EP3090957B1 - Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort - Google Patents

Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort Download PDF

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Publication number
EP3090957B1
EP3090957B1 EP16175337.1A EP16175337A EP3090957B1 EP 3090957 B1 EP3090957 B1 EP 3090957B1 EP 16175337 A EP16175337 A EP 16175337A EP 3090957 B1 EP3090957 B1 EP 3090957B1
Authority
EP
European Patent Office
Prior art keywords
valve
liquid
tubular wall
wall
support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP16175337.1A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3090957A1 (fr
Inventor
Gaëtan Painchaud
Guillaume Grevin
Xavier Julia
Thierry Decock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nemera la Verpilliere SAS
Original Assignee
Nemera la Verpilliere SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Nemera la Verpilliere SAS filed Critical Nemera la Verpilliere SAS
Priority to EP25184660.6A priority Critical patent/EP4596110A2/fr
Priority to EP22201129.8A priority patent/EP4147990B1/fr
Publication of EP3090957A1 publication Critical patent/EP3090957A1/fr
Application granted granted Critical
Publication of EP3090957B1 publication Critical patent/EP3090957B1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
    • B65D47/2031—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure the element being formed by a slit, narrow opening or constrictable spout, the size of the outlet passage being able to be varied by increasing or decreasing the pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B05B11/00444—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means with provision for filtering or cleaning the air flow drawn into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
    • B65D47/2056—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type
    • B65D47/2081—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type in which the deformation raises or lowers the valve port
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

Definitions

  • the invention relates to the field of the distribution of liquid in the form of drops, in particular in the pharmaceutical field, for example ophthalmic or auricular liquid.
  • a liquid distribution device comprising an elastomeric diaphragm forming a valve, arranged between a support and a cover mounted on the reservoir.
  • the diaphragm comprises an annular peripheral bead and is held on the device by pinching this bead between the upper surface of the support and the lower surface of the cover. Maintaining the diaphragm in the device is therefore ensured by pinching in the axial direction of the device.
  • a disadvantage of this type of assembly is that when a user presses on the reservoir to release liquid, the liquid exerts pressure on the diaphragm in the axial direction in order to open it, and a such pressure can generate liquid leaks at the periphery of the diaphragm. This risk of leakage is all the more likely that the parts have dimensions or relative positions which may vary, due to manufacturing tolerances.
  • the presence of a leak in the device is troublesome, and all the more so if the liquid does not contain a preservative, because the liquid is found in undesirable places of the device, which promotes the development of bacteria and can subsequently contaminate the liquid.
  • the object of the present invention is in particular to provide a dispensing device in which sterility is improved.
  • the inner and outer tubular walls are arranged in such a way that they effect a radial compression of the fixing wall of the valve, that is to say that they press on either side of the wall fixing, in the radial direction, corresponding to the direction perpendicular to the axis of the tubular walls, this radial compression ensuring a seal of the valve.
  • the dispensing device comprises, in the zone for fixing the valve, three concentric tubes, possibly of short length, the inner tube corresponding to the inner tubular wall, the intermediate tube corresponding to the fixing wall of the valve and the outer tube corresponding to the outer tubular wall.
  • These tubes all have the same axis, corresponding to the axis of the dispensing device, this axis generally being an axis of revolution of the device, in particular of the reservoir, corresponding to the direction in which the liquid leaves the valve. It is understood that, to ensure a satisfactory seal, the diameter of the inner tubular wall is slightly greater than the diameter of the fixing wall, itself slightly greater than the diameter of the outer tubular wall.
  • the proposed device requires less precision in the dimensions of the fastening elements. In fact, pinching via the tubes guarantees a good seal, even if the components have relative positions that may vary slightly in the axial direction due to manufacturing tolerances or positioning tolerances during assembly in the axial direction.
  • the outer or inner tubular wall can advantageously constitute a wall for centering the valve, which facilitates its assembly.
  • tubular walls is advantageous in terms of compactness. Indeed, the axial position of the fixing zone can be moved further downstream of the dispensing device, for example on either side of the part forming a valve, which can make it possible to reduce the diameter of the dispensing tip . Furthermore, since the seal is exerted by tubular walls, the compression surface exerted by the fixing elements is increased, which provides better sealing.
  • the proposed device is very useful in cases where it is desired to dispense a liquid containing no preservative. Indeed, with this type of liquid, compliance with sealing must be particularly reliable.
  • the dispensed liquid is, in this example, a pharmaceutical liquid, such as ophthalmic or auricular liquid.
  • the device 10 comprises a dispensing endpiece 12, mounted by screwing on the neck of a reservoir 13.
  • the device 10 is configured so as to dispense liquid following pressure exerted by the user on the reservoir 13.
  • the reservoir is elastically deformable, so as to resume its shape after pressure exerted by the user.
  • the device 10, at least the reservoir 13 has an axis X of revolution, also corresponding to the liquid ejection direction.
  • the tip 12 includes a support 14, a valve 16, a spring 17, a cover 18 and a hydrophobic filter 20.
  • the support 14 comprises, in this example, a part 22, arranged at the proximal end of the endpiece, for fixing the support to the reservoir 13.
  • This part 22 comprises an outer skirt 24, threaded so as to be screwed onto the neck of the reservoir 13, and an internal skirt 26, of tubular shape, making it possible to ensure the seal between the reservoir and the dispensing nozzle 10.
  • the support 14 also comprises an intermediate part 28, forming a seat for the valve 16.
  • This intermediate part 28 has substantially the shape of a disc, extending in a radial plane R perpendicular to the axis X.
  • the disc 28 is delimited, on its distal face, by an outer tubular wall 30. This wall forms a peripheral skirt of the disc 28, it extends perpendicularly to the disc 28, in the form of an X-axis tube, high enough to receive valve 16, as described below.
  • THE disc 28 comprises, in the lower vicinity of the tubular wall 30, an annular rib 32, making it possible to delimit a groove for centering and receiving the edge of the valve 16.
  • the disc 28 also comprises a cylindrical central part 34 for closing of the valve, projecting from its center, from the distal side of the disc 28 and carrying, at its distal end, a bearing surface 36 of the valve 16.
  • This part 34 forms a closing pin allowing the opening or closing of the valve 16.
  • the disc 28 is also traversed by a channel 38 for passage of liquid coming from the reservoir.
  • This channel 38 leads to a cavity 40, delimited in particular by a recess made at the distal surface of the disc 28.
  • This cavity 40 also leads to a second liquid passage channel 42, delimited by the pin 34 and the valve 16.
  • channels 38 and 42 have an axis substantially parallel to the X axis.
  • the disc 28, the outer tubular wall 30 and the obturation pin 34 define a tubular cavity for receiving the valve 16.
  • the support 14 comprises a channel 44 for the passage of air into the reservoir, this channel 44 leading to a housing 46 for receiving the hydrophobic filter 20, this housing 46 being cylindrical, open at its proximal end for the insertion of the filter 20.
  • the valve 16 comprises a central cylindrical part 48, an annular peripheral skirt 50, the central part 48 and the skirt 50 being interconnected by a web of material 52.
  • the web 52 carries, on its distal surface, a seat 53 of support of the spring 17.
  • the distal part 54 of the central part 48 is a part forming a valve, ensuring the blocking and the passage of liquid, by cooperation with the support surface 36.
  • the surface 36 forms a support for the part 54 forming a valve when the latter is in liquid blocking configuration.
  • the upper surface of part 48 comprises a channel 56 for ejecting the liquid, leading to a form 58 for metering a drop.
  • the skirt 50 forms a fixing edge of the valve 16 on the support, for the permanent fixing of the valve relative to the reservoir 13. It consists of a fixing wall 50, tubular with axis X, of diameter slightly greater than the inside diameter of the outer tubular wall 30.
  • valve 16 is entirely made of an elastomeric material. Nevertheless, provision can be made for the valve to include certain parts made of an elastomeric material and other parts of a more rigid material, in particular the part 53 forming a support for the spring 17.
  • the part forming a valve 54, the veil 52 and the fixing wall 50 are made of elastomeric material.
  • the cover 18 is attached by snap-fastening to the support 16, thanks to snap-fastening means 59.
  • the snap-fastening means 59 make it possible to carry out a snap-fastening of the cover 18 with respect to the support 14 following an assembly in the axial direction X. It carries an inner tubular wall 60, of axis X and of diameter slightly greater than the diameter of the fixing wall 50 of the valve.
  • the cover 18 also comprises an outer casing 62 forming an outer skirt, extending towards the proximal direction with respect to the rest of the cover 18, as well as a bottom 64, so that the wall 60, the bottom 64 and the envelope 62 delimit a groove intended to sandwich the fixing wall 50 and the outer tubular wall 30.
  • the cover 18 largely covers the valve 16, while being however crossed in its center by the central part 48 of the valve. To this end, the cover 18 delimits a cylindrical cavity by means of a tubular inner skirt 66, having a function of centering the valve 16. The skirt 66 also delimits a groove 68 forming a support seat for the spring 17.
  • the pressure of the fluid in the channel 42 deforms the part forming a valve 54, so as to cause it to pass from its liquid blocking configuration to a liquid passage configuration, by detachment of the part 54 with respect to the support surface. 36. This deformation is facilitated by the compression of the spring 17 under the pressure of the liquid. The liquid is then dispensed in the form of drops.
  • the assembly comprises a step of assembling the end piece 12, then followed by a step of screwing this end piece 12 onto the tank 13.
  • the assembly of the endpiece 12 begins with a step of installing the valve 16 on the support 14, by inserting the fixing wall 50 of the valve inside the tubular wall 30 of the support 14. This step is illustrated on the figure 2a , it is followed by a step of inserting the spring 17 around the central part 48 of the valve, illustrated in the figure 2b .
  • a step of installing the cover 18 above the valve 16, illustrated in the figure 2c by inserting the inner tubular wall 60 inside the fixing wall 50.
  • This installation of the cover 18 is completed by snapping the cover onto the support 14, illustrated in the 2d figure , this snap-fastening being simultaneous with the permanent fixing of the valve 16 on the endpiece 12, sandwiched between the inner 60 and outer 30 tubular walls.
  • the veil 52 is under elastic stress so as to press the end 54 against the surface 36. This pressing is further facilitated by the return force of the spring.
  • the static sealing achieved around the fixing wall 50, by pinching the walls 60 and 30, is particularly effective. Indeed, when the liquid escapes from the reservoir 13, it exerts a pressure on the valve 16 in the X direction, and this pressure in the X direction does not affect the fixing part 50, the fixing of the valve being ensured by compression in the radial direction R.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Devices For Dispensing Beverages (AREA)
  • Feeding And Controlling Fuel (AREA)
  • Springs (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Check Valves (AREA)
EP16175337.1A 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort Active EP3090957B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP25184660.6A EP4596110A2 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP22201129.8A EP4147990B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0956278A FR2950036B1 (fr) 2009-09-11 2009-09-11 Dispositif de distribution de liquide
EP10768998.6A EP2475585B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide
PCT/FR2010/051877 WO2011030062A1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP10768998.6A Division EP2475585B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide
EP10768998.6A Division-Into EP2475585B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide

Related Child Applications (3)

Application Number Title Priority Date Filing Date
EP25184660.6A Division EP4596110A2 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP22201129.8A Division EP4147990B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP22201129.8A Division-Into EP4147990B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort

Publications (2)

Publication Number Publication Date
EP3090957A1 EP3090957A1 (fr) 2016-11-09
EP3090957B1 true EP3090957B1 (fr) 2023-08-09

Family

ID=42097280

Family Applications (5)

Application Number Title Priority Date Filing Date
EP16175337.1A Active EP3090957B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP22201129.8A Active EP4147990B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP10768998.6A Active EP2475585B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide
EP25184660.6A Pending EP4596110A2 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP16175332.2A Withdrawn EP3090956A1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une valve formant clapet

Family Applications After (4)

Application Number Title Priority Date Filing Date
EP22201129.8A Active EP4147990B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP10768998.6A Active EP2475585B1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide
EP25184660.6A Pending EP4596110A2 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort
EP16175332.2A Withdrawn EP3090956A1 (fr) 2009-09-11 2010-09-09 Dispositif de distribution de liquide comprenant une valve formant clapet

Country Status (10)

Country Link
US (1) US8863998B2 (enrdf_load_stackoverflow)
EP (5) EP3090957B1 (enrdf_load_stackoverflow)
JP (1) JP5739890B2 (enrdf_load_stackoverflow)
CN (1) CN102712395B (enrdf_load_stackoverflow)
BR (1) BR112012005428B1 (enrdf_load_stackoverflow)
ES (1) ES2961272T3 (enrdf_load_stackoverflow)
FR (1) FR2950036B1 (enrdf_load_stackoverflow)
IN (1) IN2012DN02150A (enrdf_load_stackoverflow)
PL (1) PL3090957T3 (enrdf_load_stackoverflow)
WO (1) WO2011030062A1 (enrdf_load_stackoverflow)

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FR2929249B1 (fr) 2008-03-27 2012-02-17 Rexam Pharma La Verpilliere Dispositif de distribution de liquide contenu dans un reservoir
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WO2016172712A2 (en) 2015-04-23 2016-10-27 Sydnexis, Inc. Ophthalmic composition
US11382909B2 (en) 2014-09-05 2022-07-12 Sydnexis, Inc. Ophthalmic composition
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JP2018510668A (ja) 2015-01-12 2018-04-19 ケダリオン セラピューティックス，インコーポレイテッド 微小液滴の繰り出し装置及び方法
EP3302426A4 (en) 2015-05-29 2018-12-05 Sydnexis, Inc. D2o stabilized pharmaceutical formulations
KR102550534B1 (ko) 2017-01-20 2023-07-03 노파르티스 아게 압전 유체 분배기
WO2018141350A1 (de) * 2017-02-01 2018-08-09 Silgan Dispensing Systems Hemer Gmbh Austragvorrichtung für ein flüssiges medium
JP7345452B2 (ja) 2017-08-30 2023-09-15 ノボ・ノルデイスク・エー／エス より少ない防腐剤を有する薬剤のための複数回使用薬剤送達装置
EP3675926B1 (en) 2017-08-30 2024-02-07 Novo Nordisk A/S Flow communication unit with preservative
CN111712219A (zh) 2017-12-08 2020-09-25 科达莱昂治疗公司 流体递送对准系统
US20190314197A1 (en) 2018-04-12 2019-10-17 Kedalion Therapeutics, Inc. Topical Ocular Delivery Methods and Devices for Use in the Same
US12350194B1 (en) 2018-04-12 2025-07-08 Bausch + Lomb Ireland Limited Topical ocular delivery of fluids with controlled mass dosing and wireless communication
CN112041003A (zh) 2018-04-13 2020-12-04 诺和诺德股份有限公司 具有未连接构造和连接构造的流动连通单元
FR3080844B1 (fr) * 2018-05-07 2020-06-05 Horus Pharma Dispositif de conditionnement et distribution d'un produit avec flacon et embout doseur muni d'un filtre
CN112334099A (zh) 2018-07-03 2021-02-05 科达莱昂治疗公司 局部眼部递送设备以及使用所述局部眼部递送设备的方法
US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
US12097145B2 (en) 2019-03-06 2024-09-24 Bausch + Lomb Ireland Limited Vented multi-dose ocular fluid delivery system
CN114245788A (zh) * 2019-08-15 2022-03-25 奥布里斯特封闭瑞士有限公司 封闭件
US12290472B2 (en) 2020-04-17 2025-05-06 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
US11938057B2 (en) 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
IL297215A (en) 2020-04-17 2022-12-01 Kedallon Therapeutics Inc Hydrodynamically actuated preservative free dispensing system
US12090087B2 (en) 2020-04-17 2024-09-17 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir
EP4212451B1 (de) 2020-10-02 2024-09-11 Aptar Radolfzell GmbH Tropfenspender
US11904330B2 (en) * 2022-02-28 2024-02-20 L'oreal Cosmetic dispenser with accordion bladder valve system

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US8863998B2 (en) 2014-10-21
FR2950036A1 (fr) 2011-03-18
US20120223106A1 (en) 2012-09-06
BR112012005428B1 (pt) 2019-07-09
EP4596110A2 (fr) 2025-08-06
EP4147990B1 (fr) 2025-06-25
EP3090956A1 (fr) 2016-11-09
EP3090957A1 (fr) 2016-11-09
CN102712395B (zh) 2015-02-11
ES2961272T3 (es) 2024-03-11
BR112012005428A2 (pt) 2016-04-12
JP2013504496A (ja) 2013-02-07
WO2011030062A1 (fr) 2011-03-17
EP2475585A1 (fr) 2012-07-18
JP5739890B2 (ja) 2015-06-24
IN2012DN02150A (enrdf_load_stackoverflow) 2015-08-07
PL3090957T3 (pl) 2024-01-03
FR2950036B1 (fr) 2011-12-16
EP2475585B1 (fr) 2018-01-17
CN102712395A (zh) 2012-10-03
EP4147990A1 (fr) 2023-03-15

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