EP3122310B1 - Transfer device for media, comprising a non-releasably lockable adapter - Google Patents

Description

• ein an der Flasche positionierbares erstes inneres Adapterteil und
• ein mit dem ersten Adapterteil wechselwirkendes in Längsrichtung der Flasche verschiebbares äußeres zweites Adapterteil mit einem Überleitungselement, wie Nadel als Punktionsnadel, Kanüle, Spike oder Perforationseinrichtung, zum Durchstechen des Verschlusses.

The invention relates to a transfer device for removing or transferring a medium from or into a bottle with a bottle neck, which can be closed by means of a closure

• a first inner adapter part that can be positioned on the bottle and
• an outer second adapter part that interacts with the first adapter part and is displaceable in the longitudinal direction of the bottle and has a transfer element, such as a needle as a puncture needle, cannula, spike or perforation device, for piercing the closure.

Numerous drugs for infusion, injection or instillation are supplied as dry substances and are only mixed with water or another solvent to form a solution or suspension shortly before use / administration. Other liquid preparations must be diluted before use.

The dry substance is usually supplied in an injection bottle, a so-called vial. Primarily liquid drugs are also offered in vials. To connect this bottle to another container or an infusion device, a connector (transfer device) can be used, into which the head of the vial is pressed and the membrane of the vial is perforated. The other container can, for. For example, another injection bottle, infusion bag, solvent bag, or syringe.

According to the prior art, these connectors, also known as adapters and composed of adapter parts, can have a steel cannula or a plastic spike in the center, which is surrounded by a collar forming a hollow cylindrical body, which is attached to the flange-like edge with, in particular, a flanged cap of the vial made of aluminum snaps open. The puncture needle starts from the bottom wall of the collar, in particular in the form of the steel cannula, and extends in the longitudinal direction of the hollow cylindrical body. Such adapters no longer meet today's requirements for vial adapters, for several reasons.

According to regulations such as Technical Rules for Hazardous Substances (TRGS 525) of the Federal Institute for Occupational Safety and Health and Cytostatics in the Health Service (M620) of the Employer's Liability Insurance Association for Health Service and Welfare, the release of hazardous substances, such as z. B. drugs to avoid or reduce. This applies in particular to the preparation of hazardous and medicinal substances.

Such a release leads to exposure of staff, patients and the environment. This enables the released substances to be absorbed via inhalation, the skin or orally. The release itself can e.g. B. via the formation of aerosols, splashes during preparation, leakage of the adapter, when removing the adapter or possibly caused by broken glass, as well as by injury from a contaminated cannula.

On the one hand, the previously known vial adapters of the prior art basically do not offer any aerosol and leak tightness.

On the other hand, there is also no protection against injury with a contaminated needle, as required by the accident prevention regulation TRBA 250. Likewise, exposure by removing the adapter is not avoided.

The second reason is that the closure of the puncture needle has to be punctured centrally in order to ensure a leak-tight connection of the vial. In the case of vial adapters used according to the prior art, however, there is the risk that the vial will tilt when it is snapped into the collar. This results in a primarily eccentric puncture of the closure. When the vial is then fully pushed in, the cannula is then forced into a central position. This leads to tension in the closure of the vial, which leads to Leaks next to the cannula can result. This can happen in the case of toxic substances such as B. cytostatics, lead to the endangerment of staff and patients.

Regardless of this, the corresponding adapters generally do not offer any aerosol or leak tightness.

A transfer device according to EP 1 430 864 B1 consists of a cap-like outer guide part and a tubular inner guide part, which are telescopically displaceable with respect to one another. When not in use, the origins of the inner guide part snap into recesses on the inside of the outer guide part. If the transfer device is pushed onto a vial, tongue-like elements extending from the inner guide part are bent outwards, with the result that the outer guide part is adjusted outward in the region of the recesses, so that the locking between the inner and outer guide parts is canceled. It is also disadvantageous that the transfer device can be removed from the vial after use without any problems, so that there is again a risk of injury to the user.

From the DE 10 2005 006 771 A1 a transfer device is known which comprises a needle holder with a transfer needle which is axially adjustable in a hollow cylindrical structure. The structure has a wall-shaped stop which can be placed on the opening of a storage container to be pierced and which is penetrated by the transfer needle when the transfer device is actuated.

A transfer device after the DE 698 08 432 T2 has an actuator in order to be able to axially adjust a first part having a mandrel to a second part surrounding a closure of a bottle by turning.

Of the DE 10 2005 006 771 A1 a fluid transfer device can be seen which comprises a sleeve-shaped guide structure with a needle holder with a puncture needle surrounded by this. The sleeve-shaped guide structure has a Embodiment axially extending movable sleeve strips, which have clamping elements for gripping a bead-like edge of a vial.

A transfer device after the WO 2009/029390 A1 has an inner and an outer adapter part which are ultrasonically welded in the flange-like edge area. The transfer device surrounds a vial, which in turn is surrounded by an envelope with which the transfer device latches.

These constructions also have the disadvantage that, after the transfer device has been used, it is possible to detach it from the vials without problems.

Because the vial and connector can be separated, there is also the disadvantage of the risk of contamination by e.g. B. inhalation or through the skin or the formation of aerosols when removing the needle from the vial.

the U.S. 5,364,386 A relates to an infusion device which has a first adapter part which surrounds a bottle, and a second adapter part which is displaceable along the first adapter part and which has a transfer element in the form of a cannula. There is the possibility that the first adapter part is connected to the second adapter part in two different positions.

Subject of WO 2007/101798 A2 is a transfer device with a cylindrical first part and a cap-shaped second part which is displaceable relative to the first part. The first part surrounds a vial. Projections extend from the first and second parts and cooperate to hold the parts in a desired position relative to one another. There is the possibility that the projections can be brought into grip.

Subject of EP 0 335 378 A2 is a liquid container comprising a tubular capsule with a cap which in turn houses a pressing element which is at Rotation of the cap causes a vial to be adjustable in the direction of a control device having a cannula in order to enforce the closure of the vial.

Another transfer device is in DE6503460 A1 described.

The present invention is inter alia. The underlying task is to provide a transfer device, i.e. a vial connector or adapter, which offers increased exposure security.

According to a further aspect, it should be ensured that, if necessary, an aerosol-tightness already exists when the vial, that is to say the bottle, is pierced.

One aspect is aimed at avoiding a hazardous leakage after the closure has been pierced.

Another aspect to be emphasized is that by keeping the adapter on the vial or around the vial, aerosols that are created by the separation process do not escape. The adapter should also provide aerosol-tightness during use.

Another aspect of the invention is that an injury after the use of the transfer device by the transfer element such as needle, cannula, spike, perforation device is excluded.

To solve one or more aspects, the invention provides that the first adapter part is permanently fixed to the bottle or around the bottle after the second adapter part has been moved along the first adapter part in the direction of the closure and the second adapter part is locked, and that the second adapter part has a hood or pot geometry with a cylindrical circumferential wall and an inner hollow cylindrical section running coaxially to this and surrounded by it, from which a sealing element extends, which seals the second adapter part against the first adapter part when the first and second adapter parts are assembled.

Radially adjustable fixing elements can extend from the first adapter part, via which the first adapter part is permanently fixed to the bottle after the second adapter part has been moved along the first adapter part in the direction of the closure and the second adapter part locked if the transfer device is properly handled.

In particular, the invention is characterized in that the first and second adapter parts surround the bottle in such a way that a closed envelope results, so that aerosol-tightness and leakage security is provided. For this purpose, in particular the first adapter part is cup-shaped and receives the bottle body. The second adapter part, from which the transition element extends, likewise has a hood-shaped or pot-shaped geometry that can latch with the first adapter part. In addition, a seal can extend from the second adapter part in order to seal the first and second adapter parts with respect to the bottle.

According to the invention, a transfer device is made available which, after use, that is to say after the closure has been pierced, can no longer be detached from the bottle, which is mainly referred to as a vial below. It can be provided that, before the transfer device is used, unintentional touching of the tip of the transfer element is excluded, so that the risk of injury is avoided.

It should be noted that the transition element is, for. B. can be a needle, a cannula, a spike or some other perforation device. So far is one There is no limitation of the invention. Rather, the term transfer element is intended to cover any suitable element that enables a medium transfer. Various terms are therefore also used, in particular puncture needle or cannula, without thereby restricting the teaching according to the invention.

In particular, the invention is characterized in that the first adapter part comprises a shell section surrounding the bottle circumferentially and having a hollow cylinder geometry with an end edge running on the bottle closure side - also called a shell wall - a bottom section that at least partially covers the bottom of the bottle, preferably completely, and a holding section running at the front edge, from which the fixing elements, which can be tongue-like or web-like, extend, which can be pivoted, bent or spread in the radial direction of the first adapter part and which extend in the direction of the longitudinal axis of the first adapter part.

After the vial has been introduced into the first adapter part, the fixing elements can consequently be supported at the transition between the bottle neck and the bottle body, with the result that the first adapter part can no longer be detached from the vial.

It is preferably provided that the holding section is a ring section running in the end edge region of the casing section, which z. B. can be fixed as clamped or glued to the edge of the jacket wall, which extends at least in sections along the inside of the jacket section and has first projections which extend in the axial direction and extend over the end edge. The latter opens up the possibility that the first and second adapter parts can be locked to one another. For this purpose, according to an alternative, second projections proceed from the outside of the jacket wall, which can be locked or locked in guides such as link slots of the second adapter part when the adapter parts are locked. The second projections cannot then be removed from the guides during normal handling of the transfer device.

In a further development of the invention, it is proposed that the second adapter part have an outer hollow cylindrical section and a boundary wall running transversely to its longitudinal axis, from which the puncture needle - i.e. the transfer element - starts or which is penetrated by the puncture needle.

Each guide for one projection has a first section starting from the free end edge of the outer cylinder section and running in its longitudinal direction, which merges into a second section running transversely to the first section, in which the second projection guided in this can be fixed and locked , which protrudes radially from the outside of the jacket wall of the holding section of the first adapter part.

In particular, it is provided that the second section of the guide has a cross-sectional reduction in the axial direction, the axial extent of which is smaller than the axial extent between the maximum distance between the first and second protrusions. Before and after the axial cross-sectional reduction, the axial extent between the boundary wall and the edge of the second section of the guide facing away from it should be at least equal to the maximum distance between distant sections of the first and second projections in the axial direction. Thus, the second adapter part must first be guided in the axial direction, i.e. in the longitudinal direction of the vial in the first section of the guide, i.e. adjusted in the direction of the first adapter part, in order to then rotate the second projections into the end section of the second section of the guide, which is limited by the cross-sectional reduction to be introduced and to be fixed there, so that there is no releasability between the first and second adapter part.

At least the delimitation of the second section of the guide facing away from the delimitation wall, i.e. on the bottle side, forming the inner edge in the direction of the delimitation wall should run at least partially inclined to the longitudinal axis of the first adapter part and thus the transfer device and enclose an obtuse angle to the longitudinal axis.

In order to enable the first adapter part to be guided to the second adapter part without tilting, a proposal of the invention provides that the inner cross section of the hollow cylindrical section of the second adapter part corresponds to the outer cross section of the jacket section of the first adapter part.

Safe guidance is also ensured by the overlapping of the adapter parts or by the previously explained axially extending guides such as link slots or by z. B. ensures long ribs that extend from one of the adapter parts or a sealing element connected to this, in particular from the second adapter part.

In a further development of the invention it is provided that an inner hollow cylindrical section runs coaxially to the outer hollow cylinder-shaped section of the second adapter part, with the one referred to as the first protective element preferably being arranged in a displaceable manner, with the tip of the when the first adapter part is not connected to the second adapter part Puncture needle runs between the protective element and the boundary wall of the outer hollow cylindrical section. This measure ensures that if the second adapter part is not connected to the first adapter part, injury from the puncture needle is avoided.

In order to enable secure fixation, i.e. to ensure non-detachability between the adapter parts, the invention further provides that the second projection in the projection of the outside of the jacket section has a rectangular or trapezoidal geometry with a corner, which when the first and second adapter parts are fixed to one another interacts with a cross-sectional reduction of the second portion of the guide causing step to prevent loosening.

A further embodiment of a transfer device according to the invention, which is no longer detachable from the vial after the closure has been pierced, provides that the first adapter part of the transfer device has a first, outer hollow cylindrical section extending on the bottle side and a first, extending from this inner hollow cylindrical section of smaller cross-section, that the first outer hollow cylindrical section axially extending the fixing elements forming tongue-shaped sections with radially inward projections in the respective free end area for gripping a section of the bottle, in particular its bead-like edge, and the second adapter part a second outer hollow cylindrical Has portion which is displaceable along the outside of the first outer hollow cylindrical portion of the first adapter part, that with the first outer hollow cylindrical portion of the first adapter part surrounded by the second outer hollow cylindrical portion an outwardly directed radial adjustment of the tongue-shaped portions is prevented or substantially prevented, and that from the second outer hollow cylindrical section of the second adapter part a third outer hollow cylindrical section of smaller cross section starts, within which a second inner hollow cylindrical section can be displaced as a second part of the second adapter part, from which the puncture needle extends.

According to the invention, a transfer device is presented which consists of the first adapter part, which can be fixed to a bottle or its neck, and a two-part second adapter part, which are axially displaceable to one another and to the first adapter part. The outer part of the second adapter part has the effect that when the hollow cylindrical section of larger cross section covers the first outer hollow cylindrical section of the first adapter part over a defined axial length, the tongue-shaped sections, in particular engaging behind the bead-like edge of the bottle, can no longer be adjusted outwards with the result that loosening from the bottle is impossible. At the same time, the adapter parts lock in place in order to prevent the second adapter part from being pulled back.

In particular, it is provided that the outer part of the second adapter part latches to the first adapter part. Preferably, a projection protruding radially inward from the second outer hollow cylindrical section of the second adapter part acts like a rib with a recess or step or an equivalent change in the geometry of the first hollow cylindrical section of the first Adapter part together in such a way that an axial displacement of the second adapter part to the first adapter part against the direction of penetration is prevented.

In a further development of the invention, it is proposed that an axial adjustment of the second adapter part to the first adapter part via a first removable fuse and of the second inner section to the third outer section of the second adapter part is prevented via a second removable fuse.

In the case of existing fuses, the first and second adapter parts consequently form a rigid unit - viewed in the axial direction. If the first fuse is removed after the transfer device has been pushed onto a vial, the second adapter part can be shifted as a sub-unit in the direction of penetration, whereby the desired locking between the first and second adapter part takes place with the result that the tongue-shaped, the radially after inwardly protruding projections having fixing elements are no longer adjustable to the outside, so that a detachment from the bottle is excluded.

When the first fuse is removed and the second fuse remains, however, the penetration needle cannot be adjusted relative to the outer part of the second adapter part. If the transfer device is fixed to the bottle by adjusting the second adapter part, i.e. after removing the first securing device, the second securing device is removed so that the second inner section is axially in the direction of the outer part of the second adapter part, which has the second and third outer hollow cylindrical section of the bottle is displaceable so that the cannula extending from the inner part of the second adapter part can pierce the closure.

In order to exclude the risk of injury from the penetration tip when the transfer device is not connected to a bottle, a further development provides that a protective element, referred to as a second protective element, extends from the first inner section of the first adapter part, between the and the second inner section of the second adapter part when the transfer device is not in use the tip of the penetration needle runs.

The adapter parts or their sections should be geometrically designed such that when the second adapter part is axially displaced to the first adapter part, the third outer section is guided on the outside and the second inner section of the second adapter part is guided along the first inner section of the first adapter part on the inside.

In particular, the first fuse should have a geometry of a ring section which, when the transfer device is not in use, penetrates a slot running in the third outer section of the second adapter part and engages in a recess such as a groove in the outer wall of the first inner section of the first adapter part.

It is preferably provided that the second inner section of the second adapter part has, on the puncture needle tip side, a base wall penetrated by the puncture needle and, facing away from the puncture needle tips, a preferably encircling flange section directed radially outward from its peripheral wall, in particular from the outer end region of the second inner section of the second adapter part, whose effective radial Extension is at least the same, preferably greater than the outer cross section of the third outer section of the second adapter part. This flange section serves as a handle in order to be able to axially adjust the second adapter part relative to the first adapter part or the inner section of the second adapter part relative to its outer section.

Furthermore, it is provided that the second securing device can also have a geometry of a second ring section, which is fixed between the free end edge of the third outer section and the flange section of the second inner section of the second adapter part when axially immovable between the first and second adapter parts.

In a further development, it is provided that the first and / or second protective element, by means of which the puncture needle tip, when the transfer device is not in use, against a unwanted contact is protected, is a disk element, wherein the first, preferably both the first and the second protective element, are axially displaceable in the first and second adapter part.

Furthermore, by means of undercuts or snap connections, it can be ensured that when the first and second adapter parts are put together, they cannot be detached from one another when used properly, even if they have not yet been fixed on a bottle. These measures create a closed system. Injury from the puncture needle is excluded.

A further development of the invention provides that with the first outer hollow cylindrical section of the first adapter part latched to the second outer hollow cylindrical section of the second adapter part in the use position of the transfer device between the second and third outer hollow cylindrical section of the second adapter part, the intermediate wall extending between the first outer hollow cylindrical section and the first inner hollow cylindrical section of the first adapter part extending intermediate wall rests.

To the second adapter part after the first adapter part to the required extent the bottle, d. H. in particular surrounds its bead-like edge extending from the bottle neck, to be able to move axially for locking the first adapter part, the second securing element remains between the third outer section and the second inner section of the second adapter part.

In a further development of the invention it is provided that, when the second securing element is present between the third outer section and the second inner section of the second adapter part, the third outer section and the second inner section are locked in such a way that axial adjustment against the penetration direction of the penetration needle is prevented.

Optionally, the invention is characterized in that when the second part is adjusted in the penetration direction of the puncture needle, the second adapter part interacts with the first adapter part in such a way that adjustment of the second adapter part to the first adapter part against the penetration direction is prevented.

The first and second adapter parts are designed in such a way that when they surround the bottle, they form a closed container, through which an escape of aerosol or, after piercing the closure, an escape of the medium present in the bottle to the outside is excluded, so that contamination z. B. by inhalation, through the skin, possibly. Oral, can not be done. The second element having the transition element can have a seal by means of which the second adapter part is sealed off from the bottle, in particular from both the bottle and the first adapter part.

In other words, the invention is also characterized by a transfer device for removing or transferring a medium from or into a bottle with a bottle neck, which can be closed via a closure, comprising a first adapter part that can be positioned on the bottle and a first adapter part that interacts with the first adapter part A second adapter part which is displaceable in the longitudinal direction of the bottle and has a transition element for protruding through the closure, wherein when the first and second adapter parts are pushed into one another, they form a closed container surrounding the bottle. It is provided that the second adapter part has a seal by means of which the second adapter part is sealed off from the first adapter part. The adapter parts are also inseparable.

In a further development of the invention it is provided that the insolubility of the adapter parts is achieved by the engagement of projections in recesses, which can only be displaced relative to one another in the direction of penetration of the transfer element such as cannula and can no longer be separated in the opposite direction.

The latching can be done by tongue-like elements that have latching hooks, which in turn interact with corresponding elements. The tongue-like elements can have different lengths.

The invention also includes sealing elements that prevent liquids, dusts, aerosols or the like from escaping from a closed space. These sealing elements can seal the adapter parts to one another or to one another. As a possible configuration, sealing elements are possible which have recesses, depressions, projections, which can also be circumferential and ring-shaped, or the like, in order to close off the space from the surroundings. The sealing elements can lie between the outer parts of the adapter, between the inner or the inner and outer parts of the adapter. The sealing elements can optionally also seal directly with respect to the bottle.

The sealing elements can also be designed in such a way that guide channels are formed so that the adapter parts can be shifted into one another or bottles into the adapter parts more easily.

Further refinements result from the claims.

The teaching according to the invention results, inter alia. the advantage that aerosol-tightness is already provided when the vial, i.e. the bottle, is pierced.

The invention also enables a leakage leading to a hazard to be avoided after the closure has been pierced.

The fact that the adapter remains in place prevents aerosols from occurring on the vial or around the vial, which result from the separation process. Aerosol-tightness is also ensured during use.

Another advantage of the invention to be emphasized is that an injury after the use of the transfer device by the transfer element such as needle, cannula, spike, perforation device is excluded.

The invention also relates to a kit consisting of a container with a medical agent, a bag with solvent for dissolving the medical agent and a transfer device for mixing the solvent with the medical agent.

The invention is defined by the claims.

Further details, advantages and features of the invention also emerge from the following description of preferred exemplary embodiments, which can be taken from the drawing.

Fig. 1

eine Explosionsdarstellung einer ersten Ausführungsform einer Transfervorrichtung,

Fig. 2

ein erstes Adapterteil der Transfervorrichtung gemäß Fig. 1,

Fig. 3

ein zweites Adapterteil der Transfervorrichtung gemäß Fig. 1,

Fig. 4a), 4b)

die Transfervorrichtung gemäß Fig. 1 in Draufsicht und im Schnitt entlang der Linie C-C,

Fig. 5a), 5b)

die Transfervorrichtung gemäß Fig. 1 in Draufsicht und im Schnitt entlang der Linie D-D,

Fig. 6a), 6b)

die Transfervorrichtung gemäß Fig. 1 in Draufsicht und im Schnitt entlang der Linie E-E,

Fig. 7a), 7b)

die Transfervorrichtung gemäß Fig. 1 in Draufsicht und im Schnitt entlang der Linie F-F,

Fig. 8

eine Seitenansicht einer zweiten Ausführungsform einer Transfervorrichtung,

Fig. 9

die Transfervorrichtung gemäß Fig. 8 in Draufsicht,

Fig. 10

die Transfervorrichtung gemäß Fig. 8 und 9 im Schnitt entlang der Linie A-A,

Fig. 11a), 11b)

die Transfervorrichtung gemäß Fig. 8 mit zugeordnetem Vial in Draufsicht und im Schnitt entlang der Linie B-B,

Fig. 12 a), 12b)

die Transfervorrichtung gemäß Fig. 8 in Draufsicht und im Schnitt entlang der Linie C-C,

Fig. 13a), 13b)

die Transfervorrichtung gemäß Fig. 8 in Draufsicht und im Schnitt entlang der Linie D-D,

Fig. 14a), 14b)

die Transfervorrichtung gemäß Fig. 8 in Draufsicht und im Schnitt entlang der Linie E-E,

Fig. 15a), 15b)

die Transfervorrichtung gemäß Fig. 8 in Draufsicht und entlang der Linie F-F,

Fig. 16a), 16b)

die Transfervorrichtung gemäß Fig. 8 in Draufsicht und im Schnitt entlang der Linie G-G,

Fig. 17a), 17b)

die Transfervorrichtung gemäß Fig. 8 in Draufsicht und im Schnitt entlang der Linie H-H,

Fig. 18

eine Alternative zu der Ausführungsform der Transfervorrichtung gemäß der Fig. 1 bis 7b), dargestellt in Draufsicht,

Fig. 19

eine Seitenansicht der Transfervorrichtung gemäß Fig. 18,

Fig. 20

einen Schnitt entlang der Linie A-A in Fig. 18,

Fig. 20a, 20b

eine Variante der Transfervorrichtung gemäß Fig. 18 im Schnitt sowie ein Detail,

Fig. 21

ein Detail der Fig. 20,

Fig. 22

eine Explosionsdarstellung der Transfervorrichtung gemäß der Fig. 18 bis 21,

Fig. 23a), 23b)

die Transfervorrichtung gemäß Fig. 22 in Draufsicht und im Schnitt entlang der Linie B-B,

Fig. 24a), 24b)

die Transfervorrichtung gemäß Fig. 22 in Draufsicht und im Schnitt entlang der Linie C-C,

Fig. 25a), 25b)

die Transfervorrichtung gemäß Fig. 22 in Draufsicht und im Schnitt entlang der Linie D-D,

Fig. 26a), 26b)

die Transfervorrichtung gemäß Fig. 22 in Draufsicht und im Schnitt entlang der Linie E-E,

Fig. 27a), 27b)

die Transfervorrichtung gemäß Fig. 22 in Draufsicht und im Schnitt entlang der Linie F-F,

Fig. 28a), 28b)

die Transfervorrichtung gemäß Fig. 22 in Draufsicht und im Schnitt entlang der Linie G-G,

Fig. 29

eine weitere Ausführungsform einer Transfervorrichtung als Alternative zu der der Fig. 18 bis 28b), dargestellt in Draufsicht,

Fig. 30

eine Seitenansicht der Transfervorrichtung gemäß Fig. 29,

Fig. 31

einen Schnitt entlang der Linie A-A in Fig. 29,

Fig. 32

ein Detail der Fig. 31,

Fig. 33a), 33b)

die Transfervorrichtung gemäß Fig. 29 bis 32 in Draufsicht und im Schnitt entlang der Linie C-C,

Fig. 34a), 34b)

die Transfervorrichtung gemäß der Fig. 29 bis 32 in Draufsicht und im Schnitt entlang der Linie D-D,

Fig. 35a), 35b)

die Transfervorrichtung gemäß der Fig. 29 bis 32 in Draufsicht und im Schnitt entlang der Linie E-E,

Fig. 36a) 36b)

die Transfervorrichtung gemäß der Fig. 29 bis 32 in Draufsicht und im Schnitt entlang der Linie F-F,

Fig. 37a), 37b)

die Transfervorrichtung gemäß der Fig. 29 bis 32 in Draufsicht und im Schnitt entlang der Linie G-G,

Fig. 38a), 38b)

die Transfervorrichtung gemäß der Fig. 29 bis 32 in Draufsicht und im Schnitt entlang der Linie H-H und

Fig. 39

die Transfervorrichtung der Fig. 29 bis 32 in Explosionsdarstellung.

Show it:

Fig. 1

an exploded view of a first embodiment of a transfer device,

Fig. 2

a first adapter part of the transfer device according to Fig. 1 ,

Fig. 3

a second adapter part of the transfer device according to Fig. 1 ,

Fig. 4a), 4b)

the transfer device according to Fig. 1 in plan view and in section along the line CC,

Fig. 5a), 5b)

the transfer device according to Fig. 1 in plan view and in section along the line DD,

Fig. 6a), 6b)

the transfer device according to Fig. 1 in plan view and in section along the line EE,

Fig. 7a), 7b)

the transfer device according to Fig. 1 in plan view and in section along the line FF,

Fig. 8

a side view of a second embodiment of a transfer device,

Fig. 9

the transfer device according to Fig. 8 in plan view,

Fig. 10

the transfer device according to Figures 8 and 9 in section along the line AA,

Fig. 11a), 11b)

the transfer device according to Fig. 8 with assigned vial in plan view and in section along line BB,

Fig. 12 a), 12b)

the transfer device according to Fig. 8 in plan view and in section along the line CC,

Fig. 13a), 13b)

the transfer device according to Fig. 8 in plan view and in section along the line DD,

Fig. 14a), 14b)

the transfer device according to Fig. 8 in plan view and in section along the line EE,

Fig. 15a), 15b)

the transfer device according to Fig. 8 in plan view and along the line FF,

Fig. 16a), 16b)

the transfer device according to Fig. 8 in plan view and in section along the line GG,

Fig. 17a), 17b)

the transfer device according to Fig. 8 in plan view and in section along the line HH,

Fig. 18

an alternative to the embodiment of the transfer device according to FIG Figures 1 to 7b ), shown in plan view,

Fig. 19

a side view of the transfer device according to Fig. 18 ,

Fig. 20

a section along the line AA in Fig. 18 ,

Figures 20a, 20b

a variant of the transfer device according to Fig. 18 in section as well as a detail,

Fig. 21

a detail of the Fig. 20 ,

Fig. 22

an exploded view of the transfer device according to FIG Figures 18 to 21 ,

Fig. 23a), 23b)

the transfer device according to Fig. 22 in plan view and in section along the line BB,

Fig. 24a), 24b)

the transfer device according to Fig. 22 in plan view and in section along the line CC,

Fig. 25a), 25b)

the transfer device according to Fig. 22 in plan view and in section along the line DD,

Fig. 26a), 26b)

the transfer device according to Fig. 22 in plan view and in section along the line EE,

Fig. 27a), 27b)

the transfer device according to Fig. 22 in plan view and in section along the line FF,

Fig. 28a), 28b)

the transfer device according to Fig. 22 in plan view and in section along the line GG,

Fig. 29

a further embodiment of a transfer device as an alternative to that of Figures 18 to 28b ), shown in plan view,

Fig. 30

a side view of the transfer device according to Fig. 29 ,

Fig. 31

a section along the line AA in Fig. 29 ,

Fig. 32

a detail of the Fig. 31 ,

Fig. 33a), 33b)

the transfer device according to Figures 29 to 32 in plan view and in section along the line CC,

Fig. 34a), 34b)

the transfer device according to the Figures 29 to 32 in plan view and in section along the line DD,

Fig. 35a), 35b)

the transfer device according to the Figures 29 to 32 in plan view and in section along the line EE,

Fig. 36a) 36b)

the transfer device according to the Figures 29 to 32 in plan view and in section along the line FF,

Fig. 37a), 37b)

the transfer device according to the Figures 29 to 32 in plan view and in section along the line GG,

Fig. 38a), 38b)

the transfer device according to the Figures 29 to 32 in plan view and in section along the line HH and

Fig. 39

the transfer device of the Figures 29 to 32 in exploded view.

In the figures, in which basically the same elements are provided with the same reference numerals, transfer devices are shown by means of which from a bottle or a bottle, a so-called vial, fluids such as dry substances or liquids such as water or solvents that are mixed for infusion or injection purposes before their use or administration. It can also be used for instillation or for solvent bags. Incidentally, the application cases are given purely by way of example. Corresponding transfer devices are also referred to as connectors or adapters. In order to connect the bottle to another container or an infusion device, a corresponding transfer device is required in order to perforate the closure of the bottle by means of a transfer element such as a puncture needle - such as a steel cannula. B. an injection bottle, an infusion bag, a solvent bag or a syringe.

The transfer devices shown in the figures have parts which are arranged telescopically and can be adjusted relative to one another and are also referred to as the first and second adapter parts. For the sake of simplicity, the transfer device is hereinafter referred to as the connector and the vial to be connected to this is referred to as the vial. The first adapter part is also known as the vial holder and the second adapter part as the cannula holder.

Furthermore, the transition element that establishes the connection to the interior of the vial is referred to below as a cannula, without this restricting the function and design.

With regard to the specified geometries of the components, it should be noted that these are to be understood purely as examples to the effect that deviations are also possible, provided that the basic principles of the invention can be implemented. The figures are also self-explanatory. In these the features characterizing the invention are clearly recognizable.

The connector 10 according to the Figures 1 to 7 has a first adapter part 12 and a second adapter part 14 as essential elements. The first adapter part 12 has a pot geometry with a peripheral wall 16, referred to as a jacket wall, and a bottom wall 18, in order to receive a small bottle, that is to say vial 20, which can be pushed into the first adapter part 12. The bottom wall 18 ensures that the vial 20 remains in the first adapter part 12. The bottom wall 18 does not have to be completely closed for this purpose. Preferably, however, a closed bottom wall 18 is provided in order to be able to provide a closed system which offers the possibility of an aerosol and leak tightness, as will be described below.

As shown in the detailed representation of the Fig. 2 As can be seen, in the open edge area of the circumferential wall 16, which is also referred to as the jacket section, a retaining element, referred to as a ring element or ring section 22, is provided, which has elastic first projections compressible in the axial direction, some of which are identified by the reference numerals 24, 26 are. Like the detailed representation according to Fig. 2 clarified, the ring element 22 engages around the end edge of the peripheral wall 16 in sections in order to ensure a fixation.

From the area of the ring element 22 running in the interior of the jacket wall 16, web-shaped or tongue-shaped elements, also referred to as fixing elements, extend in the axial direction, some of which are identified with the reference numerals 28, 30. As in particular the exploded view after Fig. 1 as well as the Figures 4 to 7 To illustrate, the tongue-shaped elements 28, 30 run inclined to the longitudinal axis 32 of the first adapter part 12 and thus of the vial 20, as a result of which the first adapter part 12 is secured on the vial 20; because like that Figures 4 to 7 mediate, the tongue-shaped elements 28, 30 are supported, when the vial 20 is positioned in the first adapter part 12, on the connecting wall 38 which runs at an angle between the bottle neck 34 of the vial 20 and its cylindrical body 36 and is also referred to as a transition. Thus, the vial 20 can no longer be pulled out of the first adapter part 12. The first adapter part 12 is thus the vial holder.

In addition to the vial 20, it should be noted that the bottle neck 34 has a circumferential bead 40 in the region of its opening. The opening of the vial 20 is closed by a stopper 42. It should also be noted that typically after the vial 20 has been closed with the stopper 42, an aluminum crimp cap is applied. A flip-off cap made of plastic can be located on this. This flip-off cap is pulled off the aluminum crimp cap, so that an opening is created in the middle of the aluminum crimp cap so that the sealing plug 42 is visible.

The second adapter part 14, which can also be referred to as the upper adapter part or outer part, comprises a hollow cylindrical section 44 which, facing away from the vial, is bounded by a wall 46 which runs transversely to the longitudinal axis 32 and is also referred to as a boundary wall, which has a cylindrical extension 48 in the center, one of which is referred to as a cannula Penetration needle 50 goes out and on the other hand, a breakaway connector 52 is placed on the outside. The second adapter part 14 is thus the cannula holder.

In the inner wall 54 of the hollow cylindrical section 44 of the second adapter part 14 guide-forming recesses 56, 58 are formed ( Fig. 3 ), each of which is composed of an axially extending section 60 and a section 62 extending transversely to this and along the wall 46. Associated with each guide 56, 58 is a second projection 64, 66 projecting radially outward from the peripheral wall 16 of the first adapter part 12 ( Fig. 2 ) in order to be able to lock the first adapter part 12 to the second adapter part 14 in the manner described below.

An inner hollow cylindrical section 68 runs coaxially to the outer hollow cylindrical section 44, within which the cannula 50 extends, but does not protrude beyond its end edge 70, as can be seen in particular from the Figures 4 to 7 results. In accordance with the drawings, a disk-shaped protective element 72 is received in a clamping manner from the inner hollow-cylindrical section 68, in the axial direction of the inner hollow cylindrical section 68 is adjustable. When the connector 10 is not in use, however, the tip 74 of the cannula 50 runs between the protective element 72 and the wall 46 and is consequently covered on the outside so that a user is protected against injury. The protective element 72 represents a configuration that is not mandatory.

There is also the possibility that z. B. instead of the disk-shaped protective element 72 from the end edge 70 of the inner hollow cylindrical portion 68 z. B. a membrane that is destroyed when the adapter parts 12, 14 or the axial displacement of the second adapter part 14 in the direction of the vial 20 and thus the first adapter part 12 is assembled.

Like the drawing according to Fig. 2, 3 To illustrate, the inner section 62 of the guide 56, 58 running transversely to the longitudinal axis 32 has a cross-sectional reduction in the axial direction formed by a step 76. As a result of the step 76, the section 62 experiences a quasi "constriction", ie the distance between the free edge or corner 78 of the respective second projection 64, 66 and the apex area of the first projections 24, 26 is greater than the distance between the The apex of the step 76 and the opposite edge of the section 62. In order to overcome the step 76, the first projections 24, 26 must consequently be compressed. After the projection 64, 66 is located within the end section 80 of the section 62 of the guide 56, 58 running along the wall 46, the projections 24, 26 can relax again with the result that when the first adapter part 12 is turned the second adapter part 14 takes place in the direction of the step 76, the projection 64, 66 protruding from the outside of the jacket wall 16 prevents further rotation by interacting with the step 76. The first and second adapter parts 12, 14 are thus permanently connected to one another. It is likewise not possible to remove the vial 20.

In order to support an axial guidance between the adapter parts 12, 14 when they are pushed together, ribs 17, 19 running in the longitudinal direction can serve as guide rails over the jacket wall 16.

The connection of the cannula 50 to the interior of the vial 20 is self-explanatory from the Figures 4 to 7 clear. In the Fig. 4 the position is shown in which the second adapter part 14 is placed on the first adapter part 12. The second adapter part 14 with its outer hollow cylindrical section 44 surrounds the jacket wall 16 and is guided by it. In order to prevent tilting, the inner diameter of the hollow cylindrical section 44 and the outer diameter of the jacket wall 16 are correspondingly matched to one another. The guide ensures that the cannula can be displaced along the longitudinal axis 32 of the vial 20 when the first and second adapter parts 12, 14 are pushed into one another. In particular, however, the ribs 17, 19 running in the direction of the longitudinal axis serve to ensure that the adapter parts 12, 14 are aligned with one another in the correct position in order to be displaced with respect to one another. Moving is also made easier since a linear contact is produced between the adapter parts 12, 14. The ribs 17, 19 also prevent tilting.

In Fig. 5 the position shown is that the cannula 50 has penetrated the stopper 42 and the cannula tip 74 is connected to the interior of the vial 20. In this position, the projections 64, 66 protruding from the outside of the jacket wall 16 and preferably having an uneven trapezoidal geometry are located in the transition between the axially extending sections 60 of the guides 56, 58 and the sections 62 extending transversely thereto or second adapter part 14 rotated to the lower or first adapter part 12 ( Fig. 6 ), so that the second projections 64, 66 are adjusted along the sections 62 of the guides 56, 58 that extend along the wall 46. The first and second adapter parts 12, 14 are locked when the second projections 64, 66 have overcome the steps 76 in the sections 62 of the guides 56, 58 and are located in the respective end section 80 of the guides 56, 58. To overcome the steps 76, it is first necessary for the first projections 24, 26 axially projecting from the end edge of the ring element 22 to be compressed to the required extent.

The lock is designed in such a way that it can only be released with an additional tool or with at least 300 N pull-off force, for example. After the connection with the vial 20 has been ensured, the break-off connector 52 can be destroyed and the mixing procedure can take place between the medicament present in the vial 20 and a liquid that is located in a bag previously connected to the break-off connector 52. In principle, a Luer lock connection or similar is also required. possible. A syringe, bottle or similar container can also be located on the breakaway connector or the like, such as a Luer lock connection. The same applies to all embodiments.

The Figures 8 to 17 a second connector 100 can be seen which does not have all the features of the invention and which also consists of a vial holder running on the vial side as a first adapter part 112 and a second adapter part 114 having the cannula 50 as a cannula holder. The connector 100 is also designed in such a way that after it has been connected to the vial 20, an unwanted or uncontrolled detachment from the vial 20 is no longer possible, as will be explained below.

The first or inner adapter part 112 comprises a first outer hollow cylindrical section 116 surrounding the bead 40 of the vial 20 when used properly and an inner hollow cylindrical section 118 which has a smaller diameter than the outer hollow cylindrical section 116. Between the hollow cylindrical sections 116, 118, an intermediate wall 120 runs transversely, in particular perpendicular to the longitudinal axis 32 of the connector 100 and thus, in the state connected to the vial 20, to the longitudinal axis of the vial 20.

The outer hollow cylindrical section 116 has tongue-shaped sections which are separated by axially extending slots 122 and are resilient to the required extent, two of which are identified by way of example with the reference numerals 124, 126. The tongue-shaped sections 124, 126 have inwardly projecting projections (see projection 128) at the end, which grip behind the bead-like edge 40 of the vial neck, when the first adapter part 112 is properly connected to the vial 20, as can be seen below with reference to the figures.

The second or outer adapter part 114 consists of two parts which can be adjusted telescopically with respect to one another, namely an outer part 130 and an inner part 132 from which the puncture needle 50 extends. The outer part 130 comprises a section 134 designated as the second outer hollow cylindrical section and section 136 designated as the third outer hollow cylindrical section, which have diameters which differ from one another. The third outer hollow cylindrical section 136 is smaller in cross-section than the second outer hollow cylindrical section 134, the inner diameter of which is adapted to the outer diameter of the first outer hollow cylindrical section 116 of the first adapter part 112, which enables axial guidance. Furthermore, the inner diameter of the third outer hollow cylindrical section 136 is adapted to the outer diameter of the first inner hollow cylindrical section 118 of the first adapter part 112, which also results in axial guidance.

To place the connector 100 on the vial 20, the first and second adapter parts 112, 114 are secured against axial displacement relative to one another by a first securing device 138, which preferably has the geometry of a ring section. The fuse 138 runs along a further partition 140 running between the second and third hollow cylindrical sections 134, 136 and extending parallel to the partition 120 and penetrates a slot in the third outer hollow cylindrical section 136 and extends partially in a recess aligned with the slot or groove in the first inner hollow cylindrical section 118 of the first adapter part 112. Furthermore, a second securing device 146 runs between the end edge 142 of the third outer cylinder section 136 and a flange-like extension extending from the inner or second part 132 of the second adapter part 112.

The inner part 132 of the second adapter part 114 has a hollow cylindrical shape, the outer diameter of which matches the inner diameter of the first inner hollow cylindrical portion 118 of the first adapter part 112 is adapted, whereby an axial guidance is made possible. Furthermore, the second part 132 of the second adapter part 114 is secured with respect to the first inner hollow cylinder-shaped section 118 via interlocking sections, in particular a preferably circumferential rib 133, which protrudes over the circumferential wall of the hollow cylinder-shaped inner or second part 132 of the second adapter part 114 and in a correspondingly adapted recess 153 engages in the inside of the first inner hollow cylindrical section 118 of the first adapter part 112.

The drawing also shows that a projection such as a clamping rib 147 protrudes from the inside of the second outer hollow cylindrical section 134 of the second adapter part 114 and engages in an adapted recess 148 of the first outer hollow cylindrical section 116 of the first adapter part 112 in such a way that a Loosening the adapter parts 112, 114 against the direction of penetration is not possible. Thus, before the connector 100 is placed on the vial 20, there is a unit which consists of the first and second adapter parts 112, 114.

So that a user cannot come into contact with the tip 74 of the cannula 50, according to a non-mandatory configuration, according to the exemplary embodiment of FIG Fig. 1 7 a disk-shaped protective element 172 can be received in a clamping manner by the first inner hollow-cylindrical section 118 of the first adapter part 112, which can have an opening in the center in order not to hinder the penetration of the cannula 50 when the stopper 42 is penetrated. Instead of the disk element, a membrane to be destroyed can also be provided.

Based on Figures 11-17 it can be seen how the connector 100 is connected to the vial 20 and its stopper 42 is penetrated. The figures are self-explanatory in this respect.

In Fig. 11 the connector 100 is aligned with the bottle neck 34 of the vial 20 such that the longitudinal axis of the connector 100 is aligned with the longitudinal axis 32 of the vial 20 is aligned. The second adapter part 114 is arranged to the first adapter part 112 due to the securing elements 138, 146 and the interlocking projections or clamping ribs in such a way that the first adapter part 112 can overcome the bead 40 of the bottle neck 34, that is, the tongue-shaped sections 124, 126 after can be spread on the outside in order to then spring back as soon as the bead 40 has been overcome and the projections 128 of the tongues 124, 126 can thus engage behind the bead 40. The positioning of the connector 100 after reaching behind the bead 40 is that Fig. 13 refer to.

Then the first securing device 138 extending along the partition 140 and securing the first and second adapter parts 112, 114 against axial displacement is removed ( Fig. 14 ), so that an axial displacement of the second adapter part 114 takes place when there is further axial force. Before that, the holding force generated by the protrusion or protrusions 133 or also referred to as a rib clamping rib, which connects the inner or second part 132 of the second adapter part 114 to the first inner hollow-cylindrical section 118 of the first adapter part 112, is overcome.

In the Fig. 15 the position is shown in which the second outer hollow cylindrical section 134 surrounds the first outer hollow cylindrical section 116 of the first adapter part 112 to such an extent that the tongue-shaped elements 124, 126, which can also be referred to as sections, can no longer be bent outward. At the same time, the projection 147, which previously prevented the second adapter part 114 from being withdrawn to the first adapter part 112, engages behind a recess in the free edge area of the tongue-shaped elements 124, 126, adapted by a step-shaped cutout 148, which ensures that a retraction of the second adapter part 114, i.e. a axial adjustment against the direction of penetration is not possible.

The second outer hollow cylindrical section 134 thus acts at the end as a clamping ring for the first outer hollow cylindrical section 116 of the first adapter part 112, which can also be referred to as a bell, whereby a after outwardly directed radial adjustment of the tongue-shaped elements 124, 126 is prevented. This creates a closed space before the stopper is pierced, so that no aerosols that arise through the opening of the vial can escape to the outside.

The resulting locking is designed so that this can only be done with an additional tool or pulling forces of z. B. 300 N can be solved. This ensures that the connector 100 remains connected to the vial 20 even after use.

The second securing device 146 is then removed so that the inner part 132 of the second adapter part 114, which has the cannula 50, can be adjusted in the penetration direction by exerting an axial force on the flange-like handle 144 in order to penetrate the stopper 42, as is shown in a comparison of FIG Figures 15-17 made clear. During the last axial adjustment of the inner part 132 of the second adapter part 114, the disc-shaped protective element 172 is pressed by the inside transverse wall 150 of the inner part 132 penetrated by the cannula 50 to rest against the outside of the stopper 42 or the aluminum cap covering it on the outside. Furthermore, the projection or the clamping rib 133 protruding radially from the outer wall of the hollow cylindrical section of the inner part 132 of the second adapter part 114 engages in a recess present in the inner wall of the first inner hollow cylindrical section 118 of the first adapter part 112 or engages behind a step 152, in order to exclude a retraction of the inner part 132 of the second adapter part 114.

After the second adapter part 114 is properly fixed, then the breakaway connector 52, on the previously z. B. a bag is applied, be destroyed in order to carry out the desired mixing procedure.

The Figures 18 to 28 is an alternative to the embodiment of FIG Figures 1 to 7 can be seen, so that the same reference numerals are used in principle for the same elements. The representations of the corresponding transfer device 200 to be referred to as a connector are self-explanatory.

In the case of the transfer device or the connector 200, the adapter parts cannot be detached by locking an outer or second adapter part 214 with the first adapter part 212 surrounding the vial 20. This has the advantage that when the adapter parts 212, 214 are assembled, they surround a closed space, in which the pierced closure stopper 42 of the vial 20 is located.

The first adapter part 212 has a pot geometry with a circumferential wall 216 and a bottom wall 218 in order to receive the vial 20. Likewise, a ring element 222 is provided in the open edge area of the circumferential wall 216, from which web-shaped or tongue-shaped elements extend in the axial direction and are identified by way of example with the reference symbols 228 and 230. Like in particular the Figures 20, 21 and 22nd To illustrate, the tongue-shaped elements 228, 230 run inclined to the longitudinal axis 232 of the connector 200 and thus of the vial 20, whereby the first adapter part 212 and the vial 20 form a solid unit when the vial 20 is properly received by the first adapter part 212; because in this case, when the vial 20 is positioned in the first adapter part 212, the tongue-shaped elements 228, 230 are supported on the connecting wall 38 running between the bottle neck 34 of the vial 20 and its cylindrical body 36. Thus, the vial 20 can no longer be pulled out of the first adapter part 212.

From the ring element 222, which is connected, such as glued or welded, to the end edge of the cup-shaped first adapter part 212, further inwardly protruding tongue-shaped elements 223, 231 proceed, which according to the illustration according to, for example, FIG Fig. 25 abut against the circumferential surface, that is to say the cylindrical body 36 of the vial 20. The tongue-shaped second elements 223, 231, which are longer than the tongue-shaped first elements 228, 230 serving as a safety device, serve as a positioning aid for the first adapter part 212 so that it surrounds the vial 20 concentrically.

The first adapter part 212 has latching depressions delimited by elevations on the circumferential side, like the sectional illustration according to FIG Fig. 20 made clear. By way of example, two locking depressions are identified by the reference numerals 310, 312. The projections delimiting the latching depressions 310, 312 have a tooth-shaped geometry such that their flanks on the slide-in side with respect to the second adapter part 214, ie the upper boundaries in the drawings, run ramp-shaped in such a way that the second adapter part 214 can be pushed onto the first adapter part 212 or pushing the first adapter part 212 into the second adapter part 214 is made possible, since projections 322, 324 of tongue-shaped elements 314, 316, 318, 320 that extend in the axial direction of the second adapter part 214 slide along the corresponding flanks . The opposite flanks have a correspondingly inclined course, so that when the projections 322, 324 emanating from the tongue-shaped elements 314, 316 engage in a latching recess 310, 312, the adapter parts 312, 314 can no longer be pulled apart with the usual introduction of force.

The axially extending tongue-like elements 314, 316, 318, 320 with the inwardly directed projections 322, 324 at their ends start from a ring element 326 which is fixed as welded in the opening area of the second adapter part 214. In this area, the second adapter part 214 has a bell-shaped geometry, like the sectional illustration in particular according to FIG Fig. 20 made clear. Correspondingly, the ring-shaped element 326 has a bead-like edge 328, which is connected, such as welded, to the bell-like extension 330 of the second adapter part 214. The tongue-like elements 314, 316, 318, 320 are inclined in the direction of the interior of the second adapter part 214 and are designed to be resilient in such a way that the first and second adapter parts 212, 214 can easily be pushed into one another, but - as explained above - they are prevented from being pulled apart . The lock is designed in such a way that it can only be released with an additional tool or with at least 300 N pull-off force, for example.

Furthermore, the inner wall of the cylindrical section of the second adapter part 214 is lined with a seal 332 which, when the adapter parts 212, 214 are assembled, rests in a sealing manner on the jacket wall 216 of the first adapter part 212. This creates a closed space. If the bottom wall 218 of the first adapter part 212 is also closed, the vial 20 is completely closed off from the environment. This is the preferred embodiment.

From the Fig. 22 it also results that the seal 332 can have circumferential annular elevations 333.

As in the embodiment of Figures 1 to 7 runs concentrically to the hollow cylindrical circumferential wall 244 of the second adapter part 214, which merges into a boundary or bottom wall 245, an inner hollow cylindrical section 268, which at the end has an inwardly directed, preferably circumferential projection 270 which, when the first and second adapter parts 212, 214 are assembled, forms the bead-like edge 40 of the vial 20 engages behind, such. B. the detailed representation according to Fig. 21 made clear. This provides an additional safeguard against the adapter parts 212, 214 being pulled apart.

Furthermore, a stop, preferably designed as a circumferential ring or web 217, extends from the jacket wall 216 and consequently extends radially from the circumferential wall. The free outer edge of the second adapter part 214 rests against the stop when the adapter parts 212, 214 have been properly assembled and the cannula 50 has thus penetrated into the vial 20 to the required extent.

In the Figures 23a) to 28b ) the connection of the cannula 50 to the interior of the vial 20 is illustrated in a self-explanatory manner. So is in the Figure 23a ), b) the attachment of the first adapter part 212 surrounding the vial 20 to the second adapter part 214 is shown. the Figure 24a ), b) shows the connection. In the Figure 25a ), b) a position is shown in which the projections 322, 324 protruding from the tongue-like elements 314, 316, 318, 320 in their end region are already in a locking recess or recess 310 engage so that there is a locking position, but the plug 42 is not yet fully pierced.

the Figure 26a ), b) reflect a position in which the first adapter part 212 has been pushed further into the second adapter part 214. Another deeper intervention is that Figure 27a ), b). In the Figure 28a ), b) the end position is shown in which the free edge of the second adapter part 214 rests against the annular projection 217 of the first adapter part 212, which serves as a stop. At the same time, the inwardly directed, preferably at least partially circumferential, protrusion 270 extending from the edge area of the inner hollow cylindrical section 268 of the second adapter part 214 engages behind the bead-like extension 40 of the vial 20. After the adapter parts 212, 214 are pushed together and the second adapter part 214 rests against the through the The stopper formed in the projection 217 is completely pierced by the cannula 50.

Of course, a stop is not a mandatory feature. Rather, an optical display such as a color marking can also serve to make the user recognizable that the adapter parts 212, 214 are pushed into one another to an extent that the stopper 42 is pierced by the cannula 50 to the required extent.

After the adapter parts 212, 214 have been properly pushed together, the break-off connector 52 extending from the bottom wall 245 of the second adapter part 214 can then be removed.

With regard to the locking recesses or depressions 310, 312 and the locking projections 322, 324, it should be noted that, according to an alternative, a connection between the adapter parts 212, 214 is also possible in that the locking recesses 310, 312 are sections of a thread into which the projections 322, 324 engage so that the first adapter part 212 is joined to the second adapter part 214 in the manner of a screw connection. However, it is also impossible to detach, since in the final state at least one of the inner cylindrical section 268 moves internally protruding projection 270 engages behind the bead-like edge 40 of the vial 20. Of course, several projections or a circumferential projection can also be provided.

The Figures 20a, 20b FIG. 10 is an embodiment of the transfer device 200 of FIG Figures 18 to 28 refer to. Since the structure is basically the same, the same reference symbols are used for the same elements. The embodiment of the den Figures 20a and 20b to be removed transfer device differs from that of the Figures 18 to 28 to the effect that no inwardly directed projection extends from the inner hollow cylindrical section 268 and engages behind the bead-like edge 40 of the vial 20. Otherwise the same construction can be found. In particular, it can also be seen from the figures that the circumferential or jacket wall 216 of the first adapter part 212 with the ring element 222 runs in the annular gap 269 running between the inner hollow cylindrical section 268 and the circumferential wall 244 when the adapter parts 212, 214 are assembled. The annular gap 269 thus offers a guide when the adapter parts 212, 214 are pushed together. At the same time, a seal takes place between the ring element 222 and the annular gap 269 and thus between the adapter parts 212, 214.

An embodiment according to the invention of a transfer device to be referred to as a connector is the Figures 29 to 39 refer to. In principle, the same reference numerals are used for the same elements. In the case of the transfer device 400, too, there is basically an inseparability between a first adapter part 412 surrounding the vial 20 with the sealing plug 42 and a second adapter part 414 with a hood or cup-shaped geometry as soon as the first and second adapter parts 412, 414 are connected to one another by latching . Furthermore, the first and second adapter parts 412, 414 surround a closed space which surrounds the vial 20, the space already being closed before the cannula 50 proceeding from the second adapter part 414 penetrates the sealing plug 42.

Basically unsolvable means that loosening without tools or with the action of a pull-off force of less than 300 N is not possible.

The first adapter part 412 has a pot geometry with a peripheral wall 216 and a bottom wall 218 in order to receive the vial 20. From the circumferential wall 216, which is also referred to as the jacket wall, detent depressions bounded by elevations emanate, two of which are identified by way of example with the reference numerals 310 and 312. The projections delimiting the latching depressions 310, 312 have a tooth-shaped geometry such that their flanks running in relation to the second adapter part 414, ie the upper delimitations in the drawings, run ramp-shaped. This enables the second adapter part 414 to be pushed onto the first adapter part 412 or the first adapter part 412 to be pushed into the second adapter part 414 without problems, as will be explained below. The structure of the locking recesses 310, 312 and the projections delimiting them are shown in FIG Fig. 32 clearly recognizable.

So that when the first and second adapter parts 412, 414 are assembled, loosening, i. H. a pulling apart against the direction of penetration of the cannula 50 is no longer possible, radially inwardly projecting projections 423, 425 of tongue-shaped elements running in the axial direction of the second adapter part 414 act with the locking depressions 310, 312, some of which are exemplified with the reference numerals 416, 418 , 420, 424 are marked. The tongue-shaped elements 416, 418, 420, 424, which form locking hooks with their radially inwardly projecting projections 423, 425, are based on a ring element 430 which is firmly connected to the second or outer adapter part 414, in particular by welding or gluing. Other types of fastening are also possible.

The ring element 430 is preferably fixed in the inner area of a bell-like extension 432 of the second adapter part 414, such as in particular the Fig. 31 made clear. The tongue-shaped elements 416, 418, 420, 424 extending from the ring element 430 in the direction of the bottom wall 434 running transversely to the longitudinal axis of the adapter part 414 span a circumferential edge, that is to say an envelope which is adapted to the outer circumference of the first adapter part 412, so that when the first adapter part 412 with the vial 20 is inserted into the second or outer adapter part 414, there is no tilting, rather a secure axial guidance is ensured.

In order to seal the first adapter part 412 against the second adapter part 414 when it is plugged together, a seal 436 extends from the inside of the second adapter part 414 and consists of an inner section 438 running in the longitudinal direction of the adapter part 414 and an outer section parallel to this and forming a gap 446 exists. In section, the seal 436 has the geometry of a U with unequal legs, the shorter leg of which runs on the outside. In the gap extends an edge section 440 of an inner hollow cylindrical section 444 running coaxially to the circumferential wall 442 of the second adapter part 414, as also from FIG Fig. 32 is clearly evident. The seal 436 is glued to the hollow cylindrical section 444 or connected in some other suitable manner or otherwise fastened such as clamped. The outer side of the outer section 446 of the seal 436 runs in alignment with the outer surface of the hollow cylindrical section 444, as is also shown in FIG Fig. 32 can be seen. When the first and second adapter parts 412, 414 are pushed together, the outer section 446 of the seal 436 slides along the inside of the peripheral wall 216 of the first adapter part 412 and thus seals the outer adapter part 414 from the first or inner adapter part 412.

Again Fig. 39 As can be seen, the inner surface of the inner section 438 of the seal 436 has longitudinal ribs 439 which serve to guide the vial 20. Furthermore, the inner section 438 is beveled on the inside starting from its edge (line 441), as in FIG Fig. 32 made clear. As a result, the vial 20 is also guided. At the same time, the vial 20 is sealed off, as in FIG Fig. 32 made clear. Furthermore, there are projections 447 on the outside of the outer section 446 of the seal 436, as a result of which a seal takes place between the first adapter part 412 and the second adapter part 414 in the area of the latching depressions 310, 312. This creates a seal between the first and second adapter part 412, 414 guaranteed. As mentioned, the seal also rests on the vial 20 or its inclined neck section (connecting wall 38).

The interaction of the locking projections 423, 425 of the tongue-shaped locking elements 416, 418, 420, 424 with the locking depressions 310, 312 ensures, due to their geometry, that after the locking projections 423, 425 hook into one of the depressions 310, 312, the adapter parts 412 , 414 is no longer possible, rather before penetration of the plug 42, only a sliding into one another in the direction of penetration is permitted. This creates a closed space before the stopper is pierced, so that no aerosols that arise through the opening of the vial can escape to the outside.

The penetration takes place by further pushing together to an extent that the cannula 50 penetrates the stopper 42 and the cannula 50 pierces the stopper 42 completely. The adapter parts 412, 414 can be pushed into one another until the lower edge of the second adapter part 414 or the ring element 430 running in this area comes to rest on a radially circumferential web 217 which protrudes from the circumferential wall 216 of the first adapter part 412, as also in connection with the embodiment of FIG Figures 18 to 28 the case is.

The interaction of the first and second adapter parts 412, 414 until the cannula 50 has completely penetrated the sealing plug 42 results from the Figures 33 to 38 that are self-explanatory.

This is how in Fig. 33 the placement of the upper or second adapter part 414 on the lower or inner or first adapter part 412 is shown after the vial 20 has been inserted into the lower adapter part 412.

From the Fig. 34 it can be seen that the lower adapter part 412 has been pushed to a certain extent into the outer adapter part 414 without the cannula being removed Closure plug 42 penetrated. Independently of this, however, the latching hooks formed by the projections 423, 425 protruding radially inward from the tongue-shaped elements 416, 418, 420, 424 already latch with the first latching recess 310.

The further nesting of the adapter parts 412, 414 results from the further figures, wherein in FIG Fig. 38 the first adapter part 412 is pushed into the outer adapter part 414 to such an extent that the latter rests against the circumferential stop 217, that is to say that it can no longer be pushed into one another. In this position, the cannula 50 has penetrated the closure plug 42 to the required extent. The connector 52 can then be canceled in order to, for. B. initiate the mixing process via a hose of a solvent bag. Of course, a stop 217 is not absolutely necessary. Rather, it can also be made clear to a user by means of an optical marking, such as a circumferential ring, that the adapter parts 412, 414 are pushed into one another to the required extent so that the cannula 50 has pierced the stopper 42 to a sufficient extent.

Another embodiment of the den Figures 29 to 39 Please refer to the embodiments to be taken. So there is the possibility that the first or inner adapter part 412 z. B. in the delivery state, in which a vial is not yet surrounded, is plugged together with the second or outer adapter part 414 in such a way that the bottom side of the first adapter part 412 is pushed into the outer or second adapter part 414, which ensures that the tip the cannula 50 cannot be detected. Pushing in is limited by the latching hooks, that is, by the latching elements 416, 418, 420, 424 with their latching projections 423, 425. This ensures that the cannula 50 cannot penetrate the bottom of the first adapter part 412. The latching hooks can have different lengths, so that the bottom side of the adapter part 412 rests on the shorter hook. 10 Connector / transfer device 100 Connector / transfer device 12th first adapter part 112 first adapter part 14th second adapter part 114 second adapter part 16 Circumferential wall / jacket wall 116 outer hollow cylindrical section 17.19 Ribs 118 inner hollow cylindrical section 18th Bottom wall, section 120 Partition 20th Vial / bottle 122 Slots 22nd Retaining element / ring element / section 124 tongue-shaped section / element 24 Ledges 126 tongue-shaped section / element 26th Ledges 128 head Start 28 Element / fixing element 130 outer adapter part 30th Element / fixing element 132 inner hollow cylindrical section 32 Longitudinal axis 133 Rib / protrusion / clamping rib 34 Bottleneck 134 second outer hollow cylindrical section 36 cylindrical body 136 third outer hollow cylindrical section 38 Connection wall / transition 138 first backup 40 bead 140 Partition 42 Plug / sealing plug 147 Projection / clamping rib 44 hollow cylindrical section 150 Transverse wall 46 Wall / boundary wall 152 step 48 Appendix 142 Forehead 50 Penetration needle / cannula 144 section 52 Breakaway connector 146 Fuse element 54 Inner wall 148 Cutout 56 Consolidation / leadership 153 Recess 58 Consolidation / leadership 172 Protective element 60 section 62 section 64 head Start 66 head Start 68 inner hollow cylindrical section 70 Forehead 72 Protective element 74 Cannula tip / tip 76 step 78 Edge / corner 80 End section 200 Connector / transfer device 400 Connector / transfer device 212 Adapter part 412 Adapter part 214 Adapter part 414 Adapter part 216 Jacket wall 416 tongue-shaped element 217 Web / protrusion 418 tongue-shaped element 218 Bottom wall / section 420 tongue-shaped element 222 Ring element / section 223 tongue-shaped element 423 head Start 228 Element / fixing element 424 tongue-shaped element 230 Element / fixing element 425 head Start 231 another tongue-shaped element 430 Ring element 244 Perimeter wall 432 extension 245 Boundary / floor wall 434 Bottom wall 268 inner wood-cylindrical section 436 poetry 269 Annular gap 438 inner section 270 head Start 439 Longitudinal ribs 440 Edge section 310 Locking recess / recess 441 line 312 Locking recess / recess 442 Perimeter wall 314 element 444 hollow cylindrical section 316 element 446 outer section 318 element 447 Ledges 320 element 322 head Start 324 head Start 326 Ring element 328 edge 330 extension 332 poetry 333 annular elevation

Claims (11)

1. A transfer device (400) for the withdrawal or delivery of a medium out of or into a bottle (20) with a neck (34), that is sealable by a closure (42), comprising

   - an inner first adapter component (412) that can be positioned on the bottle, and

   - a second adapter component (414), which interacts with the first adapter component, is moveable in the longitudinal direction of the bottle, and comprises a delivery element (50) for piercing the closure,

   characterized in that
   whereby after moving the second adapter component (414) along the first adapter component (412) in the direction of the closure (42) and locking of the second adapter component, the first adapter component is secured in position non-detachably at the bottle (20) or around the bottle, and in that the second adapter component (414) possesses a hood- or cup-shaped geometry with a cylindrical circumferential wall (442) and, extending coaxial to and surrounding by the latter, an inner hollow-cylindrical section (444), from which originates a sealing element (436) which, when the first and the second adapter components (412, 414) have been assembled, seals the second adapter component against the first adapter component.
2. The transfer device according to claim 1,
   characterized in that
   the sealing element (436) possesses a U-shaped geometry having non-isosceles legs in section, with an inner and an outer leg, in between which extends in sections the inner hollow-cylindrical section (444).
3. The transfer device according to claim 1 or 2,
   characterized in that
   the second adapter component (414), in its position when surrounding the first adapter component (412), is sealed against the first adapter component by the sealing element (436) embodied as an insert.
4. The transfer device of at least one of the preceding claims,
   characterized in that
   the cylindrical circumferential wall (442) comprises first latching elements (416, 418, 420, 423, 424, 425) or the latter originate from the second adapter component or an element connected to the latter, and in that the first latching elements interact with second latching elements (310, 312) of the first adapter component (412), extending on the casing wall side, in such a manner that an adjustment of the second adapter component relative to the first adapter component against the penetration direction of the puncture needle (50) is prevented.
5. The transfer device of at least one of the preceding claims,
   characterized in that
   from the second adapter component (414) originates at least one first latching element (418, 420, 424), which preferably is embodied as an axially extending bendable tongue element with a latching projection (423, 425) at its end side, with the latching projection extending in the direction of the longitudinal axis of the second adapter component (414) or of the transfer device (400), and preferably engaging in latching depressions (310, 312), bordered by tooth-like projections, of the first adapter component (412).
6. The transfer device of at least claim 5,
   characterized in that
   the at least one tongue element (416, 418, 420, 424) originates from an annular element (430), as the element, that is joined, such as welded, to the outer hollow-cylindrical section (442) of the second adapter component (414).
7. The transfer device of at least one of the preceding claims,
   characterized in that
   from the casing wall (216) of the first adapter component (412) protrudes a limit stop, such as a circumferential annular projection (217), with which, when the first and the second adapter components (412, 414) are properly connected, the latter is in contact with.
8. The transfer device of at least one of the preceding claims,
   characterized in that
   when the transfer device (400) is secured in position at or around the bottle (20), the first and the second adapter components (412, 414) form a surrounding sealed envelope that surrounds the bottle at least in the area of the closure element (42).
9. The transfer device of at least one of the preceding claims,
   characterized in that
   when the first and the second adapter components (412, 414) have been at least partially pushed into each other, they form a sealed container that surrounds the bottle (20).
10. The transfer device of at least one of the preceding claims,
    characterized in that
    during an adjustment of the second adapter component (414) in the penetration direction of the puncture needle (50), the first adapter component (414) interacts with the second adapter component in such a manner, that an adjustment of the second adapter component relative to the first adapter component against the penetration direction is prevented.
11. A Kit, consisting of a container with a medical agent, a bag with a dissolving agent for dissolving the medical agent, as well as a transfer device, of at least one of the preceding claims, for mixing the dissolving agent with the medical agent.

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