first adapter part is also known as the vial holder and the second adapter part as the cannula holder.
  • transition element that establishes the connection to the interior of the vial is referred to below as a cannula, without this restricting the function and design.
  • the connector 10 has a first adapter part 12 and a second adapter part 14 as essential elements.
  • the first adapter part 12 has a pot geometry with a peripheral wall 16, referred to as a jacket wall, and a bottom wall 18, in order to receive a small bottle, that is to say vial 20, which can be pushed into the first adapter part 12.
  • the bottom wall 18 ensures that the vial 20 remains in the first adapter part 12.
  • the bottom wall 18 does not have to be completely closed for this purpose.
  • a closed bottom wall 18 is provided in order to be able to provide a closed system which offers the possibility of an aerosol and leak tightness, as will be described below.
  • a retaining element referred to as a ring element or ring section 22
  • a ring element 22 which has elastic first projections compressible in the axial direction, some of which are identified by the reference numerals 24, 26 are.
  • the ring element 22 engages around the end edge of the peripheral wall 16 in sections in order to ensure a fixation.
  • the tongue-shaped elements 28, 30 run inclined to the longitudinal axis 32 of the first adapter part 12 and thus of the vial 20, as a result of which the first adapter part 12 is secured on the vial 20; because like that Figures 4 to 7 mediate, the tongue-shaped elements 28, 30 are supported, when the vial 20 is positioned in the first adapter part 12, on the connecting wall 38 which runs at an angle between the bottle neck 34 of the vial 20 and its cylindrical body 36 and is also referred to as a transition.
  • the vial 20 can no longer be pulled out of the first adapter part 12.
  • the first adapter part 12 is thus the vial holder.
  • the bottle neck 34 has a circumferential bead 40 in the region of its opening.
  • the opening of the vial 20 is closed by a stopper 42.
  • an aluminum crimp cap is applied typically after the vial 20 has been closed with the stopper 42.
  • a flip-off cap made of plastic can be located on this. This flip-off cap is pulled off the aluminum crimp cap, so that an opening is created in the middle of the aluminum crimp cap so that the sealing plug 42 is visible.
  • the second adapter part 14 which can also be referred to as the upper adapter part or outer part, comprises a hollow cylindrical section 44 which, facing away from the vial, is bounded by a wall 46 which runs transversely to the longitudinal axis 32 and is also referred to as a boundary wall, which has a cylindrical extension 48 in the center, one of which is referred to as a cannula Penetration needle 50 goes out and on the other hand, a breakaway connector 52 is placed on the outside.
  • the second adapter part 14 is thus the cannula holder.
  • guide-forming recesses 56, 58 are formed ( Fig. 3 ), each of which is composed of an axially extending section 60 and a section 62 extending transversely to this and along the wall 46.
  • a second projection 64, 66 projecting radially outward from the peripheral wall 16 of the first adapter part 12 ( Fig. 2 ) in order to be able to lock the first adapter part 12 to the second adapter part 14 in the manner described below.
  • An inner hollow cylindrical section 68 runs coaxially to the outer hollow cylindrical section 44, within which the cannula 50 extends, but does not protrude beyond its end edge 70, as can be seen in particular from the Figures 4 to 7 results.
  • a disk-shaped protective element 72 is received in a clamping manner from the inner hollow-cylindrical section 68, in the axial direction of the inner hollow cylindrical section 68 is adjustable.
  • the protective element 72 represents a configuration that is not mandatory.
  • the inner section 62 of the guide 56, 58 running transversely to the longitudinal axis 32 has a cross-sectional reduction in the axial direction formed by a step 76.
  • the section 62 experiences a quasi "constriction", ie the distance between the free edge or corner 78 of the respective second projection 64, 66 and the apex area of the first projections 24, 26 is greater than the distance between the The apex of the step 76 and the opposite edge of the section 62.
  • the first projections 24, 26 must consequently be compressed.
  • the projections 24, 26 can relax again with the result that when the first adapter part 12 is turned the second adapter part 14 takes place in the direction of the step 76, the projection 64, 66 protruding from the outside of the jacket wall 16 prevents further rotation by interacting with the step 76.
  • the first and second adapter parts 12, 14 are thus permanently connected to one another. It is likewise not possible to remove the vial 20.
  • ribs 17, 19 running in the longitudinal direction can serve as guide rails over the jacket wall 16.
  • connection of the cannula 50 to the interior of the vial 20 is self-explanatory from the Figures 4 to 7 clear.
  • Fig. 4 the position is shown in which the second adapter part 14 is placed on the first adapter part 12.
  • the second adapter part 14 with its outer hollow cylindrical section 44 surrounds the jacket wall 16 and is guided by it.
  • the inner diameter of the hollow cylindrical section 44 and the outer diameter of the jacket wall 16 are correspondingly matched to one another.
  • the guide ensures that the cannula can be displaced along the longitudinal axis 32 of the vial 20 when the first and second adapter parts 12, 14 are pushed into one another.
  • the ribs 17, 19 running in the direction of the longitudinal axis serve to ensure that the adapter parts 12, 14 are aligned with one another in the correct position in order to be displaced with respect to one another. Moving is also made easier since a linear contact is produced between the adapter parts 12, 14.
  • the ribs 17, 19 also prevent tilting.
  • Fig. 5 the position shown is that the cannula 50 has penetrated the stopper 42 and the cannula tip 74 is connected to the interior of the vial 20.
  • the projections 64, 66 protruding from the outside of the jacket wall 16 and preferably having an uneven trapezoidal geometry are located in the transition between the axially extending sections 60 of the guides 56, 58 and the sections 62 extending transversely thereto or second adapter part 14 rotated to the lower or first adapter part 12 ( Fig. 6 ), so that the second projections 64, 66 are adjusted along the sections 62 of the guides 56, 58 that extend along the wall 46.
  • the first and second adapter parts 12, 14 are locked when the second projections 64, 66 have overcome the steps 76 in the sections 62 of the guides 56, 58 and are located in the respective end section 80 of the guides 56, 58. To overcome the steps 76, it is first necessary for the first projections 24, 26 axially projecting from the end edge of the ring element 22 to be compressed to the required extent.
  • the lock is designed in such a way that it can only be released with an additional tool or with at least 300 N pull-off force, for example.
  • the break-off connector 52 can be destroyed and the mixing procedure can take place between the medicament present in the vial 20 and a liquid that is located in a bag previously connected to the break-off connector 52.
  • a Luer lock connection or similar is also required. possible.
  • a syringe, bottle or similar container can also be located on the breakaway connector or the like, such as a Luer lock connection. The same applies to all embodiments.
  • a second connector 100 can be seen which does not have all the features of the invention and which also consists of a vial holder running on the vial side as a first adapter part 112 and a second adapter part 114 having the cannula 50 as a cannula holder.
  • the connector 100 is also designed in such a way that after it has been connected to the vial 20, an unwanted or uncontrolled detachment from the vial 20 is no longer possible, as will be explained below.
  • the first or inner adapter part 112 comprises a first outer hollow cylindrical section 116 surrounding the bead 40 of the vial 20 when used properly and an inner hollow cylindrical section 118 which has a smaller diameter than the outer hollow cylindrical section 116. Between the hollow cylindrical sections 116, 118, an intermediate wall 120 runs transversely, in particular perpendicular to the longitudinal axis 32 of the connector 100 and thus, in the state connected to the vial 20, to the longitudinal axis of the vial 20.
  • the outer hollow cylindrical section 116 has tongue-shaped sections which are separated by axially extending slots 122 and are resilient to the required extent, two of which are identified by way of example with the reference numerals 124, 126.
  • the tongue-shaped sections 124, 126 have inwardly projecting projections (see projection 128) at the end, which grip behind the bead-like edge 40 of the vial neck, when the first adapter part 112 is properly connected to the vial 20, as can be seen below with reference to the figures.
  • the second or outer adapter part 114 consists of two parts which can be adjusted telescopically with respect to one another, namely an outer part 130 and an inner part 132 from which the puncture needle 50 extends.
  • the outer part 130 comprises a section 134 designated as the second outer hollow cylindrical section and section 136 designated as the third outer hollow cylindrical section, which have diameters which differ from one another.
  • the third outer hollow cylindrical section 136 is smaller in cross-section than the second outer hollow cylindrical section 134, the inner diameter of which is adapted to the outer diameter of the first outer hollow cylindrical section 116 of the first adapter part 112, which enables axial guidance.
  • the inner diameter of the third outer hollow cylindrical section 136 is adapted to the outer diameter of the first inner hollow cylindrical section 118 of the first adapter part 112, which also results in axial guidance.
  • first and second adapter parts 112, 114 are secured against axial displacement relative to one another by a first securing device 138, which preferably has the geometry of a ring section.
  • the fuse 138 runs along a further partition 140 running between the second and third hollow cylindrical sections 134, 136 and extending parallel to the partition 120 and penetrates a slot in the third outer hollow cylindrical section 136 and extends partially in a recess aligned with the slot or groove in the first inner hollow cylindrical section 118 of the first adapter part 112.
  • a second securing device 146 runs between the end edge 142 of the third outer cylinder section 136 and a flange-like extension extending from the inner or second part 132 of the second adapter part 112.
  • the inner part 132 of the second adapter part 114 has a hollow cylindrical shape, the outer diameter of which matches the inner diameter of the first inner hollow cylindrical portion 118 of the first adapter part 112 is adapted, whereby an axial guidance is made possible. Furthermore, the second part 132 of the second adapter part 114 is secured with respect to the first inner hollow cylinder-shaped section 118 via interlocking sections, in particular a preferably circumferential rib 133, which protrudes over the circumferential wall of the hollow cylinder-shaped inner or second part 132 of the second adapter part 114 and in a correspondingly adapted recess 153 engages in the inside of the first inner hollow cylindrical section 118 of the first adapter part 112.
  • the drawing also shows that a projection such as a clamping rib 147 protrudes from the inside of the second outer hollow cylindrical section 134 of the second adapter part 114 and engages in an adapted recess 148 of the first outer hollow cylindrical section 116 of the first adapter part 112 in such a way that a Loosening the adapter parts 112, 114 against the direction of penetration is not possible.
  • a projection such as a clamping rib 147 protrudes from the inside of the second outer hollow cylindrical section 134 of the second adapter part 114 and engages in an adapted recess 148 of the first outer hollow cylindrical section 116 of the first adapter part 112 in such a way that a Loosening the adapter parts 112, 114 against the direction of penetration is not possible.
  • a disk-shaped protective element 172 can be received in a clamping manner by the first inner hollow-cylindrical section 118 of the first adapter part 112, which can have an opening in the center in order not to hinder the penetration of the cannula 50 when the stopper 42 is penetrated.
  • a membrane to be destroyed can also be provided.
  • the connector 100 is aligned with the bottle neck 34 of the vial 20 such that the longitudinal axis of the connector 100 is aligned with the longitudinal axis 32 of the vial 20 is aligned.
  • the second adapter part 114 is arranged to the first adapter part 112 due to the securing elements 138, 146 and the interlocking projections or clamping ribs in such a way that the first adapter part 112 can overcome the bead 40 of the bottle neck 34, that is, the tongue-shaped sections 124, 126 after can be spread on the outside in order to then spring back as soon as the bead 40 has been overcome and the projections 128 of the tongues 124, 126 can thus engage behind the bead 40.
  • the positioning of the connector 100 after reaching behind the bead 40 is that Fig. 13 refer to.
  • the first securing device 138 extending along the partition 140 and securing the first and second adapter parts 112, 114 against axial displacement is removed ( Fig. 14 ), so that an axial displacement of the second adapter part 114 takes place when there is further axial force.
  • the holding force generated by the protrusion or protrusions 133 or also referred to as a rib clamping rib which connects the inner or second part 132 of the second adapter part 114 to the first inner hollow-cylindrical section 118 of the first adapter part 112, is overcome.
  • the position is shown in which the second outer hollow cylindrical section 134 surrounds the first outer hollow cylindrical section 116 of the first adapter part 112 to such an extent that the tongue-shaped elements 124, 126, which can also be referred to as sections, can no longer be bent outward.
  • the projection 147 which previously prevented the second adapter part 114 from being withdrawn to the first adapter part 112, engages behind a recess in the free edge area of the tongue-shaped elements 124, 126, adapted by a step-shaped cutout 148, which ensures that a retraction of the second adapter part 114, i.e. a axial adjustment against the direction of penetration is not possible.
  • the second outer hollow cylindrical section 134 thus acts at the end as a clamping ring for the first outer hollow cylindrical section 116 of the first adapter part 112, which can also be referred to as a bell, whereby a after outwardly directed radial adjustment of the tongue-shaped elements 124, 126 is prevented. This creates a closed space before the stopper is pierced, so that no aerosols that arise through the opening of the vial can escape to the outside.
  • the resulting locking is designed so that this can only be done with an additional tool or pulling forces of z. B. 300 N can be solved. This ensures that the connector 100 remains connected to the vial 20 even after use.
  • the second securing device 146 is then removed so that the inner part 132 of the second adapter part 114, which has the cannula 50, can be adjusted in the penetration direction by exerting an axial force on the flange-like handle 144 in order to penetrate the stopper 42, as is shown in a comparison of FIG Figures 15-17 made clear.
  • the disc-shaped protective element 172 is pressed by the inside transverse wall 150 of the inner part 132 penetrated by the cannula 50 to rest against the outside of the stopper 42 or the aluminum cap covering it on the outside.
  • the projection or the clamping rib 133 protruding radially from the outer wall of the hollow cylindrical section of the inner part 132 of the second adapter part 114 engages in a recess present in the inner wall of the first inner hollow cylindrical section 118 of the first adapter part 112 or engages behind a step 152, in order to exclude a retraction of the inner part 132 of the second adapter part 114.
  • the breakaway connector 52 on the previously z. B. a bag is applied, be destroyed in order to carry out the desired mixing procedure.
  • FIG. 18 to 28 is an alternative to the embodiment of FIG Figures 1 to 7 can be seen, so that the same reference numerals are used in principle for the same elements.
  • the representations of the corresponding transfer device 200 to be referred to as a connector are self-explanatory.
  • the adapter parts cannot be detached by locking an outer or second adapter part 214 with the first adapter part 212 surrounding the vial 20.
  • the first adapter part 212 has a pot geometry with a circumferential wall 216 and a bottom wall 218 in order to receive the vial 20.
  • a ring element 222 is provided in the open edge area of the circumferential wall 216, from which web-shaped or tongue-shaped elements extend in the axial direction and are identified by way of example with the reference symbols 228 and 230.
  • the tongue-shaped elements 228, 230 run inclined to the longitudinal axis 232 of the connector 200 and thus of the vial 20, whereby the first adapter part 212 and the vial 20 form a solid unit when the vial 20 is properly received by the first adapter part 212; because in this case, when the vial 20 is positioned in the first adapter part 212, the tongue-shaped elements 228, 230 are supported on the connecting wall 38 running between the bottle neck 34 of the vial 20 and its cylindrical body 36. Thus, the vial 20 can no longer be pulled out of the first adapter part 212.
  • tongue-shaped elements 223, 231 From the ring element 222, which is connected, such as glued or welded, to the end edge of the cup-shaped first adapter part 212, further inwardly protruding tongue-shaped elements 223, 231 proceed, which according to the illustration according to, for example, FIG Fig. 25 abut against the circumferential surface, that is to say the cylindrical body 36 of the vial 20.
  • the first adapter part 212 has latching depressions delimited by elevations on the circumferential side, like the sectional illustration according to FIG Fig. 20 made clear.
  • two locking depressions are identified by the reference numerals 310, 312.
  • the projections delimiting the latching depressions 310, 312 have a tooth-shaped geometry such that their flanks on the slide-in side with respect to the second adapter part 214, ie the upper boundaries in the drawings, run ramp-shaped in such a way that the second adapter part 214 can be pushed onto the first adapter part 212 or pushing the first adapter part 212 into the second adapter part 214 is made possible, since projections 322, 324 of tongue-shaped elements 314, 316, 318, 320 that extend in the axial direction of the second adapter part 214 slide along the corresponding flanks .
  • the opposite flanks have a correspondingly inclined course, so that when the projections 322, 324 emanating from the tongue-shaped elements 314, 316 engage in a latching recess 310, 312, the adapter parts 312, 314 can no longer be pulled apart with the usual introduction of force.
  • the axially extending tongue-like elements 314, 316, 318, 320 with the inwardly directed projections 322, 324 at their ends start from a ring element 326 which is fixed as welded in the opening area of the second adapter part 214.
  • the second adapter part 214 has a bell-shaped geometry, like the sectional illustration in particular according to FIG Fig. 20 made clear.
  • the ring-shaped element 326 has a bead-like edge 328, which is connected, such as welded, to the bell-like extension 330 of the second adapter part 214.
  • the tongue-like elements 314, 316, 318, 320 are inclined in the direction of the interior of the second adapter part 214 and are designed to be resilient in such a way that the first and second adapter parts 212, 214 can easily be pushed into one another, but - as explained above - they are prevented from being pulled apart .
  • the lock is designed in such a way that it can only be released with an additional tool or with at least 300 N pull-off force, for example.
  • the inner wall of the cylindrical section of the second adapter part 214 is lined with a seal 332 which, when the adapter parts 212, 214 are assembled, rests in a sealing manner on the jacket wall 216 of the first adapter part 212. This creates a closed space. If the bottom wall 218 of the first adapter part 212 is also closed, the vial 20 is completely closed off from the environment. This is the preferred embodiment.
  • seal 332 can have circumferential annular elevations 333.
  • a stop preferably designed as a circumferential ring or web 217, extends from the jacket wall 216 and consequently extends radially from the circumferential wall.
  • the free outer edge of the second adapter part 214 rests against the stop when the adapter parts 212, 214 have been properly assembled and the cannula 50 has thus penetrated into the vial 20 to the required extent.
  • connection of the cannula 50 to the interior of the vial 20 is illustrated in a self-explanatory manner. So is in the Figure 23a ), b) the attachment of the first adapter part 212 surrounding the vial 20 to the second adapter part 214 is shown. the Figure 24a ), b) shows the connection. In the Figure 25a ), b) a position is shown in which the projections 322, 324 protruding from the tongue-like elements 314, 316, 318, 320 in their end region are already in a locking recess or recess 310 engage so that there is a locking position, but the plug 42 is not yet fully pierced.
  • the Figure 26a ), b) reflect a position in which the first adapter part 212 has been pushed further into the second adapter part 214.
  • the end position is shown in which the free edge of the second adapter part 214 rests against the annular projection 217 of the first adapter part 212, which serves as a stop.
  • a stop is not a mandatory feature. Rather, an optical display such as a color marking can also serve to make the user recognizable that the adapter parts 212, 214 are pushed into one another to an extent that the stopper 42 is pierced by the cannula 50 to the required extent.
  • the break-off connector 52 extending from the bottom wall 245 of the second adapter part 214 can then be removed.
  • a connection between the adapter parts 212, 214 is also possible in that the locking recesses 310, 312 are sections of a thread into which the projections 322, 324 engage so that the first adapter part 212 is joined to the second adapter part 214 in the manner of a screw connection.
  • the inner cylindrical section 268 moves internally protruding projection 270 engages behind the bead-like edge 40 of the vial 20.
  • several projections or a circumferential projection can also be provided.
  • FIG. 10 is an embodiment of the transfer device 200 of FIG Figures 18 to 28 refer to. Since the structure is basically the same, the same reference symbols are used for the same elements.
  • the embodiment of the den Figures 20a and 20b to be removed transfer device differs from that of the Figures 18 to 28 to the effect that no inwardly directed projection extends from the inner hollow cylindrical section 268 and engages behind the bead-like edge 40 of the vial 20. Otherwise the same construction can be found.
  • the circumferential or jacket wall 216 of the first adapter part 212 with the ring element 222 runs in the annular gap 269 running between the inner hollow cylindrical section 268 and the circumferential wall 244 when the adapter parts 212, 214 are assembled.
  • the annular gap 269 thus offers a guide when the adapter parts 212, 214 are pushed together.
  • a seal takes place between the ring element 222 and the annular gap 269 and thus between the adapter parts 212, 214.
  • FIG. 29 to 39 An embodiment according to the invention of a transfer device to be referred to as a connector is the Figures 29 to 39 refer to.
  • the same reference numerals are used for the same elements.
  • the transfer device 400 there is basically an inseparability between a first adapter part 412 surrounding the vial 20 with the sealing plug 42 and a second adapter part 414 with a hood or cup-shaped geometry as soon as the first and second adapter parts 412, 414 are connected to one another by latching .
  • the first and second adapter parts 412, 414 surround a closed space which surrounds the vial 20, the space already being closed before the cannula 50 proceeding from the second adapter part 414 penetrates the sealing plug 42.
  • unsolvable means that loosening without tools or with the action of a pull-off force of less than 300 N is not possible.
  • the first adapter part 412 has a pot geometry with a peripheral wall 216 and a bottom wall 218 in order to receive the vial 20.
  • a peripheral wall 216 which is also referred to as the jacket wall
  • detent depressions bounded by elevations emanate, two of which are identified by way of example with the reference numerals 310 and 312.
  • the projections delimiting the latching depressions 310, 312 have a tooth-shaped geometry such that their flanks running in relation to the second adapter part 414, ie the upper delimitations in the drawings, run ramp-shaped.
  • the tongue-shaped elements 416, 418, 420, 424, which form locking hooks with their radially inwardly projecting projections 423, 425, are based on a ring element 430 which is firmly connected to the second or outer adapter part 414, in particular by welding or gluing. Other types of fastening are also possible.
  • the ring element 430 is preferably fixed in the inner area of a bell-like extension 432 of the second adapter part 414, such as in particular the Fig. 31 made clear.
  • the tongue-shaped elements 416, 418, 420, 424 extending from the ring element 430 in the direction of the bottom wall 434 running transversely to the longitudinal axis of the adapter part 414 span a circumferential edge, that is to say an envelope which is adapted to the outer circumference of the first adapter part 412, so that when the first adapter part 412 with the vial 20 is inserted into the second or outer adapter part 414, there is no tilting, rather a secure axial guidance is ensured.
  • a seal 436 extends from the inside of the second adapter part 414 and consists of an inner section 438 running in the longitudinal direction of the adapter part 414 and an outer section parallel to this and forming a gap 446 exists.
  • the seal 436 has the geometry of a U with unequal legs, the shorter leg of which runs on the outside.
  • an edge section 440 of an inner hollow cylindrical section 444 running coaxially to the circumferential wall 442 of the second adapter part 414, as also from FIG Fig. 32 is clearly evident.
  • the seal 436 is glued to the hollow cylindrical section 444 or connected in some other suitable manner or otherwise fastened such as clamped.
  • the outer side of the outer section 446 of the seal 436 runs in alignment with the outer surface of the hollow cylindrical section 444, as is also shown in FIG Fig. 32 can be seen.
  • the inner surface of the inner section 438 of the seal 436 has longitudinal ribs 439 which serve to guide the vial 20. Furthermore, the inner section 438 is beveled on the inside starting from its edge (line 441), as in FIG Fig. 32 made clear. As a result, the vial 20 is also guided. At the same time, the vial 20 is sealed off, as in FIG Fig. 32 made clear. Furthermore, there are projections 447 on the outside of the outer section 446 of the seal 436, as a result of which a seal takes place between the first adapter part 412 and the second adapter part 414 in the area of the latching depressions 310, 312. This creates a seal between the first and second adapter part 412, 414 guaranteed. As mentioned, the seal also rests on the vial 20 or its inclined neck section (connecting wall 38).
  • the interaction of the locking projections 423, 425 of the tongue-shaped locking elements 416, 418, 420, 424 with the locking depressions 310, 312 ensures, due to their geometry, that after the locking projections 423, 425 hook into one of the depressions 310, 312, the adapter parts 412 , 414 is no longer possible, rather before penetration of the plug 42, only a sliding into one another in the direction of penetration is permitted. This creates a closed space before the stopper is pierced, so that no aerosols that arise through the opening of the vial can escape to the outside.
  • the penetration takes place by further pushing together to an extent that the cannula 50 penetrates the stopper 42 and the cannula 50 pierces the stopper 42 completely.
  • the adapter parts 412, 414 can be pushed into one another until the lower edge of the second adapter part 414 or the ring element 430 running in this area comes to rest on a radially circumferential web 217 which protrudes from the circumferential wall 216 of the first adapter part 412, as also in connection with the embodiment of FIG Figures 18 to 28 the case is.
  • FIG. 33 This is how in Fig. 33 the placement of the upper or second adapter part 414 on the lower or inner or first adapter part 412 is shown after the vial 20 has been inserted into the lower adapter part 412.
  • FIG Fig. 38 the first adapter part 412 is pushed into the outer adapter part 414 to such an extent that the latter rests against the circumferential stop 217, that is to say that it can no longer be pushed into one another.
  • the cannula 50 has penetrated the closure plug 42 to the required extent.
  • the connector 52 can then be canceled in order to, for. B. initiate the mixing process via a hose of a solvent bag.
  • a stop 217 is not absolutely necessary.
  • the latching hooks can have different lengths, so that the bottom side of the adapter part 412 rests on the shorter hook.
  • 10 Connector / transfer device 100 Connector / transfer device 12th first adapter part 112 first adapter part 14th second adapter part 114 second adapter part 16 Circumferential wall / jacket wall 116 outer hollow cylindrical section 17.19 Ribs 118 inner hollow cylindrical section 18th Bottom wall, section 120 Partition 20th Vial / bottle 122 Slots 22nd Retaining element / ring element / section 124 tongue-shaped section / element 24 Ledges 126 tongue-shaped section / element 26th Ledges 128 head Start 28 Element / fixing element 130 outer adapter part 30th Element / fixing element 132 inner hollow cylindrical section 32 Longitudinal axis 133 Rib / protrusion / clamping rib 34 Bottleneck 134 second outer hollow cylindrical section 36 cylindrical body 136 third outer hollow cylindrical section 38 Connection wall / transition 138 first backup 40 bead 140 Partition 42 Plug

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Fluid Mechanics (AREA)
  • Physics & Mathematics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
  • Devices For Opening Bottles Or Cans (AREA)
  • Unwinding Webs (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Massaging Devices (AREA)
  • Seal Device For Vehicle (AREA)
  • Cigarettes, Filters, And Manufacturing Of Filters (AREA)
  • Pens And Brushes (AREA)
  • Sealing Of Jars (AREA)
EP15712326.6A 2014-03-27 2015-03-20 Transfervorrichtung für medien mit unlösbar verrastbarem adapter Active EP3122310B1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL15712326T PL3122310T3 (pl) 2014-03-27 2015-03-20 Przyrząd do przenoszenia substancji wyposażony w adapter, tworzący nierozłączne połączenie zatrzaskowe
EP21176118.4A EP3895680A1 (de) 2014-03-27 2015-03-20 Transfervorrichtung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102014104281.6A DE102014104281B3 (de) 2014-03-27 2014-03-27 Transfervorrichtung
PCT/EP2015/055922 WO2015144581A2 (de) 2014-03-27 2015-03-20 Transfervorrichtung

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP21176118.4A Division-Into EP3895680A1 (de) 2014-03-27 2015-03-20 Transfervorrichtung
EP21176118.4A Division EP3895680A1 (de) 2014-03-27 2015-03-20 Transfervorrichtung

Publications (2)

Publication Number Publication Date
EP3122310A2 EP3122310A2 (de) 2017-02-01
EP3122310B1 true EP3122310B1 (de) 2021-08-25

Family

ID=52807785

Family Applications (2)

Application Number Title Priority Date Filing Date
EP15712326.6A Active EP3122310B1 (de) 2014-03-27 2015-03-20 Transfervorrichtung für medien mit unlösbar verrastbarem adapter
EP21176118.4A Pending EP3895680A1 (de) 2014-03-27 2015-03-20 Transfervorrichtung

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP21176118.4A Pending EP3895680A1 (de) 2014-03-27 2015-03-20 Transfervorrichtung

Country Status (16)

Country Link
US (2) US10716736B2 (ru)
EP (2) EP3122310B1 (ru)
JP (3) JP7046601B2 (ru)
KR (4) KR102115719B1 (ru)
AU (1) AU2015238584B2 (ru)
CA (1) CA2948042C (ru)
DE (1) DE102014104281B3 (ru)
DK (1) DK3122310T3 (ru)
EA (1) EA033927B1 (ru)
ES (1) ES2898630T3 (ru)
IL (4) IL282376B (ru)
LT (1) LT3122310T (ru)
PL (1) PL3122310T3 (ru)
PT (1) PT3122310T (ru)
UA (1) UA117960C2 (ru)
WO (1) WO2015144581A2 (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7547300B2 (en) 2006-04-12 2009-06-16 Icu Medical, Inc. Vial adaptor for regulating pressure
JP5829608B2 (ja) 2009-07-29 2015-12-09 アイシーユー・メディカル・インコーポレーテッド 流体移行デバイスおよびその使用方法
KR102481494B1 (ko) 2011-12-22 2022-12-26 아이씨유 메디칼 인코퍼레이티드 의료용 유체 전달 시스템, 유체 전달 방법, 전자 의료용 유체 전달 시스템, 및 전자 의료용 유체 전달 시스템 이용 방법
US9089475B2 (en) 2013-01-23 2015-07-28 Icu Medical, Inc. Pressure-regulating vial adaptors
WO2015047980A1 (en) * 2013-09-26 2015-04-02 GYRUS ACMI, INC. (d/b/a OLYMPUS SURGICAL TECHNOLOGIES AMERICA) Endoscope sheath deflection devices
CA2931195C (en) 2013-11-25 2019-09-24 Icu Medical, Inc. Methods and systems for filling iv bags with therapeutic fluid
JP6710758B2 (ja) 2015-12-04 2020-06-17 アイシーユー・メディカル・インコーポレーテッド 医療用流体を移送するための電子式医療用流体移送装置
USD851745S1 (en) 2016-07-19 2019-06-18 Icu Medical, Inc. Medical fluid transfer system
EP3487468A4 (en) 2016-07-25 2020-03-25 ICU Medical, Inc. SYSTEMS, METHODS AND COMPONENTS FOR TRAPPING AIR BUBBLES IN MODULES AND MEDICAL FLUID TRANSFER SYSTEMS.
WO2018039065A1 (en) 2016-08-22 2018-03-01 Eli Lilly And Company Secured medication transfer system
WO2018064206A1 (en) * 2016-09-30 2018-04-05 Icu Medical, Inc. Pressure-regulating vial access devices and methods
USD907193S1 (en) 2018-02-21 2021-01-05 Eli Lilly And Company Secured medication transfer set
EP4282393A3 (en) * 2018-05-11 2024-02-14 Bristol-Myers Squibb Company Serially-connectable drug modules for combinatorial drug delivery device
US11590057B2 (en) 2020-04-03 2023-02-28 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
USD946752S1 (en) * 2020-05-07 2022-03-22 Bn Intellectual Properties, Inc. Vial cage
USD937408S1 (en) * 2020-07-03 2021-11-30 Novandi Chemistry AB Container to transport chemical substances
EP4225254A2 (en) 2020-10-09 2023-08-16 ICU Medical, Inc. Fluid transfer device and method of use for same
WO2024154713A1 (ja) * 2023-01-16 2024-07-25 テルモ株式会社 ホルダ及び採取キット

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3503460A1 (de) * 1984-02-24 1985-09-05 Farmitalia Carlo Erba S.p.A., Mailand/Milano Sicherheitseinrichtung zum verbinden einer injektionsspritze mit dem mund oder der oeffnung einer ein pharmazeutisches praeparat enthaltenden flasche oder einem kleinen rohr zur abgabe eines pharmazeutischen praeparats von der injektionsspritze
EP0311787A2 (en) * 1987-10-14 1989-04-19 FARMITALIA CARLO ERBA S.r.l. Apparatus with safety locking members, for connecting a syringe to a bottle containing a medicament
EP0335378A2 (en) * 1988-03-31 1989-10-04 Nissho Corporation Fluid container
EP0614653A2 (en) * 1993-02-05 1994-09-14 Suntory Limited Fluid delivery system
US5364386A (en) * 1993-05-05 1994-11-15 Hikari Seiyaku Kabushiki Kaisha Infusion unit
US5503302A (en) * 1995-01-25 1996-04-02 Primary Delivery Systems, Inc. Sealed container puncturer and spray dispensing device
US6537263B1 (en) * 1998-09-24 2003-03-25 Biodome Device for connecting a receptacle and a container and ready-for-use set comprising same
DE102005006771A1 (de) * 2005-02-15 2006-08-17 Disetronic Licensing Ag Fluidtransfervorrichtung
WO2007101798A2 (en) * 2006-03-07 2007-09-13 Novo Nordisk A/S A drug storage and delivery device
WO2007140238A2 (en) * 2006-05-25 2007-12-06 Bayer Healthcare Llc Reconstitution device
US20130199669A1 (en) * 2007-08-01 2013-08-08 Hospira, Inc. Medicament admixing system
DE102012113002A1 (de) * 2012-10-01 2014-04-03 Medac Gesellschaft für klinische Spezialpräparate mbH Transfervorrichtung zur Entnahme oder Übergabe eines Fluids

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52151288A (en) 1976-04-30 1977-12-15 Union Carbide Corp Aseptic coupling device for conduit
CA1302837C (en) * 1987-04-02 1992-06-09 David Scarrow Apparatus for contacting material such as a drug with a fluid
JPH0638834B2 (ja) 1990-09-21 1994-05-25 光製薬株式会社 輸液容器
GB9108655D0 (en) 1991-04-23 1991-06-12 Waverley Pharma Ltd Improved multi-use liquid dispensers
US5893397A (en) * 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
JP3478320B2 (ja) 1997-01-16 2003-12-15 ニプロ株式会社 連通手段を備えた薬剤容器
GB9701413D0 (en) * 1997-01-24 1997-03-12 Smithkline Beecham Biolog Novel device
FR2789369B1 (fr) * 1999-02-10 2001-04-27 Biodome Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
JP4132554B2 (ja) 2000-03-15 2008-08-13 凸版印刷株式会社 プラスチックキャップ
JP4341239B2 (ja) * 2002-12-19 2009-10-07 ニプロ株式会社 液体移注具
DK2664550T3 (da) * 2003-10-30 2019-11-11 Simplivia Healthcare Ltd Indretning til sikker håndtering af lægemiddel
GB2461086B (en) 2008-06-19 2012-12-05 Cilag Gmbh Int Injection device
EP2351548B1 (en) * 2008-11-21 2016-01-27 Terumo Kabushiki Kaisha Connector
AU2010310457B2 (en) * 2009-10-23 2015-07-02 Amgen Inc. Vial adapter and system
WO2011140596A1 (en) 2010-05-11 2011-11-17 Noble House Group Pty. Ltd. Medical sampling port
CA2877466C (en) * 2012-06-27 2020-07-28 Carmel Pharma Ab Medical connecting device

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3503460A1 (de) * 1984-02-24 1985-09-05 Farmitalia Carlo Erba S.p.A., Mailand/Milano Sicherheitseinrichtung zum verbinden einer injektionsspritze mit dem mund oder der oeffnung einer ein pharmazeutisches praeparat enthaltenden flasche oder einem kleinen rohr zur abgabe eines pharmazeutischen praeparats von der injektionsspritze
EP0311787A2 (en) * 1987-10-14 1989-04-19 FARMITALIA CARLO ERBA S.r.l. Apparatus with safety locking members, for connecting a syringe to a bottle containing a medicament
EP0335378A2 (en) * 1988-03-31 1989-10-04 Nissho Corporation Fluid container
EP0614653A2 (en) * 1993-02-05 1994-09-14 Suntory Limited Fluid delivery system
US5364386A (en) * 1993-05-05 1994-11-15 Hikari Seiyaku Kabushiki Kaisha Infusion unit
US5503302A (en) * 1995-01-25 1996-04-02 Primary Delivery Systems, Inc. Sealed container puncturer and spray dispensing device
US6537263B1 (en) * 1998-09-24 2003-03-25 Biodome Device for connecting a receptacle and a container and ready-for-use set comprising same
DE102005006771A1 (de) * 2005-02-15 2006-08-17 Disetronic Licensing Ag Fluidtransfervorrichtung
WO2007101798A2 (en) * 2006-03-07 2007-09-13 Novo Nordisk A/S A drug storage and delivery device
WO2007140238A2 (en) * 2006-05-25 2007-12-06 Bayer Healthcare Llc Reconstitution device
US20130199669A1 (en) * 2007-08-01 2013-08-08 Hospira, Inc. Medicament admixing system
DE102012113002A1 (de) * 2012-10-01 2014-04-03 Medac Gesellschaft für klinische Spezialpräparate mbH Transfervorrichtung zur Entnahme oder Übergabe eines Fluids

Also Published As

Publication number Publication date
JP2021100583A (ja) 2021-07-08
IL274249B (en) 2021-05-31
WO2015144581A3 (de) 2015-11-19
US20200297582A1 (en) 2020-09-24
IL248041B (en) 2020-10-29
KR20210080602A (ko) 2021-06-30
PT3122310T (pt) 2021-11-23
KR20200059321A (ko) 2020-05-28
KR20220121841A (ko) 2022-09-01
AU2015238584A1 (en) 2016-09-29
UA117960C2 (uk) 2018-10-25
IL282376B (en) 2022-08-01
DK3122310T3 (da) 2021-11-22
PL3122310T3 (pl) 2022-03-14
CA2948042A1 (en) 2015-10-01
KR102115719B1 (ko) 2020-05-29
ES2898630T3 (es) 2022-03-08
DE102014104281B3 (de) 2015-09-10
IL274249A (en) 2020-06-30
IL248041A0 (en) 2016-11-30
IL282376A (en) 2021-06-30
US10716736B2 (en) 2020-07-21
EA201691942A1 (ru) 2016-12-30
JP2023164810A (ja) 2023-11-14
IL278278B (en) 2021-09-30
EA033927B1 (ru) 2019-12-10
KR102270200B1 (ko) 2021-06-30
KR20160138162A (ko) 2016-12-02
WO2015144581A2 (de) 2015-10-01
JP2017509466A (ja) 2017-04-06
EP3895680A1 (de) 2021-10-20
AU2015238584B2 (en) 2019-01-24
KR102581612B1 (ko) 2023-09-25
LT3122310T (lt) 2021-12-27
JP7046601B2 (ja) 2022-04-04
CA2948042C (en) 2020-01-14
US20170007501A1 (en) 2017-01-12
KR102424269B1 (ko) 2022-07-25
EP3122310A2 (de) 2017-02-01

Similar Documents

Publication Publication Date Title
EP3122310B1 (de) Transfervorrichtung für medien mit unlösbar verrastbarem adapter
EP2903583B1 (de) Transfervorrichtung zur entnahme oder übergabe eines fluids
DE69605204T2 (de) Vorrichtung mit originalitätssicherung zum anschluss an einen geschlossenen behälter
DE60019446T2 (de) Flüssigkeitstransferset für phiolen und andere medizinische behälter
EP2252249B1 (de) Mischvorrichtung
DE69428005T2 (de) Flüssigkeitsabgabesystem
DE60315006T2 (de) Vorrichtung zum mischen von medizinischen flüssigkeiten
EP2531164B1 (de) Vorrichtung zum entnehmen eines fluids aus einem behälter
DE69515885T2 (de) Behälter für pharmazeutische Produkte mit zwei gesonderten Komponenten, mit Mitteln zu deren Mischung und dosierter Ausgabe sowie Verfahren zum Zusammenstellen des Behälters
DE69006483T2 (de) Vorgeschlitzte injektionsstelle.
DE69124525T2 (de) SICHERHEITSSPRITZE MIT AUSTAUSCHBAREM UND EINZIEHBAREM NADELTRäGER
DE2817618A1 (de) Behaelter mit verschluss
WO2003008021A1 (de) Vorrichtung zur abgabe von medien
WO2016120155A1 (de) Vorrichtung zum überführen einer flüssigkeit zwischen einem lagerbehälter und mindestens einem weiteren gebrauchsbehälter
DE102004044288A1 (de) Vorrichtung zur Verbindung eines rohrförmigen Teils, insbesondere einer Kanüle, mit dem Inneren einer Flasche oder dergleichen
DE69715747T2 (de) Vorrichtung zum Befüllen und zum Verabreichen des Inhalts von Spritzen
WO2009089638A1 (de) Nadeleinheit mit einer zwischen nadelträger und nadelverpackungshülse angeordneten hülse
DE202013011561U1 (de) Verschluss-System, insbesondere Spritzenverschluss und Behälter fürpharmazeutische Präparate, insbesondere Spritze für medizinische Zwecke
EP2712603B1 (de) Medizinischer Behälter
EP0597220A2 (de) Medizinisches Übertragungsgerät
DE29612534U1 (de) Infusionsset
WO2011023748A1 (de) Spritzenbehälter für eine spritze
WO2010063441A1 (de) Injektionsanordnung
WO2007062775A1 (de) Vorrichtung zum überleiten von flüssigkeiten, suspensionen und/oder feststoffen von einem ersten gefäss in ein zweites gefäss
DE2442856B2 (de) Verschlusskappe fuer eine mit einem durchstechbaren stoepsel versehene arzneimittelflasche

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20161020

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1231729

Country of ref document: HK

PUAG Search results despatched under rule 164(2) epc together with communication from examining division

Free format text: ORIGINAL CODE: 0009017

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20181204

B565 Issuance of search results under rule 164(2) epc

Effective date: 20181204

RIC1 Information provided on ipc code assigned before grant

Ipc: A61J 1/20 20060101AFI20181129BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 502015015108

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: A61J0001200000

Ipc: A61J0001160000

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RIC1 Information provided on ipc code assigned before grant

Ipc: A61J 1/20 20060101ALI20210208BHEP

Ipc: A61J 1/16 20060101AFI20210208BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20210318

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 502015015108

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: GERMAN

Ref country code: AT

Ref legal event code: REF

Ref document number: 1423049

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210915

REG Reference to a national code

Ref country code: FI

Ref legal event code: FGE

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

Effective date: 20211117

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Ref document number: 3122310

Country of ref document: PT

Date of ref document: 20211123

Kind code of ref document: T

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20211116

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

Ref country code: GR

Ref legal event code: EP

Ref document number: 20210403108

Country of ref document: GR

Effective date: 20211209

REG Reference to a national code

Ref country code: NL

Ref legal event code: FP

REG Reference to a national code

Ref country code: EE

Ref legal event code: FG4A

Ref document number: E021598

Country of ref document: EE

Effective date: 20211109

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210825

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210825

REG Reference to a national code

Ref country code: NO

Ref legal event code: T2

Effective date: 20210825

REG Reference to a national code

Ref country code: SK

Ref legal event code: T3

Ref document number: E 38775

Country of ref document: SK

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2898630

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20220308

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 502015015108

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210825

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210825

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20220527

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210825

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210825

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220320

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230526

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20150320

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GR

Payment date: 20240320

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IS

Payment date: 20240313

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LT

Payment date: 20240222

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20240320

Year of fee payment: 10

Ref country code: IE

Payment date: 20240321

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: AT

Payment date: 20240321

Year of fee payment: 10

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210825

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210825

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: RO

Payment date: 20240314

Year of fee payment: 10

Ref country code: FI

Payment date: 20240320

Year of fee payment: 10

Ref country code: EE

Payment date: 20240320

Year of fee payment: 10

Ref country code: DE

Payment date: 20240328

Year of fee payment: 10

Ref country code: CZ

Payment date: 20240308

Year of fee payment: 10

Ref country code: BG

Payment date: 20240321

Year of fee payment: 10

Ref country code: PT

Payment date: 20240307

Year of fee payment: 10

Ref country code: GB

Payment date: 20240215

Year of fee payment: 10

Ref country code: SK

Payment date: 20240312

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: TR

Payment date: 20240311

Year of fee payment: 10

Ref country code: SE

Payment date: 20240320

Year of fee payment: 10

Ref country code: PL

Payment date: 20240219

Year of fee payment: 10

Ref country code: NO

Payment date: 20240322

Year of fee payment: 10

Ref country code: LV

Payment date: 20240315

Year of fee payment: 10

Ref country code: IT

Payment date: 20240329

Year of fee payment: 10

Ref country code: FR

Payment date: 20240328

Year of fee payment: 10

Ref country code: DK

Payment date: 20240326

Year of fee payment: 10

Ref country code: BE

Payment date: 20240320

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20240401

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20240429

Year of fee payment: 10